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Application
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ATP11C Antibody (PA5-109426) in WB
Western blot analysis of ATP11C in extracts of various cell lines. Samples were incubated with ATP11C Polyclonal antibody (Product # PA5-109426) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
Product Details
PA5-109426
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 430-650 of human ATP11C (NP_775965.2).
Conjugate
Unconjugated
Form
Liquid
Concentration
2.22 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2854837
Product Specific Information
Immunogen sequence: DGHKYKGVTQ EVDGLSQTDG TLTYFDKVDK NREELFLRAL CLCHTVEIKT NDAVDGATES AELTYISSSP DEIALVKGAK RYGFTFLGNR NGYMRVENQR KEIEEYELLH TLNFDAVRRR MSVIVKTQEG DILLFCKGAD SAVFPRVQNH EIELTKVHVE RNAMDGYRTL CVAFKEIAPD DYERINRQLI EAKMALQDRE EKMEKVFDDI ETNMNLIGAT A
Target Information
The ATP11C gene encodes a protein that belongs to the P4-ATPase family, specifically functioning as a phospholipid-transporting ATPase. ATP11C plays a critical role in the maintenance of phospholipid asymmetry across the cell membrane by transporting aminophospholipids from the outer leaflet to the inner leaflet of the plasma membrane. This activity is essential for various biological processes, including cell membrane integrity, cell signaling, and apoptosis. ATP11C is particularly important in hematopoiesis, influencing the development of B cells and red blood cells. Mutations or dysregulation in ATP11C can lead to disruptions in cell membrane dynamics and are associated with immunological disorders and anemia. Research on ATP11C continues to focus on its role in phospholipid transport and its implications for cellular function and disease, particularly in the context of blood-related disorders.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Atpase 11c, p type; ATPase class VI type 11C; ATPase IQ; ATPase, class VI, type 11C; P4-ATPase flippase complex alpha subunit ATP11C; Phospholipid-transporting ATPase 11C; Phospholipid-transporting ATPase IG; probable phospholipid-transporting ATPase 11C; probable phospholipid-transporting ATPase IG
Gene Aliases: A330005H02Rik; AI315324; ATP11C; ATPIG; ATPIQ; Ig
UniProt ID: (Human) Q8NB49, (Mouse) Q9QZW0
Entrez Gene ID: (Human) 286410, (Mouse) 320940
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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