Product References
Antibody feedback regulates immune memory after SARS-CoV-2 mRNA vaccination.
Nature
Schaefer-Babajew D,Wang Z,Muecksch F,Cho A,Loewe M,Cipolla M,Raspe R,Johnson B,Canis M,DaSilva J,Ramos V,Turroja M,Millard KG,Schmidt F,Witte L,Dizon J,Shimeliovich I,Yao KH,Oliveira TY,Gazumyan A,Gaebler C,Bieniasz PD,Hatziioannou T,Caskey M,Nussenzweig MC
47-0086-42 was used in Flow cytometry/Cell sorting to indicate that pre-existing high-affinity antibodies bias germinal centre and memory B cell selection through two distinct mechanisms: (1) by lowering the activation threshold for B cells, thereby permitting abundant lower-affinity clones to participate in the immune response; and (2) through direct masking of their cognate epitopes.
Sun Jan 01 00:00:00 EST 2023
Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course.
Nature immunology
Muri J,Cecchinato V,Cavalli A,Shanbhag AA,Matkovic M,Biggiogero M,Maida PA,Moritz J,Toscano C,Ghovehoud E,Furlan R,Barbic F,Voza A,De Nadai G,Cervia C,Zurbuchen Y,Taeschler P,Murray LA,Danelon-Sargenti G,Moro S,Gong T,Piffaretti P,Bianchini F,Crivelli V,Podešvová L,Pedotti M,Jarrossay D,Sgrignani J,Thelen S,Uhr M,Bernasconi E,Rauch A,Manzo A,Ciurea A,Rocchi MBL,Varani L,Moser B,Bottazzi B,Thelen M,Fallon BA,Boyman O,Mantovani A,Garzoni C,Franzetti-Pellanda A,Uguccioni M,Robbiani DF
47-0086-42 was used in Flow cytometry/Cell sorting to show that given the role of chemokines in orchestrating immune cell trafficking, naturally arising chemokine antibodies may modulate the inflammatory response and thus bear therapeutic potential.
Sat Apr 01 00:00:00 EDT 2023
Tocilizumab-treated convalescent COVID-19 patients retain the cross-neutralization potential against SARS-CoV-2 variants.
iScience
Chauvin C,Levillayer L,Roumier M,Nielly H,Roth C,Karnam A,Bonam SR,Bourgarit A,Dubost C,Bousquet A,Le Burel S,Mestiri R,Sene D,Galland J,Vasse M,Groh M,Le Marchand M,Vassord-Dang C,Gautier JF,Pham-Thi N,Verny C,Pitard B,Planchais C,Mouquet H,Paul R,Simon-Loriere E,Bayry J,Gilardin L,Sakuntabhai A
47-0086-42 was used in Flow cytometry/Cell sorting to observe that SARS-CoV-2-specific IgG1 titers depended on disease severity but not on tocilizumab treatment.
Fri Mar 17 00:00:00 EDT 2023
Plasma and memory antibody responses to Gamma SARS-CoV-2 provide limited cross-protection to other variants.
The Journal of experimental medicine
Agudelo M,Muecksch F,Schaefer-Babajew D,Cho A,DaSilva J,Bednarski E,Ramos V,Oliveira TY,Cipolla M,Gazumyan A,Zong S,Rodrigues DAS,Lira GS,Conde L,Aguiar RS,Ferreira OC,Tanuri A,Affonso KC,Galliez RM,Castineiras TMPP,Echevarria-Lima J,Bozza MT,Vale AM,Bieniasz PD,Hatziioannou T,Nussenzweig MC
47-0086-42 was used in Flow cytometry/Cell sorting to suggest that exposure to variants generally provides more limited protection to other variants.
Mon Sep 05 00:00:00 EDT 2022
Humoral immunity to SARS-CoV-2 elicited by combination COVID-19 vaccination regimens.
