Product References
Macrophage-intrinsic DUOX1 contributes to type 2 inflammation and mucus metaplasia during allergic airway disease.
Mucosal immunology
Morris CR,Habibovic A,Dustin CM,Schiffers C,Lin MC,Ather JL,Janssen-Heininger YMW,Poynter ME,Utermohlen O,Krönke M,van der Vliet A
MCD4530 was used in Flow cytometry/Cell sorting to reveal a contribution of macrophage-intrinsic DUOX1 in macrophage recruitment upon chronic HDM challenge, as well as features of macrophage activation that impact on type 2 inflammation and remodeling.
Sun May 01 00:00:00 EDT 2022
Tumor Cell-Derived Angiopoietin-2 Promotes Metastasis in Melanoma.
Cancer research
Abdul Pari AA,Singhal M,Hübers C,Mogler C,Schieb B,Gampp A,Gengenbacher N,Reynolds LE,Terhardt D,Géraud C,Utikal J,Thomas M,Goerdt S,Hodivala-Dilke KM,Augustin HG,Felcht M
MCD4530 was used in Flow Cytometry to reveal that tumor cells can be a source of ANGPT2 in the tumor microenvironment and that tumor cell-derived ANGPT2 augments metastatic colonization by protecting tumor cells from oxidative stress.
Mon Jun 15 00:00:00 EDT 2020
Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism.
eLife
Crespo M,Gonzalez-Teran B,Nikolic I,Mora A,Folgueira C,Rodríguez E,Leiva-Vega L,Pintor-Chocano A,Fernández-Chacón M,Ruiz-Garrido I,Cicuéndez B,Tomás-Loba A,A-Gonzalez N,Caballero-Molano A,Beiroa D,Hernández-Cosido L,Torres JL,Kennedy NJ,Davis RJ,Benedito R,Marcos M,Nogueiras R,Hidalgo A,Matesanz N,Leiva M,Sabio G
MCD4530 was used in Flow cytometry/Cell sorting to demonstrate that neutrophils contribute to the maintenance of daily hepatic homeostasis through the regulation of the neutrophil elastase/c-Jun NH2-terminal kinase/Bmal1 (NE/JNK/Bmal1) axis.
Tue Dec 08 00:00:00 EST 2020
Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.
Cell metabolism
Halbrook CJ,Pontious C,Kovalenko I,Lapienyte L,Dreyer S,Lee HJ,Thurston G,Zhang Y,Lazarus J,Sajjakulnukit P,Hong HS,Kremer DM,Nelson BS,Kemp S,Zhang L,Chang D,Biankin A,Shi J,Frankel TL,Crawford HC,Morton JP,Pasca di Magliano M,Lyssiotis CA
MCD4530 was used in Flow cytometry/Cell sorting to characterise the role of macrophages in pancreatic ductal adenocarcinoma and possibilities for pancreatic cancer therapy.
Tue Jun 04 00:00:00 EDT 2019
Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer.
Cell metabolism
Li W,Tanikawa T,Kryczek I,Xia H,Li G,Wu K,Wei S,Zhao L,Vatan L,Wen B,Shu P,Sun D,Kleer C,Wicha M,Sabel M,Tao K,Wang G,Zou W
MCD4530 was used in Flow cytometry/Cell sorting to study the mechanisms by which aerobic glycolysis in triple-negative breast cancer tumours controls myeloid-derived suppressor cells and immunosuppression via a CEBPB pathway.
Tue Jul 03 00:00:00 EDT 2018
Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis.
Scientific reports
Williams SK,Fairless R,Maier O,Liermann PC,Pichi K,Fischer R,Eisel ULM,Kontermann R,Herrmann A,Weksler B,Romero N,Couraud PO,Pfizenmaier K,Diem R
Published figure using CD45 monoclonal antibody (Product # MCD4530) in Flow Cytometry
Tue Sep 11 00:00:00 EDT 2018
Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs.
The Journal of clinical investigation
Cheng L,Ma J,Li J,Li D,Li G,Li F,Zhang Q,Yu H,Yasui F,Ye C,Tsao LC,Hu Z,Su L,Zhang L
MCD4530 was used in flow cytometry to study the impact of modulating IFN-I signaling during suppressive combined antiretroviral therapy
Tue Jan 03 00:00:00 EST 2017
Glycosylphosphatidylinositol-Anchored Anti-HIV scFv Efficiently Protects CD4 T Cells from HIV-1 Infection and Deletion in hu-PBL Mice.
Journal of virology
Ye C,Wang W,Cheng L,Li G,Wen M,Wang Q,Zhang Q,Li D,Zhou P,Su L
MCD4530 was used in Flow cytometry/Cell sorting to conclude that GPI-scFv X5-modified CD4 T cells could potentially be used as a genetic intervention against both R5- and X4-tropic HIV-1 infections.
Wed Feb 01 00:00:00 EST 2017
Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury.
The Journal of clinical investigation
Farrar CA,Tran D,Li K,Wu W,Peng Q,Schwaeble W,Zhou W,Sacks SH
MCD4530 was used in Immunohistochemistry-immunofluorescence to describe how collectin-11 recognises an abnormal pattern of L-fucose on postischemic renal tubule cells and activates a destructive inflammatory response.
