Product References
Gammaherpesvirus-mediated repression reveals EWSR1 to be a negative regulator of B cell responses.
Proceedings of the National Academy of Sciences of the United States of America
Wang Y,Feswick A,Apostolou V,Petkov PM,Moser EK,Tibbetts SA
Published figure using CD93 (AA4.1) monoclonal antibody (Product # 17-5892-82) in Flow Cytometry
Tue Aug 09 00:00:00 UTC 2022
Lymph node formation and B cell homeostasis require IKK-α in distinct endothelial cell-derived compartments.
Proceedings of the National Academy of Sciences of the United States of America
McCorkell KA,Jayachandran N,Cully MD,Freund-Brown J,Weinkopff T,Monslow J,Hu Y,Puré E,Freedman BD,Alvarez JI,Cancro MP,May MJ
17-5892-82 was used in Flow cytometry/Cell sorting to reveal that IKK-α in distinct EC-derived compartments is uniquely required to promote B cell homeostasis and LN development, and establish that LEC-intrinsic IKK-α is absolutely essential for LN formation.
Tue Nov 30 00:00:00 UTC 2021
Hyper-metabolic B cells in the spleens of old mice make antibodies with autoimmune specificities.
Immunity & ageing : I & A
Frasca D,Romero M,Garcia D,Diaz A,Blomberg BB
Published figure using CD93 (AA4.1) monoclonal antibody (Product # 17-5892-82) in Flow Cytometry
Sat Feb 27 00:00:00 UTC 2021
Essential requirement for polypyrimidine tract binding proteins 1 and 3 in the maturation and maintenance of mature B cells in mice.
European journal of immunology
Monzón-Casanova E,Bates KJ,Smith CWJ,Turner M
17-5892-82 was used in Flow Cytometry to show that the polypyrimidine tract binding proteins (PTBP) PTBP1 and PTBP3 bind to a large and overlapping set of transcripts in B cells.
Wed Sep 01 00:00:00 UTC 2021
Peptidylprolyl isomerase C (Ppic) regulates invariant Natural Killer T cell (iNKT) differentiation in mice.
European journal of immunology
Paiva RS,Ramos CV,Azenha SR,Alves C,Basto AP,Graca L,Martins VC
17-5892-82 was used in Flow Cytometry to show that Ppic is dispensable for myeloid cells, platelets, erythrocytes, αβ and γδ T lymphocytes in vivo in the steady state, while being involved in B and iNKT cell differentiation.
Sun Aug 01 00:00:00 UTC 2021
Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody.
Cell
Singh M,Jackson KJL,Wang JJ,Schofield P,Field MA,Koppstein D,Peters TJ,Burnett DL,Rizzetto S,Nevoltris D,Masle-Farquhar E,Faulks ML,Russell A,Gokal D,Hanioka A,Horikawa K,Colella AD,Chataway TK,Blackburn J,Mercer TR,Langley DB,Goodall DM,Jefferis R,Gangadharan Komala M,Kelleher AD,Suan D,Rischmueller M,Christ D,Brink R,Luciani F,Gordon TP,Goodnow CC,Reed JH
17-5892 was used in Flow cytometry/Cell sorting to reveal a pre-neoplastic stage in human lymphomagenesis and a cascade of somatic mutations leading to an iconic pathogenic autoantibody.
Thu Mar 05 00:00:00 UTC 2020
Antibody Feedback Limits the Expansion of B Cell Responses to Malaria Vaccination but Drives Diversification of the Humoral Response.
Cell host & microbe
McNamara HA,Idris AH,Sutton HJ,Vistein R,Flynn BJ,Cai Y,Wiehe K,Lyke KE,Chatterjee D,Kc N,Chakravarty S,Lee Sim BK,Hoffman SL,Bonsignori M,Seder RA,Cockburn IA
17-5892 was used in Flow cytometry/Cell sorting to suggest that antibody feedback drives the diversification of immune responses and that vaccination for malaria will require targeting multiple antigens.
Wed Oct 07 00:00:00 UTC 2020
Respiratory syncytial virus infection exacerbates pneumococcal pneumonia via Gas6/Axl-mediated macrophage polarization.
The Journal of clinical investigation
Shibata T,Makino A,Ogata R,Nakamura S,Ito T,Nagata K,Terauchi Y,Oishi T,Fujieda M,Takahashi Y,Ato M
17-5892 was used in Flow cytometry/Cell sorting to identify potentially novel cellular and molecular cascades triggered by RSV infection to exacerbate secondary pneumococcal pneumonia.
Mon Jun 01 00:00:00 UTC 2020
Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production.
