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Application
FIGURE: 1 / 6
CIRBP Antibody (PA5-109544) in ICC/IF
Immunofluorescence analysis of CIRBP in HeLa cells. Samples were incubated with CIRBP Polyclonal antibody (Product # PA5-109544). Blue: DAPI for nuclear staining.
Product Details
PA5-109544
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of human CIRBP (NP_001271.1).
Conjugate
Unconjugated
Form
Liquid
Concentration
0.14 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2854955
Product Specific Information
Immunogen sequence: MASDEGKLFV GGLSFDTNEQ SLEQVFSKYG QISEVVVVKD RETQRSRGFG FVTFENIDDA KDAMMAMNGK SVDGRQIRVD QAGKSSDNRS RGYRGGSAGG RGFFRGGRGR GRGFSRGGGD RGYGGNRFES RSGGYGGSRD YYSSRSQSGG YSDRSSGGSY RDSYDSYATH NE
Target Information
CIRBP is cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. It acts as a translational activator and seems to play an essential role in cold-induced suppression of cell proliferation. It binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. This protein acts as a translational repressor and promotes assembly of stress granules (SGs), when overexpressed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A18 hnRNP; cold inducible RNA-binding protein; Cold-inducible RNA-binding protein; glycine-rich RNA binding protein; Glycine-rich RNA-binding protein CIRP; testicular tissue protein Li 39
Gene Aliases: A18HNRNP; CIRBP; CIRP; R74941
UniProt ID: (Human) Q14011, (Rat) P60825, (Mouse) P60824
Entrez Gene ID: (Human) 1153, (Rat) 81825, (Mouse) 12696
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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