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Product Details
BSM-0391M-HRP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG
Class
Monoclonal
Type
Antibody
Clone
C11F2
Immunogen
Recombinded CRP protein (amino acids 19-224).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
Target Information
CRP (C-reactive protein) is a major cyclic, pentameric acute phase protein compound consisting of five identical, noncovalently bound, nonglycosylated subunits. Eeach subunit is made up of 206 amino acids, and has a molecular weight of 24 kDa. CRP is produced by the liver, and its plasma levels rise dramatically during inflammatory processes occurring in the body. CRP is an initiator of classical complement cascade, binds to several nuclear components (chromatin, histones, etc.), plays an important role in innate immunity, and mediates activities associated with pre-immune nonspecific host resistance. Specifically, there is a 100-1000 fold increase of CRP in response to injury, infection or inflammation. CRP is opsonic, an initiator of the classical complement cascade, and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. CRP is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host, and initiates pathogen elimination by interacting with humoral and cellular effector systems in the blood. Patients with elevated basal levels of CRP have been shown to be an increased risk for hypertension and cardiovascular disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c reactive; C-reactive protein; C-reactive protein member of the pentraxin family; C-reactive protein, member of the pentraxin family; C-reactive protein, petaxin related; CSRP; CYRP; D1S181E; DKFZp686M148; DKFZp686M149; MGC149895; MGC88244; pentraxin 1; RP11-419N10.4
Gene Aliases: Aa1249; Ab1-341; Ab2-196; Ac1-114; Ac1262; Ac2-069; AI255847; Ba2-693; CRP; PTX1
UniProt ID: (Human) P02741, (Mouse) P14847, (Rat) P48199
Entrez Gene ID: (Human) 1401, (Mouse) 12944, (Rat) 25419
acute-phase response
inflammatory response
opsonization
positive regulation of gene expression
negative regulation of macrophage derived foam cell differentiation
negative regulation of lipid storage
positive regulation of superoxide anion generation
negative regulation of vasodilation
defense response to Gram-positive bacterium
regulation of interleukin-8 secretion
complement activation, classical pathway
regulation of low-density lipoprotein particle clearance
negative regulation of superoxide anion generation
wound healing
positive regulation of nitric oxide biosynthetic process
protein polymerization
cellular response to calcium ion
positive regulation of dendrite development
response to hypoxia
aging
response to radiation
response to lead ion
response to estradiol
response to testosterone
response to ethanol
cellular response to interleukin-6
cellular response to nitric oxide
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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