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Alomone Labs, LTD
Bombesin Receptor 3 (extracellular) Polyclonal Antibody
Application
FIGURE: 1 / 5
Bombesin Receptor 3 (extracellular) Antibody (ABR-003-200UL) in IHC (P)
Expression of BRS3 in rat testes - Immunohistochemical staining of paraffin embeddedrat testes section using Anti-Bombesin Receptor 3 (extracellular) Antibody (#ABR-003), (1:50). The area of the efferent ductules nearthe epididymis is shown. Intense stain (brown) is specific for the pseudostratified epithelium of the efferent ductules. DAB is used for the color reaction. H&E is used as the counterstain.
Product Details
ABR-003-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)SNVYTFRDPNKNMTFE, corresponding to amino acid residues 186-201 of human BRS3, 2nd extracellular loop
Conjugate
Unconjugated
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
BRS3 expression has been reported in lung (normal and cancer), nasal mucosa, placenta, and uterus. ESTs have been isolated from normal brain and kidney cancer libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bombesin like receptor 3; Bombesin receptor subtype-3; bombesin-like receptor 3; BRS 3; BRS-3; G-protein coupled receptor; RP1-196E23.3
Gene Aliases: BB3; BB3R; BRS-3; BRS3
UniProt ID: (Human) P32247, (Mouse) O54798, (Rat) Q8K418
Entrez Gene ID: (Human) 680, (Mouse) 12209, (Rat) 260319
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