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Peptide sequence: NRCVYSTTKA AVIGLTKSVA ADFIQQGIRC NCVCPGTVDT PSLQERIQAR
Sequence homology: Cow: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria. Also acts as a 3-hydroxybutyrate dehydrogenase (PubMed:16380372). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: (R)-beta-hydroxybutyrate dehydrogenase; 3-hydroxybutyrate dehydrogenase type 2; 4-oxo-L-proline reductase; dehydrogenase/reductase (SDR family) member 6; Dehydrogenase/reductase SDR family member 6; FLJ13261; Oxidoreductase UCPA; R-beta-hydroxybutyrate dehydrogenase; Short chain dehydrogenase/reductase family 15C member 1; short chain dehydrogenase/reductase family 15C, member 1
Gene Aliases: BDH2; DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR; UNQ6308; UNQ6308/PRO20933
UniProt ID: (Human) Q9BUT1
Entrez Gene ID: (Human) 56898
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