Product References
Bisdemethoxycurcumin, a curcumin, protects chondrocytes, and reduces cartilage inflammation via the NRF2/HO-1/NLRP3 pathway.
Immunity, inflammation and disease
Jin G,Xu W,Tang H,Cui Y,Zhang H
Published figure using Aggrecan Neo polyclonal antibody (Product # PA1-1746) in Western Blot
Thu Feb 01 00:00:00 UTC 2024
Synergetic enrichment of aggrecan in nucleus pulposus cells by scAAV6-shRNA-mediated knockdown of aggrecanase-1 and aggrecanase-2.
Experimental biology and medicine (Maywood, N.J.)
Mern DS,Thomé C
Published figure using Aggrecan Neo polyclonal antibody (Product # PA1-1746) in Western Blot
Sat Jul 01 00:00:00 UTC 2023
E7 Peptide Enables BMSC Adhesion and Promotes Chondrogenic Differentiation of BMSCs Via the LncRNA H19/miR675 Axis.
Bioengineering (Basel, Switzerland)
Shi W,Wu J,Pi Y,Yan X,Hu X,Cheng J,Yu H,Shao Z
PA1-1746 was used in Western Blotting to examine differentially expressed genes of BMSCs induced by E7 compared to RGD.
Fri Jun 30 00:00:00 UTC 2023
E7 Peptide Enables BMSC Adhesion and Promotes Chondrogenic Differentiation of BMSCs Via the LncRNA H19/miR675 Axis.
Bioengineering (Basel, Switzerland)
Shi W,Wu J,Pi Y,Yan X,Hu X,Cheng J,Yu H,Shao Z
PA1-1746 was used in Western Blotting to examine differentially expressed genes of BMSCs induced by E7 compared to RGD.
Fri Jun 30 00:00:00 UTC 2023
Maltol ameliorates intervertebral disc degeneration through inhibiting PI3K/AKT/NF-κB pathway and regulating NLRP3 inflammasome-mediated pyroptosis.
Inflammopharmacology
Gong Y,Qiu J,Jiang T,Li Z,Zhang W,Zheng X,He Z,Chen W,Wang Z,Feng X,Wang M,Hong Z
PA1-1746 was used in Western Blotting to suggest that MA slowed IDD development through the PI3K/AKT/NF-κB signaling pathway and NLRP3 inflammasome-mediated pyroptosis, indicating that MA appeared to be a viable medication for IDD treatment.
Wed Feb 01 00:00:00 UTC 2023
Maltol ameliorates intervertebral disc degeneration through inhibiting PI3K/AKT/NF-κB pathway and regulating NLRP3 inflammasome-mediated pyroptosis.
Inflammopharmacology
Gong Y,Qiu J,Jiang T,Li Z,Zhang W,Zheng X,He Z,Chen W,Wang Z,Feng X,Wang M,Hong Z
PA1-1746 was used in Western Blotting to suggest that MA slowed IDD development through the PI3K/AKT/NF-κB signaling pathway and NLRP3 inflammasome-mediated pyroptosis, indicating that MA appeared to be a viable medication for IDD treatment.
Wed Feb 01 00:00:00 UTC 2023
Paroxetine Attenuates Chondrocyte Pyroptosis and Inhibits Osteoclast Formation by Inhibiting NF-κB Pathway Activation to Delay Osteoarthritis Progression.
Drug design, development and therapy
Zheng X,Qiu J,Gao N,Jiang T,Li Z,Zhang W,Gong Y,Hong Z,Hong H
PA1-1746 was used in Immunohistochemistry to examine whether paroxetine can inhibit pyroptosis and reduce osteoclast formation, thereby delaying the destruction of knee joints.
Wed Aug 23 00:00:00 UTC 2023
Paroxetine Attenuates Chondrocyte Pyroptosis and Inhibits Osteoclast Formation by Inhibiting NF-κB Pathway Activation to Delay Osteoarthritis Progression.
Drug design, development and therapy
Zheng X,Qiu J,Gao N,Jiang T,Li Z,Zhang W,Gong Y,Hong Z,Hong H
PA1-1746 was used in Immunohistochemistry to examine whether paroxetine can inhibit pyroptosis and reduce osteoclast formation, thereby delaying the destruction of knee joints.
Wed Aug 23 00:00:00 UTC 2023
Role of Ciliary Protein Intraflagellar Transport Protein 88 in the Regulation of Cartilage Thickness and Osteoarthritis Development in Mice.
Arthritis & rheumatology (Hoboken, N.J.)
Coveney CR,Zhu L,Miotla-Zarebska J,Stott B,Parisi I,Batchelor V,Duarte C,Chang E,McSorley E,Vincent TL,Wann AKT
PA1-1746 was used in Immunohistochemistry to demonstrate that IFT88 is chondroprotective, regulating AC thickness, potentially by thresholding a Hh response to physiological loading that controls cartilage calcification.
