Product References
Exosomes from Ub‑HBcAg‑overexpressing dendritic cells induce T‑lymphocyte differentiation and enhance cytotoxic T‑lymphocyte activity.
Experimental and therapeutic medicine
Yang Y,Liu K,Zhou W,Dai S
14-0281-82 was used in In vitro Assay to suggest the potential of Dexs-Ub-HBcAg for development as a future therapeutic option for the elimination of HBV.
Sat Apr 01 00:00:00 EDT 2023
Histone deficiency and accelerated replication stress in T cell aging.
The Journal of clinical investigation
Kim C,Jin J,Ye Z,Jadhav RR,Gustafson CE,Hu B,Cao W,Tian L,Weyand CM,Goronzy JJ
14-0281-82 was used in Flow Cytometry to show that naive T cells from older individuals as well as miR-181ab1-deficient murine T cells develop excessive replication stress after activation due to reduced histone expression and delayed S-phase cell cycle progression.
Tue Jun 01 00:00:00 EDT 2021
Senescent T Cell Induces Brown Adipose Tissue "Whitening" Via Secreting IFN-γ.
Frontiers in cell and developmental biology
Pan XX,Yao KL,Yang YF,Ge Q,Zhang R,Gao PJ,Ruan CC,Wu F
Published figure using CD28 monoclonal antibody (Product # 14-0281-82) in Flow Cytometry
Tue Mar 23 00:00:00 EDT 2021
VX-765 reduces neuroinflammation after spinal cord injury in mice.
Neural regeneration research
Chen J,Chen YQ,Shi YJ,Ding SQ,Shen L,Wang R,Wang QY,Zha C,Ding H,Hu JG,Lü HZ
Published figure using CD28 monoclonal antibody (Product # 14-0281-82) in Flow Cytometry
Wed Sep 01 00:00:00 EDT 2021
Repurposing the anthelmintic praziquantel to treat psoriasis.
British journal of pharmacology
Hao L,Mao Y,Park J,Bae EJ,Park BH
14-0281-82 was used in flow cytometry to provide the first preclinical evidence that praziquantel may effectively treat psoriasis, and suggest that praziquantel alleviates symptoms in mice by inhibiting STAT3 phosphorylation, thereby suppressing Th17 immune responses.
Wed Dec 01 00:00:00 EST 2021
Exuberant fibroblast activity compromises lung function via ADAMTS4.
Nature
Boyd DF,Allen EK,Randolph AG,Guo XJ,Weng Y,Sanders CJ,Bajracharya R,Lee NK,Guy CS,Vogel P,Guan W,Li Y,Liu X,Novak T,Newhams MM,Fabrizio TP,Wohlgemuth N,Mourani PM,Wight TN,Schultz-Cherry S,Cormier SA,Shaw-Saliba K,Pekosz A,Rothman RE,Chen KF,Yang Z,Webby RJ,Zhong N,Crawford JC,Thomas PG
14-0281-86 was used in T-Cell Activation to demonstrate that respiratory viral infection induces distinct fibroblast activation states, which we term extracellular matrix (ECM)-synthesizing, damage-responsive and interferon-responsive states.
Sun Nov 01 00:00:00 EDT 2020
Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells.
Brain, behavior, and immunity
Piras G,Rattazzi L,Paschalidis N,Oggero S,Berti G,Ono M,Bellia F,D'Addario C,Dell'Osso B,Pariante CM,Perretti M,D'Acquisto F
14-0281-82 was used in Flow Cytometry to identify a novel factor, a small protein of approximately 21 kDa encoded by the gene 2610019F03Rik, thus named Immuno-moodulin, associated with overexpressing Annexin-A1 exclusively in T cells, as a novel peripheral determinant that modulates anxiety behavior.
Wed Jul 01 00:00:00 EDT 2020
Dynamic regulation of chromatin organizer SATB1 via TCR-induced alternative promoter switch during T-cell development.
Nucleic acids research
Patta I,Madhok A,Khare S,Gottimukkala KP,Verma A,Giri S,Dandewad V,Seshadri V,Lal G,Misra-Sen J,Galande S
14-0281 was used in Flow cytometry/Cell sorting to study the mechanism regulating expression of SATB1 during T-cell development.
Fri Jun 19 00:00:00 EDT 2020
Interleukin-38 protects against sepsis by augmenting immunosuppressive activity of CD4+ CD25+ regulatory T cells.
Journal of cellular and molecular medicine
Ge Y,Huang M,Wu Y,Dong N,Yao YM
14-0281-82 was used in Flow Cytometry to investigate the role of IL-38 in mediating the activity of CD4+ CD25+ Tregs during sepsis.
Wed Jan 01 00:00:00 EST 2020
Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells.
Cell reports
Shin B,Benavides GA,Geng J,Koralov SB,Hu H,Darley-Usmar VM,Harrington LE
14-0281 was used in Flow cytometry/Cell sorting to study the role of mitochondrial oxidative phosphorylation in pathogenic Th17 differentiation.
Tue Feb 11 00:00:00 EST 2020
Modulation of Vaccine-Induced HIV-1-Specific Immune Responses by Co-Electroporation of PD-L1 Encoding DNA.
Vaccines
Tannig P,Peter AS,Lapuente D,Klessing S,Damm D,Tenbusch M,Überla K,Temchura V
14-0281-82 was used in Flow Cytometry to indicate that co-electroporation of soluble checkpoint ectodomains together with DNA-based vaccines has modulatory effects on vaccine-induced immune responses that could improve vaccine efficacies.
Tue Jan 14 00:00:00 EST 2020
Human pDCs Are Superior to cDC2s in Attracting Cytolytic Lymphocytes in Melanoma Patients Receiving DC Vaccination.
Cell reports
van Beek JJP,Flórez-Grau G,Gorris MAJ,Mathan TSM,Schreibelt G,Bol KF,Textor J,de Vries IJM
14-0281 was used in Flow cytometry/Cell sorting to show that pDCs and cDC2s display a striking difference in chemokine secretion, which correlates with the recruitment of distinct types of immune effector cells.
Tue Jan 28 00:00:00 EST 2020
Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance.
Nature communications
Martens R,Permanyer M,Werth K,Yu K,Braun A,Halle O,Halle S,Patzer GE,Bošnjak B,Kiefer F,Janssen A,Friedrichsen M,Poetzsch J,Kohli K,Lueder Y,Gutierrez Jauregui R,Eckert N,Worbs T,Galla M,Förster R
14-0281-82 was used in Functional assay to provide fundamental insights into mechanisms that control homing of lymph-derived immune cells.
Fri Feb 28 00:00:00 EST 2020
In drug-induced, immune-mediated hepatitis, interleukin-33 reduces hepatitis and improves survival independently and as a consequence of FoxP3+ T-cell activity.
Cellular & molecular immunology
Cottagiri M,Nyandjo M,Stephens M,Mantilla JJ,Saito H,Mackay IR,Rose NR,Njoku DB
14-0281-82 was used in Flow Cytometry to suggest that, in anesthetic, immune-mediated hepatitis, IL-33 does not regulate the CD4+ T-cell proliferation that initiates hepatitis, but IL-33, likely independent of ST2, reduces hepatitis via upregulation of Foxp3+CD4+CD25+ T cells.
Thu Aug 01 00:00:00 EDT 2019
STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death.
The Journal of experimental medicine
Wu J,Chen YJ,Dobbs N,Sakai T,Liou J,Miner JJ,Yan N
14-0281 was used in Functional assays to uncover a critical IFN-independent function of STING that regulates calcium homeostasis, ER stress, and T cell survival.
Mon Apr 01 00:00:00 EDT 2019
Inhibition of phosphodiesterase-4 attenuates murine ulcerative colitis through interference with mucosal immunity.
British journal of pharmacology
Li H,Fan C,Feng C,Wu Y,Lu H,He P,Yang X,Zhu F,Qi Q,Gao Y,Zuo J,Tang W
14-0281 was used in Functional assays to demonstrate that inhibition of PDE4 by apremilast protected against ulcerative colitis, by interfering with mucosal immunity in mice.
Mon Jul 01 00:00:00 EDT 2019
CXCL14 suppresses human papillomavirus-associated head and neck cancer through antigen-specific CD8+ T-cell responses by upregulating MHC-I expression.
Oncogene
Westrich JA,Vermeer DW,Silva A,Bonney S,Berger JN,Cicchini L,Greer RO,Song JI,Raben D,Slansky JE,Lee JH,Spanos WC,Pyeon D
14-0281-82 was used in In vitro Assay to show that the CXCL14-mediated antitumor CD8+ T-cell responses require antigen specificity.
Fri Nov 01 00:00:00 EDT 2019
HLA-G dimer targets Granzyme B pathway to prolong human renal allograft survival.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Ajith A,Portik-Dobos V,Nguyen-Lefebvre AT,Callaway C,Horuzsko DD,Kapoor R,Zayas C,Maenaka K,Mulloy LL,Horuzsko A
14-0281 was used in T-Cell Activation to study the role of Human Leukocyte antigen G in human renal allograft survival.
Mon Apr 01 00:00:00 EDT 2019
Heligmosomoides polygyrus bakeri Infection Decreases Smad7 Expression in Intestinal CD4+ T Cells, Which Allows TGF-β to Induce IL-10-Producing Regulatory T Cells That Block Colitis.
Journal of immunology (Baltimore, Md. : 1950)
Hang L,Kumar S,Blum AM,Urban JF,Fantini MC,Weinstock JV
14-0281 was used in Flow cytometry/Cell sorting to show that infection with H. polygyrus bakeri causes down-modulation in Smad7 expression in intestinal CD4+ T cells, which allows the TGF-β produced in response to the infection to induce the Tregs that prevent colitis.
Mon Apr 15 00:00:00 EDT 2019
Mice expressing the variant rs1143679 allele of ITGAM (CD11b) show impaired DC-mediated T cell proliferation.
Mammalian genome : official journal of the International Mammalian Genome Society
Avery JT,Jimenez RV,Blake JL,Wright TT,Leόn-Ruiz B,Schoeb TR,Szalai AJ,Bullard DC
14-0281-82 was used in Flow Cytometry to suggest that the 77His variant of CD11b can compromise the ability of DCs to induce antigen-driven T cell proliferation.
Tue Oct 01 00:00:00 EDT 2019
Qa-1-Restricted CD8+ T Cells Can Compensate for the Absence of Conventional T Cells during Viral Infection.
Cell reports
Anderson CK,Reilly EC,Lee AY,Brossay L
14-0281 was used in Flow cytometry/Cell sorting to study compensatory mechanisms in immune responses to viruses when classical T cell immunity has been evaded.
Tue Apr 09 00:00:00 EDT 2019
Prim-O-glucosylcimifugin enhances the antitumour effect of PD-1 inhibition by targeting myeloid-derived suppressor cells.
Journal for immunotherapy of cancer
Gao W,Zhang X,Yang W,Dou D,Zhang H,Tang Y,Zhong W,Meng J,Bai Y,Liu Y,Yang L,Chen S,Liu H,Yang C,Sun T
14-0281-82 was used in Flow Cytometry to investigate if a potential option for enhancing the efficacy of PD-1 inhibitors in clinical applications exists.
Wed Aug 28 00:00:00 EDT 2019
Non-digestible oligosaccharides scFOS/lcFOS facilitate safe subcutaneous immunotherapy for peanut allergy.
Clinical and molecular allergy : CMA
Wagenaar L,van Roest M,Kruijssen LJW,Simons PJ,Boon L,Vonk MM,van Esch BCAM,Knippels LMJ,Garssen J,Pieters RHH,Smit JJ
14-0281 was used in an ELISA assay to show that scFOS/lcFOS diet improves the safety of SCIT, as evidenced by lower anaphylactic responses without compromising the efficacy in a mouse model for peanut allergy.
Fri Oct 06 00:00:00 EDT 2023
Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity.
Frontiers in immunology
Zhang H,Hu Q,Zhang M,Yang F,Peng C,Zhang Z,Huang C
14-0281 was used in in vitro experiments to investigate the molecular mechanisms through which the transcription factor Bach2 controls autoimmunity.
Mon Oct 19 00:00:00 EDT 2020
Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity.
Frontiers in immunology
Zhang H,Hu Q,Zhang M,Yang F,Peng C,Zhang Z,Huang C
14-0281 was used in in vitro experiments to investigate the molecular mechanisms through which the transcription factor Bach2 controls autoimmunity.
Mon Oct 19 00:00:00 EDT 2020
Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression.
