Product References
T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation.
Frontiers in immunology
Vos WG,van Os BW,den Toom M,Beckers L,van Roomen CPAA,van Tiel CM,Mohapatra BC,Band H,Nitz K,Weber C,Atzler D,de Winther MPJ,Bosmans LA,Lutgens E,Seijkens TTP
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Thu Mar 21 00:00:00 UTC 2024
VHL loss reprograms the immune landscape to promote an inflammatory myeloid microenvironment in renal tumorigenesis.
The Journal of clinical investigation
Wolf MM,Madden MZ,Arner EN,Bader JE,Ye X,Vlach L,Tigue ML,Landis MD,Jonker PB,Hatem Z,Steiner KK,Gaines DK,Reinfeld BI,Hathaway ES,Xin F,Tantawy MN,Haake SM,Jonasch E,Muir A,Weiss VL,Beckermann KE,Rathmell WK,Rathmell JC
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Mon Apr 15 00:00:00 UTC 2024
Platelet factors attenuate inflammation and rescue cognition in ageing.
Nature
Schroer AB,Ventura PB,Sucharov J,Misra R,Chui MKK,Bieri G,Horowitz AM,Smith LK,Encabo K,Tenggara I,Couthouis J,Gross JD,Chan JM,Luke A,Villeda SA
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Tue Aug 01 00:00:00 UTC 2023
Group 3 Innate Lymphoid Cells Exacerbate Lupus Nephritis by Promoting B Cell Activation in Kidney Ectopic Lymphoid Structures.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Li F,Liang Z,Zhong H,Hu X,Tang Z,Zhu C,Shen J,Han X,Lin R,Zheng R,Tang R,Peng H,Zheng X,Mo C,Chen P,Wang X,Wen Q,Li J,Xia X,Ye H,Qiu Y,Yu J,Fu D,Liu J,Wang R,Xie H,Guo Y,Li X,Fan J,Liu Q,Mao H,Chen W,Zhou Y
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Fri Dec 01 00:00:00 UTC 2023
Fate mapping RNA-sequencing reveal Malat1 regulates Sca1+ progenitor cells to vascular smooth muscle cells transition in vascular remodeling.
Cellular and molecular life sciences : CMLS
Lyu L,Li Z,Wen Z,He Y,Wang X,Jiang L,Zhou X,Huang C,Wu Y,Chen T,Guo X
14-0452-82 was used in Flow cytometry/Cell sorting to find that suppression of lncRNA Malat1 promoted Sca1+ cells to differentiate into SMCs in vivo, resulting in excess SMC accumulation in neointima and vessel stenosis.
Thu Apr 06 00:00:00 UTC 2023
The meningeal transcriptional response to traumatic brain injury and aging.
eLife
Bolte AC,Shapiro DA,Dutta AB,Ma WF,Bruch KR,Kovacs MA,Royo Marco A,Ennerfelt HE,Lukens JR
14-0452-82 was used in Immunohistochemistry to find that aging alone induced upregulation of meningeal genes involved in antibody production by B cells and type I IFN signaling.
Tue Jan 03 00:00:00 UTC 2023
p21 facilitates chronic lung inflammation via epithelial and endothelial cells.
Aging
Levi N,Papismadov N,Majewska J,Roitman L,Wigoda N,Eilam R,Tsoory M,Rotkopf R,Ovadya Y,Akiva H,Regev O,Krizhanovsky V
14-0452-82 was used in Immunohistochemistry-immunofluorescence to implicate p21 as a critical regulator of chronic bronchitis and a driver of chronic airway inflammation and lung destruction.
Thu Mar 30 00:00:00 UTC 2023
Transient expansion and myofibroblast conversion of adipogenic lineage precursors mediate bone marrow repair after radiation.
JCI insight
Zhong L,Yao L,Holdreith N,Yu W,Gui T,Miao Z,Elkaim Y,Li M,Gong Y,Pacifici M,Maity A,Busch TM,Joeng KS,Cengel K,Seale P,Tong W,Qin L
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Fri Apr 08 00:00:00 UTC 2022
Lenvatinib for effectively treating antiangiogenic drug-resistant nasopharyngeal carcinoma.
Cell death & disease
Sun Q,Wang Y,Ji H,Sun X,Xie S,Chen L,Li S,Zeng W,Chen R,Tang Q,Zuo J,Hou L,Hosaka K,Lu Y,Liu Y,Ye Y,Yang Y
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Fri Aug 19 00:00:00 UTC 2022
Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis.
Science advances
Ma L,Tang Q,Gao X,Lee J,Lei R,Suzuki M,Zheng D,Ito K,Frenette PS,Dawlaty MM
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Fri Mar 04 00:00:00 UTC 2022
Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections.
Cell reports
Brandi P,Conejero L,Cueto FJ,Martínez-Cano S,Dunphy G,Gómez MJ,Relaño C,Saz-Leal P,Enamorado M,Quintas A,Dopazo A,Amores-Iniesta J,Del Fresno C,Nistal-Villán E,Ardavín C,Nieto A,Casanovas M,Subiza JL,Sancho D
14-0452-82 was used in Flow cytometry/Cell sorting to show that intranasal prophylaxis with MV130 modulates the lung immune landscape and provides long-term heterologous protection against viral respiratory infections in mice.
Tue Jan 04 00:00:00 UTC 2022
Increased susceptibility to organic dust exposure-induced inflammatory lung disease with enhanced rheumatoid arthritis-associated autoantigen expression in HLA-DR4 transgenic mice.
Respiratory research
Poole JA,Mikuls TR,Thiele GM,Gaurav R,Nelson AJ,Duryee MJ,Mitra A,Hunter C,Wyatt TA,England BR,Ascherman DP
14-0452-82 was used in Immunohistochemistry to support a model in which environmental insults trigger enhanced post-translational protein modification and lung inflammation sharing immunopathological features with RA-associated lung disease in the selected immunogenetic background of HLA-DR4 mice.
Sat Jun 18 00:00:00 UTC 2022
Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon inflammation induced by sub-chronic stress.
Scientific reports
Martín-Hernández D,Gutiérrez IL,González-Prieto M,MacDowell KS,Robledo-Montaña J,Tendilla-Beltrán H,Calleja-Rodríguez N,Bris ÁG,Ulecia-Morón C,Moreno B,Caso JR,García-Bueno B,Rodrigues-Mascarenhas S,Marín-Jiménez I,Leza JC,Menchén L
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Tue Mar 08 00:00:00 UTC 2022
Stroke induces disease-specific myeloid cells in the brain parenchyma and pia.
Nature communications
Beuker C,Schafflick D,Strecker JK,Heming M,Li X,Wolbert J,Schmidt-Pogoda A,Thomas C,Kuhlmann T,Aranda-Pardos I,A-Gonzalez N,Kumar PA,Werner Y,Kilic E,Hermann DM,Wiendl H,Stumm R,Meyer Zu Hörste G,Minnerup J
14-0452-82 was used in Immunohistochemistry to characterise tissue-resident leukocytes in meninges and brain parenchyma and discover that leukocytes respond differently to stroke depending on their site of residence.
Thu Feb 17 00:00:00 UTC 2022
Early innate and adaptive immune perturbations determine long-term severity of chronic virus and Mycobacterium tuberculosis coinfection.
Immunity
Xu W,Snell LM,Guo M,Boukhaled G,Macleod BL,Li M,Tullius MV,Guidos CJ,Tsao MS,Divangahi M,Horwitz MA,Liu J,Brooks DG
14-0452-82 was used in Miscellaneous to examine how chronic viral infections alter the pulmonary microenvironment to foster coinfection and worsen disease severity.
Tue Mar 09 00:00:00 UTC 2021
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Mon Jul 05 00:00:00 UTC 2021
Monocyte-derived dendritic cells link localized secretory IgA deficiency to adaptive immune activation in COPD.
Mucosal immunology
Richmond BW,Mansouri S,Serezani A,Novitskiy S,Blackburn JB,Du RH,Fuseini H,Gutor S,Han W,Schaff J,Vasiukov G,Xin MK,Newcomb DC,Jin L,Blackwell TS,Polosukhin VV
14-0452 was used in Immunohistochemistry to indicate that endogenous bacteria in SIgA-deficient airways orchestrate a persistent and pathologic T lymphocyte response through monocyte recruitment and moDC differentiation.
Mon Mar 01 00:00:00 UTC 2021
Monocyte-derived dendritic cells link localized secretory IgA deficiency to adaptive immune activation in COPD.
Mucosal immunology
Richmond BW,Mansouri S,Serezani A,Novitskiy S,Blackburn JB,Du RH,Fuseini H,Gutor S,Han W,Schaff J,Vasiukov G,Xin MK,Newcomb DC,Jin L,Blackwell TS,Polosukhin VV
14-0452 was used in Immunohistochemistry to indicate that endogenous bacteria in SIgA-deficient airways orchestrate a persistent and pathologic T lymphocyte response through monocyte recruitment and moDC differentiation.
Mon Mar 01 00:00:00 UTC 2021
Cuprizone-induced demyelination triggers a CD8-pronounced T cell recruitment.
Glia
Kaddatz H,Joost S,Nedelcu J,Chrzanowski U,Schmitz C,Gingele S,Gudi V,Stangel M,Zhan J,Santrau E,Greiner T,Frenz J,Müller-Hilke B,Müller M,Amor S,van der Valk P,Kipp M
14-0452-82 was used in Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation to investigate if metabolic oligodendrocyte injury, caused by feeding the copper chelator cuprizone, is a potent trigger for peripheral immune cell recruitment into the central nervous system (CNS).
Thu Apr 01 00:00:00 UTC 2021
A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system.
Computational and structural biotechnology journal
Shen Y,Jiang L,Iyer VS,Raposo B,Dubnovitsky A,Boddul SV,Kasza Z,Wermeling F
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Wed Nov 10 00:00:00 UTC 2021
Low Dose Chronic Angiotensin II Induces Selective Senescence of Kidney Endothelial Cells.
Frontiers in cell and developmental biology
Khan I,Schmidt MO,Kallakury B,Jain S,Mehdikhani S,Levi M,Mendonca M,Welch W,Riegel AT,Wilcox CS,Wellstein A
14-0452-82 was used in Immunohistochemistry to evaluate the contribution of cellular senescence to the effect of chronic exposure to low dose angiotensin II in a model that mimics long term tissue damage.
Wed Apr 19 00:00:00 UTC 2023
Murine myeloid cell MCPIP1 suppresses autoimmunity by regulating B-cell expansion and differentiation.
Disease models & mechanisms
Dobosz E,Lorenz G,Ribeiro A,Würf V,Wadowska M,Kotlinowski J,Schmaderer C,Potempa J,Fu M,Koziel J,Lech M
14-0452-81 was used in Immunohistochemistry (Paraffin) to show that depletion of MCPIP1 in macrophages and granulocytes (Mcpip1fl/fl-LysMcre+ C57BL/6 mice) is sufficient to trigger severe autoimmune disease.
Thu Mar 18 00:00:00 UTC 2021
Murine myeloid cell MCPIP1 suppresses autoimmunity by regulating B-cell expansion and differentiation.
Disease models & mechanisms
Dobosz E,Lorenz G,Ribeiro A,Würf V,Wadowska M,Kotlinowski J,Schmaderer C,Potempa J,Fu M,Koziel J,Lech M
14-0452-81 was used in Immunohistochemistry (Paraffin) to show that depletion of MCPIP1 in macrophages and granulocytes (Mcpip1fl/fl-LysMcre+ C57BL/6 mice) is sufficient to trigger severe autoimmune disease.
Thu Mar 18 00:00:00 UTC 2021
The Role of IgM Antibodies in T Cell Lymphoma Protection in a Novel Model Resembling Anaplastic Large Cell Lymphoma.
Journal of immunology (Baltimore, Md. : 1950)
Jiang C,Zhao ML,Ramos L,Dobaczewska K,Herbert R,Hobbie K,Mikulski Z,Verkoczy L,Diaz M
14-0452-82 was used in Immunohistochemistry-immunofluorescence to implicate autoreactive IgM Abs in protection against T cell lymphoma.
Sat May 15 00:00:00 UTC 2021
Defining the Mechanistic Correlates of Protection Conferred by Whole-Cell Vaccination against Pseudomonas aeruginosa Acute Murine Pneumonia.
Infection and immunity
Sen-Kilic E,Blackwood CB,Huckaby AB,Horspool AM,Weaver KL,Malkowski AC,Witt WT,Bevere JR,Damron FH,Barbier M
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Tue Jan 19 00:00:00 UTC 2021
Defining the Mechanistic Correlates of Protection Conferred by Whole-Cell Vaccination against Pseudomonas aeruginosa Acute Murine Pneumonia.
Infection and immunity
Sen-Kilic E,Blackwood CB,Huckaby AB,Horspool AM,Weaver KL,Malkowski AC,Witt WT,Bevere JR,Damron FH,Barbier M
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Tue Jan 19 00:00:00 UTC 2021
Polyvinyl alcohol hydrolysis rate and molecular weight influence human and murine HSC activity ex vivo.
Stem cell research
Sudo K,Yamazaki S,Wilkinson AC,Nakauchi H,Nakamura Y
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Fri Oct 01 00:00:00 UTC 2021
Role of CXCL5 in Regulating Chemotaxis of Innate and Adaptive Leukocytes in Infected Lungs Upon Pulmonary Influenza Infection.
Frontiers in immunology
Guo L,Li N,Yang Z,Li H,Zheng H,Yang J,Chen Y,Zhao X,Mei J,Shi H,Worthen GS,Liu L
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Tue Feb 08 00:00:00 UTC 2022
Role of CXCL5 in Regulating Chemotaxis of Innate and Adaptive Leukocytes in Infected Lungs Upon Pulmonary Influenza Infection.
Frontiers in immunology
Guo L,Li N,Yang Z,Li H,Zheng H,Yang J,Chen Y,Zhao X,Mei J,Shi H,Worthen GS,Liu L
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Tue Feb 08 00:00:00 UTC 2022
Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute ischemia.
Cell death & disease
Zaccagnini G,Greco S,Longo M,Maimone B,Voellenkle C,Fuschi P,Carrara M,Creo P,Maselli D,Tirone M,Mazzone M,Gaetano C,Spinetti G,Martelli F
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Sat May 01 00:00:00 UTC 2021
Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute ischemia.
Cell death & disease
Zaccagnini G,Greco S,Longo M,Maimone B,Voellenkle C,Fuschi P,Carrara M,Creo P,Maselli D,Tirone M,Mazzone M,Gaetano C,Spinetti G,Martelli F
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Sat May 01 00:00:00 UTC 2021
Ibrutinib does not prevent kidney fibrosis following acute and chronic injury.
Scientific reports
Belliere J,Casemayou A,Colliou E,El Hachem H,Kounde C,Piedrafita A,Feuillet G,Schanstra JP,Faguer S
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Mon Jun 07 00:00:00 UTC 2021
High-throughput analysis of lung immune cells in a combined murine model of agriculture dust-triggered airway inflammation with rheumatoid arthritis.
PloS one
Gaurav R,Mikuls TR,Thiele GM,Nelson AJ,Niu M,Guda C,Eudy JD,Barry AE,Wyatt TA,Romberger DJ,Duryee MJ,England BR,Poole JA
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Thu Jul 08 00:00:00 UTC 2021
High-throughput analysis of lung immune cells in a combined murine model of agriculture dust-triggered airway inflammation with rheumatoid arthritis.
PloS one
Gaurav R,Mikuls TR,Thiele GM,Nelson AJ,Niu M,Guda C,Eudy JD,Barry AE,Wyatt TA,Romberger DJ,Duryee MJ,England BR,Poole JA
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Thu Jul 08 00:00:00 UTC 2021
Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4.
Life science alliance
Mendes A,Gigan JP,Rodriguez Rodrigues C,Choteau SA,Sanseau D,Barros D,Almeida C,Camosseto V,Chasson L,Paton AW,Paton JC,Argüello RJ,Lennon-Duménil AM,Gatti E,Pierre P
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Mon Feb 01 00:00:00 UTC 2021
Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4.
Life science alliance
Mendes A,Gigan JP,Rodriguez Rodrigues C,Choteau SA,Sanseau D,Barros D,Almeida C,Camosseto V,Chasson L,Paton AW,Paton JC,Argüello RJ,Lennon-Duménil AM,Gatti E,Pierre P
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Mon Feb 01 00:00:00 UTC 2021
Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans.
eLife
Hill DL,Whyte CE,Innocentin S,Lee JL,Dooley J,Wang J,James EA,Lee JC,Kwok WW,Zand MS,Liston A,Carr EJ,Linterman MA
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Tue Nov 02 00:00:00 UTC 2021
Metabolic preconditioning in CD4+ T cells restores inducible immune tolerance in lupus-prone mice.
JCI insight
Wilson CS,Stocks BT,Hoopes EM,Rhoads JP,McNew KL,Major AS,Moore DJ
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Fri Oct 08 00:00:00 UTC 2021
The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation.
Nature communications
Shang M,Yang H,Yang R,Chen T,Fu Y,Li Y,Fang X,Zhang K,Zhang J,Li H,Cao X,Gu J,Xiao J,Zhang Q,Liu X,Yu Q,Wang T
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Mon Mar 29 00:00:00 UTC 2021
Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid.
The Journal of biological chemistry
Zhao Y,Cheng R,Zhao Y,Ge W,Yang Y,Ding Z,Xu X,Wang Z,Wu Z,Zhang J
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Fri Oct 01 00:00:00 UTC 2021
Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.
Cancers
Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Thu Oct 07 00:00:00 UTC 2021
Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation.
eLife
Wilfahrt D,Philips RL,Lama J,Kizerwetter M,Shapiro MJ,McCue SA,Kennedy MM,Rajcula MJ,Zeng H,Shapiro VS
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Protein Assays and Analysis
Thu Dec 02 00:00:00 UTC 2021
Mechanism of a COVID-19 nanoparticle vaccine candidate that elicits a broadly neutralizing antibody response to SARS-CoV-2 variants.
Science advances
Zhang YN,Paynter J,Sou C,Fourfouris T,Wang Y,Abraham C,Ngo T,Zhang Y,He L,Zhu J
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry (Frozen)
Fri Oct 22 00:00:00 UTC 2021
Mechanism of a COVID-19 nanoparticle vaccine candidate that elicits a broadly neutralizing antibody response to SARS-CoV-2 variants.
Science advances
Zhang YN,Paynter J,Sou C,Fourfouris T,Wang Y,Abraham C,Ngo T,Zhang Y,He L,Zhu J
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry (Frozen)
Fri Oct 22 00:00:00 UTC 2021
Nuclear PTEN deficiency and heterozygous PTEN loss have distinct impacts on brain and lymph node size.
Biochemical and biophysical research communications
Igarashi A,Kato T,Sesaki H,Iijima M
14-0452-82 was used in Immunohistochemistry-frozen tissue to investigate the impact of a combination of heterozygous PTEN loss and nuclear PTEN loss on the size of various organs, including the brain, liver, thymus, spleen, and inguinal lymph node.
Fri May 28 00:00:00 UTC 2021
SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation.
