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Bioss
C5b-9 Polyclonal Antibody
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Application
FIGURE: 1 / 2
C5b-9 Antibody (BS-2673R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded rat liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with C5b-9 Polyclonal Antibody, Unconjugated (bs-2673R) at 1:500 overnight at 4°C, followed by a conjugated secondary for 20 minutes and DAB ... View More
Product Details
BS-2673R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Purified Human SC5b-9 Complex.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The complement system is a fundamental part of innate immunity, consisting of over 45 genes that encode various complement components, regulators, and receptors. The complement C5b-9 complex, also known as the Membrane Attack Complex (MAC), plays a crucial role in the immune defense mechanism. It includes the sequential assembly of proteins C5b, C6, C7, C8, and multiple copies of C9. This complex forms transmembrane channels that puncture the cell membrane of target cells, leading to cell lysis. Specifically, MAC has significant implications in mediating cell death in both pathogenic organisms and cancer cells. The genes involved are clustered across the human genome, mainly organized in three significant loci. The understanding of the C5b-9 complex's function extends beyond its antimicrobial roles to include its interactions with tumor cells, where it can induce cell death and influence cancer progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: anaphylatoxin; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; C5a anaphylatoxin; C5b-9; Complement C5; Complement component C6; Complement component C7; Complement component C9; MAC Complex; Membrane Attack Complex; prepro-C5
Gene Aliases: A530026G17; ARMD15; AW111623; C5; C5a; C5b; C5D; C6; C7; C9; C9D; CPAMD4; ECLZB; Gm1238; Hc; RGD1561905
UniProt ID: (Human) P01031, (Human) P13671, (Rat) Q811M5, (Human) P10643, (Human) P02748, (Mouse) P06683, (Rat) Q62930
Entrez Gene ID: (Human) 727, (Rat) 362119, (Human) 729, (Mouse) 12274, (Rat) 24237, (Rat) 117517, (Human) 730, (Mouse) 109828, (Human) 735, (Mouse) 12279, (Rat) 117512
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