The Journal of experimental medicine
Wang Z,Muecksch F,Muenn F,Cho A,Zong S,Raspe R,Ramos V,Johnson B,Ben Tanfous T,DaSilva J,Bednarski E,Guzman-Cardozo C,Turroja M,Millard KG,Tober-Lau P,Hillus D,Yao KH,Shimeliovich I,Dizon J,Kaczynska A,Jankovic M,Gazumyan A,Oliveira TY,Caskey M,Bieniasz PD,Hatziioannou T,Kurth F,Sander LE,Nussenzweig MC,Gaebler C
47-0086-42 was used in Flow cytometry/Cell sorting to compare vaccine-specific antibody and memory B cell responses following two-dose mRNA, single-dose Ad26.COV.2S, and two-dose ChAdOx1, or combination ChAdOx1/mRNA vaccination.
Mon Oct 03 00:00:00 EDT 2022
Antibody evolution to SARS-CoV-2 after single-dose Ad26.COV2.S vaccine in humans.
The Journal of experimental medicine
Cho A,Muecksch F,Wang Z,Ben Tanfous T,DaSilva J,Raspe R,Johnson B,Bednarski E,Ramos V,Schaefer-Babajew D,Shimeliovich I,Dizon JP,Yao KH,Schmidt F,Millard KG,Turroja M,Jankovic M,Oliveira TY,Gazumyan A,Gaebler C,Caskey M,Hatziioannou T,Bieniasz PD,Nussenzweig MC
47-0086-42 was used in Flow cytometry/Cell sorting to help explain why boosting Ad.26.COV.2 vaccine recipients with mRNA vaccines is effective and why the Ad26.COV2.S vaccine can maintain some protective efficacy against severe disease during the Omicron surge.
Mon Aug 01 00:00:00 EDT 2022
Orthotopic T-cell receptor replacement in primary human T cells using CRISPR-Cas9-mediated homology-directed repair.
STAR protocols
Moosmann C,Müller TR,Busch DH,Schober K
47-0086-42 was used in Flow Cytometry to demonstrate the use of CRISPR-Cas9 for simultaneous editing of T-cell receptor α- and β-chains in primary human T cells.
Fri Mar 18 00:00:00 EDT 2022
Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection.
Nature
Wang Z,Muecksch F,Schaefer-Babajew D,Finkin S,Viant C,Gaebler C,Hoffmann HH,Barnes CO,Cipolla M,Ramos V,Oliveira TY,Cho A,Schmidt F,Da Silva J,Bednarski E,Aguado L,Yee J,Daga M,Turroja M,Millard KG,Jankovic M,Gazumyan A,Zhao Z,Rice CM,Bieniasz PD,Caskey M,Hatziioannou T,Nussenzweig MC
47-0086-42 was used in Flow Cytometry to report on a cohort of 63 individuals who have recovered from COVID-19 assessed at 1.3, 6.2 and 12 months after SARS-CoV-2 infection.
Thu Jul 01 00:00:00 EDT 2021
mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants.
Nature
Wang Z,Schmidt F,Weisblum Y,Muecksch F,Barnes CO,Finkin S,Schaefer-Babajew D,Cipolla M,Gaebler C,Lieberman JA,Oliveira TY,Yang Z,Abernathy ME,Huey-Tubman KE,Hurley A,Turroja M,West KA,Gordon K,Millard KG,Ramos V,Da Silva J,Xu J,Colbert RA,Patel R,Dizon J,Unson-O'Brien C,Shimeliovich I,Gazumyan A,Caskey M,Bjorkman PJ,Casellas R,Hatziioannou T,Bieniasz PD,Nussenzweig MC
47-0086-42 was used in Flow Cytometry to report on the antibody and memory B cell responses of a cohort of 20 volunteers who received the Moderna (mRNA-1273) or Pfizer-BioNTech (BNT162b2) vaccine against SARS-CoV-21-4.
Thu Apr 01 00:00:00 EDT 2021
Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease.
The Journal of experimental medicine
Agudelo M,Palus M,Keeffe JR,Bianchini F,Svoboda P,Salát J,Peace A,Gazumyan A,Cipolla M,Kapoor T,Guidetti F,Yao KH,Elsterová J,Teislerová D,Chrdle A,Hönig V,Oliveira T,West AP,Lee YE,Rice CM,MacDonald MR,Bjorkman PJ,Růžek D,Robbiani DF,Nussenzweig MC
47-0086-42 was used in Flow Cytometry to report on the human neutralizing antibody response to TBEV in a cohort of infected and vaccinated individuals.
