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Product Details
H00008313-M02
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
3B6
Immunogen
AXIN2 (NP_004646, 611 a.a. approximately 710 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: EEGDRSQDVW QWMLESERQS KPKPHSAQST KKAYPLESAR SSPGERASRH HLWGGNSGHP RTTPRAHLFT QDPAMPPLTP PNTLAQLEEA CRRLAEVSKP
Target Information
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Axil; Axin like protein; Axin-2; Axin-like protein; Axis inhibition protein 2; Conductin; DKFZp781B0869; MGC10366; MGC126582
Gene Aliases: AXIL; AXIN2; ODCRCS
UniProt ID: (Human) Q9Y2T1
Entrez Gene ID: (Human) 8313
positive regulation of protein phosphorylation
intramembranous ossification
secondary heart field specification
chondrocyte differentiation involved in endochondral bone morphogenesis
regulation of transcription, DNA-templated
cell proliferation
negative regulation of cell proliferation
dorsal/ventral axis specification
positive regulation of epithelial to mesenchymal transition
positive regulation of cell death
Wnt signaling pathway
bone mineralization
regulation of mismatch repair
cellular protein localization
negative regulation of catenin import into nucleus
odontogenesis
positive regulation of GTPase activity
maintenance of DNA repeat elements
negative regulation of osteoblast differentiation
mRNA stabilization
regulation of chondrocyte development
regulation of centromeric sister chromatid cohesion
cellular response to organic cyclic compound
negative regulation of canonical Wnt signaling pathway
Wnt signaling pathway involved in somitogenesis
positive regulation of canonical Wnt signaling pathway
beta-catenin-TCF complex assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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