Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: MAGLTVRDPA VDRSLRSVFV GNIPYEATEE QLKDIFSEVG PVVSFRLVYD RETGKPKGYG FCEYQDQETA LSAMRNLNGR EFSGRALRVD NAASEKNKEE LKSLGTGAPV IESPYGETIS PEDAPESISK AVASLPPEQM FELMKQMKLC VQNSPQEARN MLLQNPQLAY ALLQAQVVMR; Positive Samples: HeLa, Jurkat, HepG2, SW620, Mouse testis, Mouse thymus; Cellular Location: Nucleus
CSTF2 is one of three (including CSTF1 and CSTF3) cleavage stimulation factors which combine to form CSTF which is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. CSTF2 contains a ribonucleoprotein-type RNA binding domain. CSTF2 is upregulated during activation of B cells which results in the switch of IgM heavy chain mRNA from membrane bound form to the secreted form.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alphaCstF-64 variant 4; betaCstF-64 variant 1; betaCstF-64 variant 2; betaCstF-64 variant 3; CF-1 64 kDa subunit; Cleavage stimulation factor 64 kDa subunit; Cleavage stimulation factor subunit 2; cleavage stimulation factor, 3' pre-RNA subunit 2, 64 kDa; cleavage stimulation factor, 3' pre-RNA, subunit 2; cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kD; cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa; CstF 64; CSTF 64 kDa subunit
Gene Aliases: C630034J23Rik; CstF-64; CSTF2; Cstf64; mir-3112
UniProt ID: (Human) P33240, (Mouse) Q8BIQ5
Entrez Gene ID: (Human) 1478, (Rat) 683927, (Mouse) 108062
Molecular Function:
mRNA polyadenylation factor
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