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Invitrogen
CD357 (AITR/GITR) Chimeric Recombinant Rabbit Monoclonal Antibody (YGITR765)
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CD357 (AITR/GITR) Chimeric Antibody (MA5-48021) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of GITR in mouse splenocytes using CD357 (AITR/GITR) Chimeric Monoclonal Antibody (Product # MA5-48021). Paraformaldehyde-fixed cells were immobilized on cover slips and stained with CD357 (AITR/GITR) Chimeric Monoclonal Antibody at 10 µg/mL for 1h followed by Alexa Fluor488 secondary antibody (1 µg/mL), showing membrane staining in a subset of cells. The nucl... View More
Product Details
MA5-48021
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
YGITR765
Immunogen
nB2/6TG cells transfected with mouse GITR injected into DA rats.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.02% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3074464
Product Specific Information
Specificity: This antibody binds murine GITR.
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. It is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD357; Glucocorticoid-induced TNFR-related protein; PRO364; Tumor necrosis factor receptor superfamily member 18; UNQ319
Gene Aliases: AITR; Gitr; Tnfrsf18
UniProt ID: (Mouse) O35714
Entrez Gene ID: (Mouse) 21936
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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