The Journal of experimental medicine
Lau A,Avery DT,Jackson K,Lenthall H,Volpi S,Brigden H,Russell AJ,Bier J,Reed JH,Smart JM,Cole T,Choo S,Gray PE,Berglund LJ,Hsu P,Wong M,O'Sullivan M,Boztug K,Meyts I,Uzel G,Notarangelo LD,Brink R,Goodnow CC,Tangye SG,Deenick EK
Published figure using CD93 (AA4.1) monoclonal antibody (Product # 17-5892-82) in Flow Cytometry
Mon Feb 03 00:00:00 UTC 2020
Checkpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation.
Cell reports
Xiao S,Bod L,Pochet N,Kota SB,Hu D,Madi A,Kilpatrick J,Shi J,Ho A,Zhang H,Sobel R,Weiner HL,Strom TB,Quintana FJ,Joller N,Kuchroo VK
17-5892 was used in Flow cytometry/Cell sorting to show that mice with B cell-specific Tim-1 deletion develop tissue inflammation in multiple organs including spontaneous paralysis with inflammation in the central nervous system (CNS).
Tue Jul 14 00:00:00 UTC 2020
c-Myb Exacerbates Atherosclerosis through Regulation of Protective IgM-Producing Antibody-Secreting Cells.
Cell reports
Shikatani EA,Besla R,Ensan S,Upadhye A,Khyzha N,Li A,Emoto T,Chiu F,Degousee N,Moreau JM,Perry HM,Thayaparan D,Cheng HS,Pacheco S,Smyth D,Noyan H,Zavitz CCJ,Bauer CMT,Hilgendorf I,Libby P,Swirski FK,Gommerman JL,Fish JE,Stampfli MR,Cybulsky MI,Rubin BB,Paige CJ,Bender TP,McNamara CA,Husain M,Robbins CS
17-5892-82 was used in Flow Cytometry to identify the nuclear transcription factor c-Myb as an important mediator of atherosclerotic disease in mice.
Tue May 21 00:00:00 UTC 2019
Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction.
Immunity
Li X,Gadzinsky A,Gong L,Tong H,Calderon V,Li Y,Kitamura D,Klein U,Langdon WY,Hou F,Zou YR,Gu H
17-5892-82 was used in Flow Cytometry to show that deleting E3 ubiquitin ligases Cbl and Cbl-b (Cbls) in GC B cells results in the early exit of high-affinity antigen-specific B cells from the GC reaction and thus impaired clonal expansion.
Tue Mar 20 00:00:00 UTC 2018
LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells.
Immunity
Lino AC,Dang VD,Lampropoulou V,Welle A,Joedicke J,Pohar J,Simon Q,Thalmensi J,Baures A,Flühler V,Sakwa I,Stervbo U,Ries S,Jouneau L,Boudinot P,Tsubata T,Adachi T,Hutloff A,Dörner T,Zimber-Strobl U,de Vos AF,Dahlke K,Loh G,Korniotis S,Goosmann C,Weill JC,Reynaud CA,Kaufmann SHE,Walter J,Fillatreau S
17-5892 was used in Flow cytometry/Cell sorting to identify a natural plasma cell subset that distinctively expresses the inhibitory receptor LAG-3 and mediates this function in vivo.
Tue Jul 17 00:00:00 UTC 2018
A protocol for generating induced T cells by reprogramming B cells in vivo.
Cell regeneration (London, England)
Weng Q,Hu F,Zhang M,Dong Y,Lv C,Wang Y,Liu X,Wang J
Published figure using CD93 (AA4.1) monoclonal antibody (Product # 17-5892-82) in Flow Cytometry
Sat Sep 01 00:00:00 UTC 2018
TLR9 Signaling Suppresses the Canonical Plasma Cell Differentiation Program in Follicular B Cells.
Frontiers in immunology
Baptista BJA,Granato A,Canto FB,Montalvão F,Tostes L,de Matos Guedes HL,Coutinho A,Bellio M,Vale AM,Nobrega A
17-5892 was used in Flow cytometry/Cell sorting to identify unexpected, opposing roles for Toll-like receptor4 and TLR9 in the control of plasma B cell differentiation programmes.
Mon Sep 30 00:00:00 UTC 2019
TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK.
The Journal of experimental medicine
Schweighoffer E,Nys J,Vanes L,Smithers N,Tybulewicz VLJ
17-5892 was used in Flow cytometry/Cell sorting to demonstrate two distinct signalling pathways for TLR4, one via the BCR and the other through MYD88.
Mon May 01 00:00:00 UTC 2017
Age-Associated B Cells Express a Diverse Repertoire of VH and Vκ Genes with Somatic Hypermutation.
