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Proteintech
MAN1B1 Monoclonal Antibody (3C9F10), CoraLite® Plus 488
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Product Details
CL488-68121
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
3C9F10
Immunogen
MAN1B1 fusion protein Ag28302
Conjugate
CoraLite® Plus 488
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: LFLRKAEDF GNRLMPAFRT PSKIPYSDVN IGTGVAHPPR WTSDSTVAEV TSIQLEFREL SRLTGDKKFQ EAVEKVTQHI HGLSGKKDGL VPMFINTHSG LFTHLGVFTL GARADSYYEY LLKQWIQGGK QETQLLEDYV EAIEGVRTHL LRHSEPSKLT FVGELAHGRF SAKMDHLVCF LPGTLALGVY HGLPASHMEL AQELMETCYQ MNRQMETGLS PEIVHFNLYP QPGRRDVEVK PADRHNLLRP ETVESLFYLY RVTGDRKYQD WGWEILQSFS RFTRVPSGGY SSINNVQDPQ KPEPRDKMES FFLGETLKYL FLLFSDDPNL LSLDAYVFNT EAHPLPIWTP A
Target Information
Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2, but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man5-6GlcNAc2. Tremblay L.O., Glycobiology 9:1073-1078(1999) [PubMed: 10521544]. Gonzalez D.S., J. Biol. Chem. 274:21375-21386(1999) [PubMed: 10409699]. Clark H.F., Genome Res. 13:2265-2270(2003) [PubMed: 12975309].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3.2.1.113; endoplasmic Reticulum Class I alpha-mannosidase; Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1; ER alpha 1,2-mannosidase; ER alpha-1,2-mannosidase; ER mannosidase 1; ERMan1; Man9GlcNAc2-specific processing alpha-mannosidase; Man9GlcNAc2-specific-processing alpha-mannosidase; Mannosidase alpha class 1B member 1; mannosidase, alpha, class 1B, member 1; RP11-350O14.2
Gene Aliases: ERMAN1; ERManI; MAN1B1; MANA-ER; MRT15; UNQ747/PRO1477
UniProt ID: (Human) Q9UKM7
Entrez Gene ID: (Human) 11253
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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