The Journal of clinical investigation
Kawano Y,Zavidij O,Park J,Moschetta M,Kokubun K,Mouhieddine TH,Manier S,Mishima Y,Murakami N,Bustoros M,Pistofidis RS,Reidy M,Shen YJ,Rahmat M,Lukyanchykov P,Karreci ES,Tsukamoto S,Shi J,Takagi S,Huynh D,Sacco A,Tai YT,Chesi M,Bergsagel PL,Roccaro AM,Azzi J,Ghobrial IM
14-0281 was used in Functional assays to study the therapeutic potential of blocking type 1 interferon signalling to inhibit multiple myeloma-driven regulatory T cell expansion and immunosuppression.
Fri Jun 01 00:00:00 EDT 2018
A temporally dynamic Foxp3 autoregulatory transcriptional circuit controls the effector Treg programme.
The EMBO journal
Bending D,Paduraru A,Ducker CB,Prieto Martín P,Crompton T,Ono M
14-0281 was used in Functional assays to study the effects of inflammation on the flux of new Foxp3 expressors and the rate of Foxp3 transcription.
Wed Aug 15 00:00:00 EDT 2018
Amelioration of autoimmunity with an inhibitor selectively targeting all active centres of the immunoproteasome.
British journal of pharmacology
Basler M,Maurits E,de Bruin G,Koerner J,Overkleeft HS,Groettrup M
14-0281 was used in Functional assays to investigate the selectivity and biological activity of LU-005i, a recently described inhibitor of the immunoproteasome.
Mon Jan 01 00:00:00 EST 2018
Calcineurin B in CD4+ T Cells Prevents Autoimmune Colitis by Negatively Regulating the JAK/STAT Pathway.
Frontiers in immunology
Mencarelli A,Vacca M,Khameneh HJ,Acerbi E,Tay A,Zolezzi F,Poidinger M,Mortellaro A
14-0281 was used in Functional assays to delineate the role of the Calcineurin-nuclear factor of activated T-cells pathway in immune homeostasis of the intestine.
Mon Apr 08 00:00:00 EDT 2019
Immunization with α-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model.
Glia
Villadiego J,Labrador-Garrido A,Franco JM,Leal-Lasarte M,De Genst EJ,Dobson CM,Pozo D,Toledo-Aral JJ,Roodveldt C
Published figure using CD28 monoclonal antibody (Product # 14-0281-82) in T-Cell Activation
Mon Jan 01 00:00:00 EST 2018
Aire controls the recirculation of murine Foxp3+ regulatory T-cells back to the thymus.
European journal of immunology
Cowan JE,Baik S,McCarthy NI,Parnell SM,White AJ,Jenkinson WE,Anderson G
14-0281 was used in Flow cytometry/Cell sorting to re-defines requirements for late stage intrathymic αβT-cell development, and demonstrates that Aire controls a CCR6-CCL20 axis that determines the developmental makeup of the intrathymic T-Reg pool.
Tue May 01 00:00:00 EDT 2018
A Restricted Role for FcγR in the Regulation of Adaptive Immunity.
Journal of immunology (Baltimore, Md. : 1950)
Fransen MF,Benonisson H,van Maren WW,Sow HS,Breukel C,Linssen MM,Claassens JWC,Brouwers C,van der Kaa J,Camps M,Kleinovink JW,Vonk KK,van Heiningen S,Klar N,van Beek L,van Harmelen V,Daxinger L,Nandakumar KS,Holmdahl R,Coward C,Lin Q,Hirose S,Salvatori D,van Hall T,van Kooten C,Mastroeni P,Ossendorp F,Verbeek JS
14-0281 was used in Functional assays to elucidate a redundant role for activating FcγRs in the modulation of the adaptive immune response in vivo.
Sun Apr 15 00:00:00 EDT 2018
Bu‑Shen‑Ning‑Xin decoction suppresses osteoclastogenesis by modulating RANKL/OPG imbalance in the CD4+ T lymphocytes of ovariectomized mice.
International journal of molecular medicine
Zhang JL,Qiu XM,Zhang N,Tang W,Gober HJ,Li DJ,Wang L
14-0281 was used in Flow cytometry/Cell sorting to investigate the immune modulatory effects of BSNXD on CD4+ T cells, receptor activation of nuclear factor κB ligand/osteoprotegerin imbalance, skeletal parameters and osteoclastogenesis.
Sun Jul 01 00:00:00 EDT 2018
Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.
eLife
Moretti FA,Klapproth S,Ruppert R,Margraf A,Weber J,Pick R,Scheiermann C,Sperandio M,Fässler R,Moser M
Published figure using CD28 monoclonal antibody (Product # 14-0281-82) in Flow Cytometry
Thu Sep 06 00:00:00 EDT 2018
T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells.
Nature communications
Kim HR,Mun Y,Lee KS,Park YJ,Park JS,Park JH,Jeon BN,Kim CH,Jun Y,Hyun YM,Kim M,Lee SM,Park CS,Im SH,Jun CD
Published figure using CD28 monoclonal antibody (Product # 14-0281-82) in Western Blot
Fri Sep 07 00:00:00 EDT 2018
Single cell analysis of kynurenine and System L amino acid transport in T cells.
Nature communications
Sinclair LV,Neyens D,Ramsay G,Taylor PM,Cantrell DA
14-0281 was used in Functional assays to show that the ability of T cells to transport kynurenine is restricted to cells activated by the T-cell antigen receptor or proinflammatory cytokines.
Thu May 17 00:00:00 EDT 2018
Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease.
JCI insight
Moreno-Fernandez ME,Giles DA,Stankiewicz TE,Sheridan R,Karns R,Cappelletti M,Lampe K,Mukherjee R,Sina C,Sallese A,Bridges JP,Hogan SP,Aronow BJ,Hoebe K,Divanovic S
14-0281 was used in Functional assays to demonstrate that β-oxidation links metabolism and immune responsiveness.
Thu Mar 22 00:00:00 EDT 2018
Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells.
PloS one
Tong H,Miyake Y,Mi-Ichi F,Iwakura Y,Hara H,Yoshida H
14-0281 was used in Functional assays to study the role of Apaf1 in immune responses.
Tue Jul 24 00:00:00 EDT 2018
IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation.
Nature communications
Zhao M,Tan Y,Peng Q,Huang C,Guo Y,Liang G,Zhu B,Huang Y,Liu A,Wang Z,Li M,Gao X,Wu R,Wu H,Long H,Lu Q
14-0281 was used in Functional assays to show reduced expression of the transcription factor RFX1 in CD4+ T cells from patients with systemic lupus erythematosus which leads to IL-17A overexpression through increased histone H3 acetylation and decreased DNA methylation.
Thu Feb 08 00:00:00 EST 2018
Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8+ T Cell Expansion and Differentiation.
Cell reports
Dimitriou ID,Lee K,Akpan I,Lind EF,Barr VA,Ohashi PS,Samelson LE,Rottapel R
14-0281 was used in in vitro experiments to show that induction of the adaptor molecule 3BP2 is a sensor of TCR signal strength and is critical for sustaining CD8+ T cell proliferation and regulating effector and memory differentiation.
Tue Jul 31 00:00:00 EDT 2018
Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections.
Frontiers in immunology
Heinonen T,Ciarlo E,Théroude C,Pelekanou A,Herderschee J,Le Roy D,Roger T
14-0281 was used in Flow cytometry/Cell sorting to investigate if SIRT5 deficiency effects immune cell development, cytokine production and proliferation by macrophages and splenocytes exposed to microbial and immunological stimuli.
Wed Oct 02 00:00:00 EDT 2019
The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection.
Nature immunology
Moffett HF,Cartwright ANR,Kim HJ,Godec J,Pyrdol J,Äijö T,Martinez GJ,Rao A,Lu J,Golub TR,Cantor H,Sharpe AH,Novina CD,Wucherpfennig KW
14-0281 was used in Immunoprecipitation to show CD8+ T cell function in chronic viral infection can be modified by microRNA miR-31.
Sat Jul 01 00:00:00 EDT 2017
Regulatory T cells promote myelin regeneration in the central nervous system.
Nature neuroscience
Dombrowski Y,O'Hagan T,Dittmer M,Penalva R,Mayoral SR,Bankhead P,Fleville S,Eleftheriadis G,Zhao C,Naughton M,Hassan R,Moffat J,Falconer J,Boyd A,Hamilton P,Allen IV,Kissenpfennig A,Moynagh PN,Evergren E,Perbal B,Williams AC,Ingram RJ,Chan JR,Franklin RJM,Fitzgerald DC
14-0281 was used in Functional assays to elucidate the role of regulatory T cells in promoting oligodendrocyte differentiation andmyelination in the central nervous system.
Mon May 01 00:00:00 EDT 2017
CTCF-Mediated Enhancer-Promoter Interaction Is a Critical Regulator of Cell-to-Cell Variation of Gene Expression.
Molecular cell
Ren G,Jin W,Cui K,Rodrigez J,Hu G,Zhang Z,Larson DR,Zhao K
Published figure using CD28 monoclonal antibody (Product # 14-0281-82) in Flow Cytometry
Thu Sep 21 00:00:00 EDT 2017
Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function.
Nature protocols
Kurachi M,Kurachi J,Chen Z,Johnson J,Khan O,Bengsch B,Stelekati E,Attanasio J,McLane LM,Tomura M,Ueha S,Wherry EJ
14-0281 was used in Functional assays to develop an optimised mouse CD8 T cell retroviral transduction protocol for in vivo assessment of gene function.
Fri Sep 01 00:00:00 EDT 2017
Staphylococcal serine protease-like proteins are pacemakers of allergic airway reactions to Staphylococcus aureus.
The Journal of allergy and clinical immunology
Stentzel S,Teufelberger A,Nordengrün M,Kolata J,Schmidt F,van Crombruggen K,Michalik S,Kumpfmüller J,Tischer S,Schweder T,Hecker M,Engelmann S,Völker U,Krysko O,Bachert C,Bröker BM
14-0281 was used in in vitro experiments to identify Spls as triggering allergens released by S aureus, opening prospects for diagnosis and causal therapy of asthma.
Wed Feb 01 00:00:00 EST 2017
The Transcription Factor T-Bet Is Regulated by MicroRNA-155 in Murine Anti-Viral CD8+ T Cells via SHIP-1.
Frontiers in immunology
Hope JL,Stairiker CJ,Spantidea PI,Gracias DT,Carey AJ,Fike AJ,van Meurs M,Brouwers-Haspels I,Rijsbergen LC,Fraietta JA,Mueller YM,Klop RC,Stelekati E,Wherry EJ,Erkeland SJ,Katsikis PD
14-0281 was used in Flow cytometry/Cell sorting to show that the proliferative effect of miR-155 on CD8+T cells is mediated by T-bet. T-bet levels in CTL were controlledin vivoby miR-155viaSH2 (Src homology 2)-containing inositol phosphatase-1 (SHIP-1), a known direct target of miR-155, and SHIP-1 directly downregulated T-bet.
Sat Jan 09 00:00:00 EST 2021
Transmembrane Tumor Necrosis Factor Controls Myeloid-Derived Suppressor Cell Activity via TNF Receptor 2 and Protects from Excessive Inflammation during BCG-Induced Pleurisy.
Frontiers in immunology
Chavez-Galan L,Vesin D,Uysal H,Blaser G,Benkhoucha M,Ryffel B,Quesniaux VFJ,Garcia I
14-0281-82 was used in In vitro Assay to provide insight into the crucial role played by the transmembrane TNF/TNF receptor 2 pathway in myeloid-derived suppressor cell suppressive activity required during acute pleural infection to attenuate excessive inflammation generated by the infection.
Wed Nov 20 00:00:00 EST 2019
Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.
Frontiers in immunology
Ciarlo E,Heinonen T,Théroude C,Herderschee J,Mombelli M,Lugrin J,Pfefferlé M,Tyrrell B,Lensch S,Acha-Orbea H,Le Roy D,Auwerx J,Roger T
14-0281 was used in Immunohistochemistry to investigate the impact of SIRT2 on antimicrobial host defenses, showing that SIRT2 deficiency increases survival of mice with chronic staphylococcal infection.
Wed Nov 09 00:00:00 EST 2022
Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine.
PLoS pathogens
Prados-Rosales R,Carreño L,Cheng T,Blanc C,Weinrick B,Malek A,Lowary TL,Baena A,Joe M,Bai Y,Kalscheuer R,Batista-Gonzalez A,Saavedra NA,Sampedro L,Tomás J,Anguita J,Hung SC,Tripathi A,Xu J,Glatman-Freedman A,Jacobs WR,Chan J,Porcelli SA,Achkar JM,Casadevall A
14-0281 was used in Flow cytometry/Cell sorting to develop capsular polysaccharide conjugates for enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice.
Wed Mar 01 00:00:00 EST 2017
Lamtor1 Is Critically Required for CD4+ T Cell Proliferation and Regulatory T Cell Suppressive Function.
