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Invitrogen
CLN5 Polyclonal Antibody
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Application
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CLN5 Antibody (PA5-88837) in IHC (P)
Immunohistochemistry analysis of CLN5 in paraffin-embedded human appendix. Samples were incubated with CLN5 Polyclonal antibody (Product # PA5-88837) using a dilution of 1:150 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-88837
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 47-358 of human CLN5 (NP_006484.2).
Conjugate
Unconjugated
Form
Liquid
Concentration
2.8 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2805163
Product Specific Information
Immunogen sequence: IPSRRHWPVP YKRFDFRPKP DPYCQAKYTF CPTGSPIPVM EGDDDIEVFR LQAPVWEFKY GDLLGHLKIM HDAIGFRSTL TGKNYTMEWY ELFQLGNCTF PHLRPEMDAP FWCNQGAACF FEGIDDVHWK ENGTLVQVAT ISGNMFNQMA KWVKQDNETG IYYETWNVKA SPEKGAETWF DSYDCSKFVL RTFNKLAEFG AEFKNIETNY TRIFLYSGEP TYLGNETSVF GPTGNKTLGL AIKRFYYPFK PHLPTKEFLL SLLQIFDAVI VHKQFYLFYN FEYWFLPMKF PFIKITYEEI PLPIRNKTLS GL; Positive Samples: Mouse heart, Rat heart; Cellular Location: Lysosome
Target Information
This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function.[provided by RefSeq, Oct 2008].
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bis(monoacylglycero)phosphate synthase CLN5; BMP synthase CLN5; ceroid-lipofuscinosis; Ceroid-lipofuscinosis neuronal protein 5; ceroid-lipofuscinosis neuronal protein 5 homolog; Palmitoyl protein thioesterase CLN5; Protein CLN5; S-depalmitoylase CLN5
Gene Aliases: A730075N08Rik; BMPS; CLN5; NCL
UniProt ID: (Human) O75503, (Mouse) Q3UMW8
Entrez Gene ID: (Human) 1203, (Rat) 306128, (Mouse) 211286
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