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Invitrogen
ATOH8 Polyclonal Antibody
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Application
FIGURE: 1 / 1
ATOH8 Antibody (PA5-95898) in WB
Western blot analysis of ATOH8 in extracts of various cell lines. Samples were incubated with ATOH8 Polyclonal antibody (Product # PA5-95898) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
Product Details
PA5-95898
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human ATOH8 (NP_1162162)
Conjugate
Unconjugated
Form
Liquid
Concentration
1.35 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2807700
Product Specific Information
Positive Samples: mouse brain, mouse kidney, rat brain rat kidney
Immunogen sequence: LRPRILLCAP PARPAPSAPP APPAPPESTV RPAPPTRPGE SSYSSISHVI YNNHQDSSAS PRKRPGEATA ASSEIKALQQ TRRLLANARE RTRVHTISAA F
Target Information
Basic helix-loop-helix (bHLH) transcription factors play important roles in differentiation processes during embryonic development of vertebrates. ATOH8 (MATH6) is a tissue-restricted member of the atonal superfamily of bHLH transcription factors that exhibits 43-57% identity in the bHLH domain with other mammalian atonal paralogs including the NeuroD and Neurogenin factors. In the mouse, ATOH8 has been implicated in the specification and differentiation of neuronal cell lineages in the brain and may also participate in kidney development. Recent studies show that ATOH8 is a novel component of the pancreatic transcriptional network during embryonic development and suggest a potential role as a modulator of the differentiation program initiated by the pro-endocrine factor Neurog3. It is indispensable for early embryonic development, suggesting a more widespread function for this factor in tissue-specific differentiation processes that are dependent on class II bHLH genes.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: basic helix-loop-helix transcription factor 6; Helix-loop-helix protein mATH-6; mATH6; Okadin; Protein atonal homolog 8; Transcription factor Atoh8
Gene Aliases: 4933425C05Rik; Ath6; Atoh8; bHLHa21; Hath6; Math6; okadin; RGD1561512
UniProt ID: (Mouse) Q99NA2
Entrez Gene ID: (Mouse) 71093, (Rat) 500200
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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