Journal of immunology (Baltimore, Md. : 1950)
Russell Knode LM,Naradikian MS,Myles A,Scholz JL,Hao Y,Liu D,Ford ML,Tobias JW,Cancro MP,Gearhart PJ
17-5892 was used in Flow cytometry/Cell sorting to show that quiescent ABCs are Ag-experienced cells that accumulate during T cell-dependent responses to diverse Ags during the life of an individual.
Wed Mar 01 00:00:00 UTC 2017
IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia.
Cancer discovery
Pylayeva-Gupta Y,Das S,Handler JS,Hajdu CH,Coffre M,Koralov SB,Bar-Sagi D
17-5892 was used in Flow cytometry/Cell sorting to identify a previously unrecognised role for IL35-producing CD1d(hi)CD5(+) B cells in the pathogenesis of pancreatic cancer.
Tue Mar 01 00:00:00 UTC 2016
mTOR has distinct functions in generating versus sustaining humoral immunity.
The Journal of clinical investigation
Jones DD,Gaudette BT,Wilmore JR,Chernova I,Bortnick A,Weiss BM,Allman D
17-5892 was used in Flow cytometry/Cell sorting to conclude that mTOR signalling plays critical but diverse roles in early and late phases of antibody responses and plasma cell differentiation.
Tue Nov 01 00:00:00 UTC 2016
Heterozygous Mutation in IκBNS Leads to Reduced Levels of Natural IgM Antibodies and Impaired Responses to T-Independent Type 2 Antigens.
Frontiers in immunology
Pedersen GK,Ádori M,Stark JM,Khoenkhoen S,Arnold C,Beutler B,Karlsson Hedestam GB
17-5892 was used in Flow cytometry/Cell sorting to identify a role for the atypical IκB protein IκBNS in humoral immunity.
Mon Mar 14 00:00:00 UTC 2016
Trypanosoma brucei Co-opts NK Cells to Kill Splenic B2 B Cells.
PLoS pathogens
Frenkel D,Zhang F,Guirnalda P,Haynes C,Bockstal V,Radwanska M,Magez S,Black SJ
17-5892 was used in Flow cytometry/Cell sorting to investigate the mechanism by which natural killer cells in Trypanosoma brucei infected mice kill B cells, suppress humoral immunity and induce early mortality.
Fri Jul 01 00:00:00 UTC 2016
Survival of Igα-Deficient Mature B Cells Requires BAFF-R Function.
Journal of immunology (Baltimore, Md. : 1950)
Levit-Zerdoun E,Becker M,Pohlmeyer R,Wilhelm I,Maity PC,Rajewsky K,Reth M,Hobeika E
17-5892 was used in Flow cytometry/Cell sorting to assess the importance of the expression of a functional B-cell receptor for B cell maintenance.
Tue Mar 01 00:00:00 UTC 2016
Endogenous DNA Damage Leads to p53-Independent Deficits in Replicative Fitness in Fetal Murine Fancd2-/- Hematopoietic Stem and Progenitor Cells.
Stem cell reports
Yoon YM,Storm KJ,Kamimae-Lanning AN,Goloviznina NA,Kurre P
17589282 was used in flow cytometry to investigate Fanconi anemia function in hematopoietic stem cells
Tue Nov 08 00:00:00 UTC 2016
IgD attenuates the IgM-induced anergy response in transitional and mature B cells.
Nature communications
Sabouri Z,Perotti S,Spierings E,Humburg P,Yabas M,Bergmann H,Horikawa K,Roots C,Lambe S,Young C,Andrews TD,Field M,Enders A,Reed JH,Goodnow CC
17-5892 was used in Flow cytometry/Cell sorting to define the RNA landscape of the in vivo anergy response, comprising 220 induced sequences including a core set of 97.
Thu Nov 10 00:00:00 UTC 2016
Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs.
Nature communications
Lai M,Gonzalez-Martin A,Cooper AB,Oda H,Jin HY,Shepherd J,He L,Zhu J,Nemazee D,Xiao C
17-5892 was used in Flow cytometry/Cell sorting to examine the regulation B-cell development and tolerance by different members of the miR-17~92 family microRNAs.
Tue Aug 02 00:00:00 UTC 2016
Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors.
Nature communications
Cheng H,Ang HY,A El Farran C,Li P,Fang HT,Liu TM,Kong SL,Chin ML,Ling WY,Lim EK,Li H,Huber T,Loh KM,Loh YH,Lim B
17-5892 was used in Flow cytometry/Cell sorting to demonstrate how it is possible to reprogram mouse embryonic fibroblasts into engraftable blood progenitors.
Mon Nov 21 00:00:00 UTC 2016
ATP11C Facilitates Phospholipid Translocation across the Plasma Membrane of All Leukocytes.
