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Invitrogen
CD300b Polyclonal Antibody
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Application
FIGURE: 1 / 1
CD300b Antibody (PA5-120746) in WB
Western blot analysis of CD300b in extracts of various cell lines. Samples were incubated with CD300b Polyclonal antibody (Product # PA5-120746) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-120746
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-201 of human CD300LB (NP_777552.3).
Conjugate
Unconjugated
Form
Liquid
Concentration
1.95 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2914318
Product Specific Information
Positive test controls include: Mouse lung, Rat lung.
Immunogen sequence: MWLPPALLLL SLSGCFSIQG PESVRAPEQG SLTVQCHYKQ GWETYIKWWC RGVRWDTCKI LIETRGSEQG EKSDRVSIKD NQKDRTFTVT MEGLRRDDAD VYWCGIERRG PDLGTQVKVI VDPEGAASTT ASSPTNSNMA VFIGSHKRNH YMLLVFVKVP ILLILVTAIL WLKGSQRVPE EPGEQPIYMN FSEPLTKDMA T
Target Information
CD300 molecule-like family member b (CD300LB), also known as CLM-7, is a gene located on chromosome 17q25.1, encoding an immunoreceptor that belongs to the CD300 family of molecules. CD300LB is primarily expressed on the surface of myeloid cells, including dendritic cells and macrophages, where it plays an essential role in modulating immune responses. The receptor is involved in the regulation of cell activation and inflammatory responses through its interactions with phosphatidylserine and other lipid ligands, which can lead to either activation or inhibition of immune cell functions. CD300LB influences processes like antigen presentation, phagocytosis, and cytokine production, thereby impacting innate immune responses and the maintenance of immune homeostasis. Its expression and activity are of particular interest in contexts like autoimmunity, infection, and cancer, where it may contribute to disease progression and serve as a potential therapeutic target in modulating immune functions.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD300 antigen like family member B; CD300 antigen-like family member B; CD300 molecule-like family member b; CD300b; CLM-7; CMRF-35-like molecule-7; CMRF35-A2; CMRF35-like molecule 7; immune activating receptor CD300b; Immune receptor expressed on myeloid cells 3; IREM-3; Leukocyte mono-Ig-like receptor 5; TREM-5; Triggering receptor expressed on myeloid cells 5
Gene Aliases: CD300B; CD300LB; CLM-7; CLM7; CMRF35-A2; CMRF35A2; Gm253; IREM-3; IREM3; LMIR5; TREM-5; TREM5; UNQ2530/PRO6029
UniProt ID: (Human) A8K4G0, (Mouse) Q3U497
Entrez Gene ID: (Human) 124599, (Mouse) 217304, (Rat) 501738
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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