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Invitrogen
CD41/CD61 Monoclonal Antibody (PAC-1), Alexa Fluor™ 488
Application
FIGURE: 1 / 2
CD41/CD61 Antibody (MA5-44123) in Flow
Separation of human thrombocytes (red-filled) from lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human PHA stimulated peripheral whole blood stained using anti-human CD41/61 (PAC-1) Alexa Fluor® 488 Monoclonal antibody (Product # MA5-44123) using a dilution of 4 µL reagent/100 µL of peripheral whole blood.
Product Details
MA5-44123
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgM, kappa
Class
Monoclonal
Type
Antibody
Clone
PAC-1
Immunogen
Human platelets
Conjugate
Excitation/Emission Max
499/520 nm
View spectra
Form
Liquid
Purification
Size-exclusion chromatography
Storage buffer
TBS with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4° C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2913055
Product Specific Information
This antibody recognizes an extracellular activation-induced conformational epitope PAC-1 on CD41/CD61 complex (gpIIb/IIIa), also known as integrin alpha IIb beta 3, a receptor which mediates platelet aggregation.
Target Information
CD41 is a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD61 non-covalently associates with CD41.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alphaIIb protein; antigen CD61; CD41; CD61; GPalpha IIb; GPIIb; GPIIIa; Integrin alpha-2b; Integrin alpha-IIb; integrin beta 3; Integrin beta-3; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); platelet fibrinogen receptor, alpha subunit; platelet glycoprotein IIb of IIb/IIIa complex; Platelet membrane glycoprotein IIb; Platelet membrane glycoprotein IIIa; platelet-specific antigen BAK; protein phosphatase 1, regulatory subunit 93
Gene Aliases: BDPLT16; BDPLT2; CD41; CD41B; CD61; GP2B; GP3A; GPIIb; GPIIIa; GT; GTA; HPA3; ITGA2B; ITGAB; ITGB3; PPP1R93
UniProt ID: (Human) P08514, (Human) P05106
Entrez Gene ID: (Human) 3674, (Human) 3690
protein binding
identical protein binding
metal ion binding
extracellular matrix binding
fibrinogen binding
virus receptor activity
fibronectin binding
protease binding
protein disulfide isomerase activity
platelet-derived growth factor receptor binding
coreceptor activity
fibroblast growth factor binding
enzyme binding
C-X3-C chemokine binding
insulin-like growth factor I binding
neuregulin binding
vascular endothelial growth factor receptor 2 binding
cell adhesion molecule binding
integrin
platelet degranulation
positive regulation of leukocyte migration
cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
extracellular matrix organization
platelet aggregation
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
cell-substrate junction assembly
blood coagulation
positive regulation of endothelial cell migration
negative regulation of macrophage derived foam cell differentiation
negative regulation of lipid storage
smooth muscle cell migration
cell growth
cell migration
platelet activation
positive regulation of vascular endothelial growth factor receptor signaling pathway
cell-substrate adhesion
activation of protein kinase activity
negative regulation of lipid transport
heterotypic cell-cell adhesion
substrate adhesion-dependent cell spreading
tube development
apolipoprotein A-I-mediated signaling pathway
wound healing
regulation of bone resorption
negative regulation of low-density lipoprotein particle receptor biosynthetic process
viral entry into host cell
vascular endothelial growth factor receptor signaling pathway
mesodermal cell differentiation
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of lipoprotein metabolic process
leukocyte migration
negative chemotaxis
angiogenesis involved in wound healing
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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