PloS one
Yabas M,Jing W,Shafik S,Bröer S,Enders A
17-5892 was used in Flow cytometry/Cell sorting to identify the P4-type ATPase ATP11C as a flippase that selectively transports phosphatidylserine and phosphatidylethanolamine to the inner leaflet of the plasma membrane in immune cells.
Mon Jul 25 00:00:00 UTC 2016
A Gammaherpesvirus Noncoding RNA Is Essential for Hematogenous Dissemination and Establishment of Peripheral Latency.
mSphere
Feldman ER,Kara M,Oko LM,Grau KR,Krueger BJ,Zhang J,Feng P,van Dyk LF,Renne R,Tibbetts SA
17-5892 was used in Flow cytometry/Cell sorting to reveal that the MHV68 ncRNA TMER4 facilitates hematogenous dissemination of Gammaherpesvirus and establishment of latency at peripheral sites.
Fri Apr 01 00:00:00 UTC 2016
BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.
The Journal of experimental medicine
Jacque E,Schweighoffer E,Tybulewicz VL,Ley SC
17-5892 was used in Flow cytometry/Cell sorting to reveal a potentially critical role for the MEK5-ERK5 MAP kinase signalling pathway in BAFF-induced mature B cell survival and homeostatic maintenance of B2 cell numbers.
Mon Jun 01 00:00:00 UTC 2015
Distinct Transcriptomic Features are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen.
Frontiers in immunology
Kleiman E,Salyakina D,De Heusch M,Hoek KL,Llanes JM,Castro I,Wright JA,Clark ES,Dykxhoorn DM,Capobianco E,Takeda A,Renauld JC,Khan WN
17-5892 was used in Flow cytometry/Cell sorting to study developmental plasticity among splenic B-cell subsets as well as receptor revision in peripheral tolerance.
Thu Feb 26 00:00:00 UTC 2015
Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production.
Journal of immunology (Baltimore, Md. : 1950)
Mills RE,Lam VC,Tan A,Cresalia N,Oksenberg N,Zikherman J,Anderson M,Weiss A,Hermiston ML
17-5892 was used in Flow cytometry/Cell sorting to identify a novel autoreactivityassociated locus and validate Tlr9 as a candidate gene within the locus.
Wed Apr 15 00:00:00 UTC 2015
Cutting Edge: DNase II deficiency prevents activation of autoreactive B cells by double-stranded DNA endogenous ligands.
Journal of immunology (Baltimore, Md. : 1950)
Pawaria S,Moody K,Busto P,Nündel K,Choi CH,Ghayur T,Marshak-Rothstein A
17-5892 was used in Flow cytometry/Cell sorting to determine whether an inability of TLR9 to detect endogenous DNA could explain the absence of dsDNA-reactive autoantibodies in double-knockout mice.
Sun Feb 15 00:00:00 UTC 2015
Cellular Dynamics of Memory B Cell Populations: IgM+ and IgG+ Memory B Cells Persist Indefinitely as Quiescent Cells.
Journal of immunology (Baltimore, Md. : 1950)
Jones DD,Wilmore JR,Allman D
17-5892 was used in Flow cytometry/Cell sorting to demonstrate that once established, both IgG-positive and less frequent IgM-positive memory populations are exceptionally stable, with little evidence of attrition or cellular turnover.
Sun Nov 15 00:00:00 UTC 2015
B cell-intrinsic CD84 and Ly108 maintain germinal center B cell tolerance.
Journal of immunology (Baltimore, Md. : 1950)
Wong EB,Soni C,Chan AY,Domeier PP,Abraham T,Limaye N,Khan TN,Elias MJ,Chodisetti SB,Wakeland EK,Rahman ZS
17-5892 was used in Flow cytometry/Cell sorting to investigate the effect of B cell-intrinsic polymorphic SLAM receptors on germinal center B cell tolerance.
Fri May 01 00:00:00 UTC 2015
Immature B Cell Egress from Bone Marrow Is SOCS3 Independent.
PloS one
Nadrah K,Beck TC,Pereira JP
17-5892 was used in Flow cytometry/Cell sorting to investigate the role of suppressor of cytokine signaling 3 (SOCS3) in mediating immature B cell egress from the bone marrow, and other biological processes controlled by CXCR4 signalling.
Fri May 06 00:00:00 UTC 2016
A gammaherpesvirus Bcl-2 ortholog blocks B cell receptor-mediated apoptosis and promotes the survival of developing B cells in vivo.
PLoS pathogens
Coleman CB,McGraw JE,Feldman ER,Roth AN,Keyes LR,Grau KR,Cochran SL,Waldschmidt TJ,Liang C,Forrest JC,Tibbetts SA
17-5892 was used in Flow cytometry/Cell sorting to test whether murine gammaherpesvirus 68 vBcl-2 can promote the survival of developing B cells that undergo BCR-mediated selection.
