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Invitrogen
CCL23 Polyclonal Antibody
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Application
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CCL23 Antibody (PA5-46958) in Neu
Neutralization of CCL23 in BaF3 mouse pro‚B cell line transfected with human CCR1. Samples were incubated in CCL23 polyclonal antibody (Product # PA5-46958). Recombinant Human CCL23/MPIF‚1 chemoattracts the BaF3 mouse pro‚B cell line transfected with human CCR1 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin. Chemotaxis elicited by Recombinant Human CCL23/MPIF‚1 (0.04 µg/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Hum... View More
Product Details
PA5-46958
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human CCL23/Ck beta 8-1 Met46-Asn137
Conjugate
Unconjugated
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2608480
Product Specific Information
In direct ELISAs and Western blots, approximately 20% cross-reactivity with recombinant human MPIF-1 is observed. This antibody neutralizes the biological activity of human CCL23/Ck beta 8-1. This antibody will also neutralize the biological activity of recombinant human MPIF-1 at a 10-fold higher Ig concentration.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.20 EU per 1 µg of the antibody by the LAL method.
Target Information
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-C motif chemokine 23; C6 beta-chemokine; chemokine (C-C motif) ligand 23; Ck beta 8-1; CK-beta-8; CKB-8; Macrophage inflammatory protein 3; MIP-3; MIP-3CK-BETA-8; MPIF-1; MPIF-1Ckb-8-1; Myeloid progenitor inhibitory factor 1; small inducible cytokine subfamily A (Cys-Cys), member 23; Small-inducible cytokine A23
Gene Aliases: CCL23; CK-BETA-8; Ckb-8; Ckb-8-1; CKb8; hmrp-2a; MIP-3; MIP3; MPIF-1; MPIF1; SCYA23
UniProt ID: (Human) P55773
Entrez Gene ID: (Human) 6368
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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