Mon May 02 00:00:00 EDT 2016
In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America
Kirschbaum K,Sonner JK,Zeller MW,Deumelandt K,Bode J,Sharma R,Krüwel T,Fischer M,Hoffmann A,Costa da Silva M,Muckenthaler MU,Wick W,Tews B,Chen JW,Heiland S,Bendszus M,Platten M,Breckwoldt MO
MCD4530 was used in flow cytometry to use MRI to track iron oxide nanoparticles in vivo
Tue Nov 15 00:00:00 EST 2016
General control non-derepressible 2 (GCN2) in T cells controls disease progression of autoimmune neuroinflammation.
Journal of neuroimmunology
Keil M,Sonner JK,Lanz TV,Oezen I,Bunse T,Bittner S,Meyer HV,Meuth SG,Wick W,Platten M
MCD4530 was used in flow cytometry to investigate the role of general control non-derepressible 2 in resolving autoimmune neuroinflammation
Mon Aug 15 00:00:00 EDT 2016
Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells.
Proceedings of the National Academy of Sciences of the United States of America
Kim K,Skora AD,Li Z,Liu Q,Tam AJ,Blosser RL,Diaz LA,Papadopoulos N,Kinzler KW,Vogelstein B,Zhou S
MCD4530 was used in flow cytometry to identify a relationship between resistant cancers and myeloid-derived suppressor cells
Tue Aug 12 00:00:00 EDT 2014
CD4+ T lymphocyte ablation prevents pancreatic carcinogenesis in mice.
Cancer immunology research
Zhang Y,Yan W,Mathew E,Bednar F,Wan S,Collins MA,Evans RA,Welling TH,Vonderheide RH,di Magliano MP
Published figure using CD45 monoclonal antibody (Product # MCD4530) in Flow Cytometry
Thu May 01 00:00:00 EDT 2014
Myeloid cell-specific ATP-binding cassette transporter A1 deletion has minimal impact on atherogenesis in atherogenic diet-fed low-density lipoprotein receptor knockout mice.
Arteriosclerosis, thrombosis, and vascular biology
Bi X,Zhu X,Gao C,Shewale S,Cao Q,Liu M,Boudyguina E,Gebre AK,Wilson MD,Brown AL,Parks JS
MCD4530 was used in Flow cytometry/Cell sorting to assess the atherosclerotic impact of myeloid cell ATP-binding cassette transporter A1.
Mon Sep 01 00:00:00 EDT 2014
Impact of isolated germline JAK2V617I mutation on human hematopoiesis.
Blood
Mead AJ,Chowdhury O,Pecquet C,Dusa A,Woll P,Atkinson D,Burns A,Score J,Rugless M,Clifford R,Moule S,Bienz N,Vyas P,Cross N,Gale RE,Henderson S,Constantinescu SN,Schuh A,Jacobsen SE
MCD4530 was used in flow cytometry to describe a germline JAK2V617I mutation in a family with hereditary thrombocytosis and characterize the hematopoietic and signaling impact of this mutation.
Thu May 16 00:00:00 EDT 2013
Nanoparticle clearance is governed by Th1/Th2 immunity and strain background.
The Journal of clinical investigation
Jones SW,Roberts RA,Robbins GR,Perry JL,Kai MP,Chen K,Bo T,Napier ME,Ting JP,Desimone JM,Bear JE
MCD4530 was used in flow cytometry to investigate nanoparticle clearance.
Mon Jul 01 00:00:00 EDT 2013
Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance.
Cancer research
Zhang Y,Yan W,Collins MA,Bednar F,Rakshit S,Zetter BR,Stanger BZ,Chung I,Rhim AD,di Magliano MP
MCD4530 was used in flow cytometry to demonstrate that IL-6 is required for the maintenance and progression of pancreatic cancer precursor lesions.
Tue Oct 15 00:00:00 EDT 2013
Mesenchymal stem cells are mobilized from the bone marrow during inflammation.
Frontiers in immunology
Koning JJ,Kooij G,de Vries HE,Nolte MA,Mebius RE
MCD4530 was used in flow cytometry to study the impact of mesenchymal stem cells to experimental allergic encephalomyelitis
Wed Mar 06 00:00:00 EST 2013
TIM-3 regulates innate immune cells to induce fetomaternal tolerance.
Journal of immunology (Baltimore, Md. : 1950)
Chabtini L,Mfarrej B,Mounayar M,Zhu B,Batal I,Dakle PJ,Smith BD,Boenisch O,Najafian N,Akiba H,Yagita H,Guleria I
MCD4530 was used in flow cytometry to determine the role of TIM-3-expressing innate immune cells in the regulation of tolerance at the fetomaternal interface.
Tue Jan 01 00:00:00 EST 2013
MyD88-dependent recruitment of monocytes and dendritic cells required for protection from pulmonary Burkholderia mallei infection.
Infection and immunity
Goodyear A,Troyer R,Bielefeldt-Ohmann H,Dow S
MCD4530 was used in flow cytometry to identify key Toll-like receptor signaling pathways, effector cells, and cytokines required for protection from respiratory B. mallei infection.
Sun Jan 01 00:00:00 EST 2012