Journal of immunology (Baltimore, Md. : 1950)
Hosokawa T,Kimura T,Nada S,Okuno T,Ito D,Kang S,Nojima S,Yamashita K,Nakatani T,Hayama Y,Kato Y,Kinehara Y,Nishide M,Mikami N,Koyama S,Takamatsu H,Okuzaki D,Ohkura N,Sakaguchi S,Okada M,Kumanogoh A
14-0281 was used in Functional assays to demonstrate that Lamtor1-deficient CD4(+) T cells exhibit marked reductions in proliferation, IL-2 production, Mechanistic target of rapamycin complex 1 activity, and expression of purine- and lipid-synthesis genes.
Fri Sep 15 00:00:00 EDT 2017
Bach2 represses the AP-1-driven induction of interleukin-2 gene transcription in CD4+ T cells.
BMB reports
Jang E,Lee HR,Lee GH,Oh AR,Cha JY,Igarashi K,Youn J
14-0281 was used in Flow cytometry/Cell sorting to investigate whether Bach2 is a component of the network of factors that regulates interleukin-2 expression.
Fri Sep 01 00:00:00 EDT 2017
Vitamin C enhances the expression of IL17 in a Jmjd2-dependent manner.
BMB reports
Song MH,Nair VS,Oh KI
14-0281 was used in Flow cytometry/Cell sorting to determine the effect of vitamin C on helper T cell lineages.
Sun Jan 01 00:00:00 EST 2017
Avoiding phagocytosis-related artifact in myeloid derived suppressor cell T-lymphocyte suppression assays.
Journal of immunological methods
Davis RJ,Silvin C,Allen CT
14-0281 was used in Flow cytometry/Cell sorting to propose model-specific validation of microbead-based MDSC assays, or use of an alternative stimulation approach such as plate bound CD3/28 antibodies.
Sun Jan 01 00:00:00 EST 2017
Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation.
eLife
Araujo L,Khim P,Mkhikian H,Mortales CL,Demetriou M
14-0281 was used in an ELISA assay to report that aerobic glycolysis and glutaminolysis co-operatively reduce UDP-GlcNAc biosynthesis and N-glycan branching in mouse T cell blasts by starving the hexosamine pathway of glucose and glutamine.
Fri Jan 06 00:00:00 EST 2017
Protein Tyrosine Phosphatase Inhibition Prevents Experimental Cerebral Malaria by Precluding CXCR3 Expression on T Cells.
Scientific reports
Van Den Ham KM,Smith LK,Richer MJ,Olivier M
14-0281 was used in Flow cytometry/Cell sorting to demonstrate that inhibition of protein tyrosine phosphatase activity significantly attenuates T cell sequestration within the brain and prevents the development of neuropathology.
Fri Jul 14 00:00:00 EDT 2017
Enhanced immunotherapy by combining a vaccine with a novel murine GITR ligand fusion protein.
Oncotarget
Morillon YM,Hammond SA,Durham NM,Schlom J,Greiner JW
14-0281 was used in Functional assays to study the efficacy of combining a recombinant poxvirus-based vaccine with a novel murine GITR ligand fusion protein in cancer immunotherapy.
Tue Sep 26 00:00:00 EDT 2017
Colorectal cancer cells suppress CD4+ T cells immunity through canonical Wnt signaling.
Oncotarget
Sun X,Liu S,Wang D,Zhang Y,Li W,Guo Y,Zhang H,Suo J
14-0281 was used in Functional assays to evaluate the role of canonical Wnt signalling in the regulation of T cell function in a mouse colorectal cancer model.
Tue Feb 28 00:00:00 EST 2017
The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells.
The Journal of biological chemistry
Chen J,Martindale JL,Cramer C,Gorospe M,Atasoy U,Drew PD,Yu S
14-0281 was used in T-Cell Activation experiments to study how HuR contributes to T helper 17 cell-mediated autoimmune neuroinflammation, and its potential therapeutic target for managing autoimmune conditions of the central nervous system.
Fri Sep 01 00:00:00 EDT 2017
The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models.
Clinical and translational allergy
Vonk MM,Wagenaar L,Pieters RHH,Knippels LMJ,Willemsen LEM,Smit JJ,van Esch BCAM,Garssen J
14-0281 was used in Functional assays to compare oral immunotherapy and subcutaneous immunotherapy models for cows milk and peanut allergy.
Fri Apr 08 00:00:00 EDT 2022
Natural Docosahexaenoic Acid in the Triglyceride Form Attenuates In Vitro Microglial Activation and Ameliorates Autoimmune Encephalomyelitis in Mice.
Nutrients
Mancera P,Wappenhans B,Cordobilla B,Virgili N,Pugliese M,Rueda F,Espinosa-Parrilla JF,Domingo JC
14-0281 was used in Flow cytometry/Cell sorting to show TG-DHA may be a promising therapeutic agent in neuroinflammatory processes and merit to be more extensively studied in human neurodegenerative disorders.
Fri Jun 30 00:00:00 EDT 2017
Broad induction of immunoregulatory mechanisms after a short course of anti-IL-7Rα antibodies in NOD mice.
BMC immunology
Vazquez-Mateo C,Collins J,Fleury M,Dooms H
14-0281 was used in an assay to evaluate the use of anti-IL7Ra antibodies to modulate autoreactive T cell responses.
Wed Mar 29 00:00:00 EDT 2017
Ex vivo modulation of the Foxo1 phosphorylation state does not lead to dysfunction of T regulatory cells.
PloS one
Penberthy KK,Buckley MW,Arandjelovic S,Ravichandran K
14-0281 was used in Functional assays to study the effect of FoxO1 phosphorylation state on T regulatory cell function.
Fri Aug 25 00:00:00 EDT 2017
Signalling strength determines proapoptotic functions of STING.
Nature communications
Gulen MF,Koch U,Haag SM,Schuler F,Apetoh L,Villunger A,Radtke F,Ablasser A
14-0281 was used in Flow cytometry/Cell sorting to demonstrate how the magnitude of STING signalling can shape distinct effector responses.
Tue Sep 05 00:00:00 EDT 2017
PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton.
eLife
Britton GJ,Ambler R,Clark DJ,Hill EV,Tunbridge HM,McNally KE,Burton BR,Butterweck P,Sabatos-Peyton C,Hampton-O'Neil LA,Verkade P,Wülfing ChC,Wraith DC
14-0281 was used in Functional assays to investigate the role of protein kinase PKCθ in linking proximal T cell and notch signaling by a spatiotemporally constrained mechanism.
Tue Jan 31 00:00:00 EST 2017
NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection.
Nature communications
Wang J,He N,Zhang N,Quan D,Zhang S,Zhang C,Yu RT,Atkins AR,Zhu R,Yang C,Cui Y,Liddle C,Downes M,Xiao H,Zheng Y,Auwerx J,Evans RM,Leng Q
14-0281 was used in Western Blotting to study whether transcriptional regulation helps conserve positively selected thymocytes from being purged by negative selection.
Mon Oct 16 00:00:00 EDT 2017
Ionic immune suppression within the tumour microenvironment limits T cell effector function.
Nature
Eil R,Vodnala SK,Clever D,Klebanoff CA,Sukumar M,Pan JH,Palmer DC,Gros A,Yamamoto TN,Patel SJ,Guittard GC,Yu Z,Carbonaro V,Okkenhaug K,Schrump DS,Linehan WM,Roychoudhuri R,Restifo NP
14-0281 was used in in vitro experiments to discover an ionic checkpoint that blocks T cell function in tumours, identifying potential new strategies for cancer immunotherapy.
Thu Sep 22 00:00:00 EDT 2016
A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.
Nature genetics
Jabara HH,Boyden SE,Chou J,Ramesh N,Massaad MJ,Benson H,Bainter W,Fraulino D,Rahimov F,Sieff C,Liu ZJ,Alshemmari SH,Al-Ramadi BK,Al-Dhekri H,Arnaout R,Abu-Shukair M,Vatsayan A,Silver E,Ahuja S,Davies EG,Sola-Visner M,Ohsumi TK,Andrews NC,Notarangelo LD,Fleming MD,Al-Herz W,Kunkel LM,Geha RS
14-0281 was used in Flow cytometry/Cell sorting to demonstrate the importance of TfR1 in adaptive immunity.
Fri Jan 01 00:00:00 EST 2016
BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers.
Nature immunology
Roychoudhuri R,Clever D,Li P,Wakabayashi Y,Quinn KM,Klebanoff CA,Ji Y,Sukumar M,Eil RL,Yu Z,Spolski R,Palmer DC,Pan JH,Patel SJ,Macallan DC,Fabozzi G,Shih HY,Kanno Y,Muto A,Zhu J,Gattinoni L,O'Shea JJ,Okkenhaug K,Igarashi K,Leonard WJ,Restifo NP
14-0281-82 was used in Flow Cytometry to investigate whether access of signal-dependent transcription factors to enhancers is dynamically regulated to shape transcriptional responses to T cell antigen receptor signalling.
Fri Jul 01 00:00:00 EDT 2016
Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis.
Nature immunology
Wei J,Long L,Yang K,Guy C,Shrestha S,Chen Z,Wu C,Vogel P,Neale G,Green DR,Chi H
14-0281 was used in Functional assays to show that autophagy is active in regulatory T cells and supports their lineage stability and survival fitness.
Tue Mar 01 00:00:00 EST 2016
Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.
The Journal of clinical investigation
Massaad MJ,Zhou J,Tsuchimoto D,Chou J,Jabara H,Janssen E,Glauzy S,Olson BG,Morbach H,Ohsumi TK,Schmitz K,Kyriacos M,Kane J,Torisu K,Nakabeppu Y,Notarangelo LD,Chouery E,Megarbane A,Kang PB,Al-Idrissi E,Aldhekri H,Meffre E,Mizui M,Tsokos GC,Manis JP,Al-Herz W,Wallace SS,Geha RS
14-0281 was used in Functional assays to investigate alterations in immune cell apoptosis during autoimmunity, showing that deficiency in NEIL3 drives increased predisposition to autoimmunity.
Tue Nov 01 00:00:00 EDT 2016
Increase of Frequency and Modulation of Phenotype of Regulatory T Cells by Atorvastatin Is Associated with Decreased Lung Inflammatory Cell Infiltration in a Murine Model of Acute Allergic Asthma.
Frontiers in immunology
Blanquiceth Y,Rodríguez-Perea AL,Tabares Guevara JH,Correa LA,Sánchez MD,Ramírez-Pineda JR,Velilla PA
14-0281 was used in Functional assays to evaluate the in vivo effect of atorvastatin on regulatory T cells, and its association with the inflammatory process in a model of allergic asthma.
Wed Nov 20 00:00:00 EST 2019
Foxp3(+) T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation.
Mucosal immunology
Yang BH,Hagemann S,Mamareli P,Lauer U,Hoffmann U,Beckstette M,Föhse L,Prinz I,Pezoldt J,Suerbaum S,Sparwasser T,Hamann A,Floess S,Huehn J,Lochner M
14-0281 was used in Flow cytometry/Cell sorting to demonstrate that Foxp3(+) T cells expressing retinoic acid-related orphan receptor-γt, represent a stable regulatory T cell lineage with a highly suppressive phenotype in vivo.
Tue Mar 01 00:00:00 EST 2016
Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection.
PLoS pathogens
Oudhoff MJ,Antignano F,Chenery AL,Burrows K,Redpath SA,Braam MJ,Perona-Wright G,Zaph C
14-0281 was used in an ELISA assay to understand how the lysine methyltransferase, SETD7, is involved in resistance to Helminth infections.
Thu Sep 01 00:00:00 EDT 2016
Intranasal immunization with heat shock protein 60 induces CD4(+) CD25(+) GARP(+) and type 1 regulatory T cells and inhibits early atherosclerosis.
Clinical and experimental immunology
Zhong Y,Tang H,Wang X,Zeng Q,Liu Y,Zhao XI,Yu K,Shi H,Zhu R,Mao X
14-0281 was used in Flow cytometry/Cell sorting to investigate the impact of nasal heat shock protein 60 on atherosclerosis and the mechanisms underlying the anti-atherosclerosis responses.
Tue Mar 01 00:00:00 EST 2016
Ubiquitination of RORγt at Lysine 446 Limits Th17 Differentiation by Controlling Coactivator Recruitment.
Journal of immunology (Baltimore, Md. : 1950)
He Z,Wang F,Ma J,Sen S,Zhang J,Gwack Y,Zhou Y,Sun Z
14-0281 was used in Flow cytometry/Cell sorting to identify a functional ubiquitination site, K446, on the transcription factor retinoid acid-related orphan receptor γ t (RORγt).
