Save up to 31% on select cell culture essentials

Bundle and save

Hamburger Menu Button
Thermo Fisher Scientific Logo
Sign in
Don't have an account ? Create Account
  • Products
    • Antibodies
    • Cell Culture Media
    • Chemicals
    • Chromatography Columns and Cartridges
    • Lab Equipment
    • Lab Plasticware and Supplies
    • Microplates
    • Oligos, Primers, Probes and Genes
    • TaqMan Real-Time PCR Assays
    • Greener Products
    • See all product categories
  • Applications
    • Bioprocessing
    • Cell Culture and Transfection
    • Cell and Gene Therapy
    • Chromatography
    • Molecular Testing
    • Digital Solutions
    • DNA and RNA Extraction and Analysis
    • Spectroscopy, Elemental and Isotope Analysis
    • See all applications and techniques
  • Services
    • 360° CDMO and CRO Solutions
    • CDMO Services
    • CRO Services
    • Custom Services
    • Enterprise Services
    • Financial and Leasing Services
    • Instrument Services
    • Lab Informatics
    • OEM and Commercial Supply
    • Training Services
    • Unity Lab Services
    • See all services
  • Help and Support
    • How to Order
    • Instrument Support
    • Learning Centers
    • Register for an Account
    • Technical Support Centers
    • See all help and support topics
  • Popular
    • TaqMan Real-Time PCR Assays
      TaqMan Real-Time PCR Assays
    • Antibodies
      Antibodies
    • Oligos, Primers & Probes
      Oligos, Primers & Probes
    • GeneArt Gene Synthesis
      GeneArt Gene Synthesis
    • Cell Culture Plastics
      Cell Culture Plastics
  • Special Offers
  • Contact Us
  • Quick Order
  • Order Status and Tracking
  • Documents and Certificates
Thermo Fisher Scientific Logo

Search Thermo Fisher Scientific

Primary Antibodies
  • Search All
  • Popular Product Areas
  • TaqMan Assays
  • Primary Antibodies
  • Secondary Antibodies
  • Isotype Controls
  • Proteins & Peptides
  • ELISA Kits
  • All Documents & Support
  • Certificates
  • SDS
  • Manuals & Protocols
  • Product FAQs
    Search button Close
            Target of Interest
            Application
            Target Species
            • Order Status
            • Quick Order
            • Sign in
              Sign in
              Don't have an account ? Create Account
              • Account
              • Check Order Status
              • Aspire Member Program
              • Connect: Lab, Data, Apps
              • Custom Products & Projects
              • Services Central

            Disclaimer

            Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

            Loading ...
            • Primary Antibodies ›
            • TNFR1 Antibodies

            Invitrogen

            CD120a (TNF Receptor I) Monoclonal Antibody (55R-170), Functional Grade, eBioscience™

            6 Published Figures
            9 References
            View all (60) TNFR1 antibodies
            Datasheet
            Protocols
            Questions & Answers
            Promotion Available
            Learn more
            Catalog # 16-1202-81
            Web quote
            You can generate a web quote (PDF) by signing in to your account and adding products to your cart. View cart and click the 'Generate a web quote' button. With your web quote document, you can get approval for your order and complete your order online.
             
            Price (USD)
            147.90
            Special offer
            Online exclusive
            Ends: 01-Jul-2025
            174.00
            Save 26.10 (15%)
             
            Check your price
            Request bulk or custom format
            Join Aspire™ for free antibodies
            Datasheet
            Protocols
            Questions & Answers

            Cite CD120a (TNF Receptor I) Monoclonal Antibody (55R-170), Functional Grade, eBioscience™

            • Antibody Testing Data (1)
            • Published Figures (6)
            Application
            CD120a (TNF Receptor I) Antibody in Functional Assay (Functional)
            Group 53 Created with Sketch.

            FIGURE: 1 / 7

            CD120a (TNF Receptor I) Antibody (16-1202-81) in Functional

            Anti-Mouse CD120a (TNF Receptor I) Functional Grade Purified inhibits the biological effects of recombinant mouse TNF alpha in a bioassay of TNF alpha induced cytotoxicity of the L929 cell line. Antibody concentration is in µg/mL.
            View Product

            CD120a (TNF Receptor I) Antibody in Functional Assay (Functional)
            CD120a (TNF Receptor I) Antibody in Neutralization (Neu)
            CD120a (TNF Receptor I) Antibody in Neutralization (Neu)
            CD120a (TNF Receptor I) Antibody in Neutralization (Neu)
            CD120a (TNF Receptor I) Antibody in Neutralization (Neu)
            CD120a (TNF Receptor I) Antibody in Neutralization (Neu)
            CD120a (TNF Receptor I) Antibody in Neutralization (Neu)

            Product Details

            16-1202-81

            Applications
            Tested Dilution
            Publications

            Flow Cytometry (Flow)

            -
            View 3 publications 3 publications

            Neutralization (Neu)

            Assay-Dependent
            View 6 publications 6 publications

            Functional Assay (Functional)

            Assay-Dependent
            -
            Product Specifications

            Species Reactivity

            Mouse

            Published species

            Human, Mouse

            Host/Isotype

            Armenian hamster / IgG

            Recommended Isotype Control

            Armenian Hamster IgG Isotype Control (eBio299Arm), Functional Grade, eBioscience™

            Class

            Monoclonal

            Type

            Antibody

            Clone

            55R-170

            Conjugate

            Functional Grade

            Form

            Liquid

            Concentration

            1 mg/mL

            Purification

            Affinity chromatography

            Storage buffer

            PBS, pH 7.2

            Contains

            no preservative

            Storage conditions

            4°C

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            RRID

            AB_1311128

            Product Specific Information

            Description: The 55R-170 monoclonal antibody reacts with mouse Tumor Necrosis Factor Receptor I (TNFRI, TNFR-p55, TNFRSF1A, CD120a). TNFRI is expressed in a variety of cell types. The soluble TNF receptors are truncated forms of cell surface receptors with neutralizing activity on both TNF-alpha and TNF-beta. It has been suggested that the proinflammatory and immunosuppressive properties of TNF segregate at the level of its receptors and that the pool of TNF bound to soluble receptors could represent a reservoir to control the TNF release.

