Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: CGLRVTAIKI DPYINIDAGT FSPYEHGEVF VLNDGGEVDL DLGNYERFLD INLYKDNNIT TGKIYQHVIN KERRGDYLGK TVQVVPHITD AVQEWVMNQA KVPVDGNKEE PQICVIELGG TIGDIEGMPF VEAFRQFQFK AKRENFCNIH VSLVPQLSAT GEQKTKPTQN SVRALRGLGL SPDLIVCRSS TPIEMAVKEK ISMFCHVNPE QVICIHDVSS TYRVPVLLEE QSIVKYFKER LHLPIGDSAS NLLFKWRNMA DRYERLQKIC SIALVGKYTK LRDCYASVFK ALEHSALAIN HKLNLMYIDS IDLEKITETE DPVKFHEAWQ KLCKADGILV PGGF
The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CTP synthase 2; CTP synthase II; CTP synthetase 2; CTP synthetase homolog; CTP synthetase type 2; CTPsH; cytidine 5'-triphosphate synthetase 2; cytidine triphosphate synthase II; UTP--ammonia ligase 2; UTP-ammonia ligase 2
Gene Aliases: A830031M15Rik; AI326475; CTPS2; Ctpsh
UniProt ID: (Human) Q9NRF8, (Mouse) P70303
Entrez Gene ID: (Human) 56474, (Mouse) 55936
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