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            • Primary Antibodies ›
            • CCL23 Antibodies

            Invitrogen

            CCL23 Polyclonal Antibody

            Advanced Verification
            View all (16) CCL23 antibodies

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            Datasheet
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            Catalog # PA5-46958
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            100 µg
             
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            Cite CCL23 Polyclonal Antibody

            • Antibody Testing Data (1)
            • Advanced Verification (1)
            Application
            CCL23 Antibody in Neutralization (Neu)
            Group 53 Created with Sketch.

            FIGURE: 1 / 2

            CCL23 Antibody (PA5-46958) in Neu

            Neutralization of CCL23 in BaF3 mouse pro‚B cell line transfected with human CCR1. Samples were incubated in CCL23 polyclonal antibody (Product # PA5-46958). Recombinant Human CCL23/MPIF‚1 chemoattracts the BaF3 mouse pro‚B cell line transfected with human CCR1 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin. Chemotaxis elicited by Recombinant Human CCL23/MPIF‚1 (0.04 µg/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Hum... View More
            View Product

            CCL23 Antibody in Neutralization (Neu)
            CCL23 Antibody

            Product Details

            PA5-46958

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            0.1 µg/mL
            -

            Neutralization (Neu)

            0.15-0.75 µg/mL
            -
            Product Specifications

            Species Reactivity

            Human

            Host/Isotype

            Goat / IgG

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            E. coli-derived recombinant human CCL23/Ck beta 8-1 Met46-Asn137
            View immunogen

            Conjugate

            Unconjugated

            Form

            Lyophilized

            Concentration

            0.2 mg/mL

            Purification

            Antigen affinity chromatography

            Storage buffer

            PBS, pH 7.4, with 5% trehalose

            Contains

            No Preservative

            Storage conditions

            -20°C, Avoid Freeze/Thaw Cycles

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            RRID

            AB_2608480

            Product Specific Information

            In direct ELISAs and Western blots, approximately 20% cross-reactivity with recombinant human MPIF-1 is observed. This antibody neutralizes the biological activity of human CCL23/Ck beta 8-1. This antibody will also neutralize the biological activity of recombinant human MPIF-1 at a 10-fold higher Ig concentration.

            Reconstitute at 0.2 mg/mL in sterile PBS.

            Endoxin level is <0.20 EU per 1 µg of the antibody by the LAL method.

            Target Information

            This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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            Cite this product

            Bioinformatics

            Protein Aliases: C-C motif chemokine 23; C6 beta-chemokine; chemokine (C-C motif) ligand 23; Ck beta 8-1; CK-beta-8; CKB-8; Macrophage inflammatory protein 3; MIP-3; MIP-3CK-BETA-8; MPIF-1; MPIF-1Ckb-8-1; Myeloid progenitor inhibitory factor 1; small inducible cytokine subfamily A (Cys-Cys), member 23; Small-inducible cytokine A23

            View more View less

            Gene Aliases: CCL23; CK-BETA-8; Ckb-8; Ckb-8-1; CKb8; hmrp-2a; MIP-3; MIP3; MPIF-1; MPIF1; SCYA23

            View more View less

            UniProt ID: (Human) P55773

            View more View less

            Entrez Gene ID: (Human) 6368

            View more View less

            Function(s)

            chemokine activity heparin binding CCR1 chemokine receptor binding cytokine intercellular signal molecule

            Process(es)

            monocyte chemotaxis cellular calcium ion homeostasis chemotaxis inflammatory response immune response signal transduction G-protein coupled receptor signaling pathway cell-cell signaling negative regulation of cell proliferation neutrophil chemotaxis positive regulation of GTPase activity lymphocyte chemotaxis positive regulation of inflammatory response chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor negative regulation of C-C chemokine binding
            It has to be done as per old AB suggested Products section.
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