Sat Feb 01 00:00:00 UTC 2014
IL-4 regulates Bim expression and promotes B cell maturation in synergy with BAFF conferring resistance to cell death at negative selection checkpoints.
Journal of immunology (Baltimore, Md. : 1950)
Granato A,Hayashi EA,Baptista BJ,Bellio M,Nobrega A
17-5892 was used in Flow cytometry/Cell sorting to analyze the effect of IL-4 on B cell maturation, and its influence on BCR-mediated negative selection.
Sun Jun 15 00:00:00 UTC 2014
Conditional deletion of ferritin h in mice reduces B and T lymphocyte populations.
PloS one
Vanoaica L,Richman L,Jaworski M,Darshan D,Luther SA,Kühn LC
17-5892 was used in Flow cytometry/Cell sorting to investigate the effect of ferritin H deletion on lymphocytes, showing that it reduces B and T lymphocyte populations.
Tue Jan 13 00:00:00 UTC 2015
The expression of Sox17 identifies and regulates haemogenic endothelium.
Nature cell biology
Clarke RL,Yzaguirre AD,Yashiro-Ohtani Y,Bondue A,Blanpain C,Pear WS,Speck NA,Keller G
Published figure using CD93 (AA4.1) monoclonal antibody (Product # 17-5892-82) in Flow Cytometry
Wed May 01 00:00:00 UTC 2013
Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival.
Proceedings of the National Academy of Sciences of the United States of America
Song J,Lokmic Z,Lämmermann T,Rolf J,Wu C,Zhang X,Hallmann R,Hannocks MJ,Horn N,Ruegg MA,Sonnenberg A,Georges-Labouesse E,Winkler TH,Kearney JF,Cardell S,Sorokin L
17-5892 was used in Flow cytometry/Cell sorting to characterise the marginal zone of the spleen, and examine how it may affect immune cell fate.
Tue Jul 30 00:00:00 UTC 2013
Autonomic dysreflexia causes chronic immune suppression after spinal cord injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhang Y,Guan Z,Reader B,Shawler T,Mandrekar-Colucci S,Huang K,Weil Z,Bratasz A,Wells J,Powell ND,Sheridan JF,Whitacre CC,Rabchevsky AG,Nash MS,Popovich PG
17-5892 was used in Flow cytometry/Cell sorting to study how autonomic dysreflexia can cause secondary immune deficiency following spinal cord injury, potentially revealing novel therapeutic targets.
Wed Aug 07 00:00:00 UTC 2013
Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10.
Journal of immunology (Baltimore, Md. : 1950)
Chen Y,Zhang J,Hwang KK,Bouton-Verville H,Xia SM,Newman A,Ouyang YB,Haynes BF,Verkoczy L
17-5892 was used in Flow cytometry/Cell sorting to study the mechanisms by which HIV is able to limit the production of broadly neutralising antibodies.
Thu Aug 01 00:00:00 UTC 2013
B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates.
Journal of immunology (Baltimore, Md. : 1950)
Ota T,Doyle-Cooper C,Cooper AB,Doores KJ,Aoki-Ota M,Le K,Schief WR,Wyatt RT,Burton DR,Nemazee D
17-5892 was used in Flow cytometry/Cell sorting to demonstrate a new mouse model for testing vaccine candidates for the routine elicitation of broadly neutralising antibodies against HIV.
Sun Sep 15 00:00:00 UTC 2013
Sox4 is required for the survival of pro-B cells.
Journal of immunology (Baltimore, Md. : 1950)
Sun B,Mallampati S,Gong Y,Wang D,Lefebvre V,Sun X
17-5892 was used in Flow cytometry/Cell sorting to investigate the role of Sox4 in development of mature B cells, showing that it is required for pro-B cell survival.
Fri Mar 01 00:00:00 UTC 2013
Bortezomib resistance can be reversed by induced expression of plasma cell maturation markers in a mouse in vitro model of multiple myeloma.
PloS one
Stessman HA,Mansoor A,Zhan F,Linden MA,Van Ness B,Baughn LB
17-5892 was used in Flow cytometry/Cell sorting to suggest a novel therapeutic approach for reversing Bz resistance in refractory multiple myeloma.
Tue Aug 05 00:00:00 UTC 2014
RAG-1 and Ly6D independently reflect progression in the B lymphoid lineage.
PloS one
Zhang Q,Esplin BL,Iida R,Garrett KP,Huang ZL,Medina KL,Kincade PW
17-5892 was used in Flow cytometry/Cell sorting to elucidate the mechanisms regulating the differentiation path from haematopoietic stem cells to B lineage lymphocytes.
Tue Apr 15 00:00:00 UTC 2014
In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation.
