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Fabgennix
Bone marrow stromal cell antigen 1 Polyclonal Antibody
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Application
FIGURE: 1 / 1
Bone marrow stromal cell antigen 1 Antibody (BST1-101AP) in WB
WB of BST1-101AP with BB cells on 10% SDS gel. 1:250 antibody dilution in DiluObuffer for 1 hour at room temperature. Apparent MW is 39 kDa. W, B of BST1-101AP with 1) Chondrocytes and 2) SKNMC cells. 1:500 antibody dilution in DiluObuffer. Apparent MW is 37 kDa.
Product Details
BST1-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 255-274 of Human Bone marrow stromal cell antigen 1. Peptide was covalently modified.Sequence:FQY SCI NDY RPV KLL QCV DH
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
CD157, also known as Bone Marrow Stromal Cell Antigen 1 (BST1), is a pleiotropic ectoenzyme and glycosylphosphatidylinositol-anchored molecule that functions both as an enzyme and a receptor. Similar to CD38, CD157 is involved in the metabolism of NAD+, which may play a role in regulating intracellular Ca2+ levels. As an enzyme, CD157 is also referred to as ADP-ribosyl cyclase 2 and DAMP-1, and it facilitates pre-B cell growth. As a receptor, CD157 is thought to initiate a signal transduction cascade upon binding to its putative ligand, leading to the phosphorylation of cytoplasmic proteins, including focal adhesion kinase (FAK). While the mechanism and functional significance of CD157-initiated signal transduction are not fully characterized, its role in cellular signaling is evident. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis, suggesting a link to polyclonal B cell abnormalities observed in the disease. This overexpression in the stromal cell population may contribute to the pathophysiology of rheumatoid arthritis, highlighting the importance of CD157/BST1 in both normal immune function and disease states.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADP-ribosyl cyclase 2; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; Antigen BP3; Bone marrow stromal antigen 1; Bone marrow stromal cell antigen 1; BP-3 alloantigen; BST-1; cADPR hydrolase 2; CD157; CD157 antigen; Cyclic ADP-ribose hydrolase 2; Leukocyte antigen 65; Ly-65; NAD(+) nucleosidase; NAD+ nucleosidase
Gene Aliases: 114/A10; A530073F09; BP-3; Bp3; BST1; Bsta1; CD157; Ly65
UniProt ID: (Human) Q10588, (Rat) Q63072, (Mouse) Q64277
Entrez Gene ID: (Human) 683, (Rat) 81506, (Mouse) 12182
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