Immunity
Lederer K,Castaño D,Gómez Atria D,Oguin TH,Wang S,Manzoni TB,Muramatsu H,Hogan MJ,Amanat F,Cherubin P,Lundgreen KA,Tam YK,Fan SHY,Eisenlohr LC,Maillard I,Weissman D,Bates P,Krammer F,Sempowski GD,Pardi N,Locci M
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Tue Dec 15 00:00:00 UTC 2020
MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype.
Cancer discovery
Sodir NM,Kortlever RM,Barthet VJA,Campos T,Pellegrinet L,Kupczak S,Anastasiou P,Swigart LB,Soucek L,Arends MJ,Littlewood TD,Evan GI
14-0452-82 was used in Immunohistochemistry to demonstrate that this Myc-driven PDAC switch is completely and immediately reversible: Myc deactivation/inhibition triggers meticulous disassembly of advanced PDAC tumor and stroma and concomitant death of tumor cells.
Wed Apr 01 00:00:00 UTC 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Mon Mar 02 00:00:00 UTC 2020
B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection.
The Journal of experimental medicine
Arroyo EN,Pepper M
14-0452-82 was used in Flow Cytometry to study antigen-specific CD4+ T follicular helper (Tfh) cells responding to Plasmodium infection in order to understand the generation and maintenance of the Tfh response.
Mon Feb 03 00:00:00 UTC 2020
Inflammation shapes pathogenesis of murine arrhythmogenic cardiomyopathy.
Basic research in cardiology
Lubos N,van der Gaag S,Gerçek M,Kant S,Leube RE,Krusche CA
14-0452 was used in Immunohistochemistry to investigate if specific immune cell populations and chemokine expression profiles modulate inflammatory and repair processes throughout arrhythmogenic cardiomyopathy progression.
Fri Jun 12 00:00:00 UTC 2020
T-B Lymphocyte Interactions Promote Type 1 Diabetes Independently of SLAM-Associated Protein.
Journal of immunology (Baltimore, Md. : 1950)
Bonami RH,Nyhoff LE,McNitt DH,Hulbert C,Felton JL,Kendall PL,Thomas JW
14-0452-82 was used in Flow Cytometry to understand how fully developed T follicular helper cells contribute to different autoimmune processes, investigating the role of signaling lymphocytic activation molecule-associated protein in type 1 diabetes and autoantibody-mediated arthritis.
Tue Dec 15 00:00:00 UTC 2020
Secreted Phospholipase A2 Group X Acts as an Adjuvant for Type 2 Inflammation, Leading to an Allergen-Specific Immune Response in the Lung.
Journal of immunology (Baltimore, Md. : 1950)
Ogden HL,Lai Y,Nolin JD,An D,Frevert CW,Gelb MH,Altemeier WA,Hallstrand TS
14-0452-82 was used in Flow Cytometry to demonstrate that exogenous and endogenous sPLA2s play an important role in peripheral sensitization, resulting in airway responses to inhaled Ags.
Mon Jun 15 00:00:00 UTC 2020
Carvacrol ameliorates acute campylobacteriosis in a clinical murine infection model.
Gut pathogens
Mousavi S,Schmidt AM,Escher U,Kittler S,Kehrenberg C,Thunhorst E,Bereswill S,Heimesaat MM
14-0452 was used in Immunohistochemistry to demonstrate the use of Carvacrol to lower the bacterial load of Campylobacter jejuni during infection and alleviate disease symptoms.
Tue Apr 12 00:00:00 UTC 2022
New insights on repeated acoustic injury: Augmentation of cochlear susceptibility and inflammatory reaction resultant of prior acoustic injury.
Hearing research
Zhang C,Frye MD,Sun W,Sharma A,Manohar S,Salvi R,Hu BH
14-0452-82 was used in Immunohistochemistry to investigate the cochlear immune response to repeated stress.
Sat Aug 01 00:00:00 UTC 2020
Synergistic factors control kinase-phosphatase organization in B-cells engaged with supported bilayers.
Molecular biology of the cell
Núñez MF,Wisser K,Veatch SL
14-0452 was used in Immunocytochemistry-immunoflourescence to activate B-cells via supported bilayers of phosphatidylcholine lipids, a natural ligand for the IgM BCR expressed in the CH27 cells used.
Thu Mar 19 00:00:00 UTC 2020
Synergistic factors control kinase-phosphatase organization in B-cells engaged with supported bilayers.
Molecular biology of the cell
Núñez MF,Wisser K,Veatch SL
14-0452 was used in Immunocytochemistry-immunoflourescence to activate B-cells via supported bilayers of phosphatidylcholine lipids, a natural ligand for the IgM BCR expressed in the CH27 cells used.
Thu Mar 19 00:00:00 UTC 2020
Pituitary Adenylate Cyclase-Activating Polypeptide Alleviates Intestinal, Extra-Intestinal and Systemic Inflammatory Responses during Acute Campylobacter jejuni-induced Enterocolitis in Mice.
Pathogens (Basel, Switzerland)
Heimesaat MM,Mousavi S,Kløve S,Genger C,Weschka D,Tamas A,Reglodi D,Bereswill S
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry (Paraffin)
Wed Sep 30 00:00:00 UTC 2020
Pituitary Adenylate Cyclase-Activating Polypeptide Alleviates Intestinal, Extra-Intestinal and Systemic Inflammatory Responses during Acute Campylobacter jejuni-induced Enterocolitis in Mice.
Pathogens (Basel, Switzerland)
Heimesaat MM,Mousavi S,Kløve S,Genger C,Weschka D,Tamas A,Reglodi D,Bereswill S
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry (Paraffin)
Wed Sep 30 00:00:00 UTC 2020
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Nature communications
Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Thu Sep 17 00:00:00 UTC 2020
Toll-Like Receptor-4 Dependent Intestinal and Systemic Sequelae Following Peroral Campylobacter coli Infection of IL10 Deficient Mice Harboring a Human Gut Microbiota.
Pathogens (Basel, Switzerland)
Kløve S,Genger C,Mousavi S,Weschka D,Bereswill S,Heimesaat MM
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Mon May 18 00:00:00 UTC 2020
Toll-Like Receptor-4 Dependent Intestinal and Systemic Sequelae Following Peroral Campylobacter coli Infection of IL10 Deficient Mice Harboring a Human Gut Microbiota.
Pathogens (Basel, Switzerland)
Kløve S,Genger C,Mousavi S,Weschka D,Bereswill S,Heimesaat MM
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Mon May 18 00:00:00 UTC 2020
Ischemia Reperfusion Injury Triggers CXCL13 Release and B-Cell Recruitment After Allogenic Kidney Transplantation.
Frontiers in immunology
Kreimann K,Jang MS,Rong S,Greite R,von Vietinghoff S,Schmitt R,Bräsen JH,Schiffer L,Gerstenberg J,Vijayan V,Dittrich-Breiholz O,Wang L,Karsten CM,Gwinner W,Haller H,Immenschuh S,Gueler F
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Mon Apr 12 00:00:00 UTC 2021
Ischemia Reperfusion Injury Triggers CXCL13 Release and B-Cell Recruitment After Allogenic Kidney Transplantation.
Frontiers in immunology
Kreimann K,Jang MS,Rong S,Greite R,von Vietinghoff S,Schmitt R,Bräsen JH,Schiffer L,Gerstenberg J,Vijayan V,Dittrich-Breiholz O,Wang L,Karsten CM,Gwinner W,Haller H,Immenschuh S,Gueler F
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Mon Apr 12 00:00:00 UTC 2021
Overcoming Immunological Challenges to Helper-Dependent Adenoviral Vector-Mediated Long-Term CFTR Expression in Mouse Airways.
Genes
Cao H,Duan R,Hu J
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Mon May 18 00:00:00 UTC 2020
Overcoming Immunological Challenges to Helper-Dependent Adenoviral Vector-Mediated Long-Term CFTR Expression in Mouse Airways.
Genes
Cao H,Duan R,Hu J
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Mon May 18 00:00:00 UTC 2020
Myeloid Cell CK2 Regulates Inflammation and Resistance to Bacterial Infection.
Frontiers in immunology
Larson SR,Bortell N,Illies A,Crisler WJ,Matsuda JL,Lenz LL
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Tue Jul 27 00:00:00 UTC 2021
Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity.
Frontiers in immunology
Myers DR,Abram CL,Wildes D,Belwafa A,Welsh AMN,Schulze CJ,Choy TJ,Nguyen T,Omaque N,Hu Y,Singh M,Hansen R,Goldsmith MA,Quintana E,Smith JAM,Lowell CA
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Mon Jun 14 00:00:00 UTC 2021
Fucoxanthin Ameliorates Atopic Dermatitis Symptoms by Regulating Keratinocytes and Regulatory Innate Lymphoid Cells.
International journal of molecular sciences
Natsume C,Aoki N,Aoyama T,Senda K,Matsui M,Ikegami A,Tanaka K,Azuma YT,Fujita T
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Sun Mar 22 00:00:00 UTC 2020
The Host-Specific Intestinal Microbiota Composition Impacts Campylobacter coli Infection in a Clinical Mouse Model of Campylobacteriosis.
Pathogens (Basel, Switzerland)
Heimesaat MM,Genger C,Klove S,Weschka D,Mousavi S,Bereswill S
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Tue Sep 29 00:00:00 UTC 2020
The Host-Specific Intestinal Microbiota Composition Impacts Campylobacter coli Infection in a Clinical Mouse Model of Campylobacteriosis.
Pathogens (Basel, Switzerland)
Heimesaat MM,Genger C,Klove S,Weschka D,Mousavi S,Bereswill S
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Tue Sep 29 00:00:00 UTC 2020
TIAM2S Mediates Serotonin Homeostasis and Provokes a Pro-Inflammatory Immune Microenvironment Permissive for Colorectal Tumorigenesis.
Cancers
Chan YL,Lai WC,Chen JS,Tseng JT,Chuang PC,Jou J,Lee CT,Sun HS
14-0452 was used in Immunohistochemistry-immunofluorescence to suggest that TIAM2S provokes a pro-inflammatory immune microenvironment permissive to colorectal tumorigenesis through the serotonin-induced immunomodulatory effects.
Wed Jul 08 00:00:00 UTC 2020
Inflammatory Immune Responses and Gut Microbiota Changes Following Campylobacter coli Infection of IL-10-/- Mice with Chronic Colitis.
Pathogens (Basel, Switzerland)
Heimesaat MM,Genger C,Biesemeier N,Klove S,Weschka D,Mousavi S,Bereswill S
14-0452 was used in Immunohistochemistry to study gastrointestinal colonisation properties, gut microbiota changes and pro-inflammatory sequelae changes following C. coli infection and chronic colitis using a mouse model.
Sat Jul 11 00:00:00 UTC 2020
Immune-modulatory Properties of the Octapeptide NAP in Campylobacter jejuni Infected Mice Suffering from Acute Enterocolitis.
Microorganisms
Heimesaat MM,Mousavi S,Kløve S,Genger C,Weschka D,Giladi E,Bereswill S,Gozes I
14-0452 was used in Immunohistochemistry to provide evidence that NAP application constitutes a promising option to combat acute campylobacteriosis.
Tue May 26 00:00:00 UTC 2020
Cep55 overexpression promotes genomic instability and tumorigenesis in mice.
Communications biology
Sinha D,Nag P,Nanayakkara D,Duijf PHG,Burgess A,Raninga P,Smits VAJ,Bain AL,Subramanian G,Wall M,Finnie JW,Kalimutho M,Khanna KK
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Wed Oct 21 00:00:00 UTC 2020
Cep55 overexpression promotes genomic instability and tumorigenesis in mice.
Communications biology
Sinha D,Nag P,Nanayakkara D,Duijf PHG,Burgess A,Raninga P,Smits VAJ,Bain AL,Subramanian G,Wall M,Finnie JW,Kalimutho M,Khanna KK
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Wed Oct 21 00:00:00 UTC 2020
Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry.
STAR protocols
Liu Z,Gu Y,Shin A,Zhang S,Ginhoux F
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Fri Jun 19 00:00:00 UTC 2020
Microbiota composition and inflammatory immune responses upon peroral application of the commercial competitive exclusion product Aviguard® to microbiota-depleted wildtype mice.
European journal of microbiology & immunology
Heimesaat MM,Weschka D,Kløve S,Genger C,Biesemeier N,Mousavi S,Bereswill S
14-0452 was used in Immunohistochemistry to surveyed the intestinal bacterial colonization properties, potential macroscopic and microscopic inflammatory sequelae and immune responses upon peroral application of the commercial competitive exclusion product Aviguard® to wildtype mice in which the gut microbiota had been depleted by antibiotic pre-treatment.
Mon Jul 27 00:00:00 UTC 2020
The conundrum of colonization resistance against Campylobacter reloaded: The gut microbota composition in conventional mice does not prevent from Campylobacter coli infection.
European journal of microbiology & immunology
Genger C,Kløve S,Mousavi S,Bereswill S,Heimesaat MM
14-0452 was used in Immunohistochemistry to study whether this also held true for Campylobacter coli.
Fri May 01 00:00:00 UTC 2020
Aging-Affected MSC Functions and Severity of Periodontal Tissue Destruction in a Ligature-Induced Mouse Periodontitis Model.
International journal of molecular sciences
Aung KT,Akiyama K,Kunitomo M,Mun AY,Tosa I,Nguyen HTT,Zhang J,Kohno T,Ono M,Hara ES,Kuboki T
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunocytochemistry
Fri Oct 30 00:00:00 UTC 2020
Aging-Affected MSC Functions and Severity of Periodontal Tissue Destruction in a Ligature-Induced Mouse Periodontitis Model.
International journal of molecular sciences
Aung KT,Akiyama K,Kunitomo M,Mun AY,Tosa I,Nguyen HTT,Zhang J,Kohno T,Ono M,Hara ES,Kuboki T
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunocytochemistry
Fri Oct 30 00:00:00 UTC 2020
Resveratrol Alleviates Acute Campylobacter jejuni Induced Enterocolitis in a Preclinical Murine Intervention Study.
Microorganisms
Heimesaat MM,Mousavi S,Escher U,Lobo de Sá FD,Peh E,Schulzke JD,Kittler S,Bücker R,Bereswill S
14-0452-82 was used in Immunohistochemistry to provides evidence that peroral resveratrol treatment exerts potent disease-alleviating effects during acute experimental campylobacteriosis.
Wed Nov 25 00:00:00 UTC 2020
Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state.
Nature communications
Kawabe T,Yi J,Kawajiri A,Hilligan K,Fang D,Ishii N,Yamane H,Zhu J,Jankovic D,Kim KS,Trinchieri G,Sher A
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Mon Jul 06 00:00:00 UTC 2020
Toll-Like Receptor-4 Is Involved in Mediating Intestinal and Extra-Intestinal Inflammation in Campylobacter coli-Infected Secondary Abiotic IL-10-/- Mice.
Microorganisms
Kløve S,Genger C,Weschka D,Mousavi S,Bereswill S,Heimesaat MM
14-0452 was used in Immunohistochemistry to provide evidence that TLR4 is involved in mediating C. coli-LOS-induced immune responses in intestinal and extra-intestinal compartments during murine campylobacteriosis.
Fri Nov 27 00:00:00 UTC 2020
Blood-Borne ST6GAL1 Regulates Immunoglobulin Production in B Cells.
Frontiers in immunology
Irons EE,Punch PR,Lau JTY
14-0452 was used in Flow cytometry/Cell sorting to determine the effect of extracellular ST6GAL1 in B cell immunoglobulin production.
Thu Mar 25 00:00:00 UTC 2021
Androgen Receptor Signaling Positively Regulates Monocytic Development.
Frontiers in immunology
Consiglio CR,Gollnick SO
14-0452 was used in Flow cytometry/Cell sorting to investigate the role of androgen signaling in monocytic differentiation with a genetic mouse model of myeloid androgen receptor (AR) knockout (MARKO) and pharmacological inhibition of AR.
Thu Apr 29 00:00:00 UTC 2021
Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO.
eLife
Adapala NS,Swarnkar G,Arra M,Shen J,Mbalaviele G,Ke K,Abu-Amer Y
14-0452 was used in Flow cytometry/Cell sorting to suggest that NEMO serves as a toolkit to fine-tune specific signals in physiologic and pathologic conditions.
Mon Mar 23 00:00:00 UTC 2020
Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer.
Nature
Yao W,Rose JL,Wang W,Seth S,Jiang H,Taguchi A,Liu J,Yan L,Kapoor A,Hou P,Chen Z,Wang Q,Nezi L,Xu Z,Yao J,Hu B,Pettazzoni PF,Ho IL,Feng N,Ramamoorthy V,Jiang S,Deng P,Ma GJ,Den P,Tan Z,Zhang SX,Wang H,Wang YA,Deem AK,Fleming JB,Carugo A,Heffernan TP,Maitra A,Viale A,Ying H,Hanash S,DePinho RA,Draetta GF
14-0452 was used in Flow cytometry/Cell sorting to investigate if a mechanistic link between KRAS* signaling and a targetable molecule driving nutrient salvage pathway in pancreatic ductal adenocarcinoma exists.
Mon Apr 01 00:00:00 UTC 2019
Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis.
Immunity
Castro-Dopico T,Dennison TW,Ferdinand JR,Mathews RJ,Fleming A,Clift D,Stewart BJ,Jing C,Strongili K,Labzin LI,Monk EJM,Saeb-Parsy K,Bryant CE,Clare S,Parkes M,Clatworthy MR
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunofluorescence
Tue Apr 16 00:00:00 UTC 2019
Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis.
Immunity
Castro-Dopico T,Dennison TW,Ferdinand JR,Mathews RJ,Fleming A,Clift D,Stewart BJ,Jing C,Strongili K,Labzin LI,Monk EJM,Saeb-Parsy K,Bryant CE,Clare S,Parkes M,Clatworthy MR
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunofluorescence
Tue Apr 16 00:00:00 UTC 2019
Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.
Cell metabolism
Camell CD,Günther P,Lee A,Goldberg EL,Spadaro O,Youm YH,Bartke A,Hubbard GB,Ikeno Y,Ruddle NH,Schultze J,Dixit VD
14-0452 was used in Flow cytometry/Cell sorting to study the role of ageing within alterations of adipose tissue.
Tue Dec 03 00:00:00 UTC 2019
Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking.
The Journal of clinical investigation
Zhang J,Supakorndej T,Krambs JR,Rao M,Abou-Ezzi G,Ye RY,Li S,Trinkaus K,Link DC
14-0452 was used in Flow cytometry/Cell sorting to show that HSPC mobilization after cDC ablation is attenuated in mice lacking CXCR2 expression.
Tue Apr 30 00:00:00 UTC 2019
Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria.
The Journal of experimental medicine
Melo-Gonzalez F,Kammoun H,Evren E,Dutton EE,Papadopoulou M,Bradford BM,Tanes C,Fardus-Reid F,Swann JR,Bittinger K,Mabbott NA,Vallance BA,Willinger T,Withers DR,Hepworth MR
14-0452-82 was used in Flow Cytometry to study the mechanisms that modulate the magnitude and quality of T cell-dependent IgA responses.
Mon Apr 01 00:00:00 UTC 2019
Inhibition of T cell activation and function by the adaptor protein CIN85.
