Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
CNTO 607 Biosimilar Recombinant Human Monoclonal Antibody
Product Details
MA5-59169
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG1
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Conjugate
Unconjugated
Form
Lyophilized
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
AB_3682187
Product Specific Information
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This antibody can also be cross referenced by the term CNTO 607.
Target Information
IL13 (Interleukin-13) is a gene located on chromosome 5q31, encoding the IL-13 cytokine, which plays a pivotal role in the immune system, particularly in the regulation of inflammatory and immune responses. IL-13 is predominantly secreted by Th2 cells and is involved in the pathogenesis of allergic reactions and chronic inflammatory conditions such as asthma and ulcerative colitis. This cytokine exerts its effects by binding to the IL-13 receptor complex, which includes IL-13R aplha 1 and IL-4R alpha. Upon binding, IL-13 activates several signaling pathways, including the JAK-STAT pathway, leading to the transcription of genes involved in the immune response. IL-13 is also implicated in tissue remodeling and fibrosis due to its ability to stimulate fibroblast proliferation and collagen production. Dysregulation of IL-13 expression or signaling is associated with various diseases, making it a target for therapeutic intervention, particularly in allergic and autoimmune conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support