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Immunogen sequence: EDCPKVDFPT AIGMVVERDD GSTLMEIDGD KGKQGGPTYY IDTNALRVPR ENMEAISPLK NGMVEDWDSF QAILDHTYKM HVKSEASLHP V
Positive Samples: HT-29, K-562, MCF7, BT-474, Mouse spleen, Mouse testis, Mouse ovary, Mouse thymus, Mouse heart; Cellular Location: Nucleus
BAF53A is a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.
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Protein Aliases: 53 kDa BRG1-associated factor A; actin-like 6; actin-like 6A; actin-like 6B; Actin-like protein 6A; actin-related protein 4; Actin-related protein Baf53a; ACTL6B; ArpNbeta; BAF complex 53 kDa subunit; BAF53; BAF53A; BRG1-associated factor 53A; BRG1/brm-associated factor 53A; hArpN alpha; hArpN beta; INO80 complex subunit K; MGC5382; MGC5382 Arp4
Gene Aliases: 2810432C06Rik; ACTL6; ACTL6A; AI851094; ARP4; ARPN-BETA; BAF53; BAF53A; C79802; INO80K; RGD1307747
UniProt ID: (Human) O96019, (Mouse) Q9Z2N8
Entrez Gene ID: (Human) 86, (Mouse) 56456, (Rat) 361925
Molecular Function: actin and actin related protein actin or actin-binding cytoskeletal protein cytoskeletal protein
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