Mon May 03 00:00:00 EDT 2021
mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants.
bioRxiv : the preprint server for biology
Wang Z,Schmidt F,Weisblum Y,Muecksch F,Barnes CO,Finkin S,Schaefer-Babajew D,Cipolla M,Gaebler C,Lieberman JA,Oliveira TY,Yang Z,Abernathy ME,Huey-Tubman KE,Hurley A,Turroja M,West KA,Gordon K,Millard KG,Ramos V,Da Silva J,Xu J,Colbert RA,Patel R,Dizon J,Unson-O'Brien C,Shimeliovich I,Gazumyan A,Caskey M,Bjorkman PJ,Casellas R,Hatziioannou T,Bieniasz PD,Nussenzweig MC
47-0086 was used in Flow cytometry/Cell sorting to suggest that the monoclonal antibodies in clinical use should be tested against newly arising variants, and that mRNA vaccines may need to be updated periodically to avoid potential loss of clinical efficacy.
Sat Jan 30 00:00:00 EST 2021
Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through 'reverse phenotyping'.
Nature communications
Fischer DS,Ansari M,Wagner KI,Jarosch S,Huang Y,Mayr CH,Strunz M,Lang NJ,D'Ippolito E,Hammel M,Mateyka L,Weber S,Wolff LS,Witter K,Fernandez IE,Leuschner G,Milger K,Frankenberger M,Nowak L,Heinig-Menhard K,Koch I,Stoleriu MG,Hilgendorff A,Behr J,Pichlmair A,Schubert B,Theis FJ,Busch DH,Schiller HB,Schober K
Published figure using CD8a monoclonal antibody (Product # 47-0086-42) in Flow Cytometry
Mon Jul 26 00:00:00 EDT 2021
Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope.
NPJ vaccines
Abernathy ME,Gristick HB,Vielmetter J,Keeffe JR,Gnanapragasam PNP,Lee YE,Escolano A,Gautam R,Seaman MS,Martin MA,Nussenzweig MC,Bjorkman PJ
47-0086-42 was used in Flow Cytometry to report characterization of Ab1245, an off-target antibody against the Env gp120-gp41 interface, from V3-glycan patch immunogen-primed and boosted macaques.
Mon Oct 25 00:00:00 EDT 2021
Evolution of antibody immunity to SARS-CoV-2.
Nature
Gaebler C,Wang Z,Lorenzi JCC,Muecksch F,Finkin S,Tokuyama M,Cho A,Jankovic M,Schaefer-Babajew D,Oliveira TY,Cipolla M,Viant C,Barnes CO,Bram Y,Breton G,Hägglöf T,Mendoza P,Hurley A,Turroja M,Gordon K,Millard KG,Ramos V,Schmidt F,Weisblum Y,Jha D,Tankelevich M,Martinez-Delgado G,Yee J,Patel R,Dizon J,Unson-O'Brien C,Shimeliovich I,Robbiani DF,Zhao Z,Gazumyan A,Schwartz RE,Hatziioannou T,Bjorkman PJ,Mehandru S,Bieniasz PD,Caskey M,Nussenzweig MC
47-0086 was used in Flow cytometry/Cell sorting to report on the humoral memory response in a cohort of 87 individuals assessed at 1.3 and 6.2 months after infection with SARS-CoV-2.
Mon Mar 01 00:00:00 EST 2021
Convergent antibody responses to SARS-CoV-2 in convalescent individuals.
Nature
Robbiani DF,Gaebler C,Muecksch F,Lorenzi JCC,Wang Z,Cho A,Agudelo M,Barnes CO,Gazumyan A,Finkin S,Hägglöf T,Oliveira TY,Viant C,Hurley A,Hoffmann HH,Millard KG,Kost RG,Cipolla M,Gordon K,Bianchini F,Chen ST,Ramos V,Patel R,Dizon J,Shimeliovich I,Mendoza P,Hartweger H,Nogueira L,Pack M,Horowitz J,Schmidt F,Weisblum Y,Michailidis E,Ashbrook AW,Waltari E,Pak JE,Huey-Tubman KE,Koranda N,Hoffman PR,West AP,Rice CM,Hatziioannou T,Bjorkman PJ,Bieniasz PD,Caskey M,Nussenzweig MC
47-0086 was used in Flow cytometry/Cell sorting to investigate if convalescent plasma samples obtained from individuals who recover from COVID-19 contain high levels of neutralizing activity.