Sat Jan 01 00:00:00 UTC 2022
Selumetinib - a potential small molecule inhibitor for osteoarthritis treatment.
Frontiers in pharmacology
Zheng X,Qiu J,Pan W,Gong Y,Zhang W,Jiang T,Chen L,Chen W,Hong Z
Published figure using Aggrecan Neo polyclonal antibody (Product # PA1-1746) in Western Blot
Sat Oct 15 00:00:00 UTC 2022
Secreted frizzled-related protein 3 was genetically and functionally associated with developmental dysplasia of the hip.
Aging
Xu R,Zhang F,Lu J,Wang K,Pan P,Sun Y,Zhang Y
Published figure using Aggrecan Neo polyclonal antibody (Product # PA1-1746) in Immunocytochemistry
Sun Apr 04 00:00:00 UTC 2021
Secreted frizzled-related protein 3 was genetically and functionally associated with developmental dysplasia of the hip.
Aging
Xu R,Zhang F,Lu J,Wang K,Pan P,Sun Y,Zhang Y
Published figure using Aggrecan Neo polyclonal antibody (Product # PA1-1746) in Immunocytochemistry
Sun Apr 04 00:00:00 UTC 2021
Platelet-Derived Growth Factor-BB Inhibits Intervertebral Disc Degeneration via Suppressing Pyroptosis and Activating the MAPK Signaling Pathway.
Frontiers in pharmacology
Zhang W,Gong Y,Zheng X,Qiu J,Jiang T,Chen L,Lu F,Wu X,Cheng F,Hong Z
PA1-1746 was used in Western Blot to indicate that PDGF-BB participates in inhibiting the occurrence and development of IDD by inhibiting pyroptosis and regulating the MAPK signaling pathway.
Tue Feb 01 00:00:00 UTC 2022
Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth.
eLife
Nandadasa S,Szafron JM,Pathak V,Murtada SI,Kraft CM,O'Donnell A,Norvik C,Hughes C,Caterson B,Domowicz MS,Schwartz NB,Tran-Lundmark K,Veigl M,Sedwick D,Philipson EH,Humphrey JD,Apte SS
PA1-1746 was used in Immunocytochemistry to analyse of umbilical cords from humans and other mammals identified differential arterial-venous proteoglycan dynamics as a determinant of these contrasting vascular responses.
Thu Sep 10 00:00:00 UTC 2020
Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth.
eLife
Nandadasa S,Szafron JM,Pathak V,Murtada SI,Kraft CM,O'Donnell A,Norvik C,Hughes C,Caterson B,Domowicz MS,Schwartz NB,Tran-Lundmark K,Veigl M,Sedwick D,Philipson EH,Humphrey JD,Apte SS
PA1-1746 was used in Immunocytochemistry to analyse of umbilical cords from humans and other mammals identified differential arterial-venous proteoglycan dynamics as a determinant of these contrasting vascular responses.
Thu Sep 10 00:00:00 UTC 2020
An in vitro and in vivo comparison of cartilage growth in chondrocyte-laden matrix metalloproteinase-sensitive poly(ethylene glycol) hydrogels with localized transforming growth factor β3.
Acta biomaterialia
Schneider MC,Chu S,Randolph MA,Bryant SJ
Published figure using Aggrecan Neo polyclonal antibody (Product # PA1-1746) in Immunocytochemistry
Mon Jul 15 00:00:00 UTC 2019
Glycoproteomic Analysis of the Aortic Extracellular Matrix in Marfan Patients.
Arteriosclerosis, thrombosis, and vascular biology
Yin 殷晓科 X,Wanga S,Fellows AL,Barallobre-Barreiro J,Lu R,Davaapil H,Franken R,Fava M,Baig F,Skroblin P,Xing Q,Koolbergen DR,Groenink M,Zwinderman AH,Balm R,de Vries CJM,Mulder BJM,Viner R,Jahangiri M,Reinhardt DP,Sinha S,de Waard V,Mayr M
PA1-1746 was used in Western Blotting to characterise the glycoproteome of the aortic extracellular matrix from patients with Marfan syndrome and relate it to aortopathy.
Sun Sep 01 00:00:00 UTC 2019
Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries.
Circulation
Suna G,Wojakowski W,Lynch M,Barallobre-Barreiro J,Yin X,Mayr U,Baig F,Lu R,Fava M,Hayward R,Molenaar C,White SJ,Roleder T,Milewski KP,Gasior P,Buszman PP,Buszman P,Jahangiri M,Shanahan CM,Hill J,Mayr M
Published figure using Aggrecan Neo polyclonal antibody (Product # PA1-1746) in Immunohistochemistry (Paraffin)
Tue Jan 09 00:00:00 UTC 2018
Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries.
