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Immunogen sequence: YPFLEAKEEF AHKTLAMDVM KPRRNDPLLT VLTQDSMTVE DVETIISETT YSGFPVVVSR ESQRLVGFVL RRDLIISIEN ARKKQDGVVS TSIIYFTEHS PPLPPYTPPT LKLRNILDLS PFTVTDLTPM EIVVDIFRKL GLRQCLVTHN GRLLGIITKK DVLKHIAQMA NQDPDSILFN; Positive Samples: SW480, U-937, HepG2, A673, NCI-H460, Mouse kidney, Mouse ovary, Mouse brain; Cellular Location: Cell membrane, Endosome membrane, Golgi apparatus membrane, Multi-pass membrane protein
Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Chloride channel protein 5; chloride channel, voltage-sensitive 5; Chloride transporter ClC-5; ClC-5; H(+)/Cl(-) exchange transporter 5; hClC-K2; voltage-gated chloride ion channel CLCN5
Gene Aliases: 5430408K11Rik; ClC-5; CLC5; CLCK2; CLCN5; D930009B12Rik; DENTS; DXImx42e; hCIC-K2; NPHL1; NPHL2; Sfc13; T25545; XLRH; XRN
UniProt ID: (Human) P51795, (Mouse) Q9WVD4
Entrez Gene ID: (Human) 1184, (Mouse) 12728
Molecular Function:
ion channel
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