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Invitrogen

CCR1 Polyclonal Antibody

Name: CCR1 Polyclonal Antibody
Brand: Invitrogen
SKU: PA141062
Price: 498.0 USD

4 Published Figures

8 References

View all (23) CCR1 antibodies

Datasheet

Protocols

Questions & Answers

Catalog # PA1-41062

Price (USD)

498.00

100 µg

Estimated availability date: 10-Jul-2025

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Datasheet

Protocols

Questions & Answers

Antibody Testing Data (3)
Published Figures (4)

Application

CCR1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 7

CCR1 Antibody (PA1-41062) in IHC (P)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded normal human spleen tissue stained with a CD191/CCR1 polyclonal antibody (Product # PA1-41062) (5 µg/mL), peroxidase-conjugate and DAB chromogen. Note granulocyte staining.

CCR1 Antibody in Western Blot, Immunohistochemistry (WB, IHC)

Product Image Gallery

Product Details

PA1-41062

Applications

Tested Dilution

Publications

Western Blot (WB)

1-3 µg/mL

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

5 µg/mL

Immunocytochemistry (ICC/IF)

Assay-Dependent

View 1 publication 1 publication

Flow Cytometry (Flow)

5-10 µL/test

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to human CCR1.

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2074018

Product Specific Information

Suggested positive control: A375, antigen standard for CCR1 (transient overexpression lysate).

Target Information

Chemokines play important roles in inflammation and are critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1 ), eotaxin, as well as several other related chemokines. Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CD276-dependent efferocytosis by tumor-associated macrophages promotes immune evasion in bladder cancer.

Nature communications

Cheng M,Chen S,Li K,Wang G,Xiong G,Ling R,Zhang C,Zhang Z,Han H,Chen Z,Wang X,Liang Y,Tian G,Zhou R,Zhu Y,Ma J,Liu J,Lin S,Xu H,Chen D,Li Y,Peng L

Published figure using CCR1 polyclonal antibody (Product # PA1-41062) in Western Blot

Mon Apr 01 00:00:00 UTC 2024

Novel Findings on CCR1 Receptor in CNS Disorders: A Pathogenic Marker Useful in Controlling Neuroimmune and Neuroinflammatory Mechanisms in Parkinson's Disease.

International journal of molecular sciences

Repici A,Capra AP,Hasan A,Bulzomì M,Campolo M,Paterniti I,Esposito E,Ardizzone A

Published figure using CCR1 polyclonal antibody (Product # PA1-41062) in Western Blot

Sun Apr 14 00:00:00 UTC 2024

Met-RANTES preserves the blood-brain barrier through inhibiting CCR1/SRC/Rac1 pathway after intracerebral hemorrhage in mice.

Fluids and barriers of the CNS

Yan J,Xu W,Lenahan C,Huang L,Ocak U,Wen J,Li G,He W,Le C,Zhang JH,Mo L,Tang J

Published figure using CCR1 polyclonal antibody (Product # PA1-41062) in Immunohistochemistry

Fri Jan 21 00:00:00 UTC 2022

Met-RANTES preserves the blood-brain barrier through inhibiting CCR1/SRC/Rac1 pathway after intracerebral hemorrhage in mice.

Fluids and barriers of the CNS

Yan J,Xu W,Lenahan C,Huang L,Ocak U,Wen J,Li G,He W,Le C,Zhang JH,Mo L,Tang J

Published figure using CCR1 polyclonal antibody (Product # PA1-41062) in Immunohistochemistry

Fri Jan 21 00:00:00 UTC 2022

Activation of the Chemokine Receptor CCR1 and Preferential Recruitment of Gαi Suppress RSV Replication: Implications for Developing Novel Respiratory Syncytial Virus Treatment Strategies.

Journal of virology

Li J,Xue L,Wang J,Meng A,Qiao J,Li M,Wang X,Meng L,Ning J,Gao X,Li W,Ma C,Wei L

PA1-41062 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to provide a new target for the development of co-antiviral inhibitors against other components of the host and co-molecular chaperone/HSP90 and provides a scientific basis for the search for effective broad-spectrum antiviral drugs.

Wed Nov 23 00:00:00 UTC 2022

CCR1 Activation Promotes Neuroinflammation Through CCR1/TPR1/ERK1/2 Signaling Pathway After Intracerebral Hemorrhage in Mice.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Yan J,Zuo G,Sherchan P,Huang L,Ocak U,Xu W,Travis ZD,Wang W,Zhang JH,Tang J

PA1-41062 was used in Western Blotting to investigate the activation of CCR1 on neuroinflammation in a mouse model of intracerebral hemorrhage (ICH) and the mechanism of CCR1/tetratricopeptide repeat 1 (TPR1)/extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway in CCR1-mediated neuroinflammation.

Wed Jul 01 00:00:00 UTC 2020

Tumor-associated neutrophils suppress antitumor immunity of NK cells through the PD-L1/PD-1 axis.

Translational oncology

Sun R,Xiong Y,Liu H,Gao C,Su L,Weng J,Yuan X,Zhang D,Feng J

PA1-41062 was used in Flow cytometry/Cell sorting to demonstrate that neutrophils can suppress the antitumor immunity of NK cells in tumor-bearing status through the PD-L1/PD-1 axis.

Thu Oct 01 00:00:00 UTC 2020

Tumor-associated neutrophils suppress antitumor immunity of NK cells through the PD-L1/PD-1 axis.

Translational oncology

Sun R,Xiong Y,Liu H,Gao C,Su L,Weng J,Yuan X,Zhang D,Feng J

PA1-41062 was used in Flow cytometry/Cell sorting to demonstrate that neutrophils can suppress the antitumor immunity of NK cells in tumor-bearing status through the PD-L1/PD-1 axis.

Thu Oct 01 00:00:00 UTC 2020

Crosstalk between CCL7 and CCR3 promotes metastasis of colon cancer cells via ERK-JNK signaling pathways.

Oncotarget

Lee YS,Kim SY,Song SJ,Hong HK,Lee Y,Oh BY,Lee WY,Cho YB

PA141062 was used in flow cytometry to study the contribution of CCL7-induced epithelial-mesenchymal transition signaling to the progression and metastasis of colon cancer

Tue Jun 14 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CD191; chemokine (C-C motif) receptor 1; chemokine (C-C) receptor 1; HM145; LD78 receptor; Macrophage inflammatory protein 1-alpha receptor; MIP-1 alpha R; MIP-1 alphaR; MIP-1alpha-R; RANTES receptor; RANTES-R

Gene Aliases: CCR1; CD191; CKR-1; CKR1; CMKBR1; CMKR1; HM145; Mip-1a-R; MIP1aR; SCYAR1

UniProt ID: (Human) P32246, (Mouse) P51675

Entrez Gene ID: (Human) 1230, (Mouse) 12768

Function(s)

phosphatidylinositol phospholipase C activity chemokine receptor activity protein binding C-C chemokine receptor activity C-C chemokine binding chemokine (C-C motif) ligand 7 binding chemokine (C-C motif) ligand 5 binding signal transducer activity G-protein coupled receptor activity

Process(es)

calcium ion transport cellular calcium ion homeostasis exocytosis chemotaxis inflammatory response immune response signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cell-cell signaling metabolic process negative regulation of gene expression myeloid cell differentiation positive regulation of cell migration negative regulation of bone mineralization leukocyte chemotaxis positive regulation of osteoclast differentiation negative regulation of innate immune response positive regulation of calcium ion transport chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade positive regulation of monocyte chemotaxis dendritic cell chemotaxis cell adhesion cell surface receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger response to wounding cytokine-mediated signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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