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ATOH1 Antibody (H00000474-B01P) in WB
Western Blot analysis of ATOH1 expression in transfected 293T cell line (H00000474-T01) by ATOH1 MaxPab polyclonal antibody.
Lane 1: ATOH1 transfected lysate(38.94 KDa).
Lane 2: Non-transfected lysate.
Lane 1: ATOH1 transfected lysate(38.94 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00000474-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ATOH1 (NP_005163.1, 1 a.a. approximately 354 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MSRLLHAEEW AEVKELGDHH RQPQPHHLPQ PPPPPQPPAT LQAREHPVYP PELSLLDSTD PRAWLAPTLQ GICTARAAQY LLHSPELGAS EAAAPRDEVD GRGELVRRSS GGASSSKSPG PVKVREQLCK LKGGVVVDEL GCSRQRAPSS KQVNGVQKQR RLAANARERR RMHGLNHAFD QLRNVIPSFN NDKKLSKYET LQMAQIYINA LSELLQTPSG GEQPPPPPAS CKSDHHHLRT AASYEGGAGN ATAAGAQQAS GGSQRPTPPG SCRTRFSAPA SAGGYSVQLD ALHFSTFEDS ALTAMMAQKN LSPSLPGSIL QPVQEENSKT SPRSHRSDGE FSPHSHYSDS DEAS
Target Information
The Drosophila atonal gene produces a protein with basic helix loop helix (bHLH) domains that plays an essential role in the development of the Drosophila nervous system. Mammalian atonal homolog 1 (MATH-1) is a helix-loop-helix (HLH) transcription factor that is structurally homologous to the product of the Drosophila proneural gene atonal. MATH-1, so known as Atoh1, Ath1 or HATH-1, is a 351 amino acid protein with an atonal-related basic HLH domain. In mice, expression of MATH-1 takes place by embryonic day 9. 5 and initially localizes to the cranial ganglions and the dorsal part of the central nervous system. Prominent expression of MATH-1 is in the dorsal part of the central nervous system but becomes restricted to the external granular layer of the cerebellum by day 18 and is undetectable in the adult nervous system. It is suggested that MATH-1 may play a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Atonal bHLH transcription factor 1; atonal homolog 1; atonal homolog bHLH transcription factor 1; bHLHa14; Class A basic helix-loop-helix protein 14; H MATH-1; hATH1; Helix-loop-helix protein hATH-1; Protein atonal homolog 1; Transcription factor ATOH1
Gene Aliases: ATH1; ATOH1; BHLHA14; HATH1; MATH-1
UniProt ID: (Human) Q92858
Entrez Gene ID: (Human) 474
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
chromatin DNA binding
protein dimerization activity
basic helix-loop-helix transcription factor
neuron migration
transcription from RNA polymerase II promoter
Notch signaling pathway
axon guidance
central nervous system development
cerebral cortex development
inner ear morphogenesis
auditory receptor cell fate specification
auditory receptor cell fate determination
negative regulation of apoptotic process
positive regulation of auditory receptor cell differentiation
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
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