Invitrogen

CD36 Polyclonal Antibody

View all (91) CD36 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-29589

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fragment corresponding to a region within amino acids 1 and 273 of Human CD36
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.71 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

0.1M tris glycine, pH 7, with 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2547065

Product Specific Information

Recommended positive controls: HeLa, HepG2, Mouse brown adipose.

Predicted reactivity: Mouse (83%), Rat (85%), Dog (80%), Pig (82%), Rhesus Monkey (92%), Bovine (81%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

CD36, also known as scavenger receptor class B member 3, is a protein that is expressed on the surface of various cell types, including macrophages, platelets, and adipocytes. It plays a role in lipid metabolism, inflammation, and atherosclerosis, and is involved in the recognition and uptake of various ligands such as oxidized low-density lipoproteins, long-chain fatty acids, and apoptotic cells. CD36 is also implicated in the pathogenesis of malaria. The protein encoded by this gene serves as a receptor for thrombospondin in platelets and various cell lines, and is the fourth major glycoprotein of the platelet surface. It binds to collagen, thrombospondin, anionic phospholipids, and oxidized LDL, and directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. Diseases associated with CD36 include Platelet Glycoprotein IV Deficiency and Coronary Heart Disease 7.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD36; CD36 antigen (collagen type I receptor, thrombospondin receptor); CD36 molecule (thrombospondin receptor); cluster determinant 36; FAT; Fatty acid translocase; Glycoprotein IIIb; GPIIIB; GPIV; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; PAS-4 protein; Platelet collagen receptor; Platelet glycoprotein 4; Platelet glycoprotein IV; scavenger receptor class B, member 3; SR-B3; Thrombospondin receptor

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Gene Aliases: BDPLT10; CD36; CHDS7; FAT; GP3B; GP4; GPIV; PASIV; SCARB3

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UniProt ID: (Human) P16671, (Mouse) Q08857

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Entrez Gene ID: (Human) 948, (Mouse) 12491

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Function(s)
low-density lipoprotein receptor activity protein binding high-density lipoprotein particle binding lipid binding low-density lipoprotein particle binding transforming growth factor beta binding thrombospondin receptor activity lipoteichoic acid receptor activity lipoprotein particle binding oleic acid binding membrane trafficking regulatory protein
Process(es)
negative regulation of transcription from RNA polymerase II promoter positive regulation of cell-matrix adhesion antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent platelet degranulation MyD88-dependent toll-like receptor signaling pathway lipid metabolic process receptor-mediated endocytosis phagocytosis, recognition immune response cell adhesion cell surface receptor signaling pathway positive regulation of cytosolic calcium ion concentration nitric oxide mediated signal transduction blood coagulation positive regulation of macrophage derived foam cell differentiation positive regulation of cholesterol storage lipid storage cGMP-mediated signaling positive regulation of blood coagulation intestinal cholesterol absorption cholesterol transport receptor internalization positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production response to lipid triglyceride transport plasma lipoprotein particle clearance low-density lipoprotein particle clearance response to stilbenoid toll-like receptor TLR6:TLR2 signaling pathway lipoprotein transport negative regulation of transcription factor import into nucleus positive regulation of I-kappaB kinase/NF-kappaB signaling apoptotic cell clearance negative regulation of growth of symbiont in host long-chain fatty acid import interleukin-1 beta secretion positive regulation of peptidyl-tyrosine phosphorylation defense response to Gram-positive bacterium intestinal absorption sensory perception of taste low-density lipoprotein particle mediated signaling positive regulation of phagocytosis, engulfment positive regulation of macrophage cytokine production positive regulation of ERK1 and ERK2 cascade cholesterol import response to fatty acid response to linoleic acid cellular response to lipopolysaccharide cellular response to lipoteichoic acid cellular response to low-density lipoprotein particle stimulus cellular response to hydroperoxide cellular response to diacyl bacterial lipopeptide positive regulation of NLRP3 inflammasome complex assembly amyloid fibril formation regulation of removal of superoxide radicals positive regulation of blood microparticle formation positive regulation of reactive oxygen species metabolic process regulation of energy homeostasis long-chain fatty acid metabolic process pattern recognition receptor signaling pathway negative regulation of systemic arterial blood pressure fatty acid metabolic process triglyceride metabolic process transport signal transduction response to mechanical stimulus negative regulation of gene expression fatty acid transport long-chain fatty acid transport plasma membrane long-chain fatty acid transport negative regulation of angiogenesis fatty acid oxidation positive regulation of MAPK cascade regulation of transcription from RNA polymerase II promoter in response to oxidative stress positive regulation of cytokine secretion cellular response to bacterial lipopeptide
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