PloS one
Vink PM,Smout WM,Driessen-Engels LJ,de Bruin AM,Delsing D,Krajnc-Franken MA,Jansen AJ,Rovers EF,van Puijenbroek AA,Kaptein A,Nolte MA,Garritsen A,van Eenennaam H
17-5892 was used in Flow cytometry/Cell sorting to study the function of TAK1 protein in the adult immune system.
Fri Sep 06 00:00:00 UTC 2013
Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions.
Nature immunology
Subrahmanyam R,Du H,Ivanova I,Chakraborty T,Ji Y,Zhang Y,Alt FW,Schatz DG,Sen R
17-5892 was used in Flow cytometry/Cell sorting to study the epigenetic basis of creating variation in immunoglobulin heavy chains.
Sat Dec 01 00:00:00 UTC 2012
IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis.
Blood
Balkhi MY,Willette-Brown J,Zhu F,Chen Z,Liu S,Guttridge DC,Karin M,Hu Y
17-5892-82 was used in Flow Cytometry to demonstrate that IKKα regulates B-lineage commitment via combined canonical and noncanonical NF-κB transcriptional activities to target Pax5 expression during hematopoiesis.
Thu Jun 07 00:00:00 UTC 2012
ZBTB1 is a determinant of lymphoid development.
The Journal of experimental medicine
Siggs OM,Li X,Xia Y,Beutler B
17-5892 was used in Flow cytometry/Cell sorting to identify a mutation causative of complete and cell-intrinsic T cell deficiency.
Mon Jan 16 00:00:00 UTC 2012
Critical role of B cell lymphoma 10 in BAFF-regulated NF-κB activation and survival of anergic B cells.
Journal of immunology (Baltimore, Md. : 1950)
Yu M,Chen Y,He Y,Podd A,Fu G,Wright JA,Kleiman E,Khan WN,Wen R,Wang D
Published figure using CD93 (AA4.1) monoclonal antibody (Product # 17-5892-82) in Flow Cytometry
Sat Dec 01 00:00:00 UTC 2012
Direct reduction of antigen receptor expression in polyclonal B cell populations developing in vivo results in light chain receptor editing.
Journal of immunology (Baltimore, Md. : 1950)
Shen S,Manser T
17-5892 was used in Flow cytometry/Cell sorting to test the role of BCR expression plays in receptor editing in an polyclonal, in vivo population of B cells.
Sun Jan 01 00:00:00 UTC 2012
Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response.
Blood
Gardam S,Turner VM,Anderton H,Limaye S,Basten A,Koentgen F,Vaux DL,Silke J,Brink R
17-5892 was used in Flow cytometry/Cell sorting to investigate the roles of cIAP1 and cIAP2 in controlling B-cell physiology.
Thu Apr 14 00:00:00 UTC 2011
Liver-expressed Igkappa superantigen induces tolerance of polyclonal B cells by clonal deletion not kappa to lambda receptor editing.
The Journal of experimental medicine
Ota T,Ota M,Duong BH,Gavin AL,Nemazee D
17-5892 was used in Flow cytometry/Cell sorting to postulate that clonal deletion is the major irreversible pathway of tolerance induction among peripheral B cells.
Mon Mar 14 00:00:00 UTC 2011
T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosis.
PLoS pathogens
Bockstal V,Guirnalda P,Caljon G,Goenka R,Telfer JC,Frenkel D,Radwanska M,Magez S,Black SJ
17-5892 was used in Flow cytometry/Cell sorting to study how infection-induced deletion of transitional B cells prevents replenishment of mature B cell compartments during T. brucei infection.
Wed Jun 01 00:00:00 UTC 2011
Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses.
European journal of immunology
Bossen C,Tardivel A,Willen L,Fletcher CA,Perroud M,Beermann F,Rolink AG,Scott ML,Mackay F,Schneider P
17-5892 was used in Flow cytometry/Cell sorting to study the functional importance of B-cell-activating factor of the TNF family processing by proteolytic cleavage.
Tue Mar 01 00:00:00 UTC 2011
Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape.
Journal of immunology (Baltimore, Md. : 1950)
Duong BH,Ota T,Aoki-Ota M,Cooper AB,Ait-Azzouzene D,Vela JL,Gavin AL,Nemazee D
17-5892 was used in Flow cytometry/Cell sorting to demonstrate the usefulness of reconstituted IgM(b) superantigen hosts in revealing pathways involved in central tolerance.
Thu Dec 01 00:00:00 UTC 2011
Cellular competition independent of BAFF/B lymphocyte stimulator results in low frequency of an autoreactive clonotype in mature polyclonal B cell compartments.
Journal of immunology (Baltimore, Md. : 1950)
Nikbakht N,Migone TS,Ward CP,Manser T
17-5892 was used in Flow cytometry/Cell sorting to investigate the role of the peripheral B cell pro-survival cytokine BAFF/BLyS in the regulation of immunological tolerance and autoreactive cells.
