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Application
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CLSTN1 Antibody (MA5-36139) in IHC (P)
Immunohistochemical analysis of CLSTN1 in paraffin-embedded human liver cancer tissue using a monoclonal antibody (Product #MA5-36139). The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (1:200) for 30 m... View More
Product Details
MA5-36139
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JE48-81
Immunogen
Recombinant protein within Human CLSTN1 aa 860-981
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
TBS, pH 7.4, with 0.05% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2890384
Target Information
CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alc-alpha; alcadein alpha; Alcadein-alpha; Alzheimer-related cadherin-like protein; cadherin-related family member 12; Calsyntenin-1; FLJ32258; Non-classical cadherin XB31alpha
Gene Aliases: 1810034E21Rik; ALC-ALPHA; alcalpha1; alcalpha2; CDHR12; CLSTN1; CS1; CST-1; CSTN1; KIAA0911; PIK3CD; XB31alpha
UniProt ID: (Human) O94985, (Mouse) Q9EPL2
Entrez Gene ID: (Human) 22883, (Mouse) 65945
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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