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Product Details
PA5-79026
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Cdk5 (273-292aa QRISAEEALQHPYFSDFCPP).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2746142
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
CDK5 is a member of the Cyclin-Dependent Kinase family that is most abundant in the mammalian brain. Active form of CDK5, which has also been called neuronal cdc2-like kinase, is a heterodimer of CDK5 and a 25 kDa protein which is derived proteolytically from a 35 kDa brain and neuron-specific protein and is essential for the kinase activity of CDK5. CDK5 has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug addiction.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDK5-SV; Cell division protein kinase 5; CR6 protein kinase; Cyclin-dependent kinase 5; Cyclin-dependent-like kinase 5; protein kinase CDK5 splicing; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit
Gene Aliases: AW048668; CDK5; CDKN5; Crk6; LIS7; PSSALRE
UniProt ID: (Human) Q00535, (Mouse) P49615, (Rat) Q03114
Entrez Gene ID: (Human) 1020, (Mouse) 12568, (Rat) 140908
p53 binding
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
ErbB-2 class receptor binding
protein binding
ATP binding
cytoskeletal protein binding
kinase activity
protein kinase binding
acetylcholine receptor activator activity
ErbB-3 class receptor binding
ephrin receptor binding
tau-protein kinase activity
nucleotide binding
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
neuron migration
synaptic transmission, dopaminergic
intracellular protein transport
nucleocytoplasmic transport
cell cycle
cell-matrix adhesion
chemical synaptic transmission
synapse assembly
skeletal muscle tissue development
motor neuron axon guidance
cell proliferation
visual learning
response to wounding
Schwann cell development
synaptic vesicle exocytosis
regulation of macroautophagy
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
sensory perception of pain
cerebellar cortex formation
hippocampus development
layer formation in cerebral cortex
central nervous system neuron development
corpus callosum development
neuron differentiation
regulation of cell migration
negative regulation of axon extension
cortical actin cytoskeleton organization
neuron projection development
negative regulation of protein ubiquitination
negative regulation of synaptic plasticity
positive regulation of protein binding
receptor catabolic process
serine phosphorylation of STAT3 protein
synaptic transmission, glutamatergic
protein localization to synapse
regulation of apoptotic process
receptor clustering
positive regulation of neuron apoptotic process
negative regulation of cell cycle
positive regulation of protein kinase activity
negative regulation of proteolysis
negative regulation of transcription, DNA-templated
positive regulation of calcium ion-dependent exocytosis
protein autophosphorylation
negative regulation of protein export from nucleus
behavioral response to cocaine
regulation of synaptic plasticity
synaptic vesicle endocytosis
rhythmic process
axon extension
oligodendrocyte differentiation
dendrite morphogenesis
cell division
neuron apoptotic process
excitatory postsynaptic potential
regulation of dendritic spine morphogenesis
calcium ion import
regulation of cell cycle arrest
positive regulation of protein targeting to membrane
negative regulation of neuron death
regulation of signal transduction by p53 class mediator
regulation of synaptic vesicle recycling
positive regulation of actin cytoskeleton reorganization
positive regulation of receptor activity
protein phosphorylation
exocytosis
apoptotic process
nervous system development
axonogenesis
associative learning
cell migration
telencephalon development
cerebellum development
cerebellar cortex development
cerebral cortex development
forebrain development
response to cocaine
regulated exocytosis
neuron projection morphogenesis
regulation of cell cycle
regulation of postsynaptic membrane potential
central nervous system development
Performance Guarantee
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