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CD49a (Integrin alpha 1) Antibody (PA5-95563) in IHC
International journal of molecular sciences 2020 -
Figure 1 Levels of epidermal CD49a + Trm cells closely correlate with disease severity in human psoriatic patients. ( A ) Representative immunohistochemistry images of acute and chronic inflamed psoriatic lesions stained with markers of CD49a + Trm cells (white arrows). n = 6/group. Magnification x20, insert white boxed region x40. Scale bar = 50 um. ( B ) Graphical analysis of correlation between Trm cell ... View More
Product Details
PA5-95563
Applications
Tested Dilution
Publications
Product Specifications
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence of human Integrin alpha 1.
Conjugate
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2807365
Product Specific Information
Synthetic peptide sequence: TEEVLVAAKKIVQRGGRQTMTALGIDTARKEAFTEAR.
Reconstitution information: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Target Information
Integrin alpha 1 (ITGA1) chain associates with the beta 1 (ITGB1) chain to form a heterodimer that functions as a dual laminin/collagen receptor in neural cells and hematopoietic cells. ITGA1 has a 206-amino acid I domain in its N-terminal half, followed by 3 divalent cation-binding sites and a C-terminal transmembrane domain with a short cytoplasmic tail. It also has 28 potential N-glycosylation sites. Human ITGA1 was expressed in a mouse fibroblast cell line as a 180-kD protein. ITGA1 is involved in the early remodeling of osteoarthritic cartilage and plays an essential role in the regulation of mesenchymal stem cell proliferation and cartilage production. It also plays an essential role in the regulation of MSC proliferation and cartilage production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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