Mon Aug 15 00:00:00 EDT 2016
CCL20-CCR6 Cytokine Network Facilitate Treg Activity in Advanced Grades and Metastatic Variants of Hepatocellular Carcinoma.
Scandinavian journal of immunology
Li WM,Liu HR
14-0281 was used in Flow cytometry/Cell sorting to study the expression of cytokines potentially known to recruit regulatory T cells in hepatocellular carcinoma.
Fri Jan 01 00:00:00 EST 2016
The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity.
Nature communications
Xu Y,Zhao F,Qiu Q,Chen K,Wei J,Kong Q,Gao B,Melo-Cardenas J,Zhang B,Zhang J,Song J,Zhang DD,Zhang J,Fan Y,Li H,Fang D
Published figure using CD28 monoclonal antibody (Product # 14-0281-82) in T-Cell Activation
Fri Jul 15 00:00:00 EDT 2016
The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity.
Nature communications
Xu Y,Zhao F,Qiu Q,Chen K,Wei J,Kong Q,Gao B,Melo-Cardenas J,Zhang B,Zhang J,Song J,Zhang DD,Zhang J,Fan Y,Li H,Fang D
Published figure using CD28 monoclonal antibody (Product # 14-0281-82) in T-Cell Activation
Fri Jul 15 00:00:00 EDT 2016
Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 (Ape1/Ref-1) Modulates Antigen Presenting Cell-mediated T Helper Cell Type 1 Responses.
The Journal of biological chemistry
Akhter N,Takeda Y,Nara H,Araki A,Ishii N,Asao N,Asao H
Published figure using CD28 monoclonal antibody (Product # 14-0281-82) in T-Cell Activation
Fri Nov 04 00:00:00 EDT 2016
Restrained Th17 response and myeloid cell infiltration into the central nervous system by human decidua-derived mesenchymal stem cells during experimental autoimmune encephalomyelitis.
Stem cell research & therapy
Bravo B,Gallego MI,Flores AI,Bornstein R,Puente-Bedia A,Hernández J,de la Torre P,García-Zaragoza E,Perez-Tavarez R,Grande J,Ballester A,Ballester S
14-0281 was used in Flow cytometry/Cell sorting to explore the therapeutic potential of DMSCs for treatment of autoimmune disorders.
Thu Mar 17 00:00:00 EDT 2016
Targeted Reconstitution of Cytokine Activity upon Antigen Binding using Split Cytokine Antibody Fusion Proteins.
The Journal of biological chemistry
Venetz D,Koovely D,Weder B,Neri D
14-0281 was used in Flow cytometry/Cell sorting to demonstrate that interleukin-12 can be reconstituted by sequential reassembly of fusion proteins based on antibody fragments and interleukin-12 subunit mutants.
Fri Aug 26 00:00:00 EDT 2016
Lymphocyte Isolation, Th17 Cell Differentiation, Activation, and Staining.
Bio-protocol
Kumar P,Kolls JK
Mon Dec 05 00:00:00 EST 2016
RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis.
Journal of neuroinflammation
Lee JK,Kannarkat GT,Chung J,Joon Lee H,Graham KL,Tansey MG
14-0281 was used in Functional assays to define potential roles for RGS10 in regulating autoimmune responses, showing that deficiency ameliorates the severity of disease in EAE.
Mon Feb 01 00:00:00 EST 2016
High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner.
Scientific reports
Polansky JK,Bahri R,Divivier M,Duitman EH,Vock C,Goyeneche-Patino DA,Orinska Z,Bulfone-Paus S
14-0281 was used in Functional assays to analyse the in vivo potential of IL15 as an immune-regulator when available at different concentrations or delivery modes.
Fri Jan 29 00:00:00 EST 2016
Effect of a Ropy Exopolysaccharide-Producing Bifidobacterium animalis subsp. lactis Strain Orally Administered on DSS-Induced Colitis Mice Model.
Frontiers in microbiology
Hidalgo-Cantabrana C,Algieri F,Rodriguez-Nogales A,Vezza T,Martínez-Camblor P,Margolles A,Ruas-Madiedo P,Gálvez J
14-0281 was used in Flow cytometry/Cell sorting to indicate that strains of B. animalis subsp. lactis producing EPS that confer a mucoid-ropy phenotype could represent promising candidates to perform further studies targeting intestinal inflammatory processes.
Mon Jul 04 00:00:00 EDT 2016
C-C chemokine receptor type-4 transduction of T cells enhances interaction with dendritic cells, tumor infiltration and therapeutic efficacy of adoptive T cell transfer.
Oncoimmunology
Rapp M,Grassmann S,Chaloupka M,Layritz P,Kruger S,Ormanns S,Rataj F,Janssen KP,Endres S,Anz D,Kobold S
14-0281 was used in in vivo experiments to study how CCR4 overexpression in CTL is a promising therapeutic strategy to enhance the efficacy of adoptive T cell transfer (ACT).
Tue Mar 01 00:00:00 EST 2016
Immunity to Lutzomyia whitmani Saliva Protects against Experimental Leishmania braziliensis Infection.
PLoS neglected tropical diseases
Gomes R,Cavalcanti K,Teixeira C,Carvalho AM,Mattos PS,Cristal JR,Muniz AC,Miranda JC,de Oliveira CI,Barral A
14-0281 was used in Flow cytometry/Cell sorting to show that Lu. whitmani salivary proteins are immunogenic in naturally exposed individuals.
Tue Nov 01 00:00:00 EDT 2016
Diffuse traumatic brain injury induces prolonged immune dysregulation and potentiates hyperalgesia following a peripheral immune challenge.
Molecular pain
Rowe RK,Ellis GI,Harrison JL,Bachstetter AD,Corder GF,Van Eldik LJ,Taylor BK,Marti F,Lifshitz J
14-0281 was used in Functional assays to investigate whether the inflammatory response to diffuse traumatic brain injury potentiates persistent pain through prolonged immune dysregulation.
Mon Dec 26 00:00:00 EST 2016
Targeting myeloid-derived suppressor cells with colony stimulating factor-1 receptor blockade can reverse immune resistance to immunotherapy in indoleamine 2,3-dioxygenase-expressing tumors.
EBioMedicine
Holmgaard RB,Zamarin D,Lesokhin A,Merghoub T,Wolchok JD
14-0281 was used in Flow cytometry/Cell sorting to study the invovlement of myeloid-derived suppressor cells in IDO-expressing B16 tumour progression and therapy resistance.
Fri Apr 01 00:00:00 EDT 2016
Notch regulates Th17 differentiation and controls trafficking of IL-17 and metabolic regulators within Th17 cells in a context-dependent manner.
Scientific reports
Coutaz M,Hurrell BP,Auderset F,Wang H,Siegert S,Eberl G,Ho PC,Radtke F,Tacchini-Cottier F
14-0281-82 was used in Flow Cytometry to elucidate whether Notch signaling is involved in the negative or positive regulation of Th17 cell differentiation.
Thu Dec 15 00:00:00 EST 2016
Intestinal Microbiota Promotes Psoriasis-Like Skin Inflammation by Enhancing Th17 Response.
PloS one
Zákostelská Z,Málková J,Klimešová K,Rossmann P,Hornová M,Novosádová I,Stehlíková Z,Kostovčík M,Hudcovic T,Štepánková R,Jůzlová K,Hercogová J,Tlaskalová-Hogenová H,Kverka M
14-0281 was used in in vitro experiments to investigate the link between gut microbiota, T cells and the formation of psoriatic lesions in a mouse model of psoriasis.
Wed Jul 26 00:00:00 EDT 2017
Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses.
Cell
Farez MF,Mascanfroni ID,Méndez-Huergo SP,Yeste A,Murugaiyan G,Garo LP,Balbuena Aguirre ME,Patel B,Ysrraelit MC,Zhu C,Kuchroo VK,Rabinovich GA,Quintana FJ,Correale J
Published figure using CD28 monoclonal antibody (Product # 14-0281-82) in T-Cell Activation
Thu Sep 10 00:00:00 EDT 2015
T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate.
Immunity
Mackay LK,Wynne-Jones E,Freestone D,Pellicci DG,Mielke LA,Newman DM,Braun A,Masson F,Kallies A,Belz GT,Carbone FR
14-0281 was used in in vitro experiments to indicate that the T-box TFs control the two cytokines, TGF-β and IL-15, which are pivotal for CD8(+)CD103(+) Trm cell development and survival.
Tue Dec 15 00:00:00 EST 2015
Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.
Cancer cell
Cole A,Wang Z,Coyaud E,Voisin V,Gronda M,Jitkova Y,Mattson R,Hurren R,Babovic S,Maclean N,Restall I,Wang X,Jeyaraju DV,Sukhai MA,Prabha S,Bashir S,Ramakrishnan A,Leung E,Qia YH,Zhang N,Combes KR,Ketela T,Lin F,Houry WA,Aman A,Al-Awar R,Zheng W,Wienholds E,Xu CJ,Dick J,Wang JC,Moffat J,Minden MD,Eaves CJ,Bader GD,Hao Z,Kornblau SM,Raught B,Schimmer AD
14-0281-82 was used in Flow Cytometry to study the inhibition of ClpP as a therapeutic strategy for human Acute Myeloid Leukaemia.
Mon Jun 08 00:00:00 EDT 2015
TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8(+) T cells.
Nature immunology
Takada K,Van Laethem F,Xing Y,Akane K,Suzuki H,Murata S,Tanaka K,Jameson SC,Singer A,Takahama Y
14-0281 was used in in vitro experiments to demonstrate a novel aspect of positive selection which tunes the responsiveness of mature CD8(+) T cells.
Thu Oct 01 00:00:00 EDT 2015
T-bet Expression by Foxp3(+) T Regulatory Cells is Not Essential for Their Suppressive Function in CNS Autoimmune Disease or Colitis.
Frontiers in immunology
McPherson RC,Turner DG,Mair I,O'Connor RA,Anderton SM
14-0281 was used in Functional assays to report no difference in the resolution of experimental autoimmune encephalomyelitis in mice that lacked T-bet expression, compared to control mice.
Thu Mar 05 00:00:00 EST 2015
Blocking stroke-induced immunodeficiency increases CNS antigen-specific autoreactivity but does not worsen functional outcome after experimental stroke.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Römer C,Engel O,Winek K,Hochmeister S,Zhang T,Royl G,Klehmet J,Dirnagl U,Meisel C,Meisel A
14-0281 was used in Immunohistochemistry to show that inhibiting stroke-induced immunodepression by pharmacological blockade of body's stress axes increases autoreactive CNS antigen-specific T-cell responses in the brain.
Wed May 20 00:00:00 EDT 2015
Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter.
European journal of immunology
Hill EV,Ng TH,Burton BR,Oakley CM,Malik K,Wraith DC
14-0281 was used in Immunopurification to investigate whether GSK3 inhibition affects IL-10 production in different subsets of mouse and human CD4+ T cells.
Wed Apr 01 00:00:00 EDT 2015
Role of glycine N-methyltransferase in the regulation of T-cell responses in experimental autoimmune encephalomyelitis.
Molecular medicine (Cambridge, Mass.)
Li CH,Lin MH,Chu SH,Tu PH,Fang CC,Yen CH,Liang PI,Huang JC,Su YC,Sytwu HK,Chen YM
14-0281 was used in Western Blotting to investigate whether glycine N-methyltransferase plays an immunomodulatory role in the pathogenesis of experimental autoimmune encephalomyelitis.
Tue Mar 24 00:00:00 EDT 2015
Dopamine inhibits the function of Gr-1+CD115+ myeloid-derived suppressor cells through D1-like receptors and enhances anti-tumor immunity.
Journal of leukocyte biology
Wu J,Zhang R,Tang N,Gong Z,Zhou J,Chen Y,Chen K,Cai W
14-0281 was used in Functional assays to investigate the therapeutic mechanism and efficacy of DA on the inhibition of cancer development.
Thu Jan 01 00:00:00 EST 2015
A novel Cd8-cis-regulatory element preferentially directs expression in CD44hiCD62L+ CD8+ T cells and in CD8αα+ dendritic cells.
Journal of leukocyte biology
Sakaguchi S,Hombauer M,Hassan H,Tanaka H,Yasmin N,Naoe Y,Bilic I,Moser MA,Hainberger D,Mayer H,Seiser C,Bergthaler A,Taniuchi I,Ellmeier W
14-0281 was used in Flow cytometry/Cell sorting to identify a novel Cd8 enhancer that directs expression in CD44(hi)CD62L(+) CD8(+) T cells, including innate-like and antigen-specific effector/memory CD8(+) T cells and in CD8αα(+) DCs.