Sat Aug 01 00:00:00 EDT 2020
Isolation of single HIV-1 Envelope specific B cells and antibody cloning from immunized rhesus macaques.
Journal of immunological methods
Wang Z,Merkenschlager J,Chen ST,Oliveira TY,Ramos V,Gordon KM,Yao KH,Jankovic M,Nussenzweig M,Escolano A
47-0086 was used in Flow cytometry/Cell sorting to describe a protocol to identify and purify single antigen-specific macaque B cells, and subsequently clone and produce macaque monoclonal antibodies.
Sun Mar 01 00:00:00 EST 2020
A broadly neutralizing macaque monoclonal antibody against the HIV-1 V3-Glycan patch.
eLife
Wang Z,Barnes CO,Gautam R,Cetrulo Lorenzi JC,Mayer CT,Oliveira TY,Ramos V,Cipolla M,Gordon KM,Gristick HB,West AP,Nishimura Y,Raina H,Seaman MS,Gazumyan A,Martin M,Bjorkman PJ,Nussenzweig MC,Escolano A
47-0086 was used in Flow cytometry/Cell sorting to report on a monoclonal antibody, Ab1485, isolated from a macaque infected with SHIVAD8 that developed broadly neutralizing serologic activity targeting the V3-glycan region of HIV-1 Env.
Wed Oct 21 00:00:00 EDT 2020
Convergent Antibody Responses to SARS-CoV-2 Infection in Convalescent Individuals.
bioRxiv : the preprint server for biology
Robbiani DF,Gaebler C,Muecksch F,Lorenzi JCC,Wang Z,Cho A,Agudelo M,Barnes CO,Gazumyan A,Finkin S,Hagglof T,Oliveira TY,Viant C,Hurley A,Hoffmann HH,Millard KG,Kost RG,Cipolla M,Gordon K,Bianchini F,Chen ST,Ramos V,Patel R,Dizon J,Shimeliovich I,Mendoza P,Hartweger H,Nogueira L,Pack M,Horowitz J,Schmidt F,Weisblum Y,Michailidis E,Ashbrook AW,Waltari E,Pak JE,Huey-Tubman KE,Koranda N,Hoffman PR,West AP,Rice CM,Hatziioannou T,Bjorkman PJ,Bieniasz PD,Caskey M,Nussenzweig MC
47-0086 was used in Flow cytometry/Cell sorting to conclude that most convalescent plasmas obtained from individuals who recover from COVID-19 do not contain high levels of neutralizing activity.
Fri May 22 00:00:00 EDT 2020
Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.
Nature
Escolano A,Gristick HB,Abernathy ME,Merkenschlager J,Gautam R,Oliveira TY,Pai J,West AP,Barnes CO,Cohen AA,Wang H,Golijanin J,Yost D,Keeffe JR,Wang Z,Zhao P,Yao KH,Bauer J,Nogueira L,Gao H,Voll AV,Montefiori DC,Seaman MS,Gazumyan A,Silva M,McGuire AT,Stamatatos L,Irvine DJ,Wells L,Martin MA,Bjorkman PJ,Nussenzweig MC
47-0086-42 was used in Flow Cytometry to develop an immunogen, RC1, that facilitates the recognition of the variable loop 3 (V3)-glycan patch on the envelope protein of HIV-1 to activate B cells that express precursors of broadly neutralizing antibodies within polyclonal repertoires.
Sat Jun 01 00:00:00 EDT 2019
T-Lymphocyte Subset Distribution and Activity in Patients With Glaucoma.
Investigative ophthalmology & visual science
Yang X,Zeng Q,Göktas E,Gopal K,Al-Aswad L,Blumberg DM,Cioffi GA,Liebmann JM,Tezel G
Published figure using CD8a monoclonal antibody (Product # 47-0086-42) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2019
Involvement of MicroRNAs in the Aging-Related Decline of CD28 Expression by Human T Cells.
