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            • Primary Antibodies ›
            • CBS Antibodies

            Invitrogen

            CBS Monoclonal Antibody (GT519)

            Advanced Verification
            2 Published Figures
            3 References
            View all (21) CBS antibodies
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            Datasheet
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            Cite CBS Monoclonal Antibody (GT519)

            • Antibody Testing Data (8)
            • Published Figures (2)
            • Advanced Verification (1)
            Application
            CBS Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            Group 53 Created with Sketch.

            FIGURE: 1 / 11

            CBS Antibody (MA5-17273) in IHC (P)

            Immunohistochemistry (Paraffin) analysis of CBS was performed in paraffin-embedded mouse kidney tissue using CBS Monoclonal Antibody (GT519) (Product # MA5-17273) at a dilution of 1:250.
            View Product

            CBS Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            CBS Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            CBS Antibody in Western Blot (WB)
            CBS Antibody in Western Blot (WB)
            CBS Antibody in Western Blot (WB)
            CBS Antibody in Western Blot (WB)
            CBS Antibody in Western Blot (WB)
            CBS Antibody in Western Blot (WB)
            CBS Antibody in Western Blot (WB)
            CBS Antibody in Western Blot (WB)
            CBS Antibody

            Product Details

            MA5-17273

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            1:500-1:3,000
            View 3 publications 3 publications

            Immunohistochemistry (Paraffin) (IHC (P))

            1:100-1:1,000
            -
            Product Specifications

            Species Reactivity

            Human, Mouse, Rat

            Published species

            Human, Mouse, Rat

            Host/Isotype

            Mouse / IgG1

            Class

            Monoclonal

            Type

            Antibody

            Clone

            GT519

            Immunogen

            Recombinant protein encompassing a sequence within the center region of human CBS. The exact sequence is proprietary.

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            0.97 mg/mL

            Purification

            Protein G

            Storage buffer

            PBS

            Contains

            no preservative

            Storage conditions

            Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            RRID

            AB_2538739

            Product Specific Information

            Recommended positive controls: HeLa, 293T, Raji, K562, mouse liver, rat liver.

            Predicted reactivity: Mouse (94%), Rat (94%), Xenopus laevis (93%), Rabbit (95%), Bovine (94%).

            Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

            Target Information

            Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            Bioinformatics

            Protein Aliases: Beta-thionase; Cystathionine beta-synthase; cystathionine-beta-synthase; Hemoprotein H-450; methylcysteine synthase; Serine sulfhydrase

            View more View less

            Gene Aliases: AI047524; AI303044; CBS; HIP4

            View more View less

            UniProt ID: (Human) P35520, (Rat) P32232, (Mouse) Q91WT9

            View more View less

            Entrez Gene ID: (Human) 875, (Rat) 24250, (Mouse) 12411

            View more View less

            Function(s)

            cystathionine beta-synthase activity cysteine synthase activity protein binding oxygen binding enzyme binding heme binding pyridoxal phosphate binding ubiquitin protein ligase binding identical protein binding protein homodimerization activity metal ion binding nitrite reductase (NO-forming) activity carbon monoxide binding nitric oxide binding modified amino acid binding S-adenosyl-L-methionine binding lyase activity lyase metabolite interconversion enzyme

            Process(es)

            cysteine biosynthetic process from serine L-serine metabolic process L-serine catabolic process cellular amino acid biosynthetic process cysteine biosynthetic process via cystathionine cysteine biosynthetic process transsulfuration L-cysteine catabolic process DNA protection homocysteine catabolic process homocysteine metabolic process oxidation-reduction process hydrogen sulfide biosynthetic process endochondral ossification blood vessel remodeling superoxide metabolic process cerebellum morphogenesis regulation of cGMP metabolic process response to nutrient levels negative regulation of apoptotic process regulation of JUN kinase activity regulation of blood vessel size response to folic acid maternal process involved in female pregnancy cartilage development involved in endochondral bone morphogenesis cellular response to hypoxia
            It has to be done as per old AB suggested Products section.
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            Performance Guarantee

            If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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