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Invitrogen
CYP3A7 Polyclonal Antibody
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Application
FIGURE: 1 / 1
CYP3A7 Antibody (PA5-120066) in WB
Western blot analysis of CYP3A7 in extracts of various cell lines. Samples were incubated with CYP3A7 Polyclonal antibody (Product # PA5-120066) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
Product Details
PA5-120066
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 244-503 of human CYP3A7 (NP_000756.3).
Conjugate
Unconjugated
Form
Liquid
Concentration
0.94 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2913638
Product Specific Information
Positive test controls include: A-549, HT-29, Mouse liver, Mouse lung, Rat liver. The target is usually found in the following locations: Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein.
Immunogen sequence: KVISFLTKSV KQIKEGRLKE TQKHRVDFLQ LMIDSQNSKD SETHKALSDL ELMAQSIIFI FAGYETTSSV LSFIIYELAT HPDVQQKVQK EIDTVLPNKA PPTYDTVLQL EYLDMVVNET LRLFPVAMRL ERVCKKDVEI NGMFIPKGVV VMIPSYVLHH DPKYWTEPEK FLPERFSKKN KDNIDPYIYT PFGSGPRNCI GMRFALVNMK LALVRVLQNF SFKPCKETQI PLKLRFGGLL LTEKPIVLKA ESRDETVSGA
Target Information
This gene, CYP3A7, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described, but it is not known whether these transcripts are normally produced.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aryl hydrocarbon hydroxylase; CYPIIIA7; Cytochrome P450 3A7; cytochrome P450, family 3, subfamily A, polypeptide 7; cytochrome P450, subfamily IIIA, polypeptide 7; Cytochrome P450-HFLA; flavoprotein-linked monooxygenase; microsomal monooxygenase; P450HLp2; xenobiotic monooxygenase
Gene Aliases: CP37; CYP3A7; CYPIIIA7; P-450(HFL33); P-450111A7; P450-HFLA
UniProt ID: (Human) P24462
Entrez Gene ID: (Human) 1551
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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