Science signaling
Kong MS,Hashimoto-Tane A,Kawashima Y,Sakuma M,Yokosuka T,Kometani K,Onishi R,Carpino N,Ohara O,Kurosaki T,Phua KK,Saito T
14-0452-82 was used in Flow Cytometry to show that CIN85 (Cbl-interacting protein of 85 kDa) limited T cell responses to T cell receptor stimulation.
Tue Feb 05 00:00:00 UTC 2019
Immunopathological properties of the Campylobacter jejuni flagellins and the adhesin CadF as assessed in a clinical murine infection model.
Gut pathogens
Schmidt AM,Escher U,Mousavi S,Tegtmeyer N,Boehm M,Backert S,Bereswill S,Heimesaat MM
14-0452-82 was used in Immunohistochemistry to study the immunopathlogical characteristics of Campylobacter jejuni and determine the role of virulence factors FlaA and FlaB and adhesin CadF.
Fri Apr 08 00:00:00 UTC 2022
Cellular localization and regulation of receptors and enzymes of the endocannabinoid system in intestinal and systemic inflammation.
Histochemistry and cell biology
Grill M,Hasenoehrl C,Kienzl M,Kargl J,Schicho R
14-0452 was used in Flow cytometry/Cell sorting to identify changes in gene expression of members of the endocannabinoid system in situ and uncovering a distinct cellular role in the regulation of the immune response to intestinal and systemic inflammation.
Tue Jan 01 00:00:00 UTC 2019
Cellular localization and regulation of receptors and enzymes of the endocannabinoid system in intestinal and systemic inflammation.
Histochemistry and cell biology
Grill M,Hasenoehrl C,Kienzl M,Kargl J,Schicho R
14-0452 was used in Flow cytometry/Cell sorting to identify changes in gene expression of members of the endocannabinoid system in situ and uncovering a distinct cellular role in the regulation of the immune response to intestinal and systemic inflammation.
Tue Jan 01 00:00:00 UTC 2019
Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.
Frontiers in immunology
Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Wed Oct 14 00:00:00 UTC 2020
Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis.
Nature communications
Ramakrishna C,Kujawski M,Chu H,Li L,Mazmanian SK,Cantin EM
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Tue May 14 00:00:00 UTC 2019
The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells.
Cell reports
Adane B,Ye H,Khan N,Pei S,Minhajuddin M,Stevens BM,Jones CL,D'Alessandro A,Reisz JA,Zaberezhnyy V,Gasparetto M,Ho TC,Kelly KK,Myers JR,Ashton JM,Siegenthaler J,Kume T,Campbell EL,Pollyea DA,Becker MW,Jordan CT
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Tue Apr 02 00:00:00 UTC 2019
Hemozoin produced by mammals confers heme tolerance.
eLife
Pek RH,Yuan X,Rietzschel N,Zhang J,Jackson L,Nishibori E,Ribeiro A,Simmons W,Jagadeesh J,Sugimoto H,Alam MZ,Garrett L,Haldar M,Ralle M,Phillips JD,Bodine DM,Hamza I
14-0452-82 was used in Flow Cytometry to show that mice deficient for the heme transporter SLC48A1 (also known as HRG1) accumulate over ten-fold excess heme in reticuloendothelial macrophage lysosomes that are 10 to 100 times larger than normal.
Tue Oct 01 00:00:00 UTC 2019
Critical Size Limit of Biodegradable Nanoparticles for Enhanced Lymph Node Trafficking and Paracortex Penetration.
Nano research
Howard GP,Verma G,Ke X,Thayer WM,Hamerly T,Baxter VK,Lee JE,Dinglasan RR,Mao HQ
14-0452-82 was used in Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation to show that 20-nm NPs drain rapidly across proximal and distal LNs following subcutaneous inoculation in mice and are retained in LNs more effectively than NPs with a number average diameter of 40-nm.
Mon Apr 01 00:00:00 UTC 2019
Contribution of LTi and TH17 cells to B cell aggregate formation in the central nervous system in a mouse model of multiple sclerosis.
Journal of neuroinflammation
Schropp V,Rohde J,Rovituso DM,Jabari S,Bharti R,Kuerten S
14-0452-82 was used in Immunohistochemistry to propose some potential candidates, which might be involved in the formation of B cell aggregates in the CNS of MP4-immunized mice.
Tue May 28 00:00:00 UTC 2019
Inducible IL-7 Hyperexpression Influences Lymphocyte Homeostasis and Function and Increases Allograft Rejection.
Frontiers in immunology
Schreiber M,Weigelt M,Karasinsky A,Anastassiadis K,Schallenberg S,Petzold C,Bonifacio E,Kretschmer K,Hommel A
14-0452 was used in Flow cytometry/Cell sorting to show that transient hyperexpression of IL-7 can impair immune regulation, through disturbances in lymphocyte development pathways, and decrease graft survival time, even under immunosuppression.
Mon Sep 14 00:00:00 UTC 2020
Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche.
Nature medicine
Maryanovich M,Zahalka AH,Pierce H,Pinho S,Nakahara F,Asada N,Wei Q,Wang X,Ciero P,Xu J,Leftin A,Frenette PS
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Fri Jun 01 00:00:00 UTC 2018
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Cell
Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Thu Jun 28 00:00:00 UTC 2018
Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation.
Immunity
Emgård J,Kammoun H,García-Cassani B,Chesné J,Parigi SM,Jacob JM,Cheng HW,Evren E,Das S,Czarnewski P,Sleiers N,Melo-Gonzalez F,Kvedaraite E,Svensson M,Scandella E,Hepworth MR,Huber S,Ludewig B,Peduto L,Villablanca EJ,Veiga-Fernandes H,Pereira JP,Flavell RA,Willinger T
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunofluorescence
Tue Jan 16 00:00:00 UTC 2018
Amphiregulin-Producing Pathogenic Memory T Helper 2 Cells Instruct Eosinophils to Secrete Osteopontin and Facilitate Airway Fibrosis.
Immunity
Morimoto Y,Hirahara K,Kiuchi M,Wada T,Ichikawa T,Kanno T,Okano M,Kokubo K,Onodera A,Sakurai D,Okamoto Y,Nakayama T
14-0452-82 was used in Flow Cytometry to find that interleukin-33 (IL-33) enhanced amphiregulin production by the IL-33 receptor, ST2hi memory T helper 2 (Th2) cells.
Tue Jul 17 00:00:00 UTC 2018
Targeted delivery of immune therapeutics to lymph nodes prolongs cardiac allograft survival.
The Journal of clinical investigation
Bahmani B,Uehara M,Jiang L,Ordikhani F,Banouni N,Ichimura T,Solhjou Z,Furtmüller GJ,Brandacher G,Alvarez D,von Andrian UH,Uchimura K,Xu Q,Vohra I,Yilmam OA,Haik Y,Azzi J,Kasinath V,Bromberg JS,McGrath MM,Abdi R
14-0452 was used in Immunohistochemistry to synthesize a nanoparticle (NP) as a carrier of anti-CD3, and optimized the conjugation strategy to coat the NP surface with MECA79 mAb (MECA79-anti-CD3-NP) to enhance LN accumulation.
Thu Nov 01 00:00:00 UTC 2018
Microbial symbionts regulate the primary Ig repertoire.
The Journal of experimental medicine
Chen Y,Chaudhary N,Yang N,Granato A,Turner JA,Howard SL,Devereaux C,Zuo T,Shrestha A,Goel RR,Neuberg D,Wesemann DR
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunofluorescence
Mon May 07 00:00:00 UTC 2018
Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner.
Frontiers in immunology
Liu R,King A,Bouillet P,Tarlinton DM,Strasser A,Heierhorst J
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Wed May 01 00:00:00 UTC 2019
Host Tumor Suppressor p18INK4c Functions as a Potent Cell-Intrinsic Inhibitor of Murine Gammaherpesvirus 68 Reactivation and Pathogenesis.
Journal of virology
Niemeyer BF,Oko LM,Medina EM,Oldenburg DG,White DW,Cool CD,Clambey ET,van Dyk LF
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Thu Mar 15 00:00:00 UTC 2018
Inactivation of mTORC1 Signaling in Osterix-Expressing Cells Impairs B-cell Differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Wang Y,Xiao M,Tao C,Chen J,Wang Z,Yang J,Chen Z,Zou Z,Liu A,Cai D,Jiang Y,Ding C,Li M,Bai X
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Sun Apr 01 00:00:00 UTC 2018
Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Kostrzewski T,Borg AJ,Meng Y,Filipovic I,Male V,Wack A,DiMaggio PA,Brady HJM
14-0452 was used in Flow cytometry/Cell sorting to reveal mechanisms in NK cell development and that E4bp4 is a central hub to process extrinsic stimuli.
Thu Feb 15 00:00:00 UTC 2018
Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of Cx37, Cx40 and Cx43.
Experimental and therapeutic medicine
Li Z,Zhang S,Cao L,Li W,Ye YC,Shi ZX,Wang ZR,Sun LX,Wang JW,Jia LT,Wang W
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Thu Feb 01 00:00:00 UTC 2018
miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling.
Nature communications
Lam J,van den Bosch M,Wegrzyn J,Parker J,Ibrahim R,Slowski K,Chang L,Martinez-Høyer S,Condorelli G,Boldin M,Deng Y,Umlandt P,Fuller M,Karsan A
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Wed Jun 20 00:00:00 UTC 2018
Tumor-immune profiling of murine syngeneic tumor models as a framework to guide mechanistic studies and predict therapy response in distinct tumor microenvironments.
PloS one
Yu JW,Bhattacharya S,Yanamandra N,Kilian D,Shi H,Yadavilli S,Katlinskaya Y,Kaczynski H,Conner M,Benson W,Hahn A,Seestaller-Wehr L,Bi M,Vitali NJ,Tsvetkov L,Halsey W,Hughes A,Traini C,Zhou H,Jing J,Lee T,Figueroa DJ,Brett S,Hopson CB,Smothers JF,Hoos A,Srinivasan R
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Mon Apr 08 00:00:00 UTC 2019
Anti-inflammatory Effects of the Octapeptide NAP in Human Microbiota-Associated Mice Suffering from Subacute Ileitis.
European journal of microbiology & immunology
Escher U,Giladi E,Dunay IR,Bereswill S,Gozes I,Heimesaat MM
14-0452 was used in Immunohistochemistry to investigate whether NAP treatment alleviates pro-inflammatory immune responses during experimental subacute ileitis.
Mon Jun 25 00:00:00 UTC 2018
Dysregulated TRAF3 and BCL2 Expression Promotes Multiple Classes of Mature Non-hodgkin B Cell Lymphoma in Mice.
Frontiers in immunology
Perez-Chacon G,Adrados M,Vallejo-Cremades MT,Lefebvre S,Reed JC,Zapata JM
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Fri Oct 25 00:00:00 UTC 2019
ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases.
Frontiers in immunology
Glal D,Sudhakar JN,Lu HH,Liu MC,Chiang HY,Liu YC,Cheng CF,Shui JW
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Thu Sep 26 00:00:00 UTC 2019
Immunomodulatory role of Keratin 76 in oral and gastric cancer.
Nature communications
Sequeira I,Neves JF,Carrero D,Peng Q,Palasz N,Liakath-Ali K,Lord GM,Morgan PR,Lombardi G,Watt FM
14-0452 was used in Flow cytometry/Cell sorting to demonstrate keratin 76 in epithelial cells regulate carcinocgenesis via communication with cells of the immune system.
Fri Aug 24 00:00:00 UTC 2018
Identification of Distinct Unmutated Chronic Lymphocytic Leukemia Subsets in Mice Based on Their T Cell Dependency.
Frontiers in immunology
Pal Singh S,de Bruijn MJW,de Almeida MP,Meijers RWJ,Nitschke L,Langerak AW,Pillai SY,Stadhouders R,Hendriks RW
14-0452 was used in Flow cytometry/Cell sorting to provide evidence for two distinct unmutated CLL subsets with a specific transcriptional signature: one is T cell-independent and B-1 cell-derived while the other arises upon antigen stimulation in the context of T-cell help.
Mon Sep 30 00:00:00 UTC 2019
Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points.
Epigenetics & chromatin
Heuston EF,Keller CA,Lichtenberg J,Giardine B,Anderson SM,Hardison RC,Bodine DM
14-0452 was used in Flow cytometry/Cell sorting to demonstrate that megakaryopoietic profiles are established early in haematopoiesis and are present in the majority of the haematopoietic progenitor population.
Mon May 28 00:00:00 UTC 2018
Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice.
Cell reports
Omata Y,Frech M,Primbs T,Lucas S,Andreev D,Scholtysek C,Sarter K,Kindermann M,Yeremenko N,Baeten DL,Andreas N,Kamradt T,Bozec A,Ramming A,Krönke G,Wirtz S,Schett G,Zaiss MM
14-0452 was used in Immunohistochemistry to elucidate the role of group 2 innate lymphoid cells in arthritis.
Tue Jul 03 00:00:00 UTC 2018
LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells.
Genome biology
Grigoryan A,Guidi N,Senger K,Liehr T,Soller K,Marka G,Vollmer A,Markaki Y,Leonhardt H,Buske C,Lipka DB,Plass C,Zheng Y,Mulaw MA,Geiger H,Florian MC
14-0452 was used in Flow cytometry/Cell sorting to show that not all histone modifications display a polar localization and that a reduction in H4K16ac amount and loss of epipolarity are specific to aged HSCs.
Wed Nov 07 00:00:00 UTC 2018
Targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles.
Scientific reports
Mandal T,Beck M,Kirsten N,Lindén M,Buske C
14-0452 was used in Flow cytometry/Cell sorting to demonstrate that targeting of AML LSCs can be improved by using functionalized and antigen directed MSNs as carriers for anti-leukemic drugs.
Wed Jan 17 00:00:00 UTC 2018
Early cellular interactions and immune transcriptome profiles in human factor VIII-exposed hemophilia A mice.
Journal of thrombosis and haemostasis : JTH
Lai JD,Cartier D,Hartholt RB,Swystun LL,van Velzen AS,den Haan JMM,Hough C,Voorberg J,Lillicrap D
14-0452 was used in Flow cytometry/Cell sorting to assess cellular interactions and expression profiles in hemophilia A mice.
Thu Mar 01 00:00:00 UTC 2018
High-affinity IgM+ memory B cells are defective in differentiation into IgM antibody-secreting cells by re-stimulation with a T cell-dependent antigen.
Scientific reports
Tashiro Y,Murakami A,Hara Y,Shimizu T,Kubo M,Goitsuka R,Kishimoto H,Azuma T
14-0452 was used in Flow cytometry/Cell sorting to demonstrate that only non-germinal centre-dependent IgM+ memomry B cells have terminal differential potential to become plasma cell during recall immune response.
Fri Sep 28 00:00:00 UTC 2018
A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche.
Nature communications
Guarnerio J,Mendez LM,Asada N,Menon AV,Fung J,Berry K,Frenette PS,Ito K,Pandolfi PP
14-0452 was used in Flow cytometry/Cell sorting to show Pml in mesenchymal stem cells regulate pro-inflammatory cytokines which may sustain leukemic cells.
Thu Jan 04 00:00:00 UTC 2018
Multidrug-resistant Pseudomonas aeruginosa aggravates inflammatory responses in murine chronic colitis.
Scientific reports
von Klitzing E,Ekmekciu I,Kühl AA,Bereswill S,Heimesaat MM
14-0452 was used in Immunohistochemistry to study whether chronic murine gut inflammation facilitates intestinal multi-drug resistant Pseudomonas aeruginosa colonisation, and whether bacterial infection subsequently worsens colonic immunopathology.
Fri Apr 27 00:00:00 UTC 2018
A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor.
Scientific reports
Wong TH,Lee CL,Su HH,Lee CL,Wu CC,Wang CC,Sheu CC,Lai RS,Leung SY,Lin CC,Wei YF,Wang CJ,Lin YC,Chen HL,Huang MS,Yen JH,Huang SK,Suen JL
14-0452 was used in Flow cytometry/Cell sorting to suggest that chronic exposure to environmental PAHs may pose a significant risk for asthma.
Mon Mar 26 00:00:00 UTC 2018
Systemic ST6Gal-1 Is a Pro-survival Factor for Murine Transitional B Cells.
Frontiers in immunology
Irons EE,Lau JTY
14-0452 was used in Magnetic cell separation to investigate the contributions of B cell intrinsic and extrinsic ST6Gal-1 to B cell development.
Fri Oct 25 00:00:00 UTC 2019
Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.
Nature medicine
West NR,Hegazy AN,Owens BMJ,Bullers SJ,Linggi B,Buonocore S,Coccia M,Görtz D,This S,Stockenhuber K,Pott J,Friedrich M,Ryzhakov G,Baribaud F,Brodmerkel C,Cieluch C,Rahman N,Müller-Newen G,Owens RJ,Kühl AA,Maloy KJ,Plevy SE,Keshav S,Travis SPL,Powrie F
14-0452 was used in Immunohistochemistry to study how cytokine oncostatin M is a potential biomarker and therapeutic target for IBD, and has particular relevance for anti-TNF-resistant patients.
Mon May 01 00:00:00 UTC 2017
The microanatomic segregation of selection by apoptosis in the germinal center.
Science (New York, N.Y.)
Mayer CT,Gazumyan A,Kara EE,Gitlin AD,Golijanin J,Viant C,Pai J,Oliveira TY,Wang Q,Escolano A,Medina-Ramirez M,Sanders RW,Nussenzweig MC
14-0452 was used in Flow cytometry/Cell sorting to visualise, purify and characterise dying germinal centres B cells in apoptosis-indicator mice.
Fri Oct 13 00:00:00 UTC 2017
Differential cytokine contributions of perivascular haematopoietic stem cell niches.
Nature cell biology
Asada N,Kunisaki Y,Pierce H,Wang Z,Fernandez NF,Birbrair A,Ma'ayan A,Frenette PS
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Wed Mar 01 00:00:00 UTC 2017
Bispecific antibody targets multiple Pseudomonas aeruginosa evasion mechanisms in the lung vasculature.
The Journal of clinical investigation
Thanabalasuriar A,Surewaard BG,Willson ME,Neupane AS,Stover CK,Warrener P,Wilson G,Keller AE,Sellman BR,DiGiandomenico A,Kubes P
14-0452 was used in Flow cytometry/Cell sorting to highlight the need to block multiple evasion and subversion mechanisms in tandem to kill P. aeruginosa.
Thu Jun 01 00:00:00 UTC 2017
Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation.
Science translational medicine
Allen E,Jabouille A,Rivera LB,Lodewijckx I,Missiaen R,Steri V,Feyen K,Tawney J,Hanahan D,Michael IP,Bergers G
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Wed Apr 12 00:00:00 UTC 2017
Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma.
The Journal of experimental medicine
Takahashi T,Asano Y,Sugawara K,Yamashita T,Nakamura K,Saigusa R,Ichimura Y,Toyama T,Taniguchi T,Akamata K,Noda S,Yoshizaki A,Tsuruta D,Trojanowska M,Sato S
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Mon Apr 03 00:00:00 UTC 2017
Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma.
