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Proteintech

ATP1A1/2 Monoclonal Antibody (3D8G1)

Name: ATP1A1/2 Monoclonal Antibody (3D8G1)
Brand: Proteintech
SKU: 68505-1-IG
Price: 4242.39 BRL

Datasheet

Protocols

Questions & Answers

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Datasheet

Protocols

Questions & Answers

Tech Support

Antibody Testing Data (5)

Application

ATP1A1/2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 5

ATP1A1/2 Antibody (68505-1-IG) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed C2C12 cells using ATP1A1/2 antibody (68505-1-Ig, Clone: 3D8G1) at dilution of 1:1,000 and CoraLite®488-Conjugated Goat Anti-Mouse IgG (H+L) (SA00013-1).

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Product Details

68505-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:5,000-1:50,000

Immunocytochemistry (ICC/IF)

1:500-1:2,000

ELISA (ELISA)

Assay-dependent

Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

3D8G1

Immunogen

ATP1A1/2 fusion protein Ag10489

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: KRMARKNCLV KNLEAVETLG STSTICSDKT GTLTQNRMTV AHMWFDNQIH EADTTEDQSG ATFDKRSPTW TALSRIAGLC NRAVFKAGQE NISVSKRDTA GDASESALLK CIELSCGSVR KMRDRNPKVA EIPFNSTNKY QLSIHEREDS PQSHVLVMKG APERILDRCS TILVQGKEIP LDKEMQDAFQ NAYMELGGLG ERVLGFCQLN LPSGKFPRGF KFDTDELNFP TEKLCFVGLM SMIDPPRAAV PDAVGKCRSA GIKVIMVTGD HPITAKAIAK GVGIISEGNE TVEDIAARLN IPMSQVNPRE AKACVVHGSD LKDMTSEQLD EILKNHTEIV FARTSPQQKL IIVE

Target Information

ATP1A1/2 is the catalytic component of the active enzyme Na+/K+-ATPase, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. The Na+/K+-ATPase is composed of a larger catalytic alpha-subunit (~110 kDa) and a small beta-subunit (~55 kDa). The alpha subunit has four isoforms identified to date: alpha 1, alpha 2, alpha 3 and alpha 4.The alpha 1 isoform is expressed ubiquitously but the alpha 2 isoform is present largely in the skeletal muscle, heart and vascular smooth muscle. The alpha 3 isoform is found almost exclusively in neurons and ovaries. The alpha 4 isoform is expressed in sperm.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: (Na+, K+)-ATPase alpha-subunit; ATPase Na+/K+ transporting alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATPase, Na+/K+ transporting, alpha 2 polypeptide; ATPase, Na+K+ transporting, alpha 1; ATPase, Na+K+ transporting, alpha 2; Na(+)/K(+) ATPase alpha(+) subunit; Na(+)/K(+) ATPase alpha-1 subunit; Na(+)/K(+) ATPase alpha-2 subunit; Na+ ,K+ -ATPase alpha subunit; Na+ /K+ ATPase alpha 1 subunit; Na+, K+-ATPase beta-subunit precursor; Na+/K+ -ATPase alpha 2 subunit; Na+/K+ ATPase 1; Na+/K+ ATPase, alpha-A(+) catalytic polypeptide; Na+/K+ ATPase, alpha-B polypeptide; Na+/K+ transporting alpha 1 polypeptide; Na+/K+ transporting alpha 2 polypeptide; Na, K-ATPase, alpha-A catalytic polypeptide; Na,K-ATPase alpha 2 subunit; Na,K-ATPase alpha-1 subunit; Na,K-ATPase catalytic subunit alpha-A protein; Sodium pump subunit alpha-1; Sodium pump subunit alpha-2; sodium-potassium ATPase catalytic subunit alpha-1; sodium-potassium ATPase catalytic subunit alpha-2; sodium-potassium-ATPase, alpha 1 polypeptide; sodium/potassium-transporting ATPase alpha-2 chain; Sodium/potassium-transporting ATPase subunit alpha-1; Sodium/potassium-transporting ATPase subunit alpha-2; unnamed protein product

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Gene Aliases: ATP1A1; ATP1A2; Atpa-1; Atpa-3; AW060654; BC010319; FHM2; KIAA0778; MHP2; mKIAA0778; Nkaa1b; RATATPA2

UniProt ID: (Human) P05023, (Pig) P05024, (Human) P50993, (Pig) D2WKD8, (Rat) P06685, (Mouse) Q8VDN2, (Rat) P06686, (Mouse) Q6PIE5

Entrez Gene ID: (Human) 476, (Pig) 397481, (Human) 477, (Pig) 396828, (Rat) 24211, (Mouse) 11928, (Rat) 24212, (Mouse) 98660

Function(s)

sodium:potassium-exchanging ATPase activity protein binding ATP binding phosphatase activity protein kinase binding protein domain specific binding ankyrin binding potassium ion binding sodium ion binding ADP binding phosphatidylinositol 3-kinase binding chaperone binding steroid hormone binding ATPase binding drug binding ATPase activity nucleotide binding hydrolase activity metal ion binding cation-transporting ATPase activity primary active transporter transporter

Process(es)

regulation of the force of heart contraction regulation of sodium ion transport cellular sodium ion homeostasis regulation of blood pressure potassium ion import establishment or maintenance of transmembrane electrochemical gradient ATP hydrolysis coupled proton transport dephosphorylation cellular potassium ion homeostasis negative regulation of glucocorticoid biosynthetic process ion transmembrane transport sodium ion export from cell response to drug negative regulation of heart contraction positive regulation of heart contraction positive regulation of striated muscle contraction relaxation of cardiac muscle cardiac muscle contraction membrane hyperpolarization cellular response to mechanical stimulus cellular response to steroid hormone stimulus regulation of cardiac muscle cell contraction membrane repolarization membrane repolarization during cardiac muscle cell action potential cell communication by electrical coupling involved in cardiac conduction response to glycoside regulation of cardiac conduction potassium ion import across plasma membrane transmembrane transport neurotransmitter uptake regulation of respiratory gaseous exchange by neurological system process potassium ion transport sodium ion transport regulation of smooth muscle contraction regulation of striated muscle contraction adult locomotory behavior visual learning regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of vasoconstriction response to nicotine locomotion negative regulation of striated muscle contraction ATP metabolic process negative regulation of cytosolic calcium ion concentration regulation of glutamate uptake involved in transmission of nerve impulse regulation of synaptic transmission, glutamatergic membrane depolarization during cardiac muscle cell action potential negative regulation of calcium ion transmembrane transport negative regulation of calcium:sodium antiporter activity energy coupled proton transmembrane transport, against electrochemical gradient sodium ion transmembrane transport potassium ion transmembrane transport transport ion transport regulation of muscle contraction metabolic process regulation of cardiac muscle contraction by calcium ion signaling

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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