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Invitrogen
CYFIP1 Polyclonal Antibody
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Application
FIGURE: 1 / 5
CYFIP1 Antibody (PA5-31984) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of CYFIP1 was performed in DIV9 rat E18 primary cortical neuron cells fixed in 4% paraformaldehyde at RT for 15 min. Green: CYFIP1 Polyclonal Antibody (Product # PA5-31984) diluted at 1:500. Red: beta Tubulin 3/ Tuj1, stained by beta Tubulin 3/ Tuj1 antibody. Blue: Fluoroshield with DAPI.
Product Details
PA5-31984
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the N-terminus region of human CYFIP1. The exact sequence is proprietary.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2549457
Product Specific Information
Recommended positive controls: HeLa, mouse brain, rat brain.
Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (93%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA. Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CYFIP1; Cytoplasmic FMR1-interacting protein 1; cytoplasmic FMRP interacting protein 1; FLJ45151; p140sra-1; selective hybridizing clone; Specifically Rac1-associated protein 1; Sra-1
Gene Aliases: CYFIP1; E030028J09Rik; KIAA0068; l(7)1Rl; l71Rl; l7Rl1; mKIAA0068; P140SRA-1; P140sra1; pl-1; SHYC; SRA-1; SRA1
UniProt ID: (Human) Q7L576, (Mouse) Q7TMB8
Entrez Gene ID: (Human) 23191, (Mouse) 20430, (Rat) 308666
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