The Journal of experimental medicine
Takahashi T,Asano Y,Sugawara K,Yamashita T,Nakamura K,Saigusa R,Ichimura Y,Toyama T,Taniguchi T,Akamata K,Noda S,Yoshizaki A,Tsuruta D,Trojanowska M,Sato S
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Mon Apr 03 00:00:00 UTC 2017
LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.
The Journal of experimental medicine
Xu X,Han L,Zhao G,Xue S,Gao Y,Xiao J,Zhang S,Chen P,Wu ZY,Ding J,Hu R,Wei B,Wang H
14-0452 was used in Flow cytometry/Cell sorting to demonstrate LRCH1 as a novel effector to restrain PKCα-DOCK8-Cdc42 module-induced T cell migration and ameliorate EAE.
Sun Jan 01 00:00:00 UTC 2017
Th2 responses are primed by skin dendritic cells with distinct transcriptional profiles.
The Journal of experimental medicine
Connor LM,Tang SC,Cognard E,Ochiai S,Hilligan KL,Old SI,Pellefigues C,White RF,Patel D,Smith AA,Eccles DA,Lamiable O,McConnell MJ,Ronchese F
14-0452 was used in Flow cytometry/Cell sorting to show the priming of Th2 responses is associated with distinct transcriptional signatures in dendritic cells in vivo, reflecting the diverse environments in which Th2 immune responses are initiated.
Sun Jan 01 00:00:00 UTC 2017
Absence of the Non-Signalling Chemerin Receptor CCRL2 Exacerbates Acute Inflammatory Responses In Vivo.
Frontiers in immunology
Regan-Komito D,Valaris S,Kapellos TS,Recio C,Taylor L,Greaves DR,Iqbal AJ
14-0452 was used in Flow cytometry/Cell sorting to investigate what role, if any, CCRL2 plays during acute inflammation.
Fri Sep 24 00:00:00 UTC 2021
Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells.
PLoS pathogens
Danahy DB,Anthony SM,Jensen IJ,Hartwig SM,Shan Q,Xue HH,Harty JT,Griffith TS,Badovinac VP
14-0452-82 was used in Flow Cytometry to directly examine the impact of sepsis on tissue resident memory CD8+ T cells in mice.
Fri Sep 01 00:00:00 UTC 2017
Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology.
PLoS pathogens
Pyle CJ,Uwadiae FI,Swieboda DP,Harker JA
14-0452-82 was used in Flow Cytometry to show that during respiratory virus infection the prototypic inflammatory cytokine IL-6 is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27.
Fri Sep 01 00:00:00 UTC 2017
Differential Role of B Cells and IL-17 Versus IFN-γ During Early and Late Rejection of Pig Islet Xenografts in Mice.
Transplantation
Kang HK,Wang S,Dangi A,Zhang X,Singh A,Zhang L,Rosati JM,Suarez-Pinzon W,Deng X,Chen X,Thorp EB,Hering BJ,Miller SD,Luo X
14-0452 was used in Immunohistochemistry-immunofluorescence to evaluate anti-donor xenogeneic immune responses during early and late rejection and determine therapeutic interventions that promote durable pig islet xenograft survival.
Tue Aug 01 00:00:00 UTC 2017
Treatment with Allogenic Mesenchymal Stromal Cells in a Murine Model of Systemic Lupus Erythematosus.
International journal of stem cells
Tani C,Vagnani S,Carli L,Querci F,Kühl AA,Spieckermann S,Cieluch CP,Pacini S,Fazzi R,Mosca M
14-0452 was used in Immunohistochemistry on paraffin embedded tissues to study whether repeated administrations of 1x106/kg body weight of allogenic mesenchymal stromal cells can be effective in improving the clinical course of a murine systemic lupus erythematosus model.
Thu Nov 30 00:00:00 UTC 2017
EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop.
Nature communications
Béguelin W,Rivas MA,Calvo Fernández MT,Teater M,Purwada A,Redmond D,Shen H,Challman MF,Elemento O,Singh A,Melnick AM
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Thu Oct 12 00:00:00 UTC 2017
DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice.
Nature communications
Ottina E,Peperzak V,Schoeler K,Carrington E,Sgonc R,Pellegrini M,Preston S,Herold MJ,Strasser A,Villunger A
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Wed Oct 18 00:00:00 UTC 2017
The Interleukin (IL)-1R1 pathway is a critical negative regulator of PyMT-mediated mammary tumorigenesis and pulmonary metastasis.
Oncoimmunology
Dagenais M,Dupaul-Chicoine J,Douglas T,Champagne C,Morizot A,Saleh M
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Tue Jan 12 00:00:00 UTC 2021
Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.
JCI insight
Azzam KM,Madenspacher JH,Cain DW,Lai L,Gowdy KM,Rai P,Janardhan K,Clayton N,Cunningham W,Jensen H,Patel PS,Kearney JF,Taylor GA,Fessler MB
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Thu Aug 17 00:00:00 UTC 2017
Multiple functional therapeutic effects of TnP: A small stable synthetic peptide derived from fish venom in a mouse model of multiple sclerosis.
PloS one
Komegae EN,Souza TA,Grund LZ,Lima C,Lopes-Ferreira M
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Thu Aug 17 00:00:00 UTC 2017
Alternative activation generates IL-10 producing type 2 innate lymphoid cells.
Nature communications
Seehus CR,Kadavallore A,Torre B,Yeckes AR,Wang Y,Tang J,Kaye J
14-0452 was used in Immunocytochemistry to demonstrate the generation of a previously unappreciated IL-10 producing type 2 innate lymphoid cell effector cell population.
Fri Dec 01 00:00:00 UTC 2017
Astaxanthin attenuates total body irradiation-induced hematopoietic system injury in mice via inhibition of oxidative stress and apoptosis.
Stem cell research & therapy
Xue XL,Han XD,Li Y,Chu XF,Miao WM,Zhang JL,Fan SJ
14-0452 was used in Flow cytometry/Cell sorting to suggest that ATX could be used as a potent therapeutic agent to protect the hematopoietic system against TBI-induced bone marrow suppression.
Mon Jan 23 00:00:00 UTC 2017
The podoplanin-CLEC-2 axis inhibits inflammation in sepsis.
Nature communications
Rayes J,Lax S,Wichaiyo S,Watson SK,Di Y,Lombard S,Grygielska B,Smith SW,Skordilis K,Watson SP
14-0452 was used in Flow cytometry/Cell sorting to demonstrate, through two mouse models of sepsis, the anti-inflammatory role of the podoplanin-CLEC-2 axis.
Thu Dec 21 00:00:00 UTC 2017
Functional characterization of the lysosomal membrane protein TMEM192 in mice.
Oncotarget
Nguyen TL,Schneppenheim J,Rudnik S,Lüllmann-Rauch R,Bernreuther C,Hermans-Borgmeyer I,Glatzel M,Saftig P,Schröder B
14-0452-82 was used in Flow Cytometry to conclude that under basal conditions in vivo the loss of TMEM192 can be efficiently compensated by alternative pathways.
Tue Jul 04 00:00:00 UTC 2017
Blocking CTLA-4 while priming with a whole cell vaccine reshapes the oligoclonal T cell infiltrate and eradicates tumors in an orthotopic glioma model.
Oncoimmunology
Field CS,Hunn MK,Ferguson PM,Ruedl C,Ancelet LR,Hermans IF
14-0452 was used in Flow cytometry/Cell sorting to study the effect of the checkpoint blockade on the efficacy of responses induced with a whole tumour-cell vaccine.
Tue Jan 12 00:00:00 UTC 2021
Early derivation of IgM memory cells and bone marrow plasmablasts.
PloS one
Papillion AM,Kenderes KJ,Yates JL,Winslow GM
14-0452 was used in Flow cytometry/Cell sorting to demonstrate that two distinct long-term IgM-positive B cell populations are generated early in response to infection but maintained bu separate mechanisms.
Fri Sep 22 00:00:00 UTC 2017
Autophagy is a signature of a signaling network that maintains hematopoietic stem cells.
PloS one
Nguyen-McCarty M,Klein PS
14-0452 was used in Flow cytometry/Cell sorting to identify the downstream effectors of mTORC1 in hematopoietic stem cells.
Fri Sep 15 00:00:00 UTC 2017
Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis.
PloS one
Tornack J,Reece ST,Bauer WM,Vogelzang A,Bandermann S,Zedler U,Stingl G,Kaufmann SH,Melchers F
14-0452-82 was used in Flow Cytometry to conclude that LT-pHSCs, together with MSCs of Mtb-infected humans and mice serve as a hitherto unappreciated quiescent cellular depot for Mtb during latent TB infection.
Tue Sep 05 00:00:00 UTC 2017
B-cell survival and development controlled by the coordination of NF-κB family members RelB and cRel.
Blood
Almaden JV,Liu YC,Yang E,Otero DC,Birnbaum H,Davis-Turak J,Asagiri M,David M,Goldrath AW,Hoffmann A
14-0452 was used in Flow cytometry/Cell sorting to demonstrate that BAFF signalling coordinates the canonical and non-canonical NF-κB pathways to ensure robust B-cell development.
Thu Mar 10 00:00:00 UTC 2016
Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.
Circulation research
Sager HB,Hulsmans M,Lavine KJ,Moreira MB,Heidt T,Courties G,Sun Y,Iwamoto Y,Tricot B,Khan OF,Dahlman JE,Borodovsky A,Fitzgerald K,Anderson DG,Weissleder R,Libby P,Swirski FK,Nahrendorf M
14-0452 was used in Flow cytometry/Cell sorting to elucidate the origin and roles of macrophages in the post-myocardial infarction remodelling of nonischaemic remote myocardium.
Fri Sep 16 00:00:00 UTC 2016
LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.
The Journal of clinical investigation
Cheng Y,Chikwava K,Wu C,Zhang H,Bhagat A,Pei D,Choi JK,Tong W
14-0452 was used in Flow cytometry/Cell sorting to investigate how LNK regulates normal B cell development or promotes leukemogenesis.
Fri Apr 01 00:00:00 UTC 2016
Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.
The Journal of clinical investigation
Massaad MJ,Zhou J,Tsuchimoto D,Chou J,Jabara H,Janssen E,Glauzy S,Olson BG,Morbach H,Ohsumi TK,Schmitz K,Kyriacos M,Kane J,Torisu K,Nakabeppu Y,Notarangelo LD,Chouery E,Megarbane A,Kang PB,Al-Idrissi E,Aldhekri H,Meffre E,Mizui M,Tsokos GC,Manis JP,Al-Herz W,Wallace SS,Geha RS
14-0452 was used in Flow cytometry/Cell sorting to investigate alterations in immune cell apoptosis during autoimmunity, showing that deficiency in NEIL3 drives increased predisposition to autoimmunity.
Tue Nov 01 00:00:00 UTC 2016
LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity.
The Journal of clinical investigation
Proekt I,Miller CN,Jeanne M,Fasano KJ,Moon JJ,Lowell CA,Gould DB,Anderson MS,DeFranco AL
14-0452 was used in Flow cytometry/Cell sorting to demonstrate how two distinct tolerance pathways can synergize to unleash organ-specific autoimmunity.
Mon Oct 03 00:00:00 UTC 2016
M-CSF improves protection against bacterial and fungal infections after hematopoietic stem/progenitor cell transplantation.
The Journal of experimental medicine
Kandalla PK,Sarrazin S,Molawi K,Berruyer C,Redelberger D,Favel A,Bordi C,de Bentzmann S,Sieweke MH
14-0452 was used in Flow cytometry/Cell sorting to study the role of M-CSF in the protection against pathogens after hematopoietic stem/progenitor cell transplantation.
Mon Oct 17 00:00:00 UTC 2016
NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells.
The Journal of experimental medicine
de Valle E,Grigoriadis G,O'Reilly LA,Willis SN,Maxwell MJ,Corcoran LM,Tsantikos E,Cornish JK,Fairfax KA,Vasanthakumar A,Febbraio MA,Hibbs ML,Pellegrini M,Banerjee A,Hodgkin PD,Kallies A,Mackay F,Strasser A,Gerondakis S,Gugasyan R
14-0452 was used in Flow cytometry/Cell sorting to identify a novel role of NFκB1 in preventing multiorgan autoimmunity through the negative regulation of Il-6 gene expression in follicular B cells.
Mon Apr 04 00:00:00 UTC 2016
The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells.
Leukemia
Saulep-Easton D,Vincent FB,Quah PS,Wei A,Ting SB,Croce CM,Tam C,Mackay F
14-0452 was used in Flow cytometry/Cell sorting to uncover a major targetable pathway important for the generation of regulatory B cells that is detrimental to immunity in chronic lymphocytic leukemia.
Fri Jan 01 00:00:00 UTC 2016
Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance.
Arteriosclerosis, thrombosis, and vascular biology
Harmon DB,Srikakulapu P,Kaplan JL,Oldham SN,McSkimming C,Garmey JC,Perry HM,Kirby JL,Prohaska TA,Gonen A,Hallowell P,Schirmer B,Tsimikas S,Taylor AM,Witztum JL,McNamara CA
14-0452 was used in Flow cytometry/Cell sorting to investigate the role of B-cell functions in obesity-induced metabolic dysfunction.
Fri Apr 01 00:00:00 UTC 2016
Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.
Mucosal immunology
Mohapatra A,Van Dyken SJ,Schneider C,Nussbaum JC,Liang HE,Locksley RM
14-0452 was used in Flow cytometry/Cell sorting to study how ILC2s link alveolar function to regulation of airway flow, revealing a key interaction between resident lymphoid and structural cells that might underlie similar organisational hierarchies in other organs.
Fri Jan 01 00:00:00 UTC 2016
A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection.
PLoS pathogens
Maelfait J,Roose K,Vereecke L,Mc Guire C,Sze M,Schuijs MJ,Willart M,Ibañez LI,Hammad H,Lambrecht BN,Beyaert R,Saelens X,van Loo G
14-0452 was used in Flow cytometry/Cell sorting to investigate the function of A20 in club cells in antiviral immunity, showing that deficiency in A20 protects against influenza virus infection.
Fri Jan 01 00:00:00 UTC 2016
Bmp signaling in colonic mesenchyme regulates stromal microenvironment and protects from polyposis initiation.
International journal of cancer
Allaire JM,Roy SA,Ouellet C,Lemieux É,Jones C,Paquet M,Boudreau F,Perreault N
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunofluorescence
Wed Jun 01 00:00:00 UTC 2016
Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.
Journal of immunology (Baltimore, Md. : 1950)
Menendez CM,Jinkins JK,Carr DJ
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Mon Aug 15 00:00:00 UTC 2016
TNF and CD28 Signaling Play Unique but Complementary Roles in the Systemic Recruitment of Innate Immune Cells after Staphylococcus aureus Enterotoxin A Inhalation.
Journal of immunology (Baltimore, Md. : 1950)
Svedova J,Tsurutani N,Liu W,Khanna KM,Vella AT
14-0452 was used in Flow cytometry/Cell sorting to investigate how Staphylococcus aureus enterotoxins spread systemically and trigger inflammatory cascades.
Wed Jun 01 00:00:00 UTC 2016
Type I IFN Does Not Promote Susceptibility to Foodborne Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950)
Pitts MG,Myers-Morales T,D'Orazio SE
14-0452 was used in Flow cytometry/Cell sorting to investigate whether type I IFN promotes susceptibility to foodborne Listeria monocytogenes.
Fri Apr 01 00:00:00 UTC 2016
Chronic Gastrointestinal Nematode Infection Mutes Immune Responses to Mycobacterial Infection Distal to the Gut.
Journal of immunology (Baltimore, Md. : 1950)
Obieglo K,Feng X,Bollampalli VP,Dellacasa-Lindberg I,Classon C,Österblad M,Helmby H,Hewitson JP,Maizels RM,Gigliotti Rothfuchs A,Nylén S
14-0452 was used in Flow cytometry/Cell sorting to show that an intestinal nematode can mute T cell responses to mycobacterial and reduce control of secondary infections outside the gut.
Tue Mar 01 00:00:00 UTC 2016
Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning.
Journal of immunology (Baltimore, Md. : 1950)
Müller AM,Florek M,Kohrt HE,Küpper NJ,Filatenkov A,Linderman JA,Hadeiba H,Negrin RS,Shizuru JA
14-0452 was used in Flow cytometry/Cell sorting to shed new light on the effects of CD4+ T cells on HSC biology.
Tue Nov 15 00:00:00 UTC 2016
This paper is the winner of an SFB Award in the Hospital Intern, Residency category: Peptide biomaterials raising adaptive immune responses in wound healing contexts.
Journal of biomedical materials research. Part A
Vigneswaran Y,Han H,De Loera R,Wen Y,Zhang X,Sun T,Mora-Solano C,Collier JH
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Mon Aug 01 00:00:00 UTC 2016
Trypanosoma cruzi Causes Paralyzing Systemic Necrotizing Vasculitis Driven by Pathogen-Specific Type I Immunity in Mice.
Infection and immunity
Roffê E,Marino APMP,Weaver J,Wan W,de Araújo FF,Hoffman V,Santiago HC,Murphy PM
14-0452 was used in Immunohistochemistry to investigate T. cruzi infection as a trigger of vasculitis.
Fri Apr 01 00:00:00 UTC 2016
Postnatal lethality and abnormal development of foregut and spleen in Ndrg4 mutant mice.
Biochemical and biophysical research communications
Qu X,Li J,Baldwin HS
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunofluorescence
Fri Feb 12 00:00:00 UTC 2016
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.
Stem cell reports
Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Tue Aug 09 00:00:00 UTC 2016
miR-150 regulates obesity-associated insulin resistance by controlling B cell functions.
Scientific reports
Ying W,Tseng A,Chang RC,Wang H,Lin YL,Kanameni S,Brehm T,Morin A,Jones B,Splawn T,Criscitiello M,Golding MC,Bazer FW,Safe S,Zhou B
14-0452 was used in Immunohistochemistry to show, for the first time, that miR-150 regulates obesity-induced metainflammation and insulin resistance by controlling adipose tissue B cell function.
Mon Feb 01 00:00:00 UTC 2016
Reprogramming the Local Lymph Node Microenvironment Promotes Tolerance that Is Systemic and Antigen Specific.
Cell reports
Tostanoski LH,Chiu YC,Gammon JM,Simon T,Andorko JI,Bromberg JS,Jewell CM
14-0452 was used in Immunofluorescence in immunohistochemistry on frozen tissues to study tolerance as a function of signals in the lymph node microenvironment, using intra-lymph node injection of polymer particles.
Tue Sep 13 00:00:00 UTC 2016
Orally administered β-glucan attenuates the Th2 response in a model of airway hypersensitivity.
SpringerPlus
Burg AR,Quigley L,Jones AV,O'Connor GM,Boelte K,McVicar DW,Orr SJ
14-0452 was used in Flow cytometry/Cell sorting to study the immunological effects of WGP containing β-1,3/1,6-glucans in a mouse model of asthma and consider its therapeutic potential.
Fri Jul 08 00:00:00 UTC 2016
CRISPR-Mediated Triple Knockout of SLAMF1, SLAMF5 and SLAMF6 Supports Positive Signaling Roles in NKT Cell Development.