Wed Apr 01 00:00:00 EDT 2015
Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Vaeth M,Zee I,Concepcion AR,Maus M,Shaw P,Portal-Celhay C,Zahra A,Kozhaya L,Weidinger C,Philips J,Unutmaz D,Feske S
14-0281 was used in Flow cytometry/Cell sorting to investigate the role of STIM1, STIM2 and SOCE on effector functions of macrophages and dendritic cells, and how these affect CRAC channel inhibition.
Sat Aug 01 00:00:00 EDT 2015
Enhancing the Quality of Antibodies to HIV-1 Envelope by GagPol-Specific Th Cells.
Journal of immunology (Baltimore, Md. : 1950)
Storcksdieck genannt Bonsmann M,Niezold T,Temchura V,Pissani F,Ehrhardt K,Brown EP,Osei-Owusu NY,Hannaman D,Hengel H,Ackerman ME,Streeck H,Nabi G,Tenbusch M,Überla K
14-0281-82 was used in Flow Cytometry to enhance the quality of antibodies to HIV-1 envelope by GagPol-Specific T helper Cells.
Sun Nov 15 00:00:00 EST 2015
Pulmonary alveolar macrophages contribute to the premetastatic niche by suppressing antitumor T cell responses in the lungs.
Journal of immunology (Baltimore, Md. : 1950)
Sharma SK,Chintala NK,Vadrevu SK,Patel J,Karbowniczek M,Markiewski MM
14-0281 was used in Flow cytometry/Cell sorting to demonstrate that alveolar macrophages are harnessed by tumours to impose immunosuppression and promote metastasis.
Mon Jun 01 00:00:00 EDT 2015
In vitro exposure to the herbicide atrazine inhibits T cell activation, proliferation, and cytokine production and significantly increases the frequency of Foxp3+ regulatory T cells.
Toxicological sciences : an official journal of the Society of Toxicology
Thueson LE,Emmons TR,Browning DL,Kreitinger JM,Shepherd DM,Wetzel SA
14-0281 was used in Functional assays to examine the impact of atrazine exposure on primary murine CD4(+) T lymphocyte frequency and function.
Sun Feb 01 00:00:00 EST 2015
Interleukin-7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression.
Shock (Augusta, Ga.)
Shindo Y,Unsinger J,Burnham CA,Green JM,Hotchkiss RS
Published figure using CD28 monoclonal antibody (Product # 14-0281-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2015
A microfluidic platform reveals differential response of regulatory T cells to micropatterned costimulation arrays.
Integrative biology : quantitative biosciences from nano to macro
Lee JH,Dustin ML,Kam LC
14-0281 was used in Functional assays to investigate differences in cell response to micropatterned surfaces by conventional and regulatory T cells.
Sun Nov 01 00:00:00 EDT 2015
Overexpression of IL-15 promotes tumor destruction via NK1.1+ cells in a spontaneous breast cancer model.
BMC cancer
Gillgrass AE,Chew MV,Krneta T,Ashkar AA
Published figure using CD28 monoclonal antibody (Product # 14-0281-82) in Immunohistochemistry
Thu Apr 16 00:00:00 EDT 2015
Amphiregulin activates regulatory T lymphocytes and suppresses CD8+ T cell-mediated anti-tumor response in hepatocellular carcinoma cells.
Oncotarget
Yuan CH,Sun XM,Zhu CL,Liu SP,Wu L,Chen H,Feng MH,Wu K,Wang FB
14-0281 was used in Flow cytometry/Cell sorting to investigate how hepatocellular carcinoma cells alter endogenous anti-tumor immunity and their related signaling pathways.
Tue Oct 13 00:00:00 EDT 2015
Murine K2P5.1 Deficiency Has No Impact on Autoimmune Neuroinflammation due to Compensatory K2P3.1- and KV1.3-Dependent Mechanisms.
International journal of molecular sciences
Bittner S,Bobak N,Hofmann MS,Schuhmann MK,Ruck T,Göbel K,Brück W,Wiendl H,Meuth SG
14-0281 was used in Functional assays to investigate the effect of K2P5.1 knockout on T cells.
Fri Jul 24 00:00:00 EDT 2015
Analyzing Th17 cell differentiation dynamics using a novel integrative modeling framework for time-course RNA sequencing data.
BMC systems biology
Intosalmi J,Ahlfors H,Rautio S,Mannerstöm H,Chen ZJ,Lahesmaa R,Stockinger B,Lähdesmäki H
14-0281 was used in Functional assays to approve the important role of quantitative dynamic modeling in identifying and studying regulatory mechanisms.
Tue Nov 17 00:00:00 EST 2015
Differences in CD44 Surface Expression Levels and Function Discriminates IL-17 and IFN-γ Producing Helper T Cells.
PloS one
Schumann J,Stanko K,Schliesser U,Appelt C,Sawitzki B
14-0281 was used in Flow cytometry/Cell sorting to investigate whether T helper cells differ in their CD44 expression and dependence on CD44 for differentiation.
Tue Apr 12 00:00:00 EDT 2016
CD11b(+)Ly6C(++)Ly6G(-) Cells with Suppressive Activity Towards T Cells Accumulate in Lungs of Influenza a Virus-Infected Mice.
European journal of microbiology & immunology
Milanez-Almeida P,Ulas T,Pasztoi M,Glage S,Schughart K,Lutz MB,Schultze JL,Huehn J
14-0281 was used in Functional assays to study the involvement of CD11b(+)Ly6C(++)Ly6G(-) cells during inflammatory resolution following Influenza A virus infection.
Tue Dec 01 00:00:00 EST 2015
Function of a Foxp3 cis-element in protecting regulatory T cell identity.
Cell
Li X,Liang Y,LeBlanc M,Benner C,Zheng Y
14-0281 was used in Flow cytometry/Cell sorting to investigate whether mechanisms exist to actively protect cell identity in response to environmental cues that confer functional plasticity.
Thu Aug 14 00:00:00 EDT 2014
The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells.
Nature immunology
Wang H,Geng J,Wen X,Bi E,Kossenkov AV,Wolf AI,Tas J,Choi YS,Takata H,Day TJ,Chang LY,Sprout SL,Becker EK,Willen J,Tian L,Wang X,Xiao C,Jiang P,Crotty S,Victora GD,Showe LC,Tucker HO,Erikson J,Hu H
14-0281 was used in Functional assays to investigate the role of Foxp1 in CD4(+) cells, showing that it is a critical negative regulator of the differentiation of follicular helper T cells.
Tue Jul 01 00:00:00 EDT 2014
Myeloid-derived suppressor cell function is diminished in aspirin-triggered allergic airway hyperresponsiveness in mice.
The Journal of allergy and clinical immunology
Shi M,Shi G,Tang J,Kong D,Bao Y,Xiao B,Zuo C,Wang T,Wang Q,Shen Y,Wang H,Funk CD,Zhou J,Yu Y
14-0281 was used in Flow cytometry/Cell sorting to characterise myeloid-derived suppressor cell accumulation and pathogenic functions in allergic airway inflammation mediated by COX-1 deficiency or aspirin treatment in mice.
Sat Nov 01 00:00:00 EDT 2014
Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity.
The EMBO journal
Jaworski M,Marsland BJ,Gehrig J,Held W,Favre S,Luther SA,Perroud M,Golshayan D,Gaide O,Thome M
14-0281 was used in Functional assays to investigate the effect of mutational inactivation of Malt1, showing that inactivation efficiently dampens immune responses but causes spontaneous autoimmunity.
Mon Dec 01 00:00:00 EST 2014
Complement c5a receptor facilitates cancer metastasis by altering T-cell responses in the metastatic niche.
Cancer research
Vadrevu SK,Chintala NK,Sharma SK,Sharma P,Cleveland C,Riediger L,Manne S,Fairlie DP,Gorczyca W,Almanza O,Karbowniczek M,Markiewski MM
14-0281 was used in Functional assays to study the impact of the complement system on cancer metastasis.
Tue Jul 01 00:00:00 EDT 2014
The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells.
Genes & development
Gerhardt DM,Pajcini KV,D'altri T,Tu L,Jain R,Xu L,Chen MJ,Rentschler S,Shestova O,Wertheim GB,Tobias JW,Kluk M,Wood AW,Aster JC,Gimotty PA,Epstein JA,Speck N,Bigas A,Pear WS
14-0281 was used in Functional assays to describe additional functions for Notch1 in embryonic haematopoietic stem cell biology.
Sat Mar 15 00:00:00 EDT 2014
Chronic hydroxychloroquine improves endothelial dysfunction and protects kidney in a mouse model of systemic lupus erythematosus.
Hypertension (Dallas, Tex. : 1979)
Gómez-Guzmán M,Jiménez R,Romero M,Sánchez M,Zarzuelo MJ,Gómez-Morales M,O'Valle F,López-Farré AJ,Algieri F,Gálvez J,Pérez-Vizcaino F,Sabio JM,Duarte J
14-0281 was used in Blocking experiments to investigate the effects of hydroxychloroquine on hypertension, endothelial dysfunction, and renal injury in a mouse model of systemic lupus erythematosus.
Fri Aug 01 00:00:00 EDT 2014
Suppressive oligodeoxynucleotides promote the generation of regulatory T cells by inhibiting STAT1 phosphorylation.
International immunopharmacology
Bode C,Wang J,Klinman DM
14-0281 was used in in vitro experiments to study the mechanism underlying the immunosuppressive activity of suppressive oligodeoxynucleotides.
Mon Dec 01 00:00:00 EST 2014
Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation.
Journal of immunology (Baltimore, Md. : 1950)
Yang CY,Li JP,Chiu LL,Lan JL,Chen DY,Chuang HC,Huang CY,Tan TH
14-0281 was used in Functional assays to study how DUSP14 negatively regulates TCR signaling and immune responses by inhibiting TAB1 activation.
Sat Feb 15 00:00:00 EST 2014
IL-18 enhances immunosuppressive responses by promoting differentiation into monocytic myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Lim HX,Hong HJ,Cho D,Kim TS
14-0281-82 was used in Flow Cytometry to study the role of IL-18 in mediating immunosuppression via specifically enhancing the differentiation and function of monocytic myeloid-derived suppressor cells.
Mon Dec 01 00:00:00 EST 2014
Leptin metabolically licenses T cells for activation to link nutrition and immunity.
Journal of immunology (Baltimore, Md. : 1950)
Saucillo DC,Gerriets VA,Sheng J,Rathmell JC,Maciver NJ
14-0281 was used in Functional assays to investigate mechanisms that link systemic nutrition to T cell function.
Wed Jan 01 00:00:00 EST 2014
Anaplerotic metabolism of alloreactive T cells provides a metabolic approach to treat graft-versus-host disease.
The Journal of pharmacology and experimental therapeutics
Glick GD,Rossignol R,Lyssiotis CA,Wahl D,Lesch C,Sanchez B,Liu X,Hao LY,Taylor C,Hurd A,Ferrara JL,Tkachev V,Byersdorfer CA,Boros L,Opipari AW
14-0281 was used in in vitro experiments to develop a model of T-cell metabolism relevant to activated lymphocytes in vivo.
Sat Nov 01 00:00:00 EDT 2014
Mouse Sertoli cells sustain de novo generation of regulatory T cells by triggering the notch pathway through soluble JAGGED1.
Biology of reproduction
Campese AF,Grazioli P,de Cesaris P,Riccioli A,Bellavia D,Pelullo M,Padula F,Noce C,Verkhovskaia S,Filippini A,Latella G,Screpanti I,Ziparo E,Starace D
14-0281 was used in Flow cytometry/Cell sorting to investigate whether conditioned medium from primary mouse Sertoli cells is able and sufficient to induce Tregs.
Sat Mar 01 00:00:00 EST 2014
Optimal attenuation of experimental autoimmune encephalomyelitis by intravenous immunoglobulin requires an intact interleukin-11 receptor.
PloS one
Figueiredo CA,Drohomyrecky PC,McCarthy SD,Leontyev D,Ma XZ,Branch DR,Dunn SE
14-0281 was used in Functional assays to investigate the mechanism of action of intravenous immunoglobulin treatment for autoimmunity, showing that optimal attenuation requires an intact interleukin-11 receptor.
Fri Oct 23 00:00:00 EDT 2015
Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis.
Cell reports
Mahata B,Zhang X,Kolodziejczyk AA,Proserpio V,Haim-Vilmovsky L,Taylor AE,Hebenstreit D,Dingler FA,Moignard V,Göttgens B,Arlt W,McKenzie AN,Teichmann SA
14-0281 was used in Functional assays to demonstrate the production of the steroid pregnenolone by Th2 cells in vitro and in vivo in a helminth infection model.
Thu May 22 00:00:00 EDT 2014
C/EBPα is dispensable for the ontogeny of PD-1+ CD4+ memory T cells but restricts their expansion in an age-dependent manner.
