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Product Details
PA5-101284
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ADCY5(Accession O95622), corresponding to amino acid residues Q867-S917.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2850723
Product Specific Information
Antibody detects endogenous levels of total ADCY5/6.
Target Information
Adenylate cyclase 5/6 encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A cyclase V; A cyclase VI; AC5; AC6; ACVI; adcy5; Adenylate cyclase type 5; Adenylate cyclase type 6; Adenylate cyclase type V; Adenylate cyclase type VI; Adenylyl cyclase 5; Adenylyl cyclase 6; adenylyl cyclase type V; ATP pyrophosphate-lyase 5; ATP pyrophosphate-lyase 6; Ca(2+)-inhibitable adenylyl cyclase
Gene Aliases: AC5; AC6; ACVI; ADCY5; ADCY6; ADCYB; AW121902; FDFM; KIAA0422; LCCS8; mKIAA0422
UniProt ID: (Human) O95622, (Human) O43306, (Rat) Q04400, (Mouse) P84309, (Rat) Q03343
Entrez Gene ID: (Human) 111, (Human) 112, (Rat) 64532, (Mouse) 224129, (Rat) 25289, (Mouse) 11512
adenylate cyclase activity
ATP binding
adenylate cyclase binding
metal ion binding
protein heterodimerization activity
receptor binding
protein binding
calcium- and calmodulin-responsive adenylate cyclase activity
protein kinase binding
nucleotide binding
lyase activity
phosphorus-oxygen lyase activity
scaffold protein binding
SNARE binding
adenosine receptor signaling pathway
cAMP biosynthetic process
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-activating dopamine receptor signaling pathway
adenylate cyclase-inhibiting dopamine receptor signaling pathway
locomotory behavior
negative regulation of neuron projection development
intracellular signal transduction
neuromuscular process controlling balance
dopamine receptor signaling pathway
cellular response to prostaglandin E stimulus
cellular response to catecholamine stimulus
maintenance of protein location in plasma membrane
renal water homeostasis
activation of adenylate cyclase activity
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
cAMP-mediated signaling
activation of protein kinase A activity
regulation of insulin secretion involved in cellular response to glucose stimulus
cellular response to glucagon stimulus
cellular response to forskolin
cyclic nucleotide biosynthetic process
negative regulation of urine volume
regulation of vasodilation
cellular response to vasopressin
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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