Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MALSTIVSQRK QIKRKAPRGF LKRVFKRKKP QLRLEK
Highest antigen sequence identity to the following orthologs - mouse 59%, rat 62%.
CENPW was initially identified as a gene that was upregulated in multiple cancers, and whose overexpression in mouse fibroblast cells gave rise to distinct cancer-specific phenotypes. It was later found to be a nuclear protein that associated with CENPT, a component of CENPA nucleosome complex in the centromere, and is required for proper kinetochore function. CENPW also specifically interacts with the nucleolar phosphoprotein nucleophosmin, also known as B23 It has been suggested that nucleophosmin functions in the assembly of the kinetochore by interacting with CENPW during interphase. Overexpression of CENPW in the SKOV-3 human ovarian cancer cell line as well as in the zebrafish embryo led to apoptosis, suggesting that high levels of CENPW induces apoptotic cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cancer-up-regulated gene 2 protein; cancer-upregulated gene 2; CANP-W; CENP-W; Centromere protein W
Gene Aliases: C6orf173; CENP-W; CENPW; CUG2
UniProt ID: (Human) Q5EE01
Entrez Gene ID: (Human) 387103
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support