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CD200R Antibody (PA5-96991) in WB
Western blot analysis of CD200R in extracts of various cell lines. Samples were incubated with CD200R Polyclonal antibody (Product # PA5-96991) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-96991
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 249-348 of human CD200R1 (NP_6201611)
Conjugate
Form
Liquid
Concentration
0.62 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2808793
Product Specific Information
Immunogen sequence: SLYIELLPVP GAKKSAKLYI PYIILTIIIL TIVGFIWLLK VNGCRKYKLN KTESTPVVEE DEMQPYASYT EKNNPLYDTT NKVKASEALQ SEVDTDLHTL; Positive Samples: U-937, NCI-H460; Cellular Location: Cell membrane, Single-pass type I membrane protein, Single-pass type I membrane protein
Target Information
CD200R (OX2R) is a receptor for the OX-2 membrane glycoprotein, and both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. CD200R is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. In mouse, CD200R is expressed primarily by peripheral blood monocytes and neutophils but also by other leucocytes including T-lymphocytes and mast cells. Further mouse studies of a gene related to CD200R suggests that the receptor may control myeloid function in a tissue-specific manner. Alternative splicing of CD200R results in multiple transcript variants. Diseases associated with CD200R dysfunction include primary hypertrophic osteoarthropathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD200 cell surface glycoprotein receptor; CD200 R1; Cell surface glycoprotein CD200 receptor 1; Cell surface glycoprotein OX2 receptor 1; cell surface glycoprotein receptor CD200; MOX2 receptor
Gene Aliases: CD200R; CD200R1; CRTR2; HCRTR2; MOX2R; OX2R; UNQ2522/PRO6015
UniProt ID: (Human) Q8TD46
Entrez Gene ID: (Human) 131450
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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