PloS one
Norrie IC,Ohlsson E,Nielsen O,Hasemann MS,Porse BT
14-0281 was used in Flow cytometry/Cell sorting to investigate the potential of the transcription factor C/EBPα as a target for the alleviation of ageing/cancer-associated immunosenescence.
Tue Sep 16 00:00:00 EDT 2014
Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation.
Cell reports
Gewies A,Gorka O,Bergmann H,Pechloff K,Petermann F,Jeltsch KM,Rudelius M,Kriegsmann M,Weichert W,Horsch M,Beckers J,Wurst W,Heikenwalder M,Korn T,Heissmeyer V,Ruland J
14-0281 was used in Flow cytometry/Cell sorting to demonstrate that targeted Malt1-paracaspase inactivation induces a lethal inflammatory syndrome with lymphocyte-dependent neurodegeneration.
Thu Nov 20 00:00:00 EST 2014
Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome.
Molecular therapy. Methods & clinical development
Shimizu K,Sakurai F,Tomita K,Nagamoto Y,Nakamura S,Katayama K,Tachibana M,Kawabata K,Mizuguchi H
14-0281 was used in Immunocytochemistry to investigate how insertion of microRNA-targeted sequences into replication-incompetent adenovirus vector genomes can suppress leaky expression of adenoviral genes.
Wed May 27 00:00:00 EDT 2015
NAD+ protects against EAE by regulating CD4+ T-cell differentiation.
Nature communications
Tullius SG,Biefer HR,Li S,Trachtenberg AJ,Edtinger K,Quante M,Krenzien F,Uehara H,Yang X,Kissick HT,Kuo WP,Ghiran I,de la Fuente MA,Arredouani MS,Camacho V,Tigges JC,Toxavidis V,El Fatimy R,Smith BD,Vasudevan A,ElKhal A
14-0281 was used in Functional assays to investigate the role of NAD+ in experimental autoimmune encephalomyelitis.
Tue Oct 07 00:00:00 EDT 2014
Experimental myocardial infarction induces altered regulatory T cell hemostasis, and adoptive transfer attenuates subsequent remodeling.
PloS one
Sharir R,Semo J,Shimoni S,Ben-Mordechai T,Landa-Rouben N,Maysel-Auslender S,Shaish A,Entin-Meer M,Keren G,George J
14-0281 was used in Functional assays to indicate that Tregs may serve as potential interventional targets for attenuating left ventricular remodeling.
Wed Sep 16 00:00:00 EDT 2015
The nuclear IκB family protein IκBNS influences the susceptibility to experimental autoimmune encephalomyelitis in a murine model.
PloS one
Kobayashi S,Hara A,Isagawa T,Manabe I,Takeda K,MaruYama T
14-0281 was used in Functional assays to investigate the role of IκBNS in autoimmunity, showing that it influences the susceptibility to experimental autoimmune encephalomyelitis.
Fri Jun 26 00:00:00 EDT 2015
CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.
eLife
Linterman MA,Denton AE,Divekar DP,Zvetkova I,Kane L,Ferreira C,Veldhoen M,Clare S,Dougan G,Espéli M,Smith KG
14-0281 was used in Flow cytometry/Cell sorting to determine the role for CD28 after T cell priming.
Mon Oct 27 00:00:00 EDT 2014
BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis.
Nature
Roychoudhuri R,Hirahara K,Mousavi K,Clever D,Klebanoff CA,Bonelli M,Sciumè G,Zare H,Vahedi G,Dema B,Yu Z,Liu H,Takahashi H,Rao M,Muranski P,Crompton JG,Punkosdy G,Bedognetti D,Wang E,Hoffmann V,Rivera J,Marincola FM,Nakamura A,Sartorelli V,Kanno Y,Gattinoni L,Muto A,Igarashi K,O'Shea JJ,Restifo NP
14-0281 was used in Flow cytometry/Cell sorting to study the role of BACH2 in the regulation of immune cell activation and differentiation.
Thu Jun 27 00:00:00 EDT 2013
Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity.
Cancer cell
Engels B,Engelhard VH,Sidney J,Sette A,Binder DC,Liu RB,Kranz DM,Meredith SC,Rowley DA,Schreiber H
14-0281 was used in Functional assays to investigate relapse after adoptive therapy, showing that relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity.
Mon Apr 15 00:00:00 EDT 2013
A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency.
The Journal of allergy and clinical immunology
Jabara HH,Ohsumi T,Chou J,Massaad MJ,Benson H,Megarbane A,Chouery E,Mikhael R,Gorka O,Gewies A,Portales P,Nakayama T,Hosokawa H,Revy P,Herrod H,Le Deist F,Lefranc G,Ruland J,Geha RS
14-0281 was used in Functional assays to identify the genetic cause of combined immunodeficiency in 2 siblings, the products of a first-cousin marriage, who experienced recurrent bacterial and candidal infections with bronchiectasis, growth delay, and early death.
Mon Jul 01 00:00:00 EDT 2013
CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria.
Mucosal immunology
Barnes MJ,Griseri T,Johnson AM,Young W,Powrie F,Izcue A
14-0281 was used in Functional assays to analyse the role of CTLA-4 in the peripheral induction of Treg cells in vitro and in vivo.
Fri Mar 01 00:00:00 EST 2013
TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment.
Journal of immunology (Baltimore, Md. : 1950)
Chen X,Wu X,Zhou Q,Howard OM,Netea MG,Oppenheim JJ
14-0281 was used in Functional assays to investigate means of promoting stability of Tregs, showing that TNFR2 is critical for stabilisation in the inflammatory environment.
Fri Feb 01 00:00:00 EST 2013
Phosphatidylinositol 3-kinase-independent signaling pathways contribute to ICOS-mediated T cell costimulation in acute graft-versus-host disease in mice.
Journal of immunology (Baltimore, Md. : 1950)
Li J,Heinrichs J,Leconte J,Haarberg K,Semple K,Liu C,Gigoux M,Kornete M,Piccirillo CA,Suh WK,Yu XZ
14-0281 was used in Functional assays to investigate ICOS signal transduction pathways involved in graft-versus-host disease, showing that PI3K--independent signaling pathways contribute to ICOS-mediated T cell costimulation.
Mon Jul 01 00:00:00 EDT 2013
Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival.
Journal of immunology (Baltimore, Md. : 1950)
Yeung MY,McGrath MM,Nakayama M,Shimizu T,Boenisch O,Magee CN,Abdoli R,Akiba H,Ueno T,Turka LA,Najafian N
14-0281 was used in in vitro experiments to show that blockade of dendritic cell-expressed TIM-4 leads to increased induction of induced regulatory T cells from naive T cells.
Tue Oct 15 00:00:00 EDT 2013
Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Baine I,Basu S,Ames R,Sellers RS,Macian F
14-0281 was used in Functional assays to identify that the transcription factor, Helios, maintains the anergic phenotype of Tregs by suppressing transcription of interleukin 2.
Fri Feb 01 00:00:00 EST 2013
Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Ammann JU,Cooke A,Trowsdale J
14-0281 was used in Functional assays to investigate a role for butyrophilin-related protein, Btn2a2, in the modulation of T lymphocytes.
Wed May 15 00:00:00 EDT 2013
Requirement for core 2 O-glycans for optimal resistance to helminth infection.
PloS one
Mullaly SC,Oudhoff MJ,Min PH,Burrows K,Antignano F,Rattray DG,Chenery A,McNagny KM,Ziltener HJ,Zaph C
14-0281 was used in Functional assays to examine the role of specific chemokine receptors, adhesion molecules and glycosyltransferases in the development of protective immunity to Trichuris muris.
Mon Sep 30 00:00:00 EDT 2013
Effects of Helicobacter suis γ-glutamyl transpeptidase on lymphocytes: modulation by glutamine and glutathione supplementation and outer membrane vesicles as a putative delivery route of the enzyme.
PloS one
Zhang G,Ducatelle R,Pasmans F,D'Herde K,Huang L,Smet A,Haesebrouck F,Flahou B
14-0281 was used in Functional assays to describe the effect of GGT from H. suis on various lymphocytes, showing that GGT leads to impaired proliferation and cell death in Jurkat T cells, CD4(+) T cells, CD8(+) T cells, and CD19(+) B cells; and that glutamine could restore proliferation.
Thu Jun 05 00:00:00 EDT 2014
Prostaglandin E₂ promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase.
Nature communications
Yao C,Hirata T,Soontrapa K,Ma X,Takemori H,Narumiya S
14-0281 was used in Functional assays to investigate the role of cAMP in Th1 differentiation, showing that prostaglandin E2 promotes differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase.
Tue Oct 22 00:00:00 EDT 2013
T cells at the site of autoimmune inflammation show increased potential for trogocytosis.
PloS one
Haastert B,Mellanby RJ,Anderton SM,O'Connor RA
14-0281 was used in Magnetic cell separation to assess the suitability of trogocytosis detection to identify disease relevant effector and regulatory T cells during autoimmune inflammation.
Thu Sep 11 00:00:00 EDT 2014
A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys.
Pharmaceuticals (Basel, Switzerland)
Ushio H,Ishibuchi S,Oshita K,Seki N,Kataoka H,Sugahara K,Adachi K,Chiba K
14-0281 was used in an ELISA assay to suggest that Y-320, an orally active inhibitor for IL-17 production, provides a useful therapy for rheumatoid arthritis (RA).
Mon Dec 23 00:00:00 EST 2013
Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade.
Nature communications
Leyva-Castillo JM,Hener P,Michea P,Karasuyama H,Chan S,Soumelis V,Li M
14-0281 was used in Functional assays to investigate the mechanisms by which thymic stromal lymphopoietin leads to Th2 initiation, showing that it occurs through an orchestrated immune cascade.
Tue Oct 07 00:00:00 EDT 2014
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.
Immunity
Hall AO,Beiting DP,Tato C,John B,Oldenhove G,Lombana CG,Pritchard GH,Silver JS,Bouladoux N,Stumhofer JS,Harris TH,Grainger J,Wojno ED,Wagage S,Roos DS,Scott P,Turka LA,Cherry S,Reiner SL,Cua D,Belkaid Y,Elloso MM,Hunter CA
14-0281 was used in Flow cytometry/Cell sorting to study the promotion of distinct Treg cell populations by the cytokines IL-27 and IFN-y, and the role they play in limiting infection induced pathology.
Fri Sep 21 00:00:00 EDT 2012
TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells.
Nature immunology
Takahashi H,Kanno T,Nakayamada S,Hirahara K,Sciumè G,Muljo SA,Kuchen S,Casellas R,Wei L,Kanno Y,O'Shea JJ
14-0281 was used in Functional assays to investigate the role of MicroRNAs on T cell plasticity, showing that TGF-β and retinoic acid induce miR-10a which targets Bcl-6 and constrains T helper plasticity.
Sun Apr 29 00:00:00 EDT 2012
Delineation of antigen-specific and antigen-nonspecific CD8(+) memory T-cell responses after cytokine-based cancer immunotherapy.
Blood
Tietze JK,Wilkins DE,Sckisel GD,Bouchlaka MN,Alderson KL,Weiss JM,Ames E,Bruhn KW,Craft N,Wiltrout RH,Longo DL,Lanier LL,Blazar BR,Redelman D,Murphy WJ
14-0281 was used in Functional assays to demonstrate that memory CD8(+) T cells can express differential phenotypes indicative of adaptive or innate effectors based on the nature of the stimuli.
Thu Mar 29 00:00:00 EDT 2012
CD28 ligation increases macrophage suppression of T-cell proliferation.
Cellular & molecular immunology
Silberman D,Bucknum A,Bartlett T,Composto G,Kozlowski M,Walker A,Werda A,Cua J,Sharpe AH,Somerville JE,Riggs JE
14-0281 was used in Functional assays to investigate the ability of exogenous T-cell costimulation to recover the peritoneal T-cell response.
Sun Jul 01 00:00:00 EDT 2012
Adoptive cell therapy for lymphoma with CD4 T cells depleted of CD137-expressing regulatory T cells.
Cancer research
Goldstein MJ,Kohrt HE,Houot R,Varghese B,Lin JT,Swanson E,Levy R
14-0281 was used in Functional assays to explore whether adoptive T-cell therapy is limited by cotransfer of Tregs, showing that cotransfer can be avoided through selection of CD4-expressing T cells and depletion of CD137-expressing Tregs.
Thu Mar 01 00:00:00 EST 2012
Long-term persistence of CD4(+) but rapid disappearance of CD8(+) T cells expressing an MHC class I-restricted TCR of nanomolar affinity.
