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OriGene

CYP2A6 Monoclonal Antibody (OTI3C1), TrueMAB™

View all (22) CYP2A6 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (4)

Application

CYP2A6 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 4

CYP2A6 Antibody (TA503832) in ICC/IF

Anti-CYP2A6 mouse monoclonal antibody (TA503832) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CYP2A6(RC222995).

CYP2A6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CYP2A6 Antibody in Flow Cytometry (Flow)

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Product Details

TA503832

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

1:150

Immunocytochemistry (ICC/IF)

1:100

Flow Cytometry (Flow)

1:100

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

OTI3C1

Immunogen

Full length human recombinant of human CYP2A6 produced in HEK293T cell.

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.72 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 1,4-cineole 2-exo-monooxygenase; Coumarin 7-hydroxylase; CYP; CYPIIA6; Cytochrome P450 2A6; Cytochrome P450 IIA3; Cytochrome P450(I); cytochrome P450, family 2, subfamily A, polypeptide 6; cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6; flavoprotein-linked monooxygenase; P450; P450 IIA3; P450(I); xenobiotic monooxygenase

Gene Aliases: CPA6; CYP2A; CYP2A3; CYP2A6; CYPIIA6; P450C2A; P450PB

UniProt ID: (Human) P11509

Entrez Gene ID: (Human) 1548

Function(s)

iron ion binding coumarin 7-hydroxylase activity arachidonic acid epoxygenase activity steroid hydroxylase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen enzyme binding heme binding oxidoreductase oxygenase metabolite interconversion enzyme

Process(es)

steroid metabolic process coumarin metabolic process drug metabolic process epoxygenase P450 pathway exogenous drug catabolic process coumarin catabolic process oxidation-reduction process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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