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Product Details
PA5-57323
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ATP11A. Recombinant protein control fragment (Product #RP-94971).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2638346
Product Specific Information
Immunogen sequence: SATGEIYLFC KGADSSIFPR VIEGKVDQIR ARVERNAVEG LRTLCVAYKR LIQEEYEGIC KLLQAAKVAL QDREKKLAEA YEQIEKDLTL LG
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.
Target Information
ATP11A is a widely expressed integral membrane ATPase. ATP11A is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium or other molecules across membranes. While the exact molecule ATP11A transports is unknown, increased expression of ATP11A mRNA has been observed in murine leukemia cells made resistant to anti-cancer drugs such as farnesyltransferase inhibitors (FTIs). Furthermore, overexpression of ATP11A provided protection against the FTI SCH66336 while knockdown of ATP11A via siRNA made cells more sensitive to this drug. Other reports suggest that elevated levels of ATP11A mRNA may also be a predictive marker of metastasis in colorectal cancer patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATPase class VI type 11A; ATPase IS; ATPase, class VI, type 11A; P4-ATPase flippase complex alpha subunit ATP11A; phospholipid-translocating ATPase; Phospholipid-transporting ATPase IH; potential phospholipid-transporting ATPase IH; RP11-120K24.1
Gene Aliases: ATP11A; ATPIH; ATPIS; KIAA1021
UniProt ID: (Human) P98196
Entrez Gene ID: (Human) 23250
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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