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Application
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CD300LB Antibody (PA5-139850) in ICC/IF
Immunofluorecent analysis of CD300LB in human cell line THP-1 using CD300LB Polyclonal Antibody (Product # PA5-139850). Staining shows localization to plasma membrane.
Product Details
PA5-139850
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CD300LB. Recombinant protein control fragment (Product #RP-108982).
Conjugate
Unconjugated
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2926852
Product Specific Information
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: SQRVPEEPGE QPIYMNFSEP LTKDMAT
Target Information
CD300 molecule-like family member b (CD300LB), also known as CLM-7, is a gene located on chromosome 17q25.1, encoding an immunoreceptor that belongs to the CD300 family of molecules. CD300LB is primarily expressed on the surface of myeloid cells, including dendritic cells and macrophages, where it plays an essential role in modulating immune responses. The receptor is involved in the regulation of cell activation and inflammatory responses through its interactions with phosphatidylserine and other lipid ligands, which can lead to either activation or inhibition of immune cell functions. CD300LB influences processes like antigen presentation, phagocytosis, and cytokine production, thereby impacting innate immune responses and the maintenance of immune homeostasis. Its expression and activity are of particular interest in contexts like autoimmunity, infection, and cancer, where it may contribute to disease progression and serve as a potential therapeutic target in modulating immune functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD300 antigen like family member B; CD300 antigen-like family member B; CD300 molecule-like family member b; CD300b; CLM-7; CMRF35-A2; CMRF35-like molecule 7; Immune receptor expressed on myeloid cells 3; IREM-3; Leukocyte mono-Ig-like receptor 5; TREM-5; Triggering receptor expressed on myeloid cells 5
Gene Aliases: CD300B; CD300LB; CLM-7; CLM7; CMRF35-A2; CMRF35A2; IREM-3; IREM3; LMIR5; TREM-5; TREM5; UNQ2530/PRO6029
UniProt ID: (Human) A8K4G0
Entrez Gene ID: (Human) 124599
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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