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Bethyl Laboratories
Bcl11a Recombinant Rabbit Monoclonal Antibody (BLR151J)
FIGURE: 1 / 3
Bcl11a Antibody (A700-151) in WB
Detection of human Bcl11a by western blot. Samples: Whole cell lysate (10 µg) from Ramos, HEK293T, Jurkat, MOLT-4, and Raji cells prepared using NETN lysis buffer. Antibody: Rabbit anti-Bcl11a recombinant monoclonal antibody [BLR151J] (A700-151 lot 1) used at 1:1,000. Secondary: HRP-conjugated goat anti-rabbit IgG (A120-101P). Detection: Chemiluminescence with an exposure time of 3 minutes. Lower Panel: Rabbit anti-COPB2 antibody (A304-523A).
Product Details
A700-151
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
BLR151J
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
purified
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-cell CLL/lymphoma 11A; B-cell CLL/lymphoma 11A (zinc finger protein); B-cell CLL/lymphoma 11A (zinc finger protein) isoform 2; B-cell lymphoma/leukemia 11A; BCL-11A; BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) isoform 1; C2H2-type zinc finger protein; COUP-TF interacting protein 1; COUP-TF-interacting protein 1; ecotropic viral integration site 9 homolog; Ecotropic viral integration site 9 protein; Ecotropic viral integration site 9 protein homolog; EVI-9; FLJ10173; FLJ34997; myeloid leukemia; Zinc finger protein 856
Gene Aliases: 2810047E18Rik; BCL-11A; BCL11A; BCL11A-L; BCL11a-M; BCL11A-S; BCL11A-XL; CTIP1; D930021L15Rik; EVI9; Evi9a; Evi9b; Evi9c; HBFQTL5; KIAA1809; mKIAA1809; ZNF856
UniProt ID: (Human) Q9H165, (Mouse) Q9QYE3
Entrez Gene ID: (Human) 53335, (Mouse) 14025
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
metal ion binding
nucleic acid binding
transcription corepressor activity
protein binding
protein heterodimerization activity
DNA-binding transcription factor
zinc finger transcription factor
C2H2 zinc finger transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
signal transduction
protein sumoylation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
negative regulation of gene expression
positive regulation of neuron projection development
negative regulation of neuron projection development
B cell differentiation
T cell differentiation
negative regulation of collateral sprouting
positive regulation of collateral sprouting
regulation of dendrite development
negative regulation of nucleic acid-templated transcription
negative regulation of dendrite development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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