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FIGURE: 1 / 1
BTLA Antibody (PA5-86927) in WB
Western blot analysis of BTLA in Lane 1: HCT116 whole cell lysate (20 µg), Lane 2: L02 whole cell lysate (20 µg), Lane 3: C6 whole cell lysate (40 µg), Lane 4: CT26 whole cell lysate (40 µg). Sample was incubated with BTLA polyclonal antibody (Product # PA5-86927) using a 1:500 dilution.
Product Details
PA5-86927
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide, corresponding to amino acids 130-180 of Human BTLA.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2803685
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
BTLA or B and T-lymphocyte attenuator is a member of the co-inhibitory receptors of the CD28 superfamily. BTLA is a lymphocyte inhibitory receptor which inhibits lymphocytes during immunes responses. BTLA is constitutively expressed on most CD4+ and CD8+ T cells and its expression progressively decreases upon T cell activation. It remains expressed on Th1 cells, but not Th2 cells. BTLA is a unique co-receptor that interacts with the tumor necrosis factor receptor superfamily member herpesvirus entry mediator (HVEM). This interation is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B and T lymphocyte associated protein; B and T lymphocyte attenuator; B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; BTLA_HUMAN; CD272; CD272 antigen; FLJ16065; MGC129743
Gene Aliases: A630002H24; BTLA; BTLA1; CD272
UniProt ID: (Human) Q7Z6A9, (Rat) Q6PNM1, (Mouse) Q7TSA3
Entrez Gene ID: (Human) 151888, (Rat) 407756, (Mouse) 208154
immune system process
immune response-regulating cell surface receptor signaling pathway
cell surface receptor signaling pathway
negative regulation of B cell proliferation
negative regulation of T cell proliferation
negative regulation of alpha-beta T cell proliferation
adaptive immune response
T cell costimulation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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