Fri Jul 01 00:00:00 UTC 2011
Impaired B cell development in the absence of Krüppel-like factor 3.
Journal of immunology (Baltimore, Md. : 1950)
Vu TT,Gatto D,Turner V,Funnell AP,Mak KS,Norton LJ,Kaplan W,Cowley MJ,Agenès F,Kirberg J,Brink R,Pearson RC,Crossley M
17-5892 was used in Flow cytometry/Cell sorting to examine the function of Klf3 in B cell development by studying B lymphopoiesis in a Klf3 knockout mouse model.
Tue Nov 15 00:00:00 UTC 2011
Antigen is required for maturation and activation of pathogenic anti-DNA antibodies and systemic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Venkatesh J,Yoshifuji H,Kawabata D,Chinnasamy P,Stanevsky A,Grimaldi CM,Cohen-Solal J,Diamond B
17-5892 was used in Flow cytometry/Cell sorting to show that estradiol administration also leads to systemic inflammation with increased B cell-activating factor and IFN levels and induction of an IFN signature.
Sun May 01 00:00:00 UTC 2011
IgM production by bone marrow plasmablasts contributes to long-term protection against intracellular bacterial infection.
Journal of immunology (Baltimore, Md. : 1950)
Racine R,McLaughlin M,Jones DD,Wittmer ST,MacNamara KC,Woodland DL,Winslow GM
17-5892 was used in Flow cytometry/Cell sorting to identify a cell population responsible for IgM production in the bone marrow that is maintained in the absence of chronic infection.
Sat Jan 15 00:00:00 UTC 2011
The actin-bundling protein L-plastin is essential for marginal zone B cell development.
Journal of immunology (Baltimore, Md. : 1950)
Todd EM,Deady LE,Morley SC
17-5892 was used in Flow cytometry/Cell sorting to study the role of the actin-bundling protein L-plastin in B cell chemotaxis.
Thu Sep 15 00:00:00 UTC 2011
Acute Disruption of Bone Marrow B Lymphopoiesis and Apoptosis of Transitional and Marginal Zone B Cells in the Spleen following a Blood-Stage Plasmodium chabaudi Infection in Mice.
Journal of parasitology research
Bockstal V,Geurts N,Magez S
17-5892 was used in Flow cytometry/Cell sorting to investigate the effects of a blood-stage Plasmodium chabaudi infection in the spleen and bone marrow of mice.
Thu Jul 14 00:00:00 UTC 2011
ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo.
The Journal of experimental medicine
Gibb DR,El Shikh M,Kang DJ,Rowe WJ,El Sayed R,Cichy J,Yagita H,Tew JG,Dempsey PJ,Crawford HC,Conrad DH
17-5892 was used in Flow cytometry/Cell sorting to investigate the role of ADAM10 cleavage events in immune cell development.
Mon Mar 15 00:00:00 UTC 2010
Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia.
Leukemia
Sanchez-Aguilera A,Rattmann I,Drew DZ,Müller LU,Summey V,Lucas DM,Byrd JC,Croce CM,Gu Y,Cancelas JA,Johnston P,Moritz T,Williams DA
17-5892 was used in Flow cytometry/Cell sorting to investigate the function of RhoH in the B-cell lineage, showing that RhoH is involved in the development of B-cell chronic lymphocytic leukemia.
Fri Jan 01 00:00:00 UTC 2010
Immature and transitional B cells are latency reservoirs for a gammaherpesvirus.
Journal of virology
Coleman CB,Nealy MS,Tibbetts SA
17-5892 was used in Flow cytometry/Cell sorting to examine whether murine gammaherpesvirus 68 establishes latency in developing B cells during a normal course of infection.
Wed Dec 01 00:00:00 UTC 2010
Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen.
Journal of immunology (Baltimore, Md. : 1950)
Duong BH,Ota T,Aït-Azzouzene D,Aoki-Ota M,Vela JL,Huber C,Walsh K,Gavin AL,Nemazee D
17-5892 was used in Flow cytometry/Cell sorting to generate mice which ubiquitously expressed a membrane-bound IgD-superantigen, to provide a model which should facilitate studies of peripheral B cell tolerance in future.
Thu Apr 15 00:00:00 UTC 2010
Regulation of the B cell receptor repertoire and self-reactivity by BAFF.
Journal of immunology (Baltimore, Md. : 1950)
Ota M,Duong BH,Torkamani A,Doyle CM,Gavin AL,Ota T,Nemazee D
17-5892 was used in Flow cytometry/Cell sorting to highlight the negative effects of excess BAFF signalling to display the positive implications of BAFF-depleting therapy.