Molecular therapy : the journal of the American Society of Gene Therapy
Engels B,Chervin AS,Sant AJ,Kranz DM,Schreiber H
14-0281 was used in Functional assays to investigate the effect of genetic engineering TCRs for nanomolar affinity, showing long-term persistence of CD4(+) but rapid disappearance of CD8(+) T cells expressing high affinity LCR.
Thu Mar 01 00:00:00 EST 2012
Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation.
Proceedings of the National Academy of Sciences of the United States of America
Castillo EF,Dekonenko A,Arko-Mensah J,Mandell MA,Dupont N,Jiang S,Delgado-Vargas M,Timmins GS,Bhattacharya D,Yang H,Hutt J,Lyons CR,Dobos KM,Deretic V
14-0281 was used in Flow cytometry/Cell sorting to study the role of autophagy during immune responses to tuberculosis.
Tue Nov 13 00:00:00 EST 2012
The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology.
PLoS pathogens
Hafalla JC,Claser C,Couper KN,Grau GE,Renia L,de Souza JB,Riley EM
14-0281 was used in an ELISA assay to investigate the differential and complex regulation that governs immune responses to malaria parasites.
Wed Feb 01 00:00:00 EST 2012
Characterization of an arachidonic acid-deficient (Fads1 knockout) mouse model.
Journal of lipid research
Fan YY,Monk JM,Hou TY,Callway E,Vincent L,Weeks B,Yang P,Chapkin RS
14-0281 was used in in vitro experiments to determine the utility of antagonising tissue arachidonic acid (AA) levels as a novel approach to suppress AA-derived eicosanoids.
Sun Jul 01 00:00:00 EDT 2012
TLR7 recognition is dispensable for influenza virus A infection but important for the induction of hemagglutinin-specific antibodies in response to the 2009 pandemic split vaccine in mice.
Journal of virology
Jeisy-Scott V,Kim JH,Davis WG,Cao W,Katz JM,Sambhara S
14-0281 was used in Flow cytometry/Cell sorting to demonstrate the important role that TLR7 plays in vaccine-induced humoral immune responses to influenza virus.
Mon Oct 01 00:00:00 EDT 2012
Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo in CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Aksoylar HI,Lampe K,Barnes MJ,Plas DR,Hoebe K
14-0281 was used in Flow cytometry/Cell sorting to establish a novel link between Gimap5 and Foxo expression and provide evidence for a regulatory mechanism that controls Foxo protein expression and may help to maintain immunological tolerance.
Sun Jan 01 00:00:00 EST 2012
Mannose-capped lipoarabinomannan from Mycobacterium tuberculosis preferentially inhibits sphingosine-1-phosphate-induced migration of Th1 cells.
Journal of immunology (Baltimore, Md. : 1950)
Richmond JM,Lee J,Green DS,Kornfeld H,Cruikshank WW
14-0281 was used in Flow cytometry/Cell sorting to examine the ability of ManLAM to desensitize T cells to other chemoattractants during mycobacterial infection.
Sat Dec 15 00:00:00 EST 2012
Prenatal cadmium exposure alters postnatal immune cell development and function.
Toxicology and applied pharmacology
Hanson ML,Holásková I,Elliott M,Brundage KM,Schafer R,Barnett JB
14-0281 was used in Functional assays to investigate the effects of prenatal exposure to Cd on the immune system of offspring, showing that exposure alters postnatal immune cell development and function.
Fri Jun 01 00:00:00 EDT 2012
In vitro culture medium influences the vaccine efficacy of Mycobacterium bovis BCG.
Vaccine
Venkataswamy MM,Goldberg MF,Baena A,Chan J,Jacobs WR,Porcelli SA
14-0281 was used in Flow cytometry/Cell sorting to review the manufacturing process of the mycobacterium bovis BCG vaccine.
Wed Feb 01 00:00:00 EST 2012
Therapeutic effects of systemic administration of chaperone αB-crystallin associated with binding proinflammatory plasma proteins.
The Journal of biological chemistry
Rothbard JB,Kurnellas MP,Brownell S,Adams CM,Su L,Axtell RC,Chen R,Fathman CG,Robinson WH,Steinman L
14-0281 was used in Functional assays to explore the mechanisms underlying the therapeutic benefit conferred by the the small heat shock protein, αB-crystallin, in inflammatory disease.
Fri Mar 23 00:00:00 EDT 2012
Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis.
PloS one
Monk JM,Hou TY,Turk HF,Weeks B,Wu C,McMurray DN,Chapkin RS
14-0281 was used in Functional assays to monitor changes in immune cell subsets and inflammatory biomarker expression in a mouse model of concurrent obesity and colitis.
Thu Jun 20 00:00:00 EDT 2013
Loss of T regulatory cell suppression following signaling through glucocorticoid-induced tumor necrosis receptor (GITR) is dependent on c-Jun N-terminal kinase activation.
The Journal of biological chemistry
Joetham A,Ohnishi H,Okamoto M,Takeda K,Schedel M,Domenico J,Dakhama A,Gelfand EW
14-0281 was used in Functional assays to demonstrate that regulation of JNK phosphorylation plays a central role in Treg cell function.
Fri May 18 00:00:00 EDT 2012
Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells.
Nature immunology
Islam SA,Chang DS,Colvin RA,Byrne MH,McCully ML,Moser B,Lira SA,Charo IF,Luster AD
14-0281 was used in Functional assays to investigate the biological activity of CCL8, showing that it promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells.
Tue Feb 01 00:00:00 EST 2011
Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3+ CD4+ T cells with limited suppressor activity.
European journal of immunology
Goudy KS,Johnson MC,Garland A,Li C,Samulski RJ,Wang B,Tisch R
14-0281 was used in Functional assays to investigate the role of IL-2 in the regulation of FoxP3(+) T reg cells in NOD mice.
Sun May 01 00:00:00 EDT 2011
Cofilin-mediated F-actin severing is regulated by the Rap GTPase and controls the cytoskeletal dynamics that drive lymphocyte spreading and BCR microcluster formation.
Journal of immunology (Baltimore, Md. : 1950)
Freeman SA,Lei V,Dang-Lawson M,Mizuno K,Roskelley CD,Gold MR
14-0281 was used in Functional assays to identify factors critical for the early cytoskeletal changes and BCR reorganisation that are involved in APC-dependent lymphocyte activation.
Thu Dec 01 00:00:00 EST 2011
Rescue of tumor-infiltrating lymphocytes from activation-induced cell death enhances the antitumor CTL response in CD5-deficient mice.
Journal of immunology (Baltimore, Md. : 1950)
Tabbekh M,Franciszkiewicz K,Haouas H,Lécluse Y,Benihoud K,Raman C,Mami-Chouaib F
14-0281-86 was used in Flow Cytometry to compare the T cell response to the B16F10 melanoma engrafted into CD5-deficient and wild-type C57BL/6 mice.
Fri Jul 01 00:00:00 EDT 2011
The plasticity of regulatory T cell function.
Journal of immunology (Baltimore, Md. : 1950)
Pillai MR,Collison LW,Wang X,Finkelstein D,Rehg JE,Boyd K,Szymczak-Workman AL,Doggett T,Griffith TS,Ferguson TA,Vignali DA
14-0281 was used in Functional assays to investigate functional capacity of Tregs lacking the ability to secrete both IL-10 and IL-3.
Tue Nov 15 00:00:00 EST 2011
TNF receptor-associated factor 3 is required for T cell-mediated immunity and TCR/CD28 signaling.
Journal of immunology (Baltimore, Md. : 1950)
Xie P,Kraus ZJ,Stunz LL,Liu Y,Bishop GA
14-0281 was used in Flow cytometry/Cell sorting to provide insights into the specific function of TNFR-associated factor 3 in T cells.
Sat Jan 01 00:00:00 EST 2011
Identification of Baicalin as an immunoregulatory compound by controlling T(H)17 cell differentiation.
PloS one
Yang J,Yang X,Chu Y,Li M
14-0281 was used in Flow cytometry/Cell sorting to show that Baicalin inhibited T(H)17 cell differentiation and thus has the potential to be used as a therapeutic for T(H)17 cell-mediated inflammatory diseases.
Wed Feb 16 00:00:00 EST 2011
Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age.
PloS one
Qin H,Suzuki K,Nakata M,Chikuma S,Izumi N,Huong le T,Maruya M,Fagarasan S,Busslinger M,Honjo T,Nagaoka H
14-0281 was used in Functional assays to investigate the role of activation-induced cytidine deaminase in T cells, showing that expression is associated with a unique IL-10-producing subset that increases with age.
Mon May 21 00:00:00 EDT 2012
Critical role of TCF-1 in repression of the IL-17 gene.
PloS one
Ma J,Wang R,Fang X,Ding Y,Sun Z
14-0281 was used in Flow cytometry/Cell sorting to show that TCF-1 is a critical factor to repress the IL-17 gene by chromatin modifications during T cell development.
Tue Feb 28 00:00:00 EST 2012
A role for IL-27p28 as an antagonist of gp130-mediated signaling.
Nature immunology
Stumhofer JS,Tait ED,Quinn WJ,Hosken N,Spudy B,Goenka R,Fielding CA,O'Hara AC,Chen Y,Jones ML,Saris CJ,Rose-John S,Cua DJ,Jones SA,Elloso MM,Grötzinger J,Cancro MP,Levin SD,Hunter CA
14-0281 was used in in vitro experiments to indicate a role for IL-27p28 as an antagonist of gp130-mediated signaling.
Wed Dec 01 00:00:00 EST 2010
An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.
Nature immunology
Berger M,Krebs P,Crozat K,Li X,Croker BA,Siggs OM,Popkin D,Du X,Lawson BR,Theofilopoulos AN,Xia Y,Khovananth K,Moresco EM,Satoh T,Takeuchi O,Akira S,Beutler B
14-0281 was used in Functional assays to investigate a new mutation in Slfn2, which causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.
Thu Apr 01 00:00:00 EDT 2010
The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma.
American journal of respiratory and critical care medicine
Naus S,Blanchet MR,Gossens K,Zaph C,Bartsch JW,McNagny KM,Ziltener HJ
14-0281 was used in Flow cytometry/Cell sorting to determine that ADAM8 plays a crucial proinflammatory role in airway inflammation.
Tue Jun 15 00:00:00 EDT 2010
Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function.
The Journal of experimental medicine
Lehnertz B,Northrop JP,Antignano F,Burrows K,Hadidi S,Mullaly SC,Rossi FM,Zaph C
14-0281 was used in Functional assays to investigate whether G9a plays a similar role in adult cells as it does during embryonic stem cell differentiation.
Mon May 10 00:00:00 EDT 2010
Overexpression of survivin initiates hematologic malignancies in vivo.
Leukemia
Small S,Keerthivasan G,Huang Z,Gurbuxani S,Crispino JD
14-0281 was used in Functional assays to investigate the extent to which survivin contributes to the initiation of tumours, showing that overexpression initiates hematologic malignancies.
Mon Nov 01 00:00:00 EDT 2010
L-selectin is dispensable for T regulatory cell function postallogeneic bone marrow transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Carlson MJ,Fulton LM,Coghill JM,West ML,Burgents JE,Wan Y,Panoskaltsis-Mortari A,Tedder TF,Blazar BR,Serody JS
14-0281 was used in Flow cytometry/Cell sorting to demonstrate that the adhesion molecule CD62L was dispensable for Treg-mediated protection from graft-versus-host disease.
Wed Dec 01 00:00:00 EST 2010
Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells.
Journal of molecular medicine (Berlin, Germany)
Polansky JK,Schreiber L,Thelemann C,Ludwig L,Krüger M,Baumgrass R,Cording S,Floess S,Hamann A,Huehn J
14-0281 was used in Flow cytometry/Cell sorting to demonstrate that the methylation state of the CpG motifs within the TSDR controls its transcriptional activity rather than a Treg-specific transcription factor network.
Fri Oct 01 00:00:00 EDT 2010
Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation.
Journal of immunology (Baltimore, Md. : 1950)
Carr EL,Kelman A,Wu GS,Gopaul R,Senkevitch E,Aghvanyan A,Turay AM,Frauwirth KA
14-0281 was used in in vitro experiments to study the role of amino acid metabolism in T cell activation.
Thu Jul 15 00:00:00 EDT 2010
Differential geminin requirement for proliferation of thymocytes and mature T cells.
Journal of immunology (Baltimore, Md. : 1950)
Karamitros D,Kotantaki P,Lygerou Z,Veiga-Fernandes H,Pachnis V,Kioussis D,Taraviras S
14-0281 was used in Functional assays to gain insight into the in vivo role of Geminin in progenitor cell division and differentiation.