Circulation
Suna G,Wojakowski W,Lynch M,Barallobre-Barreiro J,Yin X,Mayr U,Baig F,Lu R,Fava M,Hayward R,Molenaar C,White SJ,Roleder T,Milewski KP,Gasior P,Buszman PP,Buszman P,Jahangiri M,Shanahan CM,Hill J,Mayr M
Published figure using Aggrecan Neo polyclonal antibody (Product # PA1-1746) in Immunohistochemistry (Paraffin)
Tue Jan 09 00:00:00 UTC 2018
Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries.
Circulation
Suna G,Wojakowski W,Lynch M,Barallobre-Barreiro J,Yin X,Mayr U,Baig F,Lu R,Fava M,Hayward R,Molenaar C,White SJ,Roleder T,Milewski KP,Gasior P,Buszman PP,Buszman P,Jahangiri M,Shanahan CM,Hill J,Mayr M
Published figure using Aggrecan Neo polyclonal antibody (Product # PA1-1746) in Immunohistochemistry (Paraffin)
Tue Jan 09 00:00:00 UTC 2018
Suramin increases cartilage proteoglycan accumulation in vitro and protects against joint damage triggered by papain injection in mouse knees in vivo.
RMD open
Guns LA,Monteagudo S,Kvasnytsia M,Kerckhofs G,Vandooren J,Opdenakker G,Lories RJ,Cailotto F
Published figure using Aggrecan Neo polyclonal antibody (Product # PA1-1746) in Immunohistochemistry
Mon Mar 14 00:00:00 UTC 2022
Brief Report: JNK-2 Controls Aggrecan Degradation in Murine Articular Cartilage and the Development of Experimental Osteoarthritis.
Arthritis & rheumatology (Hoboken, N.J.)
Ismail HM,Miotla-Zarebska J,Troeberg L,Tang X,Stott B,Yamamoto K,Nagase H,Fosang AJ,Vincent TL,Saklatvala J
PA1-1746 was used in immunohistochemistry - paraffin section to analyze development of experimental osteoarthritis and aggrecan degradation in murine articular cartilage by JNK-2
Sun May 01 00:00:00 UTC 2016
Olive and grape seed extract prevents post-traumatic osteoarthritis damages and exhibits in vitro anti IL-1β activities before and after oral consumption.
Scientific reports
Mével E,Merceron C,Vinatier C,Krisa S,Richard T,Masson M,Lesoeur J,Hivernaud V,Gauthier O,Abadie J,Nourissat G,Houard X,Wittrant Y,Urban N,Beck L,Guicheux J
PA1-1746 was used in immunohistochemistry - paraffin section determine the effects of hydroxytyrosol and procyanidin treatment on osteoarthritis using rabbits
Mon Sep 19 00:00:00 UTC 2016
Transient anabolic effects accompany epidermal growth factor receptor signal activation in articular cartilage in vivo.
Arthritis research & therapy
Shepard JB,Jeong JW,Maihle NJ,O'Brien S,Dealy CN
PA1-1746 was used in immunohistochemistry to study EGFR-mediated anabolic signaling in articular cartilage using Mig6 conditional knockout mice
Fri Nov 14 00:00:00 UTC 2014
Interleukin-1alpha treatment of meniscal explants stimulates the production and release of aggrecanase-generated, GAG-substituted aggrecan products and also the release of pre-formed, aggrecanase-generated G1 and m-calpain-generated G1-G2.
Cell and tissue research
Lemke AK,Sandy JD,Voigt H,Dreier R,Lee JH,Grodzinsky AJ,Mentlein R,Fay J,Schünke M,Kurz B
PA1-1746 was used in Immunohistochemistry-immunofluorescence to conclude that aggrecanases are responsible for IL-1-stimulated GAG release from meniscal explants, and that IL-1 also stimulates release of G1-bearing products, by a process possibly involving hyaluronan fragmentation.
Thu Apr 01 00:00:00 UTC 2010
Transcription factor Nfat1 deficiency causes osteoarthritis through dysfunction of adult articular chondrocytes.
The Journal of pathology
Wang J,Gardner BM,Lu Q,Rodova M,Woodbury BG,Yost JG,Roby KF,Pinson DM,Tawfik O,Anderson HC
PA1-1746 was used in immunohistochemistry to study the role of transcription factor NFAT1 in osteoarthritis and its mechanism
Thu Oct 01 00:00:00 UTC 2009
Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivo.
The Biochemical journal
Sandy JD,Verscharen C
PA1-1746 was used in western blot to investigate the effect of ADAMTS activities and MMP-like activities on cartilage matrix
Sat Sep 15 00:00:00 UTC 2001
The intermediates of aggrecanase-dependent cleavage of aggrecan in rat chondrosarcoma cells treated with interleukin-1.
The Biochemical journal
Sandy JD,Thompson V,Doege K,Verscharen C
PA1-1746 was used in western blot to investigate the degradation products of aggrecan by aggrecanase in interleukin 1-treated rat chondrosarcoma cells
Sun Oct 01 00:00:00 UTC 2000
