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Product Details
83845-3-RR
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
240909E3
Immunogen
CYFIP2 fusion protein Ag8749
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: CYNGSTNRF VRTAIPFTQE PQRDKPANVQ PYYLYGSKPL NIAYSHIYSS YRNFVGPPHF KTICRLLGYQ GIAVVMEELL KIVKSLLQGT ILQYVKTLIE VMPKICRLPR HEYGSPGILE FFHHQLKDII EYAELKTDVF QSLREVGNAI LFCLLIEQAL SQEEVCDLLH AAPFQNILPR VYIKEGERLE VRMKRLEAKY APLHLVPLIE RLGTPQQIAI AREGDLLTKE RLCCGLSMFE VILTRIRSYL QDPIWRGPPP TNGVMHVDEC VEFHRLWSAM QFVYCIPVGT NEFTAEQCFG DGLNWAGCSI IVLLGQQRRF DLFDFCYHLL KVQRQDGKDE IIKNVPLKKM ADRIRKYQIL NNEVFAILNK YMKSVETDSS TVEHVRCFQP PIHQSLATTC
Target Information
CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CYFIP2; Cytoplasmic FMR1-interacting protein 2; p53-inducible protein 121
Gene Aliases: CYFIP2; KIAA1168; PIR121
UniProt ID: (Human) Q96F07
Entrez Gene ID: (Human) 26999
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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