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Proteintech

CSNK1A1 Polyclonal Antibody

14 References

View all (19) CK1 alpha antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (9)

Application

CSNK1A1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 9

CSNK1A1 Antibody (55192-1-AP) in ICC/IF

Immunofluorescent analysis of A549 cells using 55192-1-AP (CSNK1A1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

CSNK1A1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

55192-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

View 3 publications 3 publications

Immunoprecipitation (IP)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated

Form

Liquid

Concentration

0.45 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to CSNK1A1.

Target Information

CNSK1A1 (CK1 alpha 1) is a member of the casein kinase I (CKI) gene family, which encodes serine/threonine kinases that preferentially phosphorylate acidic substrates. CKI proteins are monomeric, ranging from 25 to 55 kD, and are found in the nuclei, cytoplasm, and membrane fractions of eukaryotic cells. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Casein Kinase 1α Regulates Testosterone Synthesis and Testis Development in Adult Mice.

Endocrinology

Guo H,Zhang D,Zhou Y,Sun L,Li C,Luo X,Liu J,Cui S

Mon Mar 13 00:00:00 UTC 2023

Casein Kinase 1α Regulates Testosterone Synthesis and Testis Development in Adult Mice.

Endocrinology

Guo H,Zhang D,Zhou Y,Sun L,Li C,Luo X,Liu J,Cui S

Mon Mar 13 00:00:00 UTC 2023

Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression.

iScience

Lu C,Zhang J,Wang B,Gao Q,Ma K,Pei S,Li J,Cui S

Fri May 19 00:00:00 UTC 2023

The PRMT6/PARP1/CRL4B Complex Regulates the Circadian Clock and Promotes Breast Tumorigenesis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Yang T,Huang W,Ma T,Yin X,Zhang J,Huo M,Hu T,Gao T,Liu W,Zhang D,Yu H,Teng X,Zhang M,Qin H,Yang Y,Yuan B,Wang Y

Mon May 01 00:00:00 UTC 2023

Upregulation of CSNK1A1 induced by ITGB5 confers to hepatocellular carcinoma resistance to sorafenib in vivo by disrupting the EPS15/EGFR complex.

Pharmacological research

Gu L,Jin X,Liang H,Yang C,Zhang Y

Thu Jun 01 00:00:00 UTC 2023

Upregulation of CSNK1A1 induced by ITGB5 confers to hepatocellular carcinoma resistance to sorafenib in vivo by disrupting the EPS15/EGFR complex.

Pharmacological research

Gu L,Jin X,Liang H,Yang C,Zhang Y

Thu Jun 01 00:00:00 UTC 2023

Proto-oncogene FAM83A contributes to casein kinase 1-mediated mitochondrial maintenance and white adipocyte differentiation.

The Journal of biological chemistry

Huang K,Jia Z,Li H,Peng Y,Chen X,Luo N,Song T,Wang Y,Shi X,Kuang S,Yang G

Sat Oct 01 00:00:00 UTC 2022

Pantothenate Kinase 1 Inhibits the Progression of Hepatocellular Carcinoma by Negatively Regulating Wnt/β-catenin Signaling.

International journal of biological sciences

Zi Y,Gao J,Wang C,Guan Y,Li L,Ren X,Zhu L,Mu Y,Chen SH,Zeng Z,Cao Z,Rong Z,Chen P,Zhang X,Chen T,Xin H,Li X,Li Z,Sun L,Deng Y,Li N,Nie Y

Fri Apr 15 00:00:00 UTC 2022

CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1.

The Journal of cell biology

Deng X,Sun X,Yue W,Duan Y,Hu R,Zhang K,Ni J,Cui J,Wang Q,Chen Y,Li A,Fang Y

Mon Jan 03 00:00:00 UTC 2022

CK1α upregulates the IFNAR1 expression to prompt the anti-HBV effect of type I IFN in hepatoma carcinoma cells.

Virologica Sinica

Xiong J,Jiang Y,Zhang J,Chen Y,Hu Y

Thu Dec 01 00:00:00 UTC 2022

Nicotinamide improves in vitro lens regeneration in a mouse capsular bag model.

Stem cell research & therapy

Liu X,Zhou Q,Huang Y,Fan Z,Duan H,Wang M,Li Z,Xie L

Thu May 12 00:00:00 UTC 2022

Nicotinamide improves in vitro lens regeneration in a mouse capsular bag model.

Stem cell research & therapy

Liu X,Zhou Q,Huang Y,Fan Z,Duan H,Wang M,Li Z,Xie L

Thu May 12 00:00:00 UTC 2022

Fam83d modulates MAP kinase and AKT signaling and is induced during neurogenic skeletal muscle atrophy.

Cellular signalling

Cooper LM,Hanson A,Kavanagh JA,Waddell DS

Mon Jun 01 00:00:00 UTC 2020

Differentially expressed proteins identified by TMT proteomics analysis in bone marrow microenvironment of osteoporotic patients.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Zhou Q,Xie F,Zhou B,Wang J,Wu B,Li L,Kang Y,Dai R,Jiang Y

Wed May 01 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: casein kinase 1, alpha 1; Casein kinase I isoform alpha; casein kinase I-alpha; CK I alpha; CK-I alpha; CK1; CKI alpha; CKI-alpha; clock regulator kinase; CSNK1A1/CK1; down-regulated in lung cancer; epididymis secretory sperm binding protein Li 77p; OTTHUMP00000224000; OTTHUMP00000224001; OTTHUMP00000224003; YIL035C

Gene Aliases: 2610208K14Rik; 4632404G05Rik; 5430427P18Rik; CK1; CK1a; CKIa; Csnk1a; CSNK1A1; HEL-S-77p; HLCDGP1; PRO2975

UniProt ID: (Human) P48729, (Rat) P97633

Entrez Gene ID: (Human) 1452, (Rat) 113927, (Mouse) 93687

Function(s)

protein kinase activity protein serine/threonine kinase activity protein binding ATP binding kinase activity magnesium ion binding glycoprotein binding peptide binding phosphoprotein binding nucleotide binding transferase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase

Process(es)

protein phosphorylation phagocytosis Golgi organization mitotic nuclear division signal transduction cell surface receptor signaling pathway regulation of cell shape Wnt signaling pathway peptidyl-serine phosphorylation positive regulation of proteasomal ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process intermediate filament cytoskeleton organization cell division negative regulation of canonical Wnt signaling pathway regulation of GTP binding beta-catenin destruction complex assembly beta-catenin destruction complex disassembly cell morphogenesis cell cycle phosphorylation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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