Frontiers in immunology
Teteloshvili N,Dekkema G,Boots AM,Heeringa P,Jellema P,de Jong D,Terpstra M,Brouwer E,Pawelec G,Kok K,van den Berg A,Kluiver J,Kroesen BJ
47-0086 was used in Flow cytometry/Cell sorting to study the role of microRNAs in the age-related decline in CD28 expression in human T cells.
Wed Nov 20 00:00:00 EST 2019
Disruption of PD-1 Enhanced the Anti-tumor Activity of Chimeric Antigen Receptor T Cells Against Hepatocellular Carcinoma.
Frontiers in pharmacology
Guo X,Jiang H,Shi B,Zhou M,Zhang H,Shi Z,Du G,Luo H,Wu X,Wang Y,Sun R,Li Z
Published figure using CD8a monoclonal antibody (Product # 47-0086-42) in Flow Cytometry
Thu Sep 28 00:00:00 EDT 2023
Extensive T cell cross-reactivity between diverse seasonal influenza strains in the ferret model.
Scientific reports
Reber AJ,Music N,Kim JH,Gansebom S,Chen J,York I
Published figure using CD8a monoclonal antibody (Product # 47-0086-42) in Flow Cytometry
Tue Apr 17 00:00:00 EDT 2018
PD-L1 expression and prognostic impact in glioblastoma.
Neuro-oncology
Nduom EK,Wei J,Yaghi NK,Huang N,Kong LY,Gabrusiewicz K,Ling X,Zhou S,Ivan C,Chen JQ,Burks JK,Fuller GN,Calin GA,Conrad CA,Creasy C,Ritthipichai K,Radvanyi L,Heimberger AB
Published figure using CD8a monoclonal antibody (Product # 47-0086-42) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2016
Expression of the galectin-9-Tim-3 pathway in glioma tissues is associated with the clinical manifestations of glioma.
Oncology letters
Liu Z,Han H,He X,Li S,Wu C,Yu C,Wang S
Published figure using CD8a monoclonal antibody (Product # 47-0086-42) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2016
Increased circulating IL-9-producing CD8+ T cells are associated with eosinophilia and high FeNO in allergic asthmatics.
Experimental and therapeutic medicine
Wang W,Cheng ZS,Chen YF,Lin YH
Published figure using CD8a monoclonal antibody (Product # 47-0086-42) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2016
TL1A increases expression of CD25, LFA-1, CD134 and CD154, and induces IL-22 and GM-CSF production from effector CD4 T-cells.
PloS one
Reichwald K,Jørgensen TZ,Skov S
Published figure using CD8a monoclonal antibody (Product # 47-0086-42) in Flow Cytometry
Tue Nov 10 00:00:00 EST 2015
CCL20 Secretion from the Nucleus Pulposus Improves the Recruitment of CCR6-Expressing Th17 Cells to Degenerated IVD Tissues.
PloS one
Zhang W,Nie L,Wang Y,Wang XP,Zhao H,Dongol S,Maharjan S,Cheng L
Published figure using CD8a monoclonal antibody (Product # 47-0086-42) in Flow Cytometry
Fri Oct 13 00:00:00 EDT 2017
MHC multimer-guided and cell culture-independent isolation of functional T cell receptors from single cells facilitates TCR identification for immunotherapy.
PloS one
Dössinger G,Bunse M,Bet J,Albrecht J,Paszkiewicz PJ,Weißbrich B,Schiedewitz I,Henkel L,Schiemann M,Neuenhahn M,Uckert W,Busch DH
Published figure using CD8a monoclonal antibody (Product # 47-0086-42) in Flow Cytometry
Mon Nov 11 00:00:00 EST 2013
Discordance between antibody and T cell responses in recipients of trivalent inactivated influenza vaccine.
Vaccine
Co MD,Orphin L,Cruz J,Pazoles P,Rothman AL,Ennis FA,Terajima M
Published figure using CD8a monoclonal antibody (Product # 47-0086-42) in Flow Cytometry
Mon Apr 07 00:00:00 EDT 2008
