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In direct ELISAs and Western blots, approximately 20% cross-reactivity with recombinant human MPIF-1 is observed. This antibody neutralizes the biological activity of human CCL23/Ck beta 8-1. This antibody will also neutralize the biological activity of recombinant human MPIF-1 at a 10-fold higher Ig concentration.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.20 EU per 1 µg of the antibody by the LAL method.
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C-C motif chemokine 23; C6 beta-chemokine; chemokine (C-C motif) ligand 23; Ck beta 8-1; CK-beta-8; CKB-8; Macrophage inflammatory protein 3; MIP-3; MIP-3CK-BETA-8; MPIF-1; MPIF-1Ckb-8-1; Myeloid progenitor inhibitory factor 1; small inducible cytokine subfamily A (Cys-Cys), member 23; Small-inducible cytokine A23
Gene Aliases: CCL23; CK-BETA-8; Ckb-8; Ckb-8-1; CKb8; hmrp-2a; MIP-3; MIP3; MPIF-1; MPIF1; SCYA23
UniProt ID: (Human) P55773
Entrez Gene ID: (Human) 6368
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