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A 1:1,000 dilution of PA5-77774 was sufficient for detection of Beclin2 on rat liver lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.|Predicted molecular weight at approximately 48.1kDa. Observed bands in the 50-55kDa range, varied by lysates.
Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Bcl-2; BCS2; beclin 1, autophagy related, pseudogene 1; Beclin-1 autophagy-related pseudogene 1; Beclin-1-like protein 1; Beclin-2; PFM 2; PFM2; PRDM 5; PRDM5; PRDM5 protein; similar to Beclin 1 (Coiled-coil myosin-like BCL2-interacting protein)
Gene Aliases: BECN1L1; BECN1P1; BECN2
UniProt ID: (Human) A8MW95
Entrez Gene ID: (Human) 441925, (Rat) 289269
Molecular Function:
protease inhibitor
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