PloS one
Huang B,Gomez-Rodriguez J,Preite S,Garrett LJ,Harper UL,Schwartzberg PL
14-0452 was used in Flow cytometry/Cell sorting to elucidate the contribution of the SLAM receptors in immunodysregulation observed in X-linked lymphoproliferative syndrome Type 1.
Mon Jul 24 00:00:00 UTC 2017
Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor.
Scientific reports
Brandstätter O,Schanz O,Vorac J,König J,Mori T,Maruyama T,Korkowski M,Haarmann-Stemmann T,von Smolinski D,Schultze JL,Abel J,Esser C,Takeyama H,Weighardt H,Förster I
14-0452 was used in Immunohistochemistry to highlight the physiologic importance of cell-type specific balancing of AhR/AhRR expression in response to microbial, nutritional and other environmental stimuli.
Tue May 17 00:00:00 UTC 2016
PD-1 pathway-mediated regulation of islet-specific CD4+ T cell subsets in autoimmune diabetes.
Immunoendocrinology (Houston, Tex.)
Martinov T,Spanier JA,Pauken KE,Fife BT
14-0452 was used in Flow cytometry/Cell sorting to understand the role of PD-1 in maintaining islet-specific tolerance in diabetes-resistant strains.
Wed Mar 30 00:00:00 UTC 2022
Structural and functional features of central nervous system lymphatic vessels.
Nature
Louveau A,Smirnov I,Keyes TJ,Eccles JD,Rouhani SJ,Peske JD,Derecki NC,Castle D,Mandell JW,Lee KS,Harris TH,Kipnis J
14-0452 was used in Immunohistochemistry-wholemount to investigate the mechanisms governing the entrance and exit of immune cells from the CNS.
Thu Jul 16 00:00:00 UTC 2015
Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.
Nature
Wong TN,Ramsingh G,Young AL,Miller CA,Touma W,Welch JS,Lamprecht TL,Shen D,Hundal J,Fulton RS,Heath S,Baty JD,Klco JM,Ding L,Mardis ER,Westervelt P,DiPersio JF,Walter MJ,Graubert TA,Ley TJ,Druley T,Link DC,Wilson RK
14-0452 was used in Flow cytometry/Cell sorting to investigate how prior exposure to cytotoxic therapy influences leukemogenesis and TP53 mutations in t-AML/t-MDS patients.
Thu Feb 26 00:00:00 UTC 2015
Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.
Science (New York, N.Y.)
Yoon KW,Byun S,Kwon E,Hwang SY,Chu K,Hiraki M,Jo SH,Weins A,Hakroush S,Cebulla A,Sykes DB,Greka A,Mundel P,Fisher DE,Mandinova A,Lee SW
14-0452 was used in Flow cytometry/Cell sorting to reveal that p53-induced expression of death domain 1α regulates the efficient clearance of dead cells and proper immune tolerance.
Fri Jul 31 00:00:00 UTC 2015
The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture.
Nature immunology
Astarita JL,Cremasco V,Fu J,Darnell MC,Peck JR,Nieves-Bonilla JM,Song K,Kondo Y,Woodruff MC,Gogineni A,Onder L,Ludewig B,Weimer RM,Carroll MC,Mooney DJ,Xia L,Turley SJ
14-0452 was used in Flow cytometry/Cell sorting to demonstrate that podoplanin regulates lymph node microarchitecture and fibroblastic reticular cell actomyosin contractility.
Thu Jan 01 00:00:00 UTC 2015
Inflammation rapidly reorganizes mouse bone marrow B cells and their environment in conjunction with early IgM responses.
Blood
Moreau JM,Berger A,Nelles ME,Mielnik M,Furlonger C,Cen SY,Besla R,Robbins CS,Paige CJ
14-0452 was used in Flow cytometry/Cell sorting to study the rapidity with which peripheral inflammation modifies the bone marrow compartment, and demonstrate that such modifications regulate acute IgM production within this organ.
Thu Sep 03 00:00:00 UTC 2015
Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors.
The Journal of clinical investigation
Henry CJ,Casás-Selves M,Kim J,Zaberezhnyy V,Aghili L,Daniel AE,Jimenez L,Azam T,McNamee EN,Clambey ET,Klawitter J,Serkova NJ,Tan AC,Dinarello CA,DeGregori J
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Tue Dec 01 00:00:00 UTC 2015
mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation.
The Journal of clinical investigation
Pollizzi KN,Patel CH,Sun IH,Oh MH,Waickman AT,Wen J,Delgoffe GM,Powell JD
14-0452 was used in Flow cytometry/Cell sorting to define specific roles for mTORC1 and mTORC2 in the specification of immune cell subsets.
Fri May 01 00:00:00 UTC 2015
Kindlin-3-mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells.
The Journal of experimental medicine
Ruppert R,Moser M,Sperandio M,Rognoni E,Orban M,Liu WH,Schulz AS,Oostendorp RA,Massberg S,Fässler R
14-0452 was used in Flow cytometry/Cell sorting to highlight a role for Kindlin-3 in the control of haematopoietic stem and progenitor cell homing function.
Mon Aug 24 00:00:00 UTC 2015
The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis.
Genes & development
Miyazaki M,Miyazaki K,Chen S,Chandra V,Wagatsuma K,Agata Y,Rodewald HR,Saito R,Chang AN,Varki N,Kawamoto H,Murre C
14-0452 was used in Flow cytometry/Cell sorting to show that Id2 and Id3 suppress the development and expansion of innate variant follicular helper T cells.
Sun Feb 15 00:00:00 UTC 2015
MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.
Proceedings of the National Academy of Sciences of the United States of America
Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunofluorescence
Tue Dec 29 00:00:00 UTC 2015
Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.
Cell death and differentiation
Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Tue Sep 01 00:00:00 UTC 2015
SOCS3 Deficiency in Myeloid Cells Promotes Tumor Development: Involvement of STAT3 Activation and Myeloid-Derived Suppressor Cells.
Cancer immunology research
Yu H,Liu Y,McFarland BC,Deshane JS,Hurst DR,Ponnazhagan S,Benveniste EN,Qin H
14-0452 was used in Flow cytometry/Cell sorting to assess the effect of genetic deletion of SOCS3 in myeloid cells on tumour growth.
Wed Jul 01 00:00:00 UTC 2015
The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation.
Immunity & ageing : I & A
Matsuda T,Yanase S,Takaoka A,Maruyama M
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunofluorescence
Mon Mar 02 00:00:00 UTC 2015
ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells.
PLoS biology
Gallego-Ortega D,Ledger A,Roden DL,Law AM,Magenau A,Kikhtyak Z,Cho C,Allerdice SL,Lee HJ,Valdes-Mora F,Herrmann D,Salomon R,Young AI,Lee BY,Sergio CM,Kaplan W,Piggin C,Conway JR,Rabinovich B,Millar EK,Oakes SR,Chtanova T,Swarbrick A,Naylor MJ,O'Toole S,Green AR,Timpson P,Gee JM,Ellis IO,Clark SJ,Ormandy CJ
14-0452 was used in Flow cytometry/Cell sorting to implicate ELF5 as a defining factor in the acquisition of the key aspects of the lethal phenotype in luminal A breast cancer.
Tue Dec 01 00:00:00 UTC 2015
LKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation.
EMBO reports
Walsh NC,Waters LR,Fowler JA,Lin M,Cunningham CR,Brooks DG,Rehg JE,Morse HC,Teitell MA
14-0452 was used in Flow cytometry/Cell sorting to show that LKB1 expression in B cells maintains B-cell quiescence and prevents the premature formation of germinal centers.
Mon Jun 01 00:00:00 UTC 2015
Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice.
Free radical biology & medicine
Xu G,Wu H,Zhang J,Li D,Wang Y,Wang Y,Zhang H,Lu L,Li C,Huang S,Xing Y,Zhou D,Meng A
14-0452 was used in Flow cytometry/Cell sorting to study how metformin has the potential to be used as a novel radioprotectant to ameliorate TBI-induced long-term BM injury.
Thu Oct 01 00:00:00 UTC 2015
Enhanced CD8 T cell responses through GITR-mediated costimulation resolve chronic viral infection.
PLoS pathogens
Pascutti MF,Geerman S,Slot E,van Gisbergen KP,Boon L,Arens R,van Lier RA,Wolkers MC,Nolte MA
14-0452 was used in Flow cytometry/Cell sorting to study resolution of chronic viral infection through GITR-mediated co-stimulation enhancing CD8 T cell responses.
Sun Mar 01 00:00:00 UTC 2015
Peptide-MHC-I from Endogenous Antigen Outnumber Those from Exogenous Antigen, Irrespective of APC Phenotype or Activation.
PLoS pathogens
Sei JJ,Haskett S,Kaminsky LW,Lin E,Truckenmiller ME,Bellone CJ,Buller RM,Norbury CC
14-0452 was used in Immunofluorescence to suggest that direct antigen presentation is the dominant pathway in mice during mousepox.
Mon Jun 01 00:00:00 UTC 2015
Setd1a regulates progenitor B-cell-to-precursor B-cell development through histone H3 lysine 4 trimethylation and Ig heavy-chain rearrangement.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Tusi BK,Deng C,Salz T,Zeumer L,Li Y,So CW,Morel LM,Qiu Y,Huang S
14-0452 was used in Flow cytometry/Cell sorting to investigate if Setd1a controls specific hematopoietic lineage commitment and differentiation during development, showing that it regulates progenitor B-cell-to-precursor B-cell development.
Wed Apr 01 00:00:00 UTC 2015
Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance.
Carcinogenesis
Dabydeen SA,Kang K,Díaz-Cruz ES,Alamri A,Axelrod ML,Bouker KB,Al-Kharboosh R,Clarke R,Hennighausen L,Furth PA
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Thu Jan 01 00:00:00 UTC 2015
TNF signals are dispensable for the generation of CD23+ CD21/35-high CD1d-high B cells in inflamed lymph nodes.
Cellular immunology
Kuzin II,Bouta EM,Schwarz EM,Bottaro A
14-0452 was used in Flow cytometry/Cell sorting to investigate the role of tumor necrosis factor signals in producing and maintaining B cells in inflamed lymph nodes, and their role in rheumatoid arthritis pathogenesis.
Sat Aug 01 00:00:00 UTC 2015
Limited miR-17-92 overexpression drives hematologic malignancies.
Leukemia research
Danielson LS,Reavie L,Coussens M,Davalos V,Castillo-Martin M,Guijarro MV,Coffre M,Cordon-Cardo C,Aifantis I,Ibrahim S,Liu C,Koralov SB,Hernando E
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Sun Mar 01 00:00:00 UTC 2015
Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation.
BioMed research international
Tejón G,Manríquez V,De Calisto J,Flores-Santibáñez F,Hidalgo Y,Crisóstomo N,Fernández D,Sauma D,Mora JR,Bono MR,Rosemblatt M
14-0452 was used in Flow cytometry/Cell sorting to study the contribution of different factors to the reprogramming of iTregs into IL-17-producing cells, showing that vitamin A impairs reprogramming during intestinal inflammation.
Fri Sep 02 00:00:00 UTC 2016
Serotonin and insulin-like peptides modulate leucokinin-producing neurons that affect feeding and water homeostasis in Drosophila.
The Journal of comparative neurology
Liu Y,Luo J,Carlsson MA,Nässel DR
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunofluorescence
Sat Aug 15 00:00:00 UTC 2015
Endothelial Gata5 transcription factor regulates blood pressure.
Nature communications
Messaoudi S,He Y,Gutsol A,Wight A,Hébert RL,Vilmundarson RO,Makrigiannis AP,Chalmers J,Hamet P,Tremblay J,McPherson R,Stewart AFR,Touyz RM,Nemer M
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Mon Nov 30 00:00:00 UTC 2015
Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice.
Nature communications
Singh NK,Kotla S,Dyukova E,Traylor JG,Orr AW,Chernoff J,Marion TN,Rao GN
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Wed Jun 24 00:00:00 UTC 2015
Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells.
Nature communications
Gao Y,Yang P,Shen H,Yu H,Song X,Zhang L,Zhang P,Cheng H,Xie Z,Hao S,Dong F,Ma S,Ji Q,Bartlow P,Ding Y,Wang L,Liu H,Li Y,Cheng H,Miao W,Yuan W,Yuan Y,Cheng T,Xie XQ
14-0452 was used in Flow cytometry/Cell sorting to investigate how putative small-molecule inhibitors for p18 protein are valuable for further dissecting the signalling pathways of stem cell self-renewal.
Wed Feb 18 00:00:00 UTC 2015
Evaluation of the BDCA2-DTR Transgenic Mouse Model in Chronic and Acute Inflammation.
PloS one
Mandl M,Drechsler M,Jansen Y,Neideck C,Noels H,Faussner A,Soehnlein O,Weber C,Döring Y
14-0452 was used in Flow cytometry/Cell sorting to investigate how continuous diphtheria toxin-induced pDC depletion in Apoe-/- BDCA2-DTR mice receiving a high-fat diet (HFD) for 4 weeks did not alter lesion size or composition.
Sun May 08 00:00:00 UTC 2016
CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes.
Nature communications
Mackley EC,Houston S,Marriott CL,Halford EE,Lucas B,Cerovic V,Filbey KJ,Maizels RM,Hepworth MR,Sonnenberg GF,Milling S,Withers DR
14-0452 was used in Flow cytometry/Cell sorting to investigate whether group 3 innate lymphoid cells migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues.
Fri Jan 09 00:00:00 UTC 2015
Splenic red pulp macrophages are intrinsically superparamagnetic and contaminate magnetic cell isolates.
Scientific reports
Franken L,Klein M,Spasova M,Elsukova A,Wiedwald U,Welz M,Knolle P,Farle M,Limmer A,Kurts C
14-0452 was used in Flow cytometry/Cell sorting to elucidate the intrinsic superparamagnetic nature of splenic red pulp macrophages and their effect on magnetic cell isolates.
Tue Aug 11 00:00:00 UTC 2015
Deficient Natural Killer Dendritic Cell Responses Underlay the Induction of Theiler's Virus-Induced Autoimmunity.
mBio
Chastain EM,Getts DR,Miller SD
14-0452 was used in Flow cytometry/Cell sorting to determine that disease-susceptible SJL/J mice lacked a unique innate immune population, which plays a role in early CNS virus clearance.
Tue Aug 04 00:00:00 UTC 2015
Depletion of B220+NK1.1+ cells enhances the rejection of established melanoma by tumor-specific CD4+ T cells.
Oncoimmunology
Wilson KA,Goding SR,Neely HR,Harris KM,Antony PA
14-0452 was used in Flow cytometry/Cell sorting to show that interferon-producing killer dendritic cells are an important inhibitor of the CD4(+) T cell response to melanoma.
Sat Aug 01 00:00:00 UTC 2015
A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.
Nature medicine
Herranz D,Ambesi-Impiombato A,Palomero T,Schnell SA,Belver L,Wendorff AA,Xu L,Castillo-Martin M,Llobet-Navás D,Cordon-Cardo C,Clappier E,Soulier J,Ferrando AA
14-0452 was used in Flow cytometry/Cell sorting to identify N-Me as a long-range oncogenic enhancer implicated directly in the pathogenesis of human leukaemia.
Wed Oct 01 00:00:00 UTC 2014
Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.
Nature immunology
Mahmud SA,Manlove LS,Schmitz HM,Xing Y,Wang Y,Owen DL,Schenkel JM,Boomer JS,Green JM,Yagita H,Chi H,Hogquist KA,Farrar MA
14-0452 was used in Flow cytometry/Cell sorting to study the role of TNF receptors in the thymic development of Treg cells..
Thu May 01 00:00:00 UTC 2014
In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice.
Blood
Derderian SC,Togarrati PP,King C,Moradi PW,Reynaud D,Czechowicz A,Weissman IL,MacKenzie TC
14-0452 was used in Flow cytometry/Cell sorting to develop a successful foetal conditioning strategy associated with minimal toxicity.
Thu Aug 07 00:00:00 UTC 2014
Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.
The Journal of clinical investigation
Kong G,Wunderlich M,Yang D,Ranheim EA,Young KH,Wang J,Chang YI,Du J,Liu Y,Tey SR,Zhang X,Juckett M,Mattison R,Damnernsawad A,Zhang J,Mulloy JC,Zhang J
14-0452 was used in Flow cytometry/Cell sorting to investigate the effect of combined targeting of MEK/ERK and JAK/STAT signalling on the murine myeloproliferative neoplasm.
Sun Jun 01 00:00:00 UTC 2014
Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.
The Journal of clinical investigation
Bhadra R,Moretto MM,Castillo JC,Petrovas C,Ferrando-Martinez S,Shokal U,Leal M,Koup RA,Eleftherianos I,Khan IA
14-0452 was used in Flow cytometry/Cell sorting to investigate the progressive loss of CD8+ T cell polyfunctionality during aging, using animals challenged with the obligate intracellular pathogen Encephalitozoon cuniculi.
Sun Jun 01 00:00:00 UTC 2014
The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.
The Journal of experimental medicine
Male V,Nisoli I,Kostrzewski T,Allan DS,Carlyle JR,Lord GM,Wack A,Brady HJ
14-0452 was used in Flow cytometry/Cell sorting to propose that E4bp4 is required for commitment to the NK lineage and can promote NK development by directly regulating the expression of the downstream transcription factors Eomes and Id2.
Mon Apr 07 00:00:00 UTC 2014
12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor.
The Journal of experimental medicine
Liu M,Saeki K,Matsunobu T,Okuno T,Koga T,Sugimoto Y,Yokoyama C,Nakamizo S,Kabashima K,Narumiya S,Shimizu T,Yokomizo T
14-0452 was used in Flow cytometry/Cell sorting to demonstrate the potential use of BLT2 agonists as therapeutic agents to accelerate wound healing.
Mon Jun 02 00:00:00 UTC 2014
Progressive replacement of embryo-derived cardiac macrophages with age.
The Journal of experimental medicine
Molawi K,Wolf Y,Kandalla PK,Favret J,Hagemeyer N,Frenzel K,Pinto AR,Klapproth K,Henri S,Malissen B,Rodewald HR,Rosenthal NA,Bajenoff M,Prinz M,Jung S,Sieweke MH
14-0452 was used in Flow cytometry/Cell sorting to report that the embryo-derived population of cardiac macrophages is progressively substituted for monocyte-derived macrophages within the first weeks after birth.
Mon Oct 20 00:00:00 UTC 2014
Ly49 family receptors are required for cancer immunosurveillance mediated by natural killer cells.
Cancer research
Tu MM,Mahmoud AB,Wight A,Mottashed A,Bélanger S,Rahim MM,Abou-Samra E,Makrigiannis AP
14-0452 was used in Flow cytometry/Cell sorting to evaluate the requirement of NK cells in innate immune surveillance of cancer cells, showing that Ly49 family receptors are required.
Tue Jul 15 00:00:00 UTC 2014
Central memory CD4+ T cells are responsible for the recombinant Bacillus Calmette-Guérin ΔureC::hly vaccine's superior protection against tuberculosis.
The Journal of infectious diseases
Vogelzang A,Perdomo C,Zedler U,Kuhlmann S,Hurwitz R,Gengenbacher M,Kaufmann SH
14-0452 was used in Flow cytometry/Cell sorting to investigate the T-cell population required for recombinant Bacillus Calmette-Guérin δureC::hly vaccine's enhanced protection against tuberculosis.
