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            • Primary Antibodies ›
            • CYP2A6 Antibodies

            OriGene

            CYP2A6 Monoclonal Antibody (OTI3C1), TrueMAB™

            View all (22) CYP2A6 antibodies
            Datasheet
            Protocols
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            Datasheet
            Protocols
            Questions & Answers

            Cite CYP2A6 Monoclonal Antibody (OTI3C1), TrueMAB™

            • Antibody Testing Data (4)
            Application
            CYP2A6 Antibody in Immunocytochemistry (ICC/IF)
            Group 53 Created with Sketch.

            FIGURE: 1 / 4

            CYP2A6 Antibody (TA503832) in ICC/IF

            Anti-CYP2A6 mouse monoclonal antibody (TA503832) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CYP2A6(RC222995).
            View Product

            CYP2A6 Antibody in Immunocytochemistry (ICC/IF)
            CYP2A6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            CYP2A6 Antibody in Western Blot (WB)
            CYP2A6 Antibody in Flow Cytometry (Flow)

            Product Details

            TA503832

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            1:2,000
            -

            Immunohistochemistry (Paraffin) (IHC (P))

            1:150
            -

            Immunocytochemistry (ICC/IF)

            1:100
            -

            Flow Cytometry (Flow)

            1:100
            -
            Product Specifications

            Species Reactivity

            Human

            Host/Isotype

            Mouse / IgG2a

            Class

            Monoclonal

            Type

            Antibody

            Clone

            OTI3C1

            Immunogen

            Full length human recombinant of human CYP2A6 produced in HEK293T cell.
            View immunogen

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            0.72 mg/mL

            Purification

            Affinity chromatography

            Storage buffer

            PBS with 1% BSA, 50% glycerol

            Contains

            0.02% sodium azide

            Storage conditions

            -20°C, Avoid Freeze/Thaw Cycles

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            Target Information

            This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            References (0)

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            Cite this product

            Bioinformatics

            Protein Aliases: 1,4-cineole 2-exo-monooxygenase; Coumarin 7-hydroxylase; CYP; CYPIIA6; Cytochrome P450 2A6; Cytochrome P450 IIA3; Cytochrome P450(I); cytochrome P450, family 2, subfamily A, polypeptide 6; cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6; flavoprotein-linked monooxygenase; P450; P450 IIA3; P450(I); xenobiotic monooxygenase

            View more View less

            Gene Aliases: CPA6; CYP2A; CYP2A3; CYP2A6; CYPIIA6; P450C2A; P450PB

            View more View less

            UniProt ID: (Human) P11509

            View more View less

            Entrez Gene ID: (Human) 1548

            View more View less

            Function(s)

            iron ion binding coumarin 7-hydroxylase activity arachidonic acid epoxygenase activity steroid hydroxylase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen enzyme binding heme binding oxidoreductase oxygenase metabolite interconversion enzyme

            Process(es)

            steroid metabolic process coumarin metabolic process drug metabolic process epoxygenase P450 pathway exogenous drug catabolic process coumarin catabolic process oxidation-reduction process
            It has to be done as per old AB suggested Products section.
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            If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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