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Immunogen sequence: VYGNWNGPHR LYLQMSTHGK VRFRDIASPK FSMPSPVRTV ITADFDNDQE LEIFFNNIAY RSSSANRLFR VIRREHGDPL IEELNPGDAL EPEGRGTGGV VTDFDGDGML DLILSHGESM AQPLSVFRGN QGFNNNWLRV VPRTRFGAFA RGAKVVLYTK KSGAHLRIID GGSGYLCEME PVAHFGLGKD EASSVEVTWP DGKMVSRNVA SGEMNSVLEI LYPRDEDTLQ DPAPLECGQG FSQQENGHCM DTNECIQFPF VCPRDKPVCV NTYGSYRCRT NKKCSRGYEP NEDGTACVGT LGQSPGPRPT TPTAAAATAA AAAAAGAATA APVLVDGDLN LGSVVKESCE PSC
CRTAC1 encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 68 kDa chondrocyte-expressed protein; acidic secreted protein in cartilage; ASPIC; Cartilage acidic protein 1; CEP-68; chondrocyte expressed protein 68 kDa CEP-68; FLJ10320; Protein CRTAC1-B
Gene Aliases: 2810454P21Rik; ASPIC; ASPIC1; AW047536; CEP-68; CEP68; CRTAC-1; CRTAC1; Crtac1B; Lotus; W307
UniProt ID: (Human) Q9NQ79, (Mouse) Q8R555
Entrez Gene ID: (Rabbit) 100352703, (Human) 55118, (Pig) 100037974, (Mouse) 72832, (Rat) 171438
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