Mon Dec 15 00:00:00 UTC 2014
Lipoxin A₄ modulates adaptive immunity by decreasing memory B-cell responses via an ALX/FPR2-dependent mechanism.
European journal of immunology
Ramon S,Bancos S,Serhan CN,Phipps RP
14-0452 was used in Flow cytometry/Cell sorting to reveal that lipoxin A4, a proresolving mediator, suppresses human activated and memory B-cell activities.
Sat Feb 01 00:00:00 UTC 2014
MyD88-dependent immunity to a natural model of vaccinia virus infection does not involve Toll-like receptor 2.
Journal of virology
Davies ML,Sei JJ,Siciliano NA,Xu RH,Roscoe F,Sigal LJ,Eisenlohr LC,Norbury CC
14-0452 was used in Flow cytometry/Cell sorting to investigate the ability of the innate sensing molecule Toll-like receptor 2 and the signalling molecule MyD88 to influence the innate and adaptive immune response to vaccinia virus following systemic or dermal infection.
Sat Mar 01 00:00:00 UTC 2014
Paradoxical resistance to high-fat diet-induced obesity and altered macrophage polarization in mineralocorticoid receptor-overexpressing mice.
American journal of physiology. Endocrinology and metabolism
Kuhn E,Bourgeois C,Keo V,Viengchareun S,Muscat A,Meduri G,Le Menuet D,Fève B,Lombès M
14-0452 was used in Flow cytometry/Cell sorting to investigate the in vivo metabolic impact of the mineralocorticoid receptor (MR), showing that overexpression of MR leads to resistance to high-fat diet-induced obesity and altered macrophage polarisation.
Wed Jan 01 00:00:00 UTC 2014
Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii.
Immunology and cell biology
Han SJ,Melichar HJ,Coombes JL,Chan SW,Koshy AA,Boothroyd JC,Barton GM,Robey EA
14-0452 was used in Flow cytometry/Cell sorting to show that inflammatory monocytes, but not neutrophils, produce IFN-β in response to T. gondii infection.
Sat Nov 01 00:00:00 UTC 2014
Cutting edge: CD8+ recent thymic emigrants exhibit increased responses to low-affinity ligands and improved access to peripheral sites of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Berkley AM,Fink PJ
14-0452-82 was used in Flow Cytometry to investigate if the maturation state of peripheral T cells impacts the response to bacterial infection due to intrinsic differences in TCR signaling.
Wed Oct 01 00:00:00 UTC 2014
Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response.
Journal of immunology (Baltimore, Md. : 1950)
Park KS,Bayles I,Szlachta-McGinn A,Paul J,Boiko J,Santos P,Liu J,Wang Z,Borghesi L,Milcarek C
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Sat Nov 01 00:00:00 UTC 2014
INAM plays a critical role in IFN-γ production by NK cells interacting with polyinosinic-polycytidylic acid-stimulated accessory cells.
Journal of immunology (Baltimore, Md. : 1950)
Kasamatsu J,Azuma M,Oshiumi H,Morioka Y,Okabe M,Ebihara T,Matsumoto M,Seya T
14-0452 was used in Flow cytometry/Cell sorting to investigate the in vivo function of IFN regulatory factor 3-dependent NK-activating molecule by studying a deficient mouse model.
Sat Nov 15 00:00:00 UTC 2014
Lasting antibody responses are mediated by a combination of newly formed and established bone marrow plasma cells drawn from clonally distinct precursors.
Journal of immunology (Baltimore, Md. : 1950)
Chernova I,Jones DD,Wilmore JR,Bortnick A,Yucel M,Hershberg U,Allman D
14-0452 was used in Flow cytometry/Cell sorting to investigate the role of subpopulations of bone marrow plasma cells in long-term humoral responses to T cell-dependent Ag.
Sat Nov 15 00:00:00 UTC 2014
IκBε is a key regulator of B cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific manner.
Journal of immunology (Baltimore, Md. : 1950)
Alves BN,Tsui R,Almaden J,Shokhirev MN,Davis-Turak J,Fujimoto J,Birnbaum H,Ponomarenko J,Hoffmann A
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Tue Apr 01 00:00:00 UTC 2014
B cell-specific loss of Lyn kinase leads to autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Lamagna C,Hu Y,DeFranco AL,Lowell CA
14-0452-82 was used in Flow Cytometry to demonstrate that B cell-intrinsic Lyn-dependent signalling pathways regulate B cell homeostasis and activation.
Sat Feb 01 00:00:00 UTC 2014
Antigen signal strength during priming determines effector CD4 T cell function and antigen sensitivity during influenza virus challenge.
Journal of immunology (Baltimore, Md. : 1950)
Nagaoka M,Hatta Y,Kawaoka Y,Malherbe LP
14-0452 was used in Flow cytometry/Cell sorting to compare CD4 T cell responses induced by peptides displaying varying binding half-lives with MHC class II before and after influenza virus infection.
Mon Sep 15 00:00:00 UTC 2014
Memory B cells form in aged mice despite impaired affinity maturation and germinal center kinetics.
Experimental gerontology
Goenka R,Scholz JL,Naradikian MS,Cancro MP
14-0452 was used in Flow cytometry/Cell sorting to study how age influences the overall germinal centre reaction during a primary immune response to a thymus-dependent antigen.
Sun Jun 01 00:00:00 UTC 2014
APRIL mediates peritoneal B-1 cell homeostasis.
Immunology letters
Sindhava VJ,Scholz JL,Stohl W,Cancro MP
14-0452 was used in Flow cytometry/Cell sorting to assess the contribution of BLyS and other ligands to peritoneal B-1 cell maintenance.
Fri Aug 01 00:00:00 UTC 2014
Administration of the resveratrol analogues isorhapontigenin and heyneanol-A protects mice hematopoietic cells against irradiation injuries.
BioMed research international
Wang H,Yang YL,Zhang H,Yan H,Wu XJ,Zhang CZ
14-0452 was used in Flow cytometry/Cell sorting to examine if isorhapontigenin and heyneanol-A, two analogues of resveratrol, could mitigate IR-induced BM suppression.
Mon Mar 30 00:00:00 UTC 2015
Rhof promotes murine marginal zone B cell development.
Nagoya journal of medical science
Kishimoto M,Matsuda T,Yanase S,Katsumi A,Suzuki N,Ikejiri M,Takagi A,Ikawa M,Kojima T,Kunishima S,Kiyoi H,Naoe T,Matsushita T,Maruyama M
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Fri Aug 01 00:00:00 UTC 2014
B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling.
PloS one
Kasama Y,Mizukami T,Kusunoki H,Peveling-Oberhag J,Nishito Y,Ozawa M,Kohara M,Mizuochi T,Tsukiyama-Kohara K
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunofluorescence
Mon Dec 22 00:00:00 UTC 2014
B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling.
PloS one
Kasama Y,Mizukami T,Kusunoki H,Peveling-Oberhag J,Nishito Y,Ozawa M,Kohara M,Mizuochi T,Tsukiyama-Kohara K
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunofluorescence
Mon Dec 22 00:00:00 UTC 2014
Identification of Toll-like receptor 9 as parapoxvirus ovis-sensing receptor in plasmacytoid dendritic cells.
PloS one
von Buttlar H,Siegemund S,Büttner M,Alber G
14-0452 was used in an ELISA assay to identify endosomal TLR9 as PPVO-sensing receptor in pDC.
Tue Nov 10 00:00:00 UTC 2015
Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses.
eLife
Chiba S,Ikushima H,Ueki H,Yanai H,Kimura Y,Hangai S,Nishio J,Negishi H,Tamura T,Saijo S,Iwakura Y,Taniguchi T
14-0452 was used in Flow cytometry/Cell sorting to show that recognition of tumor cells by Dectin-1 receptors leads to activation of the tumoricidal activity of NK cells.
Fri Aug 22 00:00:00 UTC 2014
Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.
PloS one
May SL,Zhou Q,Lewellen M,Carter CM,Coffey D,Highfill SL,Bucher CM,Matise I,Morse HC,O'Sullivan MG,Schutten M,Johnson C,Bellgrau D,Blazar BR,Modiano JF
14-0452 was used in Flow cytometry/Cell sorting to study how Nfatc2 and Tob1 are non-redundant regulators of lymphocyte homeostasis.
Mon Oct 19 00:00:00 UTC 2015
Activated macrophage survival is coordinated by TAK1 binding proteins.
PloS one
Mihaly SR,Morioka S,Ninomiya-Tsuji J,Takaesu G
14-0452 was used in Flow cytometry/Cell sorting to investigate the role of TAB1 and TAB2 in macrophage survival.
Fri Jan 16 00:00:00 UTC 2015
Purinergic signaling on leukocytes infiltrating the LPS-injured lung.
PloS one
Friebe D,Yang T,Schmidt T,Borg N,Steckel B,Ding Z,Schrader J
14-0452 was used in Flow cytometry/Cell sorting to investigate the role of extracellular nucleotides/nucleosides in acute lung injury, showing purinergic signaling on leukocytes infiltrating the injured lung.
Thu Jan 15 00:00:00 UTC 2015
CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.
eLife
Linterman MA,Denton AE,Divekar DP,Zvetkova I,Kane L,Ferreira C,Veldhoen M,Clare S,Dougan G,Espéli M,Smith KG
14-0452 was used in Flow cytometry/Cell sorting to determine the role for CD28 after T cell priming.
Mon Oct 27 00:00:00 UTC 2014
RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.
Nature
Lukens JR,Vogel P,Johnson GR,Kelliher MA,Iwakura Y,Lamkanfi M,Kanneganti TD
14-0452 was used in Flow cytometry/Cell sorting to investigate how mutations in SHP-1 causes inflammatory disease, showing that RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.
Thu Jun 13 00:00:00 UTC 2013
A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing.
Nature
Florian MC,Nattamai KJ,Dörr K,Marka G,Uberle B,Vas V,Eckl C,Andrä I,Schiemann M,Oostendorp RA,Scharffetter-Kochanek K,Kestler HA,Zheng Y,Geiger H
14-0452 was used in Immunocytochemistry to evaluate the role of Wnt signalling in the ageing of haematopoietic stem cells in mice.
Thu Nov 21 00:00:00 UTC 2013
Hematopoietic progenitor cell lines with myeloid and lymphoid potential.
Nature methods
Redecke V,Wu R,Zhou J,Finkelstein D,Chaturvedi V,High AA,Häcker H
14-0452 was used in Flow cytometry/Cell sorting to develop methods to investigate immune-cell differentiation and function, showing that immortalised hematopoietic progenitor cell lines can be produced, with myeloid and lymphoid potential.
Thu Aug 01 00:00:00 UTC 2013
T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens.
Immunity
Mandl JN,Monteiro JP,Vrisekoop N,Germain RN
14-0452 was used in Flow cytometry/Cell sorting to provide evidence for a connection between thymic recognition events and foreign antigen-driven T cell responses.
Thu Feb 21 00:00:00 UTC 2013
T cell factor 1 is required for group 2 innate lymphoid cell generation.
Immunity
Yang Q,Monticelli LA,Saenz SA,Chi AW,Sonnenberg GF,Tang J,De Obaldia ME,Bailis W,Bryson JL,Toscano K,Huang J,Haczku A,Pear WS,Artis D,Bhandoola A
14-0452 was used in Flow cytometry/Cell sorting to study group 2 innate lymphoid cell development.
Thu Apr 18 00:00:00 UTC 2013
Macrophage microRNA-155 promotes cardiac hypertrophy and failure.
Circulation
Heymans S,Corsten MF,Verhesen W,Carai P,van Leeuwen RE,Custers K,Peters T,Hazebroek M,Stöger L,Wijnands E,Janssen BJ,Creemers EE,Pinto YM,Grimm D,Schürmann N,Vigorito E,Thum T,Stassen F,Yin X,Mayr M,de Windt LJ,Lutgens E,Wouters K,de Winther MP,Zacchigna S,Giacca M,van Bilsen M,Papageorgiou AP,Schroen B
14-0452 was used in Flow cytometry/Cell sorting to investigate the therapeutic effects of microRNA-155 manipulation in hypertensive heart disease.
Tue Sep 24 00:00:00 UTC 2013
Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection.
Cell host & microbe
Jordan S,Ruzsics Z,Mitrović M,Baranek T,Arapović J,Krmpotić A,Vivier E,Dalod M,Jonjić S,Dölken L,Koszinowski UH
14-0452 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms of extramedullary hematopoiesis.
Wed May 15 00:00:00 UTC 2013
The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus.
Nature immunology
Keating R,Hertz T,Wehenkel M,Harris TL,Edwards BA,McClaren JL,Brown SA,Surman S,Wilson ZS,Bradley P,Hurwitz J,Chi H,Doherty PC,Thomas PG,McGargill MA
14-0452 was used in Flow cytometry/Cell sorting to investigate the immunological mechanisms that promote heterosubtypic immunity, showing that mTOR modulates the antibody response to provide cross-protective immunity to lethal infection.
Sun Dec 01 00:00:00 UTC 2013
Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells.
Nature immunology
Cohen NR,Brennan PJ,Shay T,Watts GF,Brigl M,Kang J,Brenner MB
14-0452 was used in Flow cytometry/Cell sorting to profile gene expression in invariant natural killer T cells during ontogeny and in peripheral subsets.
Tue Jan 01 00:00:00 UTC 2013
COP1 targets C/EBPα for degradation and induces acute myeloid leukemia via Trib1.
Blood
Yoshida A,Kato JY,Nakamae I,Yoneda-Kato N
14-0452 was used in Flow cytometry/Cell sorting to investigate the role of COP1 in tumourigenesis.
Thu Sep 05 00:00:00 UTC 2013
The β2 integrin-kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo.
Blood
Morrison VL,MacPherson M,Savinko T,Lek HS,Prescott A,Fagerholm SC
14-0452 was used in Flow cytometry/Cell sorting to study the implications of a mutated kindlin-3 binding site in β2 integrins in T-cell adhesion and homing responses.
Thu Aug 22 00:00:00 UTC 2013
Inflammatory neovascularization during graft-versus-host disease is regulated by αv integrin and miR-100.
Blood
Leonhardt F,Grundmann S,Behe M,Bluhm F,Dumont RA,Braun F,Fani M,Riesner K,Prinz G,Hechinger AK,Gerlach UV,Dierbach H,Penack O,Schmitt-Gräff A,Finke J,Weber WA,Zeiser R
14-0452-82 was used in Flow Cytometry to identify negative regulation of GvHD-related neovascularization by miR-100.
Thu Apr 25 00:00:00 UTC 2013
MIP-1α/CCL3-mediated maintenance of leukemia-initiating cells in the initiation process of chronic myeloid leukemia.
The Journal of experimental medicine
Baba T,Naka K,Morishita S,Komatsu N,Hirao A,Mukaida N
14-0452 was used in Flow cytometry/Cell sorting to investigate the interaction between leukaemia-initiating cells and normal hematopoietic cells at the early phase of chronic myeloid leukaemia, showing MIP-1α/CCL3-mediated maintenance of initiating cells.
Mon Nov 18 00:00:00 UTC 2013
The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain.
The Journal of experimental medicine
Schneppenheim J,Dressel R,Hüttl S,Lüllmann-Rauch R,Engelke M,Dittmann K,Wienands J,Eskelinen EL,Hermans-Borgmeyer I,Fluhrer R,Saftig P,Schröder B
14-0452 was used in Immunohistochemistry on frozen tissues to investigate the role of SPPL2a in the cleavage of type 2 transmembrane proteins, showing that it promotes B cell development and controls endosomal traffic.
Mon Jan 14 00:00:00 UTC 2013
The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain.
The Journal of experimental medicine
Schneppenheim J,Dressel R,Hüttl S,Lüllmann-Rauch R,Engelke M,Dittmann K,Wienands J,Eskelinen EL,Hermans-Borgmeyer I,Fluhrer R,Saftig P,Schröder B
14-0452 was used in Immunohistochemistry on frozen tissues to investigate the role of SPPL2a in the cleavage of type 2 transmembrane proteins, showing that it promotes B cell development and controls endosomal traffic.
Mon Jan 14 00:00:00 UTC 2013
HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.
The Journal of experimental medicine
Gautier EL,Westerterp M,Bhagwat N,Cremers S,Shih A,Abdel-Wahab O,Lütjohann D,Randolph GJ,Levine RL,Tall AR,Yvan-Charvet L
14-0452 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms leading to high metabolic rate in myeloproliferative disorders, showing that HDL and Glut1 inhibition reverse hypermetabolic state.
Mon Feb 11 00:00:00 UTC 2013
Reciprocal effects of rab7 deletion in activated and neglected T cells.
Autophagy
Roy SG,Stevens MW,So L,Edinger AL
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Mon Jul 01 00:00:00 UTC 2013
An intact immune system is required for the anticancer activities of histone deacetylase inhibitors.
Cancer research
West AC,Mattarollo SR,Shortt J,Cluse LA,Christiansen AJ,Smyth MJ,Johnstone RW
14-0452 was used in Flow cytometry/Cell sorting to clarify the role of the immune system in mediating the efficacy of HDACi against tumours, showing that an intact immune system is required for anticancer activity.
Sun Dec 15 00:00:00 UTC 2013
Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment.
Cancer research
Baird JR,Fox BA,Sanders KL,Lizotte PH,Cubillos-Ruiz JR,Scarlett UK,Rutkowski MR,Conejo-Garcia JR,Fiering S,Bzik DJ
14-0452 was used in Flow cytometry/Cell sorting to establish that cps preferentially invades tumour-associated antigen-presenting cells and restores their ability to trigger potent anti-tumour CD8(+) T-cell responses.
Mon Jul 01 00:00:00 UTC 2013
Transient B-cell depletion combined with apoptotic donor splenocytes induces xeno-specific T- and B-cell tolerance to islet xenografts.
Diabetes
Wang S,Tasch J,Kheradmand T,Ulaszek J,Ely S,Zhang X,Hering BJ,Miller SD,Luo X
14-0452 was used in Immunohistochemistry to show a robust strategy for the induction of xenodonor-specific T and B-cell tolerance.
Sun Sep 01 00:00:00 UTC 2013
A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.
eLife
Olive V,Sabio E,Bennett MJ,De Jong CS,Biton A,McGann JC,Greaney SK,Sodir NM,Zhou AY,Balakrishnan A,Foth M,Luftig MA,Goga A,Speed TP,Xuan Z,Evan GI,Wan Y,Minella AC,He L
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Tue Oct 15 00:00:00 UTC 2013
Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation.
eLife
Kerenyi MA,Shao Z,Hsu YJ,Guo G,Luc S,O'Brien K,Fujiwara Y,Peng C,Nguyen M,Orkin SH
14-0452 was used in Flow cytometry/Cell sorting to study how Lsd1-mediated concurrent repression of enhancer and promoter activity of stem and progenitor cell genes is a pivotal epigenetic mechanism required for proper hematopoietic maturation.