Fri Oct 01 00:00:00 UTC 2010
A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow.
PloS one
Pereira JP,Xu Y,Cyster JG
17-5892 was used in Flow cytometry/Cell sorting to conclude that the S1P1-S1P pathway contributes to egress of immature-B cells from bone marrow.
Thu Feb 18 00:00:00 UTC 2010
A possible contribution of retinoids to regulation of fetal B lymphopoiesis.
European journal of immunology
Chen X,Welner RS,Kincade PW
17-5892 was used in Flow cytometry/Cell sorting to determine that retinoids may partially account for rapid differentiation in foetal life, but not for all unique features of foetal progenitors.
Tue Sep 01 00:00:00 UTC 2009
Antibodies in a heavy chain knock-in mouse exhibit characteristics of early heavy chain rearrangement.
Journal of immunology (Baltimore, Md. : 1950)
Yunk L,Meng W,Cohen PL,Eisenberg RA,Luning Prak ET
17-5892 was used in Flow cytometry/Cell sorting to investigate the antibody heavy chain rearrangement that preceeds B cell receptor expression.
Wed Jul 01 00:00:00 UTC 2009
Generation of B cell memory to the bacterial polysaccharide alpha-1,3 dextran.
Journal of immunology (Baltimore, Md. : 1950)
Foote JB,Kearney JF
17-5892 was used in Flow cytometry/Cell sorting to define B1b B cells as the principal reservoir for memory to bacterial-associated polysaccharide Ags.
Sun Nov 15 00:00:00 UTC 2009
Generation of protective T cell-independent antiviral antibody responses in SCID mice reconstituted with follicular or marginal zone B cells.
Journal of immunology (Baltimore, Md. : 1950)
Guay HM,Mishra R,Garcea RL,Welsh RM,Szomolanyi-Tsuda E
17-5892 was used in Flow cytometry/Cell sorting to demonstrate the plasticity of B cell subsets in virus-infected hosts.
Wed Jul 01 00:00:00 UTC 2009
Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation.
Nature immunology
Wilker PR,Kohyama M,Sandau MM,Albring JC,Nakagawa O,Schwarz JJ,Murphy KM
17-5892 was used in Flow cytometry/Cell sorting to emphasise an unrecognised but critical function for Mef2c in BCR signalling.
Sun Jun 01 00:00:00 UTC 2008
A p38 MAPK-MEF2C pathway regulates B-cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America
Khiem D,Cyster JG,Schwarz JJ,Black BL
17-5892 was used in Flow cytometry/Cell sorting to show loss of MEF2C function results in reduced immune response to antigen and a severe defect in B-cell proliferation.
Tue Nov 04 00:00:00 UTC 2008
E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Yang Q,Kardava L,St Leger A,Martincic K,Varnum-Finney B,Bernstein ID,Milcarek C,Borghesi L
17-5892 was used in Flow cytometry/Cell sorting to show E47 controls the developmental integrity and cell cycle quiescence of hematopoietic progenitors.
Sat Nov 01 00:00:00 UTC 2008
Micro-scale flow cytometry-based and biochemical analysis of lipid signaling in primary B cell subpopulations.
Biological procedures online
Antony P,Hoek K,Sarmah B,Khan WN
17-5892 was used in Flow Cytometry to show biochemical and flow cytometric methodologies which can be used to analyse lipid signal-induced changes in B cell subpopulations.
Mon Dec 24 00:00:00 UTC 2007
Developmental switch of mouse hematopoietic stem cells from fetal to adult type occurs in bone marrow after birth.
Proceedings of the National Academy of Sciences of the United States of America
Kikuchi K,Kondo M
17-5892 was used in Flow cytometry/Cell sorting to demonstrate how foetal haematopoietic stem cells may acquire adult characteristics between 1 and 2 weeks after birth in mouse bone marrow.
Tue Nov 21 00:00:00 UTC 2006
Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival.
Proceedings of the National Academy of Sciences of the United States of America
Lesley R,Kelly LM,Xu Y,Cyster JG
17-5892 was used in Flow cytometry/Cell sorting to propose that constitutive CD40L expression by naive CD4 T cells influences the composition of the B cell repertoire.
Tue Jul 11 00:00:00 UTC 2006
Regulation of IgH gene assembly: role of the intronic enhancer and 5'DQ52 region in targeting DHJH recombination.
Journal of immunology (Baltimore, Md. : 1950)
Afshar R,Pierce S,Bolland DJ,Corcoran A,Oltz EM
17-5892-82 was used in Flow cytometry/Cell sorting to test two alternative explanations for the minimal effect of Emu deletions on primary D(H)-->J(H) rearrangement.
Wed Feb 15 00:00:00 UTC 2006