Mon Mar 01 00:00:00 EST 2010
Chemoattractant receptors and lymphocyte egress from extralymphoid tissue: changing requirements during the course of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Brown MN,Fintushel SR,Lee MH,Jennrich S,Geherin SA,Hay JB,Butcher EC,Debes GF
14-0281 was used in Functional assays to investigate the dynamics and mechanisms of T cell exit from inflamed tissues, showing that requirements change during the course of inflammation.
Fri Oct 15 00:00:00 EDT 2010
Pharmacologic inhibition of MEK-ERK signaling enhances Th17 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Tan AH,Lam KP
14-0281 was used in Flow cytometry/Cell sorting to suggest that MEK-ERK signalling negatively regulates Th17 differentiation in a T helper cell-intrinsic way.
Mon Feb 15 00:00:00 EST 2010
Myelin-reactive, TGF-β-induced regulatory T cells can be programmed to develop Th1-like effector function but remain less proinflammatory than myelin-reactive Th1 effectors and can suppress pathogenic T cell clonal expansion in vivo.
Journal of immunology (Baltimore, Md. : 1950)
O'Connor RA,Leech MD,Suffner J,Hämmerling GJ,Anderton SM
14-0281 was used in Flow cytometry/Cell sorting to assess the capacity for proinflammatory function of inducible regulatory T cells cells in vivo.
Wed Dec 15 00:00:00 EST 2010
Activation-induced T helper cell death contributes to Th1/Th2 polarization following murine Schistosoma japonicum infection.
Journal of biomedicine & biotechnology
Xu X,Wen X,Chi Y,He L,Zhou S,Wang X,Zhao J,Liu F,Su C
14-0281 was used in Functional assays to suggest that Th1 or Th2 cell apoptosis is preferentially induced by different schistosome antigens during different stages of infection.
Thu Apr 01 00:00:00 EDT 2010
Liver sinusoidal endothelial cell lectin, LSECtin, negatively regulates hepatic T-cell immune response.
Gastroenterology
Tang L,Yang J,Liu W,Tang X,Chen J,Zhao D,Wang M,Xu F,Lu Y,Liu B,Sun Q,Zhang L,He F
14-0281 was used in Functional assays to investigate the molecular basis of immune suppression in the liver.
Thu Oct 01 00:00:00 EDT 2009
Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice.
The Journal of clinical investigation
Bedoret D,Wallemacq H,Marichal T,Desmet C,Quesada Calvo F,Henry E,Closset R,Dewals B,Thielen C,Gustin P,de Leval L,Van Rooijen N,Le Moine A,Vanderplasschen A,Cataldo D,Drion PV,Moser M,Lekeux P,Bureau F
14-0281 was used in Functional assays to reveal a crucial role for IMs in maintaining immune homeostasis in the respiratory tract.
Tue Dec 01 00:00:00 EST 2009
Function of the nucleotide exchange activity of vav1 in T cell development and activation.
Science signaling
Saveliev A,Vanes L,Ksionda O,Rapley J,Smerdon SJ,Rittinger K,Tybulewicz VL
14-0281 was used in Flow cytometry/Cell sorting to demonstrate that in T-cells, the guanine nucleotide exchange factor activity of Vav1 is essential for some of its functions.
Tue Dec 15 00:00:00 EST 2009
Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression.
Journal of immunology (Baltimore, Md. : 1950)
Lin JT,Lineberry NB,Kattah MG,Su LL,Utz PJ,Fathman CG,Wu L
14-0281 was used in Functional assays to investigate the role of GRAIL in CD4 T cells, showing that proliferation is controlled by mTOR regulation of GRAIL expression.
Fri May 15 00:00:00 EDT 2009
The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3.
Journal of immunology (Baltimore, Md. : 1950)
Kohu K,Ohmori H,Wong WF,Onda D,Wakoh T,Kon S,Yamashita M,Nakayama T,Kubo M,Satake M
14-0281 was used in Functional assays to investigate the role of Runx3 in Th1 and Th2 cells.
Tue Dec 15 00:00:00 EST 2009
CD69 gene is differentially regulated in T and B cells by evolutionarily conserved promoter-distal elements.
Journal of immunology (Baltimore, Md. : 1950)
Vazquez BN,Laguna T,Carabana J,Krangel MS,Lauzurica P
14-0281 was used in Functional assays to investigate the molecular mechanism underlying mouse CD69 gene transcription in vivo in T and B cells, showing it is is differentially regulated.
Sun Nov 15 00:00:00 EST 2009
Beta-catenin/Tcf determines the outcome of thymic selection in response to alphabetaTCR signaling.
Journal of immunology (Baltimore, Md. : 1950)
Kovalovsky D,Yu Y,Dose M,Emmanouilidou A,Konstantinou T,Germar K,Aghajani K,Guo Z,Mandal M,Gounari F
14-0281-82 was used in Flow Cytometry to report that beta-catenin/Tcf signalling was activated in double-positive thymocytes in response to alphabetaTCR engagement and impacted thymocyte selection.
Tue Sep 15 00:00:00 EDT 2009
Anergic T cells are metabolically anergic.
Journal of immunology (Baltimore, Md. : 1950)
Zheng Y,Delgoffe GM,Meyer CF,Chan W,Powell JD
14-0281 was used in an ELISA assay to suggest that one mechanism responsible for the maintenance of T-cell anergy is failure to up-regulate the metabolic machinery.
Sun Nov 15 00:00:00 EST 2009
Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice.
Journal of immunology (Baltimore, Md. : 1950)
Lahl K,Mayer CT,Bopp T,Huehn J,Loddenkemper C,Eberl G,Wirnsberger G,Dornmair K,Geffers R,Schmitt E,Buer J,Sparwasser T
14-0281 was used in Functional assays to investigate whether nonfunctional Tregs carrying self-reactive T cell receptors contribute to scurfy pathogenesis.
Sun Nov 01 00:00:00 EDT 2009
Regulation of growth and survival of activated T cells by cell-transducing inhibitors of Ras.
FEBS letters
Malik NM,Gilroy DW,Kabouridis PS
14-0281-82 was used in Western Blotting to develop cell-penetrating Ras inhibitors and study their ability to inhibit T-cell activation, showing that anti-CD3/CD28-activated cells had a reduction in cell size, proliferation and increased apoptosis.
Mon Jan 05 00:00:00 EST 2009
Regulation of growth and survival of activated T cells by cell-transducing inhibitors of Ras.
FEBS letters
Malik NM,Gilroy DW,Kabouridis PS
14-0281-82 was used in Western Blotting to develop cell-penetrating Ras inhibitors and study their ability to inhibit T-cell activation, showing that anti-CD3/CD28-activated cells had a reduction in cell size, proliferation and increased apoptosis.
Mon Jan 05 00:00:00 EST 2009
Regulation of growth and survival of activated T cells by cell-transducing inhibitors of Ras.
FEBS letters
Malik NM,Gilroy DW,Kabouridis PS
14-0281-82 was used in Western Blotting to develop cell-penetrating Ras inhibitors and study their ability to inhibit T-cell activation, showing that anti-CD3/CD28-activated cells had a reduction in cell size, proliferation and increased apoptosis.
Mon Jan 05 00:00:00 EST 2009
A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1.
Cell research
Sheng H,Wang Y,Jin Y,Zhang Q,Zhang Y,Wang L,Shen B,Yin S,Liu W,Cui L,Li N
14-0281 was used in Flow cytometry/Cell sorting to investigate the role that IFNγ plays in mesenchymal stem cell mediated suppression of T cell proliferation.
Fri Aug 01 00:00:00 EDT 2008
CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease.
Nature immunology
Hadeiba H,Sato T,Habtezion A,Oderup C,Pan J,Butcher EC
14-0281 was used in in vitro experiments to identify a highly immunosuppressive population of pDCs present in lymphoid tissues.
Sat Nov 01 00:00:00 EDT 2008
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells.
The Journal of experimental medicine
Lochner M,Peduto L,Cherrier M,Sawa S,Langa F,Varona R,Riethmacher D,Si-Tahar M,Di Santo JP,Eberl G
14-0281 was used in Flow cytometry/Cell sorting to study how potentially antagonistic pro-inflammatory IL-17-producing and regulatory Foxp3(+) RORgamma t(+) T cells coexist and are tightly controlled.
Mon Jun 09 00:00:00 EDT 2008
Synthetic CD4+ T cell-targeted antigen-presenting cells elicit protective antitumor responses.
Cancer research
Caserta S,Alessi P,Guarnerio J,Basso V,Mondino A
14-0281 was used in Flow cytometry/Cell sorting to support the use of cell-free, synthetic aAPC as a specific and versatile alternative to expand peptide-specific CD4(+) T cells in adoptive and active immunotherapy.
Tue Apr 15 00:00:00 EDT 2008
Automated analysis of two- and three-color fluorescent Elispot (Fluorospot) assays for cytokine secretion.
Computer methods and programs in biomedicine
Rebhahn JA,Bishop C,Divekar AA,Jiminez-Garcia K,Kobie JJ,Lee FE,Maupin GM,Snyder-Cappione JE,Zaiss DM,Mosmann TR
14-0281 was used in an ELISpot assay to develop an automated counting program to detect and quantify Fluorospots in automated fluorescence microscope images.
Wed Oct 01 00:00:00 EDT 2008
Automated analysis of two- and three-color fluorescent Elispot (Fluorospot) assays for cytokine secretion.
Computer methods and programs in biomedicine
Rebhahn JA,Bishop C,Divekar AA,Jiminez-Garcia K,Kobie JJ,Lee FE,Maupin GM,Snyder-Cappione JE,Zaiss DM,Mosmann TR
14-0281 was used in an ELISpot assay to develop an automated counting program to detect and quantify Fluorospots in automated fluorescence microscope images.
Wed Oct 01 00:00:00 EDT 2008
APRIL (TNFSF13) regulates collagen-induced arthritis, IL-17 production and Th2 response.
European journal of immunology
Xiao Y,Motomura S,Podack ER
14-0281 was used in an ELISA assay to study the effects of a proliferation-inducing ligand (APRIL) deficiency on the mouse immune system in vitro.
Mon Dec 01 00:00:00 EST 2008
Selective suppression of lymphomas by functional loss of Hsf1 in a p53-deficient mouse model for spontaneous tumors.
Oncogene
Min JN,Huang L,Zimonjic DB,Moskophidis D,Mivechi NF
14-0281 was used in Functional assays to link the loss of Hsf1-dependent function to decreased susceptibility to spontaneous lymphomagenesis.
Thu Aug 02 00:00:00 EDT 2007
Phosphorylation of Bcl10 negatively regulates T-cell receptor-mediated NF-kappaB activation.
Molecular and cellular biology
Zeng H,Di L,Fu G,Chen Y,Gao X,Xu L,Lin X,Wen R
Published figure using CD28 monoclonal antibody (Product # 14-0281-82) in T-Cell Activation
Sun Jul 01 00:00:00 EDT 2007
Quantitative analysis of T cell homeostatic proliferation.
Cellular immunology
Li CR,Santoso S,Lo DD
14-0281 was used in in vitro experiments to characterise proliferation and apoptosis of T cells upon transfer into lymphopaenic recipients.
Mon May 19 00:00:00 EDT 2008
Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis.
The Journal of biological chemistry
Grigorian A,Lee SU,Tian W,Chen IJ,Gao G,Mendelsohn R,Dennis JW,Demetriou M
14-0281 was used in Flow cytometry/Cell sorting to investigate how the environment influences susceptibility to autoimmunity, showing that autoimmunity can be controlled through metabolite flux to N-glycan biosynthesis.
Fri Jul 06 00:00:00 EDT 2007
Prolongation of allograft survival by administration of anti-CD45RB monoclonal antibody is due to alteration of CD45RBhi: CD45RBlo T-cell proportions.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Luke PP,Deng JP,Lian D,O'Connell PJ,Garcia B,Jevnikar AM,Zhong R
14-0281-82 was used in Flow Cytometry to assess the importance of CD45RBhi T-cell depletion in murine cardiac allograft survival.
Fri Sep 01 00:00:00 EDT 2006
Pathogenic role for virus-specific CD4 T cells in mice with coronavirus-induced acute encephalitis.
The American journal of pathology
Anghelina D,Pewe L,Perlman S
14-0281 was used in an ELISpot assay to show that the host response to a single JHMV-specific immunodominant CD4 T-cell epitope is critical for severe disease.
Sat Jul 01 00:00:00 EDT 2006
C5a receptor deficiency attenuates T cell function and renal disease in MRLlpr mice.
Journal of the American Society of Nephrology : JASN
Wenderfer SE,Ke B,Hollmann TJ,Wetsel RA,Lan HY,Braun MC
14-0281 was used in an ELISA assay to indicate the role of the C5a receptor in modulating complement-dependent renal injury and Th-1 responses in MRLlpr mice.
Thu Dec 01 00:00:00 EST 2005