Tue Jun 18 00:00:00 UTC 2013
MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy.
eLife
Heinrichs S,Conover LF,Bueso-Ramos CE,Kilpivaara O,Stevenson K,Neuberg D,Loh ML,Wu WS,Rodig SJ,Garcia-Manero G,Kantarjian HM,Look AT
14-0452 was used in Flow cytometry/Cell sorting to demonstrate that low MYBL2 activity is the underlying cause of the expansion of haematopoietic progenitors in a large fraction of myeloid malignancies.
Tue Jul 16 00:00:00 UTC 2013
Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.
Development (Cambridge, England)
Liu B,Liu YF,Du YR,Mardaryev AN,Yang W,Chen H,Xu ZM,Xu CQ,Zhang XR,Botchkarev VA,Zhang Y,Xu GL
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunofluorescence
Fri Feb 01 00:00:00 UTC 2013
Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.
Development (Cambridge, England)
Liu B,Liu YF,Du YR,Mardaryev AN,Yang W,Chen H,Xu ZM,Xu CQ,Zhang XR,Botchkarev VA,Zhang Y,Xu GL
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunofluorescence
Fri Feb 01 00:00:00 UTC 2013
Temporal requirements for B cells in the establishment of CD4 T cell memory.
Journal of immunology (Baltimore, Md. : 1950)
Mollo SB,Zajac AJ,Harrington LE
14-0452 was used in Flow cytometry/Cell sorting to demonstrate the temporally and functionally distinct roles for B cells in regulating CD4 T cell responses.
Sun Dec 15 00:00:00 UTC 2013
Ebf1 and c-Myb repress rag transcription downstream of Stat5 during early B cell development.
Journal of immunology (Baltimore, Md. : 1950)
Timblin GA,Schlissel MS
14-0452 was used in Flow cytometry/Cell sorting to identify a novel pathway responsible for the transcriptional repression of Rag in developing B cells using an in vitro model system.
Fri Nov 01 00:00:00 UTC 2013
Myeloid-derived suppressor cells play crucial roles in the regulation of mouse collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Fujii W,Ashihara E,Hirai H,Nagahara H,Kajitani N,Fujioka K,Murakami K,Seno T,Yamamoto A,Ishino H,Kohno M,Maekawa T,Kawahito Y
14-0452 was used in Flow cytometry/Cell sorting to clarify that myeloid-derived suppressor cells are crucial in regulating the proinflammatory immune response in mouse collagen-induced arthritis.
Thu Aug 01 00:00:00 UTC 2013
Critical role of SAP in progression and reactivation but not maintenance of T cell-dependent humoral immunity.
Molecular and cellular biology
Zhong MC,Veillette A
14-0452 was used in Flow cytometry/Cell sorting to explore the therapeutic potential of blocking the SLAM-associated protein (SAP) for human autoimmune diseases.
Fri Mar 01 00:00:00 UTC 2013
SAP modulates B cell functions in a genetic background-dependent manner.
Immunology letters
Detre C,Yigit B,Keszei M,Castro W,Magelky EM,Terhorst C
14-0452 was used in Flow cytometry/Cell sorting to investigate the mechanism by which SLAM-associated protein modulates B cell functions.
Sat Jun 01 00:00:00 UTC 2013
Adhesion to substrates induces dendritic cell endothelization and decreases immunological response.
Immunobiology
Osterbur J,Sprague L,Muccioli M,Pate M,Mansfield K,McGinty J,Li Y,Li Y,Shirure V,Courreges MC,Benencia F
14-0452 was used in Flow cytometry/Cell sorting to investigate the effects of different soluble factors, substrates and culture surfaces on the phenotype and function of dendritic cells.
Tue Jan 01 00:00:00 UTC 2013
TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes.
Developmental biology
Bai X,Trowbridge JJ,Riley E,Lee JA,DiBiase A,Kaartinen VM,Orkin SH,Zon LI
14-0452 was used in Flow cytometry/Cell sorting to study the role of TIF1γ in murine erythropoiesis and to assess its function in other blood lineages.
Tue Jan 15 00:00:00 UTC 2013
Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen.
The Journal of comparative neurology
Gautron L,Rutkowski JM,Burton MD,Wei W,Wan Y,Elmquist JK
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunofluorescence
Fri Nov 01 00:00:00 UTC 2013
A New Murine Model for Gastrointestinal Anthrax Infection.
PloS one
Xie T,Sun C,Uslu K,Auth RD,Fang H,Ouyang W,Frucht DM
14-0452 was used in Immunofluorescence to show that antibiotic treatment of infected animals 24 h following high-dose bacterial gavage protected all animals, demonstrating the utility of this animal model in evaluating potential therapeutics.
Fri Oct 13 00:00:00 UTC 2017
TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.
PLoS genetics
Gómez-Herreros F,Romero-Granados R,Zeng Z,Alvarez-Quilón A,Quintero C,Ju L,Umans L,Vermeire L,Huylebroeck D,Caldecott KW,Cortés-Ledesma F
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Thu Jun 13 00:00:00 UTC 2013
In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation.
PloS one
Vink PM,Smout WM,Driessen-Engels LJ,de Bruin AM,Delsing D,Krajnc-Franken MA,Jansen AJ,Rovers EF,van Puijenbroek AA,Kaptein A,Nolte MA,Garritsen A,van Eenennaam H
14-0452 was used in Flow cytometry/Cell sorting to study the function of TAK1 protein in the adult immune system.
Fri Sep 06 00:00:00 UTC 2013
Molecular definition of the identity and activation of natural killer cells.
Nature immunology
Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL
14-0452 was used in Flow cytometry/Cell sorting to systematically define the transcriptome of mouse natural killer cells in several contexts.
Mon Oct 01 00:00:00 UTC 2012
Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a.
Blood
Berent-Maoz B,Montecino-Rodriguez E,Signer RA,Dorshkind K
14-0452 was used in Flow cytometry/Cell sorting to define a genetic basis for thymocyte progenitor aging.
Thu Jun 14 00:00:00 UTC 2012
Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function.
Blood
Schuettpelz LG,Gopalan PK,Giuste FO,Romine MP,van Os R,Link DC
14-0452 was used in Flow cytometry/Cell sorting to investigate the role of kruppel-like factor 7 in hematopoietic stem and progenitor cell function.
Thu Oct 11 00:00:00 UTC 2012
MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis.
Circulation research
Corsten MF,Papageorgiou A,Verhesen W,Carai P,Lindow M,Obad S,Summer G,Coort SL,Hazebroek M,van Leeuwen R,Gijbels MJ,Wijnands E,Biessen EA,De Winther MP,Stassen FR,Carmeliet P,Kauppinen S,Schroen B,Heymans S
14-0452 was used in Flow cytometry/Cell sorting to study how microRNA-155 is upregulated during acute myocarditis, which may contribute to the adverse inflammatory response to viral infection of the heart.
Fri Aug 03 00:00:00 UTC 2012
Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.
The Journal of experimental medicine
Satpathy AT,KC W,Albring JC,Edelson BT,Kretzer NM,Bhattacharya D,Murphy TL,Murphy KM
14-0452 was used in Flow cytometry/Cell sorting to identify Zbtb46 as a transcription factor selectively expressed by classical DCs and their committed progenitors.
Mon Jun 04 00:00:00 UTC 2012
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
The Journal of experimental medicine
Billiard F,Lobry C,Darrasse-Jèze G,Waite J,Liu X,Mouquet H,DaNave A,Tait M,Idoyaga J,Leboeuf M,Kyratsous CA,Burton J,Kalter J,Klinakis A,Zhang W,Thurston G,Merad M,Steinman RM,Murphy AJ,Yancopoulos GD,Aifantis I,Skokos D
14-0452 was used in Flow cytometry/Cell sorting to investigate how Dll4-Notch signaling affects pro-T cell fate and thymic DC development, showing that it is a novel Flt3-independent pathway for DC development and autoimmunity.
Mon May 07 00:00:00 UTC 2012
A role for GPx3 in activity of normal and leukemia stem cells.
The Journal of experimental medicine
Herault O,Hope KJ,Deneault E,Mayotte N,Chagraoui J,Wilhelm BT,Cellot S,Sauvageau M,Andrade-Navarro MA,Hébert J,Sauvageau G
14-0452-82 was used in Immunocytochemistry to examine the correlation between glutathione peroxidase 3 expression in leukaemia stem cells and adverse prognostic outcome.
Mon May 07 00:00:00 UTC 2012
Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation.
The Journal of experimental medicine
Boulard O,Kirchberger S,Royston DJ,Maloy KJ,Powrie FM
14-0452 was used in Flow cytometry/Cell sorting to investigate the genetic factors influencing the progression from Helicobacter hepaticus-driven colitis to tumorigenesis in a mouse model.
Mon Jul 02 00:00:00 UTC 2012
PIDDosome-independent tumor suppression by Caspase-2.
Cell death and differentiation
Manzl C,Peintner L,Krumschnabel G,Bock F,Labi V,Drach M,Newbold A,Johnstone R,Villunger A
14-0452 was used in Flow cytometry/Cell sorting to investigate the role of PIDD, RIP-1 kinase and Nemo/IKKγ in oncogenesis induced by DNA damage or oncogenic stress in gene-ablated mice.
Mon Oct 01 00:00:00 UTC 2012
Lung B cells promote early pathogen dissemination and hasten death from inhalation anthrax.
Mucosal immunology
Rayamajhi M,Delgado C,Condon TV,Riches DW,Lenz LL
14-0452 was used in Flow cytometry/Cell sorting to investigate mechanisms of Bacillus anthracis spore traffic from the lungs to the lung-draining lymph nodes in a mouse model of inhalation anthrax.
Sun Jul 01 00:00:00 UTC 2012
Incomplete TCR-β allelic exclusion accelerates spontaneous autoimmune arthritis in K/BxN TCR transgenic mice.
European journal of immunology
Auger JL,Haasken S,Steinert EM,Binstadt BA
14-0452 was used in Flow cytometry/Cell sorting to highlight dual TCR-β expression as a mechanism that can enhance the maturation of autoreactive pathogenic T cells and lead to more rapid development of autoimmune disease.
Sat Sep 01 00:00:00 UTC 2012
Peroxisome proliferator-activated receptor γ B cell-specific-deficient mice have an impaired antibody response.
Journal of immunology (Baltimore, Md. : 1950)
Ramon S,Bancos S,Thatcher TH,Murant TI,Moshkani S,Sahler JM,Bottaro A,Sime PJ,Phipps RP
14-0452 was used in Flow cytometry/Cell sorting to study how PPARγ expression in B cells is required for an efficient B cell-mediated immune response by regulating B cell differentiation and Ab production.
Thu Nov 15 00:00:00 UTC 2012
IL-21 promotes lupus-like disease in chronic graft-versus-host disease through both CD4 T cell- and B cell-intrinsic mechanisms.
Journal of immunology (Baltimore, Md. : 1950)
Nguyen V,Luzina I,Rus H,Tegla C,Chen C,Rus V
14-0452 was used in Immunohistochemistry to demonstrate that IL-21 promotes autoimmunity in chronic graft-versus-host disease through both CD4(+) T cell- and B cell-intrinsic mechanisms.
Sun Jul 15 00:00:00 UTC 2012
CD70-driven costimulation induces survival or Fas-mediated apoptosis of T cells depending on antigenic load.
Journal of immunology (Baltimore, Md. : 1950)
Wensveen FM,Unger PP,Kragten NA,Derks IA,ten Brinke A,Arens R,van Lier RA,Eldering E,van Gisbergen KP
14-0452 was used in Flow cytometry/Cell sorting to investigate how BIm-dependent apoptosis is initiated in CD8 T cells.
Tue May 01 00:00:00 UTC 2012
Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness.
Journal of immunology (Baltimore, Md. : 1950)
Sawaguchi M,Tanaka S,Nakatani Y,Harada Y,Mukai K,Matsunaga Y,Ishiwata K,Oboki K,Kambayashi T,Watanabe N,Karasuyama H,Nakae S,Inoue H,Kubo M
14-0452 was used in Flow cytometry/Cell sorting to demonstrate an indispensable role for MCs as effector cells in AHR.
Wed Feb 15 00:00:00 UTC 2012
Critical role of B cell lymphoma 10 in BAFF-regulated NF-κB activation and survival of anergic B cells.
Journal of immunology (Baltimore, Md. : 1950)
Yu M,Chen Y,He Y,Podd A,Fu G,Wright JA,Kleiman E,Khan WN,Wen R,Wang D
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Sat Dec 01 00:00:00 UTC 2012
Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase.
Journal of immunology (Baltimore, Md. : 1950)
Hasham MG,Snow KJ,Donghia NM,Branca JA,Lessard MD,Stavnezer J,Shopland LS,Mills KD
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Sat Sep 01 00:00:00 UTC 2012
Exposure to nicotine adversely affects the dendritic cell system and compromises host response to vaccination.
Journal of immunology (Baltimore, Md. : 1950)
Nouri-Shirazi M,Guinet E
14-0452 was used in Flow cytometry/Cell sorting to investigate the causal relationship between nicotine-induced dendritic cell alterations and host response to vaccines.
Thu Mar 01 00:00:00 UTC 2012
NK cells are required for costimulatory blockade induced tolerance to vascularized allografts.
Transplantation
van der Touw W,Burrell B,Lal G,Bromberg JS
14-0452 was used in Immunohistochemistry on frozen tissues to investigate the role of NK cells in allograft tolerance, showing that they are required for costimulatory blockade induced tolerance to vascularised allografts.
Thu Sep 27 00:00:00 UTC 2012
Extra-thymic physiological T lineage progenitor activity is exclusively confined to cells expressing either CD127, CD90, or high levels of CD117.
PloS one
Saran N,Pommerencke J,Witzlau K,Regelin M,Krueger A
14-0452 was used in Flow cytometry/Cell sorting to suggest that a physiological thymic microenvironment does not optimally support T cell differentiation from triple negative precursors.
Mon Jun 18 00:00:00 UTC 2012
Dominant Role of CD80-CD86 Over CD40 and ICOSL in the Massive Polyclonal B Cell Activation Mediated by LAT(Y136F) CD4(+) T Cells.
Frontiers in immunology
Chevrier S,Genton C,Malissen B,Malissen M,Acha-Orbea H
14-0452 was used in Flow cytometry/Cell sorting to determine that CD80 and CD86 costimulators play a key role in the polyclonal B cell activation mediated by Lat(Y136F) CD4(+) T cells.
Thu Aug 23 00:00:00 UTC 2012
Dominant Role of CD80-CD86 Over CD40 and ICOSL in the Massive Polyclonal B Cell Activation Mediated by LAT(Y136F) CD4(+) T Cells.
Frontiers in immunology
Chevrier S,Genton C,Malissen B,Malissen M,Acha-Orbea H
14-0452 was used in Flow cytometry/Cell sorting to determine that CD80 and CD86 costimulators play a key role in the polyclonal B cell activation mediated by Lat(Y136F) CD4(+) T cells.
Thu Aug 23 00:00:00 UTC 2012
Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation.
Immunity
Wuerzberger-Davis SM,Chen Y,Yang DT,Kearns JD,Bates PW,Lynch C,Ladell NC,Yu M,Podd A,Zeng H,Huang TT,Wen R,Hoffmann A,Wang D,Miyamoto S
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Fri Feb 25 00:00:00 UTC 2011
Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation.
Immunity
Wuerzberger-Davis SM,Chen Y,Yang DT,Kearns JD,Bates PW,Lynch C,Ladell NC,Yu M,Podd A,Zeng H,Huang TT,Wen R,Hoffmann A,Wang D,Miyamoto S
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Immunohistochemistry
Fri Feb 25 00:00:00 UTC 2011
A subset of interleukin-21+ chemokine receptor CCR9+ T helper cells target accessory organs of the digestive system in autoimmunity.
Immunity
McGuire HM,Vogelzang A,Ma CS,Hughes WE,Silveira PA,Tangye SG,Christ D,Fulcher D,Falcone M,King C
14-0452 was used in Immunohistochemistry to characterise a T helper cell subset marked by coexpression of the cytokine interleukin 21 and CCR9.
Fri Apr 22 00:00:00 UTC 2011
The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization.
Nature immunology
Ippagunta SK,Malireddi RK,Shaw PJ,Neale GA,Vande Walle L,Green DR,Fukui Y,Lamkanfi M,Kanneganti TD
14-0452 was used in Flow cytometry/Cell sorting to study how ASC shapes adaptive immunity independently of inflammasomes by modulating Dock2-dependent Rac activation and actin polymerization in DCs and lymphocytes.
Sun Sep 04 00:00:00 UTC 2011
RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity.
Blood
Wilhelm BT,Briau M,Austin P,Faubert A,Boucher G,Chagnon P,Hope K,Girard S,Mayotte N,Landry JR,Hébert J,Sauvageau G
14-0452 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms regulating self-renewal of leukemia stem cells.
Thu Jan 13 00:00:00 UTC 2011
Recent thymic emigrants are biased against the T-helper type 1 and toward the T-helper type 2 effector lineage.
Blood
Hendricks DW,Fink PJ
14-0452 was used in Flow cytometry/Cell sorting to investigate the relationships between recent thymic emigrants and T-helper type 1 and 2 cells.
Thu Jan 27 00:00:00 UTC 2011
Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells.
The Journal of experimental medicine
Hickman HD,Li L,Reynoso GV,Rubin EJ,Skon CN,Mays JW,Gibbs J,Schwartz O,Bennink JR,Yewdell JW
14-0452 was used in Immunohistochemistry on frozen tissues to demonstrate the ability of chemokines to assist antiviral CD8(+) T cells in distinguishing between antigen presenting cells.
Mon Nov 21 00:00:00 UTC 2011
Identification of semaphorin 4B as a negative regulator of basophil-mediated immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Nakagawa Y,Takamatsu H,Okuno T,Kang S,Nojima S,Kimura T,Kataoka TR,Ikawa M,Toyofuku T,Katayama I,Kumanogoh A
14-0452 was used in Flow cytometry/Cell sorting to screen semaphorins for immune involvement, identifying Sema4B as a suppressor of basophil-mediated Th2-skewing.
Tue Mar 01 00:00:00 UTC 2011
NKT cells are required for complete Freund's adjuvant-mediated protection from autoimmune diabetes.
Journal of immunology (Baltimore, Md. : 1950)
Lee IF,van den Elzen P,Tan R,Priatel JJ
14-0452 was used in Flow cytometry/Cell sorting to elucidate roles for NKT cells in the adjuvant-promoting effects of CFA on innate and adaptive immunity.
Thu Sep 15 00:00:00 UTC 2011
Anti-CD180 (RP105) activates B cells to rapidly produce polyclonal Ig via a T cell and MyD88-independent pathway.
Journal of immunology (Baltimore, Md. : 1950)
Chaplin JW,Kasahara S,Clark EA,Ledbetter JA
14-0452 was used in Flow cytometry/Cell sorting to study the effect of injection of anti-CD180 mAb into mice on the production of immunoglobulins.
Sat Oct 15 00:00:00 UTC 2011
L2pB1: a new player in autoimmunity.
Molecular immunology
Zhong X,Rothstein TL
14-0452 was used in Flow cytometry/Cell sorting to review the features of PD-L2 positive B1 cells and their contribution to autoimmunity.
Wed Jun 01 00:00:00 UTC 2011
PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection.
