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Bioss
CA13 Polyclonal Antibody
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Product Details
BS-7981R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human CA13, amino acids 131-220.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Carbonic anhydrase XII (CA XII), encoded by the CA12 gene, is one of the enzyme isoforms in the carbonic anhydrase family that catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons. CA XII is a transmembrane protein expressed in various tissues, including the kidneys, intestines, and lungs, playing crucial roles in maintaining acid-base balance, pH regulation, and electrolyte transport. Its activity is significant in organs where fluid secretion and absorption are essential processes, impacting functions such as respiration and renal bicarbonate reabsorption. CA XII is involved in physiological processes like cell proliferation and differentiation by modulating the extracellular and intracellular pH, influencing tumor microenvironment dynamics. Aberrant expression of CA XII has been noted in several cancers, including breast and colorectal cancers, where it supports tumor growth and metastasis by maintaining the acid-base homeostasis conducive to cancer cell survival. Due to its surface expression and role in maintaining pH balance, CA XII is a target of interest for therapeutic interventions aiming to disrupt tumor progression and enhance the efficacy of cancer treatments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CA-XIII; Carbonate dehydratase XIII; Carbonic anhydrase 13; Carbonic anhydrase XIII
Gene Aliases: 2310075C21Rik; CA13; Car13; CAXIII; RGD1560453
UniProt ID: (Human) Q8N1Q1, (Mouse) Q9D6N1
Entrez Gene ID: (Human) 377677, (Mouse) 71934, (Rat) 499566
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