            Applications Reported:The 55R-170 antibody has been reported for use in ELISA, neutralization of mouse TNFR I bioactivity and flow cytometric analysis.

            Applications Tested: The Functional Grade Purified 55R-170 antibody has been tested by LAL assay to verify low endotoxin levels and in bioassay for neutralization of mouse TNFR I bioactivity.

            The 55R-170 antibody at 25 µg/mL has been found to inhibit by 50% the biological effects of 1 ng/mL mouse TNF alpha in an assay of TNF alpha induced cytotoxicity of L929 cells. Detailed information and protocols about cytokine bioassays and in vitro cytokine neutralization using antibodies can be found in the BestProtocols® section.

            Storage and handling: Use in a sterile environment.

            Filtration: 0.2 µm post-manufacturing filtered.

            Purity: Greater than 90%, as determined by SDS-PAGE.

            Endotoxin Level:Less than 0.001 ng/µg antibody, as determined by LAL assay.

            Aggregation:Less than 10%, as determined by HPLC.

            Target Information

            TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily, and is one of the major TNF-alpha receptors. TNFR1 plays an important role in mediating, in cytokine mediated signaling, positive regulation of the NF-Kb pathway, positive regulation of angiogenesis, and negative regulation of gene expression. The extracellular domain of TNFR1 is also released into the circulatory system as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12. Anti-apoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with TNFR1, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of TNFR1 were found to be associated with the autosomal dominant periodic fever syndrome, and the impaired receptor clearance is thought to be a mechanism of the disease.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            Bioinformatics

            Protein Aliases: CD120a; CD120a antigen; MGC19588; n-smase activation assoc. factor; p55; p60; p62; p63; sCD120a; soluble CD120a; soluble TNFR1; sTNF RI; sTNFR I; sTNFR1; sTNFRI; TNF receptor alpha chain; TNF-alpha-R1; TNF-R1; TNF-RI; TNFR; TNFR I; TNFR-I; Tumor necrosis factor receptor; Tumor necrosis factor receptor 1; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor type I

            View more View less

            Gene Aliases: CD120a; FPF; p55; p55-R; TNF-alphaR1; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR; Tnfr-1; Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55; Tnfrsf1a

            View more View less

            UniProt ID: (Mouse) P25118

            View more View less

            Entrez Gene ID: (Mouse) 21937

            View more View less

            Function(s)

            protease binding tumor necrosis factor-activated receptor activity protein binding protein complex binding tumor necrosis factor binding transmembrane signal receptor

            Process(es)

            prostaglandin metabolic process apoptotic process defense response inflammatory response signal transduction cell surface receptor signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of gene expression negative regulation of gene expression programmed cell death cytokine-mediated signaling pathway negative regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of protein import into nucleus, translocation tumor necrosis factor-mediated signaling pathway positive regulation of tyrosine phosphorylation of Stat1 protein defense response to bacterium regulation of apoptotic process negative regulation of apoptotic process positive regulation of neuron apoptotic process positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter negative regulation of inflammatory response positive regulation of inflammatory response protein heterooligomerization
            It has to be done as per old AB suggested Products section.
            guarantee_icon

            Performance Guarantee

            If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

            Learn more
            help_icon

            We're here to help

            Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

            Contact tech support
            Ordering Plus Icon Minus Icon
            • Order Status
            • Order Help
            • Quick Order
            • Supply Center
            • eProcurement
            Support Plus Icon Minus Icon
            • Help and Support
            • Contact Us
            • Technical Support Centers
            • Documents and Certificates
            • Report a Site Issue
            Resources Plus Icon Minus Icon
            • Learning Centers
            • Promotions
            • Events and Webinars
            • Social Media
            About Thermo Fisher Plus Icon Minus Icon
            • About Us
            • Careers
            • Investors
            • News
            • Social Responsibility
            • Trademarks
            • Consumer Health Data Privacy Policy
            Our Portfolio Plus Icon Minus Icon
            • Thermo Scientific
            • Applied Biosystems
            • Invitrogen
            • Gibco
            • Ion Torrent
            • Fisher Scientific
            • Unity Lab Services
            • Patheon
            • PPD
            • Terms & Conditions
            • Privacy Information Center
            • Price & Freight Policy
            • Cookie Preferences

              Your choices regarding cookies on this site

              We and our affiliates and vendors use cookies and similar technologies to operate our sites, recognize visitors to our sites, provide secure log-in, collect statistics to optimize site functionality, and deliver content tailored to your interests. Click Accept All to accept all cookies and go directly to the site, click Reject All to reject all but cookies strictly necessary to the functioning of this site (required cookies), or click on Manage Settings to see detailed descriptions of the types of cookies and choose whether to accept certain cookies while on the site.
            © 2006-2025 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.
            united states flag icon
            United States

            Your items have has been added!


            Host server : magellan-search-green-7c4bf66445-762k8:80/100.66.72.246:80.
            git-commit: 01fb56a08528fd72f4925b2983aa4df42f9d7994
            git-url: https://github.com/thermofisher/magellan-search
            git-branch: release/2.30.1-2025.05.22-1.0