PloS one
Hemmers S,Teijaro JR,Arandjelovic S,Mowen KA
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Tue Nov 15 00:00:00 UTC 2011
Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.
Nature communications
Mkhikian H,Grigorian A,Li CF,Chen HL,Newton B,Zhou RW,Beeton C,Torossian S,Tatarian GG,Lee SU,Lau K,Walker E,Siminovitch KA,Chandy KG,Yu Z,Dennis JW,Demetriou M
14-0452 was used in Flow cytometry/Cell sorting to discover that genetic and the environment converge to dysregulate N-glycosylation in multiple sclerosis.
Tue Sep 20 00:00:00 UTC 2011
FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia.
PloS one
Liesz A,Sun L,Zhou W,Schwarting S,Mracsko E,Zorn M,Bauer H,Sommer C,Veltkamp R
14-0452 was used in Flow cytometry/Cell sorting to detect a reduction of lymphocyte brain invasion by FTY720.
Fri Oct 14 00:00:00 UTC 2011
Glycosidic Tn-based vaccines targeting dermal dendritic cells favor germinal center B-cell development and potent antibody response in the absence of adjuvant.
Blood
Freire T,Zhang X,Dériaud E,Ganneau C,Vichier-Guerre S,Azria E,Launay O,Lo-Man R,Bay S,Leclerc C
14-0452 was used in Flow cytometry/Cell sorting to study dendritic cell antigen uptake and presentation by targeting the antigen receptor, macrophage galactose-type lectin (MGL), with tumor-associated Tn antigens.
Thu Nov 04 00:00:00 UTC 2010
Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad.
Blood
Frenzel A,Labi V,Chmelewskij W,Ploner C,Geley S,Fiegl H,Tzankov A,Villunger A
14-0452 was used in Flow cytometry/Cell sorting to demonstrate the potential of BH3-only proapoptotic Bcl-2 family members to regulate excessive lymphocyte proliferation.
Thu Feb 04 00:00:00 UTC 2010
Separation of graft-versus-host disease from graft-versus-leukemia responses by targeting CC-chemokine receptor 7 on donor T cells.
Blood
Coghill JM,Carlson MJ,Panoskaltsis-Mortari A,West ML,Burgents JE,Blazar BR,Serody JS
14-0452 was used in Flow cytometry/Cell sorting to investigate the role of MHC disparity between donor and recipient, in the attenuated graft-versus-host disease responses of murine T cells lacking CCR7.
Thu Jun 10 00:00:00 UTC 2010
Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance.
Cancer research
Chin AI,Miyahira AK,Covarrubias A,Teague J,Guo B,Dempsey PW,Cheng G
14-0452 was used in Immunohistochemistry to delineate the importance of IFNAR-dependent functions in TLR3-mediated tumour suppression.
Thu Apr 01 00:00:00 UTC 2010
Notch dimerization is required for leukemogenesis and T-cell development.
Genes & development
Liu H,Chi AW,Arnett KL,Chiang MY,Xu L,Shestova O,Wang H,Li YM,Bhandoola A,Aster JC,Blacklow SC,Pear WS
14-0452 was used in Flow cytometry/Cell sorting to show that dimeric Notch transcriptional complexes are required for T-cell maturation and leukemic transformation but are dispensable for T-cell fate specification from a multipotential precursor.
Mon Nov 01 00:00:00 UTC 2010
The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development.
Science signaling
Ramadani F,Bolland DJ,Garcon F,Emery JL,Vanhaesebroeck B,Corcoran AE,Okkenhaug K
14-0452 was used in Flow cytometry/Cell sorting to study how either p110alpha or p110delta can mediate tonic signaling from the BCR, but only p110delta can contribute to antigen-dependent activation of B cells.
Tue Aug 10 00:00:00 UTC 2010
Steroid-resistant lymphatic remodeling in chronically inflamed mouse airways.
The American journal of pathology
Yao LC,Baluk P,Feng J,McDonald DM
14-0452 was used in Immunohistochemistry to suggest that lymphatic remodelling after the initial inflammatory response may influence later inflammatory episodes.
Mon Mar 01 00:00:00 UTC 2010
Dendritic cell (DC)-specific targeting reveals Stat3 as a negative regulator of DC function.
Journal of immunology (Baltimore, Md. : 1950)
Melillo JA,Song L,Bhagat G,Blazquez AB,Plumlee CR,Lee C,Berin C,Reizis B,Schindler C
14-0452 was used in Flow cytometry/Cell sorting to directly examine the role Stat3 plays in regulating dendritic cell activity.
Mon Mar 01 00:00:00 UTC 2010
Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection.
Journal of immunology (Baltimore, Md. : 1950)
McCarl CA,Khalil S,Ma J,Oh-hora M,Yamashita M,Roether J,Kawasaki T,Jairaman A,Sasaki Y,Prakriya M,Feske S
14-0452 was used in Flow cytometry/Cell sorting to reaffirm the critical role of ORAI1 for T cell function, and provide important insights into the in vivo functions of CRAC channels for T cell-mediated immunity.
Mon Nov 15 00:00:00 UTC 2010
T-bet and eomesodermin are required for T cell-mediated antitumor immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Zhu Y,Ju S,Chen E,Dai S,Li C,Morel P,Liu L,Zhang X,Lu B
14-0452 was used in Flow cytometry/Cell sorting to define T-bet and Eomes as critical regulators of T cell-mediated immune responses against tumours.
Wed Sep 15 00:00:00 UTC 2010
Mad3 negatively regulates B cell differentiation in the spleen by inducing Id2 expression.
Molecular biology of the cell
Gore Y,Lantner F,Hart G,Shachar I
14-0452 was used in Flow cytometry/Cell sorting to investigate Mad protein activity during peripheral B cell differentiation.
Tue Jun 01 00:00:00 UTC 2010
AUF1 is involved in splenic follicular B cell maintenance.
BMC immunology
Sadri N,Lu JY,Badura ML,Schneider RJ
14-0452 was used in Flow cytometry/Cell sorting to investigate the role of AUF1 in the immune system, showing that it is involved in splenic follicular B cell maintenance.
Mon Jan 11 00:00:00 UTC 2010
A novel heat-shock protein coinducer boosts stress protein Hsp70 to activate T cell regulation of inflammation in autoimmune arthritis.
Arthritis and rheumatism
Wieten L,van der Zee R,Spiering R,Wagenaar-Hilbers J,van Kooten P,Broere F,van Eden W
14-0452 was used in Neutralization to study whether the boosting of endogenous heat-shock protein expression can restore effective immunoregulation through T cells specific for stress proteins.
Thu Apr 01 00:00:00 UTC 2010
Intermediate-term hematopoietic stem cells with extended but time-limited reconstitution potential.
Cell stem cell
Benveniste P,Frelin C,Janmohamed S,Barbara M,Herrington R,Hyam D,Iscove NN
14-0452 was used in Flow cytometry/Cell sorting to investigate the presence of "intermediate-term" multipotent hematopoietic stem cells, revealing that these cells are able to sustain clones of differentiating cells for only 4-6 weeks.
Fri Jan 08 00:00:00 UTC 2010
PI3 kinase signals BCR-dependent mature B cell survival.
Cell
Srinivasan L,Sasaki Y,Calado DP,Zhang B,Paik JH,DePinho RA,Kutok JL,Kearney JF,Otipoby KL,Rajewsky K
14-0452 was used in Flow cytometry/Cell sorting to identify the molecular nature of the essential B cell survival signal delivered to BCRs.
Fri Oct 30 00:00:00 UTC 2009
Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.
Immunity
A-Gonzalez N,Bensinger SJ,Hong C,Beceiro S,Bradley MN,Zelcer N,Deniz J,Ramirez C,Díaz M,Gallardo G,de Galarreta CR,Salazar J,Lopez F,Edwards P,Parks J,Andujar M,Tontonoz P,Castrillo A
14-0452 was used in Immunofluorescence to study how liver X receptor signalling is important for both apoptotic cell clearance and the maintenance of immune tolerance.
Fri Aug 21 00:00:00 UTC 2009
AID constrains germinal center size by rendering B cells susceptible to apoptosis.
Blood
Zaheen A,Boulianne B,Parsa JY,Ramachandran S,Gommerman JL,Martin A
14-0452 was used in Flow cytometry/Cell sorting to report a link between AID-induced DNA damage and B-cell apoptosis that has implications for the development of B-cell disorders.
Thu Jul 16 00:00:00 UTC 2009
A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation.
Blood
Schuman J,Chen Y,Podd A,Yu M,Liu HH,Wen R,Chen ZJ,Wang D
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Thu May 07 00:00:00 UTC 2009
Migratory and antigen presentation functions of IFN-producing killer dendritic cells.
Cancer research
Himoudi N,Yan M,Bouma G,Morgenstern D,Wallace R,Seddon B,Buddle J,Eddaoudi A,Howe SJ,Cooper N,Anderson J
14-0452 was used in Flow cytometry/Cell sorting to study how BM-IKDCs are capable of cytotoxic killing of tumour targets, and also of potent antigen presentation after encountering antigen in the context of a viable target cell.
Sat Aug 15 00:00:00 UTC 2009
CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche.
Proceedings of the National Academy of Sciences of the United States of America
Chevrier S,Genton C,Kallies A,Karnowski A,Otten LA,Malissen B,Malissen M,Botto M,Corcoran LM,Nutt SL,Acha-Orbea H
14-0452 was used in Flow cytometry/Cell sorting to explain why CD93, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation.
Tue Mar 10 00:00:00 UTC 2009
Oncogenic Kras initiates leukemia in hematopoietic stem cells.
PLoS biology
Sabnis AJ,Cheung LS,Dail M,Kang HC,Santaguida M,Hermiston ML,Passegué E,Shannon K,Braun BS
14-0452 was used in Flow cytometry/Cell sorting to conclude that MPD-initiating activity is restricted to the HSC compartment in Kras(G12D) mice.
Tue Mar 17 00:00:00 UTC 2009
Critical roles of lysosomal acid lipase in T cell development and function.
The American journal of pathology
Qu P,Du H,Wilkes DS,Yan C
14-0452-82 was used in Flow Cytometry to conclude that the altered development and function of lal(-/-) T cells contributes to disease formation in various organs during LAL deficiency.
Sun Mar 01 00:00:00 UTC 2009
Chronic CD70-driven costimulation impairs IgG responses by instructing T cells to inhibit germinal center B cell formation through FasL-Fas interactions.
Journal of immunology (Baltimore, Md. : 1950)
Beishuizen CR,Kragten NA,Boon L,Nolte MA,van Lier RA,van Gisbergen KP
14-0452 was used in Immunohistochemistry to investigate the mechanism by which CD70 expression induces T cell-driven disruption of neutralising Ab responses, showing that this occurs by instructing T cells to inhibit germinal center B cell formation.
Sun Nov 15 00:00:00 UTC 2009
Chemokine-like receptor-1 expression by central nervous system-infiltrating leukocytes and involvement in a model of autoimmune demyelinating disease.
Journal of immunology (Baltimore, Md. : 1950)
Graham KL,Zabel BA,Loghavi S,Zuniga LA,Ho PP,Sobel RA,Butcher EC
14-0452 was used in Flow cytometry/Cell sorting to investigate the involvement of chemokine-like receptor-1 in experimental autoimmune encephalomyelitis.
Sun Nov 15 00:00:00 UTC 2009
Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950)
Schaeffer M,Han SJ,Chtanova T,van Dooren GG,Herzmark P,Chen Y,Roysam B,Striepen B,Robey EA
14-0452 was used in Flow cytometry/Cell sorting to directly observe the dynamics of T cell-parasite interactions within living tissue and further understand immune responses to persistent pathogens in the brain.
Fri May 15 00:00:00 UTC 2009
Peripheral dendritic cells are essential for both the innate and adaptive antiviral immune responses in the central nervous system.
Virology
Steel CD,Hahto SM,Ciavarra RP
14-0452-82 was used in Flow Cytometry to study the adaptive primary antiviral immune response in the CNS and the effect of dendritic cells upon this in vivo.
Sat Apr 25 00:00:00 UTC 2009
Gene expression profiling of leukemia stem cells.
Methods in molecular biology (Clifton, N.J.)
Krivtsov AV,Wang Y,Feng Z,Armstrong SA
14-0452 was used in Flow cytometry/Cell sorting to illustrate methods to isolate a leukemia stem cell population, amplify RNA, and perform microarray analyses.
Tue May 19 00:00:00 UTC 2009
Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis.
PloS one
Chan AS,Jensen KK,Skokos D,Doty S,Lederman HK,Kaplan RN,Rafii S,Rivella S,Lyden D
14-0452 was used in Flow cytometry/Cell sorting to identify Id1 as crucial for the dynamic cross-talk between bone and bone marrow haematopoietic cells.
Tue Nov 24 00:00:00 UTC 2009
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Nature immunology
Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M
14-0452-82 was used in Immunohistochemistry to investigate the hematopoietic growth factors regulating dendritic development.
Sun Jun 01 00:00:00 UTC 2008
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Nature immunology
Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M
14-0452-82 was used in Immunohistochemistry to investigate the hematopoietic growth factors regulating dendritic development.
Sun Jun 01 00:00:00 UTC 2008
Fundamental differences in the dynamics of CNS lesion development and composition in MP4- and MOG peptide 35-55-induced experimental autoimmune encephalomyelitis.
Clinical immunology (Orlando, Fla.)
Kuerten S,Javeri S,Tary-Lehmann M,Lehmann PV,Angelov DN
14-0452 was used in Immunohistochemistry to investigate the histopathological differences between two mouse models of experimental autoimmune encephalomyelitis.
Sat Nov 01 00:00:00 UTC 2008
Regulatory role of B cells in a murine model of allergic airway disease.
Journal of immunology (Baltimore, Md. : 1950)
Singh A,Carson WF,Secor ER,Guernsey LA,Flavell RA,Clark RB,Thrall RS,Schramm CM
14-0452 was used in Flow cytometry/Cell sorting to investigate the role of B cells in the resolution of allergic airway disease and induction of local inhalational tolerance.
Sun Jun 01 00:00:00 UTC 2008
Age-dependent tolerance to an endogenous tumor-associated antigen.
Vaccine
McWilliams JA,Sullivan RT,Jordan KR,McMahan RH,Kemmler CB,McDuffie M,Slansky JE
14-0452 was used in Flow cytometry/Cell sorting to determine the role of gp70 expression in the T cell response to a transplantable CT26 colon carcinoma tumour in mice.
Fri Mar 28 00:00:00 UTC 2008
Donor major histocompatibility complex class I expression determines the outcome of prenatal transplantation.
Journal of pediatric surgery
Durkin ET,Jones KA,Elnaggar D,Shaaban AF
14-0452 was used in Flow cytometry/Cell sorting to investigate whether donor cell MHC class I expression facilitates engraftment in prenatal allogeneic recipients, showing that it determines the outcome of prenatal transplantation.
Sun Jun 01 00:00:00 UTC 2008
p27 deficiency cooperates with Bcl-2 but not Bax to promote T-cell lymphoma.
PloS one
Cheng N,van de Wetering CI,Knudson CM
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Wed Apr 02 00:00:00 UTC 2008
Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease.
PloS one
Hase K,Takahashi D,Ebisawa M,Kawano S,Itoh K,Ohno H
14-0452 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying autoimmunity associated with AID mutations, showing that AID is a negative regulator of autoreactive B cells.
Thu Aug 21 00:00:00 UTC 2008
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid.
The Journal of experimental medicine
Sun CM,Hall JA,Blank RB,Bouladoux N,Oukka M,Mora JR,Belkaid Y
14-0452 was used in Flow cytometry/Cell sorting to investigate how the intestinal immune system has evolved a self-contained strategy to promote T reg cell neoconversion.
Mon Aug 06 00:00:00 UTC 2007
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease.
The Journal of experimental medicine
Lahl K,Loddenkemper C,Drouin C,Freyer J,Arnason J,Eberl G,Hamann A,Wagner H,Huehn J,Sparwasser T
14-0452 was used in Immunohistochemistry to investigate whether dysfunction or a lack of T reg cells is etiologically involved in scurfy pathogenesis, showing that selective depletion of Foxp3+ Tregs leads to scurfy.
Mon Jan 22 00:00:00 UTC 2007
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease.
The Journal of experimental medicine
Lahl K,Loddenkemper C,Drouin C,Freyer J,Arnason J,Eberl G,Hamann A,Wagner H,Huehn J,Sparwasser T
14-0452 was used in Immunohistochemistry to investigate whether dysfunction or a lack of T reg cells is etiologically involved in scurfy pathogenesis, showing that selective depletion of Foxp3+ Tregs leads to scurfy.
Mon Jan 22 00:00:00 UTC 2007
Murine CXCL14 is dispensable for dendritic cell function and localization within peripheral tissues.
Molecular and cellular biology
Meuter S,Schaerli P,Roos RS,Brandau O,Bösl MR,von Andrian UH,Moser B
14-0452 was used in Flow cytometry/Cell sorting to investigate the process of dendritic cell recruitment to peripheral tissues, showing that murine CXCL14 is dispensable for dendritic cell function and localisation.
Thu Feb 01 00:00:00 UTC 2007
Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing.
Molecular and cellular biology
Bai L,Chen Y,He Y,Dai X,Lin X,Wen R,Wang D
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Sat Sep 01 00:00:00 UTC 2007
N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration.
The Journal of biological chemistry
Lee SU,Grigorian A,Pawling J,Chen IJ,Gao G,Mozaffar T,McKerlie C,Demetriou M
14-0452 was used in Flow cytometry/Cell sorting to identify hypomorphic Golgi processing as an inherited trait that determines susceptibility to EAE and provides a unique spontaneous model of MS.
Fri Nov 16 00:00:00 UTC 2007
Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men.
The Journal of experimental medicine
Bogunovic M,Ginhoux F,Wagers A,Loubeau M,Isola LM,Lubrano L,Najfeld V,Phelps RG,Grosskreutz C,Scigliano E,Frenette PS,Merad M
14-0452 was used in Flow cytometry/Cell sorting to explore dermal DC homeostasis in mice and humans both in the steady state and after haematopoietic cell transplantation.
Mon Nov 27 00:00:00 UTC 2006
Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis.
Molecular and cellular biology
Wen R,Chen Y,Bai L,Fu G,Schuman J,Dai X,Zeng H,Yang C,Stephan RP,Cleveland JL,Wang D
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Fri Dec 01 00:00:00 UTC 2006
A role for brain-derived neurotrophic factor in B cell development.
Journal of neuroimmunology
Schuhmann B,Dietrich A,Sel S,Hahn C,Klingenspor M,Lommatzsch M,Gudermann T,Braun A,Renz H,Nockher WA
Wed Jun 01 00:00:00 UTC 2005
Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene.
Molecular and cellular biology
Pan L,Sato S,Frederick JP,Sun XH,Zhuang Y
Published figure using CD45R (B220) monoclonal antibody (Product # 14-0452-82) in Flow Cytometry
Wed Sep 01 00:00:00 UTC 1999
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-RA3-6B2-RE-AV-20170920122035.jpg?time=20220826?time=20220826 "CD45R (B220) Antibody (14-0452-82)")
